메뉴 건너뛰기




Volumn 26, Issue 11, 2016, Pages 1325-1351

Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010–2015; part 1)

Author keywords

alpidem; DAA1106; emapunil; neurodegenerative disease; neuroinflammation; PBR; PBR28; PK 11195; Ro5 4864; TSPO

Indexed keywords

AC 5216 C 11; ACETAMIDE DERIVATIVE; ARYLOXYANILIDE DERIVATIVE; BENZIMIDAZOLONE ACETAMIDE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; BENZOXAZEPINE DERIVATIVE; BENZOXAZOLONE ACETAMIDE DERIVATIVE; CHOLESTEROL DERIVATIVE; DIBENZOTHIAZEPINE DERIVATIVE; EMAPUNIL; IMIDAZOPYRIDAZINE ACETAMIDE DERIVATIVE; IMIDAZOPYRIDINE DERIVATIVE; INDOLE DERIVATIVE; ISOQUINOLINE DERIVATIVE; LIGAND; MEMBRANE PROTEIN; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; OLESOXIME; PHENYLPURINE ACETAMIDE DERIVATIVE; PURINE DERIVATIVE; PYRAZOLOPYRIMIDINE DERIVATIVE; PYRAZOLOQUINOLINE ACETAMIDE DERIVATIVE; QUINAZOLINE CARBOXAMIDE DERIVATIVE; QUINAZOLINE DERIVATIVE; QUINOLINE CARBOXAMIDE DERIVATIVE; RADIOLIGAND; RO 54864; TRANSLOCATOR PROTEIN; TRANSLOCATOR PROTEIN LIGAND; UNCLASSIFIED DRUG; UNINDEXED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; TSPO PROTEIN, HUMAN;

EID: 84992121094     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1080/13543776.2016.1230606     Document Type: Review
Times cited : (34)

References (150)
  • 1
    • 0023554261 scopus 로고
    • The peripheral-type benzodiazepine receptor: a protein of mitochondrial outer membranes utilizing porphyrins as endogenous ligands
    • Oct
    • S.H.Snyder, A.Verma, R.R.Trifiletti The peripheral-type benzodiazepine receptor:a protein of mitochondrial outer membranes utilizing porphyrins as endogenous ligands. Faseb J. 1987 Oct;1(4):282–288.
    • (1987) Faseb J , vol.1 , Issue.4 , pp. 282-288
    • Snyder, S.H.1    Verma, A.2    Trifiletti, R.R.3
  • 2
    • 33746035655 scopus 로고    scopus 로고
    • Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function
    • Aug
    • V.Papadopoulos, M.Baraldi, T.R.Guilarte, et al. Translocator protein (18kDa):new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci. 2006 Aug;27(8):402–409.
    • (2006) Trends Pharmacol Sci , vol.27 , Issue.8 , pp. 402-409
    • Papadopoulos, V.1    Baraldi, M.2    Guilarte, T.R.3
  • 3
    • 0017730392 scopus 로고
    • High-densities of benzodiazepine receptors in human cortical areas
    • C.Braestrup, R.Albrechtsen, R.F.Squires. High-densities of benzodiazepine receptors in human cortical areas. Nature. 1977;269(5630):702–704.
    • (1977) Nature , vol.269 , Issue.5630 , pp. 702-704
    • Braestrup, C.1    Albrechtsen, R.2    Squires, R.F.3
  • 4
    • 0000114680 scopus 로고
    • Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding
    • C.Braestrup, R.F.Squires. Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding. Proc Natl Acad Sci U S A. 1977;74(9):3805–3809.
    • (1977) Proc Natl Acad Sci U S A , vol.74 , Issue.9 , pp. 3805-3809
    • Braestrup, C.1    Squires, R.F.2
  • 5
    • 20844451376 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into Leydig cell mitochondria
    • Feb
    • T.Hauet, Z.-X.Yao, H.S.Bose, et al. Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into Leydig cell mitochondria. Mol Endocrinol. 2005 Feb;19(2):540–554.
    • (2005) Mol Endocrinol , vol.19 , Issue.2 , pp. 540-554
    • Hauet, T.1    Yao, Z.-X.2    Bose, H.S.3
  • 6
    • 84860279460 scopus 로고    scopus 로고
    • The role of 18 kDa mitochondrial translocator protein (TSPO) in programmed cell death, and effects of steroids on TSPO expression
    • May
    • L.Veenman, M.Gavish. The role of 18 kDa mitochondrial translocator protein (TSPO) in programmed cell death, and effects of steroids on TSPO expression. Curr Mol Med. 2012 May;12(4):398–412.
    • (2012) Curr Mol Med , vol.12 , Issue.4 , pp. 398-412
    • Veenman, L.1    Gavish, M.2
  • 7
    • 0032707529 scopus 로고    scopus 로고
    • Enigma of the peripheral benzodiazepine receptor
    • Dec
    • M.Gavish, I.Bachman, R.Shoukrun, et al. Enigma of the peripheral benzodiazepine receptor. Pharmacol Rev. 1999 Dec;51(4):629–650.
    • (1999) Pharmacol Rev , vol.51 , Issue.4 , pp. 629-650
    • Gavish, M.1    Bachman, I.2    Shoukrun, R.3
  • 8
    • 0024590270 scopus 로고
    • Effects of peripheral benzodiazepines upon the O2 consumption of neuro-blastoma cells
    • Feb
    • J.C.Larcher, J.L.Vayssiere, F.J.Lemarquer, et al. Effects of peripheral benzodiazepines upon the O2 consumption of neuro-blastoma cells. Eur J Pharmacol. 1989 Feb 28;161(2–3):197–202.
    • (1989) Eur J Pharmacol , vol.161 , Issue.2-3 , pp. 197-202
    • Larcher, J.C.1    Vayssiere, J.L.2    Lemarquer, F.J.3
  • 9
    • 67649613018 scopus 로고    scopus 로고
    • Effect of peripheral benzodiazepine receptor (PBR/TSPO) ligands on opening of Ca2+-induced pore and phosphorylation of 3.5-kDa polypeptide in rat brain mitochondria
    • Apr
    • O.V.Krestinina, D.E.Grachev, I.V.Odinokova, et al. Effect of peripheral benzodiazepine receptor (PBR/TSPO) ligands on opening of Ca2+-induced pore and phosphorylation of 3.5-kDa polypeptide in rat brain mitochondria. Biochemistry-Moscow+. 2009 Apr;74(4):421–429.
    • (2009) Biochemistry-Moscow+ , vol.74 , Issue.4 , pp. 421-429
    • Krestinina, O.V.1    Grachev, D.E.2    Odinokova, I.V.3
  • 10
    • 84923241444 scopus 로고    scopus 로고
    • Positron emission tomography and functional characterization of a complete PBR/TSPO knockout
    • R.B.Banati, R.J.Middleton, R.Chan, et al. Positron emission tomography and functional characterization of a complete PBR/TSPO knockout. Nat Commun. 2014;5:5452.
    • (2014) Nat Commun , vol.5 , pp. 5452
    • Banati, R.B.1    Middleton, R.J.2    Chan, R.3
  • 11
    • 84892892196 scopus 로고    scopus 로고
    • The role of allopregnanolone in depression and anxiety
    • Feb
    • C.Schüle, C.Nothdurfter, R.Rupprecht. The role of allopregnanolone in depression and anxiety. Prog Neurobiol. 2014 Feb;113:79–87.
    • (2014) Prog Neurobiol , vol.113 , pp. 79-87
    • Schüle, C.1    Nothdurfter, C.2    Rupprecht, R.3
  • 12
    • 84924173806 scopus 로고    scopus 로고
    • Enhancing neurosteroid synthesis–relationship to the pharmacology of translocator protein (18 kDa) (TSPO) ligands and benzodiazepines
    • Mar
    • L.Wolf, A.Bauer, D.Melchner, et al. Enhancing neurosteroid synthesis–relationship to the pharmacology of translocator protein (18 kDa) (TSPO) ligands and benzodiazepines. Pharmacopsychiatry. 2015 Mar;48(2):72–77.
    • (2015) Pharmacopsychiatry , vol.48 , Issue.2 , pp. 72-77
    • Wolf, L.1    Bauer, A.2    Melchner, D.3
  • 13
    • 84907293074 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis
    • Oct
    • L.N.Tu, K.Morohaku, P.R.Manna, et al. Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis. J Biol Chem. 2014 Oct 3;289(40):27444–27454.
    • (2014) J Biol Chem , vol.289 , Issue.40 , pp. 27444-27454
    • Tu, L.N.1    Morohaku, K.2    Manna, P.R.3
  • 14
    • 84931274608 scopus 로고    scopus 로고
    • Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation
    • Jun
    • J.Fan, E.Campioli, A.Midzak, et al. Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7261–7266.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.23 , pp. 7261-7266
    • Fan, J.1    Campioli, E.2    Midzak, A.3
  • 15
    • 0026538576 scopus 로고
    • The mitochondrial benzodiazepine receptor: evidence for association with the voltage-dependent anion channel (VDAC)
    • Feb
    • M.W.McEnery. The mitochondrial benzodiazepine receptor:evidence for association with the voltage-dependent anion channel (VDAC). J Bioenerg Biomembr. 1992 Feb;24(1):63–69.
    • (1992) J Bioenerg Biomembr , vol.24 , Issue.1 , pp. 63-69
    • McEnery, M.W.1
  • 16
    • 84934907493 scopus 로고    scopus 로고
    • Parkin-mediated responses against infection and wound involve TSPO-VDAC complex in Drosophila
    • Jul
    • J.H.Cho, J.H.Park, C.G.Chung, et al. Parkin-mediated responses against infection and wound involve TSPO-VDAC complex in Drosophila. Biochem Biophys Res Commun. 2015 Jul 17–24;463(1–2):1–6.
    • (2015) Biochem Biophys Res Commun , vol.463 , Issue.1-2 , pp. 1-6
    • Cho, J.H.1    Park, J.H.2    Chung, C.G.3
  • 17
    • 84865682758 scopus 로고    scopus 로고
    • The mitochondrial permeability transition pore (PTP) - an example of multiple molecular exaptation?
    • Nov
    • A.Vianello, V.Casolo, E.Petrussa, et al. The mitochondrial permeability transition pore (PTP) - an example of multiple molecular exaptation? Biochim Biophys Acta. 2012 Nov;1817(11):2072–2086.
    • (2012) Biochim Biophys Acta , vol.1817 , Issue.11 , pp. 2072-2086
    • Vianello, A.1    Casolo, V.2    Petrussa, E.3
  • 18
    • 67349117275 scopus 로고    scopus 로고
    • What is the mitochondrial permeability transition pore?
    • Jun
    • A.P.Halestrap. What is the mitochondrial permeability transition pore? J Mol Cell Cardiol. 2009 Jun;46(6):821–831.
    • (2009) J Mol Cell Cardiol , vol.46 , Issue.6 , pp. 821-831
    • Halestrap, A.P.1
  • 19
    • 84901008605 scopus 로고    scopus 로고
    • Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (translocator protein of 18 kDa (TSPO))
    • May
    • J.Šileikytė, E.Blachly-Dyson, R.Sewell, et al. Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (translocator protein of 18 kDa (TSPO)). J Biol Chem. 2014 May 16;289(20):13769–13781.
    • (2014) J Biol Chem , vol.289 , Issue.20 , pp. 13769-13781
    • Šileikytė, J.1    Blachly-Dyson, E.2    Sewell, R.3
  • 20
    • 77955415606 scopus 로고    scopus 로고
    • Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states
    • Oct
    • A.Batarseh, V.Papadopoulos. Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Mol Cell Endocrinol. 2010 Oct 7;327(1–2):1–12.
    • (2010) Mol Cell Endocrinol , vol.327 , Issue.1-2 , pp. 1-12
    • Batarseh, A.1    Papadopoulos, V.2
  • 21
    • 34548238745 scopus 로고    scopus 로고
    • Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response
    • L.Veenman, V.Papadopoulos, M.Gavish. Channel-like functions of the 18-kDa translocator protein (TSPO):regulation of apoptosis and steroidogenesis as part of the host-defense response. Curr Pharm Des. 2007;13(23):2385–2405.
    • (2007) Curr Pharm Des , vol.13 , Issue.23 , pp. 2385-2405
    • Veenman, L.1    Papadopoulos, V.2    Gavish, M.3
  • 22
    • 52449115923 scopus 로고    scopus 로고
    • VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis
    • Jun
    • L.Veenman, Y.Shandalov, M.Gavish. VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis. J Bioenerg Biomembr. 2008 Jun;40(3):199–205.
    • (2008) J Bioenerg Biomembr , vol.40 , Issue.3 , pp. 199-205
    • Veenman, L.1    Shandalov, Y.2    Gavish, M.3
  • 23
    • 84892174249 scopus 로고    scopus 로고
    • Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis
    • M.Karlstetter, C.Nothdurfter, A.Aslanidis, et al. Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis. J Neuroinflammation. 2014;11:3.
    • (2014) J Neuroinflammation , vol.11 , pp. 3
    • Karlstetter, M.1    Nothdurfter, C.2    Aslanidis, A.3
  • 24
    • 84896333770 scopus 로고    scopus 로고
    • The translocator protein as a drug target in Alzheimer’s disease
    • Apr
    • S.W.Chua, M.Kassiou, L.M.Ittner. The translocator protein as a drug target in Alzheimer’s disease. Expert Rev Neurother. 2014 Apr;14(4):439–448.• This article highlighted TSPO as a promising drug target for AD.
    • (2014) Expert Rev Neurother , vol.14 , Issue.4 , pp. 439-448
    • Chua, S.W.1    Kassiou, M.2    Ittner, L.M.3
  • 25
    • 84971650049 scopus 로고    scopus 로고
    • TSPO as a target for treatments of diseases, including neuropathological disorders
    • L.Veenman, A.Vainshtein, M.Gavish. TSPO as a target for treatments of diseases, including neuropathological disorders. Cell Death Dis. 2015;6:e1911.
    • (2015) Cell Death Dis , vol.6 , pp. e1911
    • Veenman, L.1    Vainshtein, A.2    Gavish, M.3
  • 26
    • 28944443373 scopus 로고    scopus 로고
    • Extragonadal synthesis of estradiol is protective against kainic acid excitotoxic damage to the hippocampus
    • Sep
    • S.Veiga, I.Azcoitia, L.M.Garcia-Segura. Extragonadal synthesis of estradiol is protective against kainic acid excitotoxic damage to the hippocampus. Neuroreport. 2005 Sep 28;16(14):1599–1603.
    • (2005) Neuroreport , vol.16 , Issue.14 , pp. 1599-1603
    • Veiga, S.1    Azcoitia, I.2    Garcia-Segura, L.M.3
  • 27
    • 78649687576 scopus 로고    scopus 로고
    • Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders
    • Dec
    • R.Rupprecht, V.Papadopoulos, G.Rammes, et al. Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nat Rev Drug Discov. 2010 Dec;9(12):971–988.•• This review provides a summary of TSPO function.
    • (2010) Nat Rev Drug Discov , vol.9 , Issue.12 , pp. 971-988
    • Rupprecht, R.1    Papadopoulos, V.2    Rammes, G.3
  • 28
    • 84896998596 scopus 로고    scopus 로고
    • Structure of the mitochondrial translocator protein in complex with a diagnostic ligand
    • Mar
    • L.Jaremko, M.Jaremko, K.Giller, et al. Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science. 2014 Mar 21;343(6177):1363–1366.
    • (2014) Science , vol.343 , Issue.6177 , pp. 1363-1366
    • Jaremko, L.1    Jaremko, M.2    Giller, K.3
  • 29
    • 84946027944 scopus 로고    scopus 로고
    • Conformational flexibility in the transmembrane protein TSPO
    • Nov
    • Ł.Jaremko, M.Jaremko, K.Giller, et al. Conformational flexibility in the transmembrane protein TSPO. Chemistry. 2015 Nov 9;21(46):16555–16563.
    • (2015) Chemistry , vol.21 , Issue.46 , pp. 16555-16563
    • Jaremko, Ł.1    Jaremko, M.2    Giller, K.3
  • 30
    • 84921829870 scopus 로고    scopus 로고
    • Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism
    • Jan
    • F.Li, J.Liu, Y.Zheng, et al. Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism. Science. 2015 Jan 30;347(6221):555–558.
    • (2015) Science , vol.347 , Issue.6221 , pp. 555-558
    • Li, F.1    Liu, J.2    Zheng, Y.3
  • 31
    • 77953560009 scopus 로고    scopus 로고
    • Three-dimensional structure of TspO by electron cryomicroscopy of helical crystals
    • Jun
    • V.M.Korkhov, C.Sachse, J.M.Short, et al. Three-dimensional structure of TspO by electron cryomicroscopy of helical crystals. Structure. 2010 Jun 9;18(6):677–687.
    • (2010) Structure , vol.18 , Issue.6 , pp. 677-687
    • Korkhov, V.M.1    Sachse, C.2    Short, J.M.3
  • 32
    • 84921931701 scopus 로고    scopus 로고
    • Protein structure. Structure and activity of tryptophan-rich TSPO proteins
    • Jan
    • Y.Z.Guo, R.C.Kalathur, Q.Liu, et al. Protein structure. Structure and activity of tryptophan-rich TSPO proteins. Science. 2015 Jan 30;347(6221):551–555.
    • (2015) Science , vol.347 , Issue.6221 , pp. 551-555
    • Guo, Y.Z.1    Kalathur, R.C.2    Liu, Q.3
  • 33
    • 0031755752 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern
    • Dec
    • H.Li, V.Papadopoulos. Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology. 1998 Dec;139(12):4991–4997.
    • (1998) Endocrinology , vol.139 , Issue.12 , pp. 4991-4997
    • Li, H.1    Papadopoulos, V.2
  • 34
    • 59649098348 scopus 로고    scopus 로고
    • PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders
    • J.Doorduin, E.F.J.de Vries, R.A.Dierckx, et al. PET imaging of the peripheral benzodiazepine receptor:monitoring disease progression and therapy response in neurodegenerative disorders. Curr Pharm Des. 2008;14(31):3297–3315.
    • (2008) Curr Pharm Des , vol.14 , Issue.31 , pp. 3297-3315
    • Doorduin, J.1    de Vries, E.F.J.2    Dierckx, R.A.3
  • 35
    • 0027238911 scopus 로고
    • Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites–current status
    • May
    • V.W.Pike, C.Halldin, C.Crouzel, et al. Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites–current status. Nucl Med Biol. 1993 May;20(4):503–525.
    • (1993) Nucl Med Biol , vol.20 , Issue.4 , pp. 503-525
    • Pike, V.W.1    Halldin, C.2    Crouzel, C.3
  • 36
    • 0036355229 scopus 로고    scopus 로고
    • The concept of in vivo imaging of neuroinflammation with [11C](R)-PK11195 PET
    • A.Cagnin, A.Gerhard, R.B.Banati. The concept of in vivo imaging of neuroinflammation with [11C](R)-PK11195 PET. Ernst Schering Res Found Workshop. 2002;39:179–191.
    • (2002) Ernst Schering Res Found Workshop , Issue.39 , pp. 179-191
    • Cagnin, A.1    Gerhard, A.2    Banati, R.B.3
  • 37
    • 36249003354 scopus 로고    scopus 로고
    • Neuroinflammation in the pathophysiology of Parkinson’s disease: evidence from animal models to human in vivo studies with [11C]-PK11195 PET
    • Oct
    • A.L.Bartels, K.L.Leenders. Neuroinflammation in the pathophysiology of Parkinson’s disease:evidence from animal models to human in vivo studies with [11C]-PK11195 PET. Mov Disord. 2007 Oct 15;22(13):1852–1856.
    • (2007) Mov Disord , vol.22 , Issue.13 , pp. 1852-1856
    • Bartels, A.L.1    Leenders, K.L.2
  • 38
    • 10744230035 scopus 로고    scopus 로고
    • Evaluation of three quinoline-carboxamide derivatives as potential radioligands for the in vivo pet imaging of neurodegeneration
    • May
    • S.Belloli, R.M.Moresco, M.Matarrese, et al. Evaluation of three quinoline-carboxamide derivatives as potential radioligands for the in vivo pet imaging of neurodegeneration. Neurochem Int. 2004 May;44(6):433–440.
    • (2004) Neurochem Int , vol.44 , Issue.6 , pp. 433-440
    • Belloli, S.1    Moresco, R.M.2    Matarrese, M.3
  • 39
    • 25144465870 scopus 로고    scopus 로고
    • Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats
    • Nov
    • E.Leonelli, J.G.Yague, M.Ballabio, et al. Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats. Mech Ageing Dev. 2005 Nov;126(11):1159–1163.
    • (2005) Mech Ageing Dev , vol.126 , Issue.11 , pp. 1159-1163
    • Leonelli, E.1    Yague, J.G.2    Ballabio, M.3
  • 40
    • 84877753769 scopus 로고    scopus 로고
    • Ligand for translocator protein reverses pathology in a mouse model of Alzheimer’s disease
    • May
    • A.M.Barron, L.M.Garcia-Segura, D.Caruso, et al. Ligand for translocator protein reverses pathology in a mouse model of Alzheimer’s disease. J Neurosci. 2013 May 15;33(20):8891–8897.
    • (2013) J Neurosci , vol.33 , Issue.20 , pp. 8891-8897
    • Barron, A.M.1    Garcia-Segura, L.M.2    Caruso, D.3
  • 41
    • 4143123246 scopus 로고    scopus 로고
    • Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand
    • Aug
    • A.Kita, H.Kohayakawa, T.Kinoshita, et al. Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. Br J Pharmacol. 2004 Aug;142(7):1059–1072.
    • (2004) Br J Pharmacol , vol.142 , Issue.7 , pp. 1059-1072
    • Kita, A.1    Kohayakawa, H.2    Kinoshita, T.3
  • 42
    • 52449100136 scopus 로고    scopus 로고
    • Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis
    • Sep
    • F.Da Settimo, F.Simorini, S.Taliani, et al. Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis. J Med Chem. 2008 Sep 25;51(18):5798–5806.
    • (2008) J Med Chem , vol.51 , Issue.18 , pp. 5798-5806
    • Da Settimo, F.1    Simorini, F.2    Taliani, S.3
  • 43
    • 67651117272 scopus 로고    scopus 로고
    • Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects
    • Jul
    • R.Rupprecht, G.Rammes, D.Eser, et al. Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science. 2009 Jul 24;325(5939):490–493.
    • (2009) Science , vol.325 , Issue.5939 , pp. 490-493
    • Rupprecht, R.1    Rammes, G.2    Eser, D.3
  • 44
    • 67650075027 scopus 로고    scopus 로고
    • Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with (11)C-AC-5216
    • Jul
    • M.Miyoshi, H.Ito, R.Arakawa, et al. Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with (11)C-AC-5216. J Nucl Med. 2009 Jul;50(7):1095–1101.
    • (2009) J Nucl Med , vol.50 , Issue.7 , pp. 1095-1101
    • Miyoshi, M.1    Ito, H.2    Arakawa, R.3
  • 45
    • 0025121160 scopus 로고
    • Pharmacological and behavioral profile of alpidem as an anxiolytic
    • May
    • B.Zivkovic, E.Morel, D.Joly, et al. Pharmacological and behavioral profile of alpidem as an anxiolytic. Pharmacopsychiatry. 1990 May;23:108–113.
    • (1990) Pharmacopsychiatry , vol.23 , pp. 108-113
    • Zivkovic, B.1    Morel, E.2    Joly, D.3
  • 46
    • 0028319015 scopus 로고
    • Comparison of the efficacy, safety and withdrawal of alpidem and alprazolam in anxious patients
    • Jul
    • L.Frattola, M.Garreau, R.Piolti, et al. Comparison of the efficacy, safety and withdrawal of alpidem and alprazolam in anxious patients. Brit J Psychiat. 1994 Jul;165:94–100.
    • (1994) Brit J Psychiat , vol.165 , pp. 94-100
    • Frattola, L.1    Garreau, M.2    Piolti, R.3
  • 47
    • 0034768233 scopus 로고    scopus 로고
    • Toxicity of alpidem, a peripheral benzodiazepine receptor ligand, but not zolpidem, in rat hepatocytes: role of mitochondrial permeability transition and metabolic activation
    • Nov
    • A.Berson, V.Descatoire, A.Sutton, et al. Toxicity of alpidem, a peripheral benzodiazepine receptor ligand, but not zolpidem, in rat hepatocytes:role of mitochondrial permeability transition and metabolic activation. J Pharmacol Exp Ther. 2001 Nov;299(2):793–800.
    • (2001) J Pharmacol Exp Ther , vol.299 , Issue.2 , pp. 793-800
    • Berson, A.1    Descatoire, V.2    Sutton, A.3
  • 48
    • 0026806389 scopus 로고
    • 2-Aryl-3-indoleacetamides (Fgin-1) - a new class of potent and specific ligands for the mitochondrial Dbi receptor (Mdr)
    • Sep
    • E.Romeo, J.Auta, A.P.Kozikowski, et al. 2-Aryl-3-indoleacetamides (Fgin-1) - a new class of potent and specific ligands for the mitochondrial Dbi receptor (Mdr). J Pharmacol Exp Ther. 1992 Sep;262(3):971–978.
    • (1992) J Pharmacol Exp Ther , vol.262 , Issue.3 , pp. 971-978
    • Romeo, E.1    Auta, J.2    Kozikowski, A.P.3
  • 49
    • 0027443448 scopus 로고
    • Stimulation of brain steroidogenesis by 2-aryl-indole-3-acetamide derivatives acting at the mitochondrial diazepam-binding inhibitor receptor complex
    • Oct
    • E.Romeo, S.Cavallaro, A.Korneyev, et al. Stimulation of brain steroidogenesis by 2-aryl-indole-3-acetamide derivatives acting at the mitochondrial diazepam-binding inhibitor receptor complex. J Pharmacol Exp Ther. 1993 Oct;267(1):462–471.
    • (1993) J Pharmacol Exp Ther , vol.267 , Issue.1 , pp. 462-471
    • Romeo, E.1    Cavallaro, S.2    Korneyev, A.3
  • 50
    • 0036264571 scopus 로고    scopus 로고
    • SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1 -acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair
    • Jun
    • B.Ferzaz, E.Brault, G.Bourliaud, et al. SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1 -acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair. J Pharmacol Exp Ther. 2002 Jun;301(3):1067–1078.
    • (2002) J Pharmacol Exp Ther , vol.301 , Issue.3 , pp. 1067-1078
    • Ferzaz, B.1    Brault, E.2    Bourliaud, G.3
  • 51
    • 79953737531 scopus 로고    scopus 로고
    • In vivo imaging of neuroinflammation in the rodent brain with [11C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa)
    • Mar
    • F.Chauveau, H.Boutin, N.Van Camp, et al. In vivo imaging of neuroinflammation in the rodent brain with [11C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa). Eur J Nucl Med Mol Imaging. 2011 Mar;38(3):509–514.
    • (2011) Eur J Nucl Med Mol Imaging , vol.38 , Issue.3 , pp. 509-514
    • Chauveau, F.1    Boutin, H.2    Van Camp, N.3
  • 52
    • 84894427619 scopus 로고    scopus 로고
    • [F-18]fluoromethyl-PBR28 as a potential radiotracer for TSPO: preclinical comparison with [C-11]PBR28 in a rat model of neuroinflammation
    • Feb
    • B.S.Moon, B.S.Kim, C.Park, et al. [F-18]fluoromethyl-PBR28 as a potential radiotracer for TSPO:preclinical comparison with [C-11]PBR28 in a rat model of neuroinflammation. Bioconjugate Chem. 2014 Feb;25(2):442–450.
    • (2014) Bioconjugate Chem , vol.25 , Issue.2 , pp. 442-450
    • Moon, B.S.1    Kim, B.S.2    Park, C.3
  • 53
    • 38149021285 scopus 로고    scopus 로고
    • The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: implications for PET imaging of neuroinflammation in lentiviral encephalitis
    • Feb
    • S.Venneti, G.Wang, C.A.Wiley. The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration:implications for PET imaging of neuroinflammation in lentiviral encephalitis. Neurobiol Dis. 2008 Feb;29(2):232–241.
    • (2008) Neurobiol Dis , vol.29 , Issue.2 , pp. 232-241
    • Venneti, S.1    Wang, G.2    Wiley, C.A.3
  • 54
    • 34547123812 scopus 로고    scopus 로고
    • Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis
    • Aug
    • T.Bordet, B.Buisson, M.Michaud, et al. Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J Pharmacol Exp Ther. 2007 Aug;322(2):709–720.
    • (2007) J Pharmacol Exp Ther , vol.322 , Issue.2 , pp. 709-720
    • Bordet, T.1    Buisson, B.2    Michaud, M.3
  • 55
    • 84885920071 scopus 로고    scopus 로고
    • TRO19622 promotes myelin repair in a rat model of demyelination
    • Nov
    • Y.Q.Li, Y.Y.Zhang, W.W.Han, et al. TRO19622 promotes myelin repair in a rat model of demyelination. Int J Neurosci. 2013 Nov;123(11):810–822.
    • (2013) Int J Neurosci , vol.123 , Issue.11 , pp. 810-822
    • Li, Y.Q.1    Zhang, Y.Y.2    Han, W.W.3
  • 56
    • 84892373557 scopus 로고    scopus 로고
    • Molecular therapeutic strategies for spinal muscular atrophies: current and future clinical trials
    • Jan
    • C.Zanetta, M.Nizzardo, C.Simone, et al. Molecular therapeutic strategies for spinal muscular atrophies:current and future clinical trials. Clin Ther. 2014 Jan;36(1):128–140.
    • (2014) Clin Ther , vol.36 , Issue.1 , pp. 128-140
    • Zanetta, C.1    Nizzardo, M.2    Simone, C.3
  • 57
    • 43849100475 scopus 로고    scopus 로고
    • Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand binding
    • Jun
    • S.Murail, J.C.Robert, Y.M.Coic, et al. Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand binding. Biochim Biophys Acta. 2008 Jun;1778(6):1375–1381.
    • (2008) Biochim Biophys Acta , vol.1778 , Issue.6 , pp. 1375-1381
    • Murail, S.1    Robert, J.C.2    Coic, Y.M.3
  • 58
    • 0028585940 scopus 로고
    • Site-directed mutagenesis of the peripheral benzodiazepine receptor: identification of amino acids implicated in the binding site of Ro5-4864
    • Dec
    • R.Farges, E.Joseph-Liauzun, D.Shire, et al. Site-directed mutagenesis of the peripheral benzodiazepine receptor:identification of amino acids implicated in the binding site of Ro5-4864. Mol Pharmacol. 1994 Dec;46(6):1160–1167.
    • (1994) Mol Pharmacol , vol.46 , Issue.6 , pp. 1160-1167
    • Farges, R.1    Joseph-Liauzun, E.2    Shire, D.3
  • 59
    • 84856429837 scopus 로고    scopus 로고
    • Computational studies on translocator protein (TSPO) and its ligands
    • G.Ortore, T.Tuccinardi, A.Martinelli. Computational studies on translocator protein (TSPO) and its ligands. Curr Top Med Chem. 2012;12(4):352–359.
    • (2012) Curr Top Med Chem , vol.12 , Issue.4 , pp. 352-359
    • Ortore, G.1    Tuccinardi, T.2    Martinelli, A.3
  • 60
    • 84883234112 scopus 로고    scopus 로고
    • Characterization and modeling of the oligomeric state and ligand binding behavior of purified translocator protein 18 kDa from Rhodobacter sphaeroides
    • Aug
    • F.Li, Y.Xia, J.Meiler, et al. Characterization and modeling of the oligomeric state and ligand binding behavior of purified translocator protein 18 kDa from Rhodobacter sphaeroides. Biochemistry-Us. 2013 Aug 27;52(34):5884–5899.
    • (2013) Biochemistry-Us , vol.52 , Issue.34 , pp. 5884-5899
    • Li, F.1    Xia, Y.2    Meiler, J.3
  • 61
    • 85029236421 scopus 로고    scopus 로고
    • Identification of novel ligands targeted to the cholesterol recognition/interaction amino acid consensus (CRAC) domain of the translocator protein (TSPO)
    • Jun
    • A.S.Midzak, N.Akula, L.Lecanu, et al. Identification of novel ligands targeted to the cholesterol recognition/interaction amino acid consensus (CRAC) domain of the translocator protein (TSPO). Endocr Rev. 2010 Jun;31(3):S2494–S94.
    • (2010) Endocr Rev , vol.31 , Issue.3 , pp. S2494
    • Midzak, A.S.1    Akula, N.2    Lecanu, L.3
  • 62
    • 84940724646 scopus 로고    scopus 로고
    • Evolving understanding of translocator protein 18 kDa (TSPO)
    • Sep
    • F.Li, J.Liu, R.M.Garavito, et al. Evolving understanding of translocator protein 18 kDa (TSPO). Pharmacol Res. 2015 Sep;99:404–409.
    • (2015) Pharmacol Res , vol.99 , pp. 404-409
    • Li, F.1    Liu, J.2    Garavito, R.M.3
  • 63
    • 84868087742 scopus 로고    scopus 로고
    • Identification of a dynamic mitochondrial protein complex driving cholesterol import, trafficking, and metabolism to steroid hormones
    • Nov
    • M.B.Rone, A.S.Midzak, L.Issop, et al. Identification of a dynamic mitochondrial protein complex driving cholesterol import, trafficking, and metabolism to steroid hormones. Mol Endocrinol. 2012 Nov;26(11):1868–1882.
    • (2012) Mol Endocrinol , vol.26 , Issue.11 , pp. 1868-1882
    • Rone, M.B.1    Midzak, A.S.2    Issop, L.3
  • 64
    • 79851473610 scopus 로고    scopus 로고
    • Mixed-affinity binding in humans with 18-kDa translocator protein ligands
    • Jan
    • D.R.J.Owen, R.N.Gunn, E.A.Rabiner, et al. Mixed-affinity binding in humans with 18-kDa translocator protein ligands. J Nucl Med. 2011 Jan;52(1):24–32.• This article contains a summary of the mixed binding affinity.
    • (2011) J Nucl Med , vol.52 , Issue.1 , pp. 24-32
    • Owen, D.R.J.1    Gunn, R.N.2    Rabiner, E.A.3
  • 65
    • 84979031920 scopus 로고    scopus 로고
    • Translocator protein 18 kDa (TSPO): an old protein with new functions?
    • May
    • F.Li, J.Liu, N.Liu, et al. Translocator protein 18 kDa (TSPO):an old protein with new functions? Biochemistry. 2016 May 9;55(20):2821–2831.
    • (2016) Biochemistry
    • Li, F.1    Liu, J.2    Liu, N.3
  • 66
    • 84945410815 scopus 로고    scopus 로고
    • Comment on “Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism
    • Oct
    • J.Wang. Comment on “Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism”. Science. 2015 Oct 30;350(6260):519.
    • (2015) Science , vol.350 , Issue.6260 , pp. 519
    • Wang, J.1
  • 67
    • 84945410815 scopus 로고    scopus 로고
    • Response to comment on “Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism
    • Oct
    • F.Li, J.Liu, Y.Zheng, et al. Response to comment on “Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism”. Science. 2015 Oct 30;350(6260):519.
    • (2015) Science , vol.350 , Issue.6260 , pp. 519
    • Li, F.1    Liu, J.2    Zheng, Y.3
  • 68
    • 84878158934 scopus 로고    scopus 로고
    • [11C]PK11195 PET imaging of spinal glial activation after nerve injury in rats
    • Oct
    • N.Imamoto, S.Momosaki, M.Fujita, et al. [11C]PK11195 PET imaging of spinal glial activation after nerve injury in rats. NeuroImage. 2013 Oct 1;79:121–128.
    • (2013) NeuroImage , vol.79 , pp. 121-128
    • Imamoto, N.1    Momosaki, S.2    Fujita, M.3
  • 70
    • 77949270219 scopus 로고    scopus 로고
    • Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation
    • Mar
    • J.Hirvonen, A.Roivainen, J.Virta, et al. Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation. Eur J Nucl Med Mol Imaging. 2010 Mar;37(3):606–612.
    • (2010) Eur J Nucl Med Mol Imaging , vol.37 , Issue.3 , pp. 606-612
    • Hirvonen, J.1    Roivainen, A.2    Virta, J.3
  • 71
    • 25844495011 scopus 로고    scopus 로고
    • Medicinal chemical properties of successful central nervous system drugs
    • Oct
    • H.Pajouhesh, G.R.Lenz. Medicinal chemical properties of successful central nervous system drugs. NeuroRx. 2005 Oct;2(4):541–553.
    • (2005) NeuroRx , vol.2 , Issue.4 , pp. 541-553
    • Pajouhesh, H.1    Lenz, G.R.2
  • 72
    • 0035865790 scopus 로고    scopus 로고
    • Labeling and evaluation of N-[11C]methylated quinoline-2-carboxamides as potential radioligands for visualization of peripheral benzodiazepine receptors
    • Feb
    • M.Matarrese, R.M.Moresco, A.Cappelli, et al. Labeling and evaluation of N-[11C]methylated quinoline-2-carboxamides as potential radioligands for visualization of peripheral benzodiazepine receptors. J Med Chem. 2001 Feb 15;44(4):579–585.
    • (2001) J Med Chem , vol.44 , Issue.4 , pp. 579-585
    • Matarrese, M.1    Moresco, R.M.2    Cappelli, A.3
  • 73
    • 0042732948 scopus 로고    scopus 로고
    • Structure-activity relationships in carboxamide derivatives based on the targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine receptor ligands
    • Aug
    • A.Cappelli, G.Pericot Mohr, A.Gallelli, et al. Structure-activity relationships in carboxamide derivatives based on the targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine receptor ligands. J Med Chem. 2003 Aug 14;46(17):3568–3571.
    • (2003) J Med Chem , vol.46 , Issue.17 , pp. 3568-3571
    • Cappelli, A.1    Pericot Mohr, G.2    Gallelli, A.3
  • 74
    • 33646199161 scopus 로고    scopus 로고
    • Synthesis, labeling, and biological evaluation of halogenated 2-quinolinecarboxamides as potential radioligands for the visualization of peripheral benzodiazepine receptors
    • Jun
    • A.Cappelli, M.Matarrese, R.M.Moresco, et al. Synthesis, labeling, and biological evaluation of halogenated 2-quinolinecarboxamides as potential radioligands for the visualization of peripheral benzodiazepine receptors. Bioorg Med Chem. 2006 Jun 15;14(12):4055–4066.
    • (2006) Bioorg Med Chem , vol.14 , Issue.12 , pp. 4055-4066
    • Cappelli, A.1    Matarrese, M.2    Moresco, R.M.3
  • 75
    • 44449123579 scopus 로고    scopus 로고
    • Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor
    • Jun
    • W.Yu, E.Wang, R.J.Voll, et al. Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor. Bioorg Med Chem. 2008 Jun 1;16(11):6145–6155.
    • (2008) Bioorg Med Chem , vol.16 , Issue.11 , pp. 6145-6155
    • Yu, W.1    Wang, E.2    Voll, R.J.3
  • 77
    • 0242299669 scopus 로고    scopus 로고
    • Expression of peripheral benzodiazepine receptor (PBR) in human tumors: relationship to breast, colorectal, and prostate tumor progression
    • Z.Han, R.S.Slack, W.Li, et al. Expression of peripheral benzodiazepine receptor (PBR) in human tumors:relationship to breast, colorectal, and prostate tumor progression. J Recept Signal Transduct Res. 2003;23(2–3):225–238.
    • (2003) J Recept Signal Transduct Res , vol.23 , Issue.2-3 , pp. 225-238
    • Han, Z.1    Slack, R.S.2    Li, W.3
  • 78
    • 79951534507 scopus 로고    scopus 로고
    • TSPO 18 kDa (PBR) targeted photosensitizers for cancer imaging (PET) and PDT
    • Feb
    • Y.Chen, M.Sajjad, Y.Wang, et al. TSPO 18 kDa (PBR) targeted photosensitizers for cancer imaging (PET) and PDT. ACS Med Chem Lett. 2011 Feb 10;2(2):136–141.
    • (2011) ACS Med Chem Lett , vol.2 , Issue.2 , pp. 136-141
    • Chen, Y.1    Sajjad, M.2    Wang, Y.3
  • 79
    • 84897411408 scopus 로고    scopus 로고
    • Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors
    • Mar
    • S.Castellano, S.Taliani, M.Viviano, et al. Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors. J Med Chem. 2014 Mar 27;57(6):2413–2428.
    • (2014) J Med Chem , vol.57 , Issue.6 , pp. 2413-2428
    • Castellano, S.1    Taliani, S.2    Viviano, M.3
  • 80
    • 84861054375 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein
    • May
    • S.Castellano, S.Taliani, C.Milite, et al. Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein. J Med Chem. 2012 May 10;55(9):4506–4510.
    • (2012) J Med Chem , vol.55 , Issue.9 , pp. 4506-4510
    • Castellano, S.1    Taliani, S.2    Milite, C.3
  • 82
    • 84937397405 scopus 로고    scopus 로고
    • Design, synthesis and anxiolytic-like activity of 1-arylpyrrolo[1,2-a]pyrazine-3-carboxamides
    • Jul
    • G.V.Mokrov, O.A.Deeva, T.A.Gudasheva, et al. Design, synthesis and anxiolytic-like activity of 1-arylpyrrolo[1,2-a]pyrazine-3-carboxamides. Bioorg Med Chem. 2015 Jul 1;23(13):3368–3378.
    • (2015) Bioorg Med Chem , vol.23 , Issue.13 , pp. 3368-3378
    • Mokrov, G.V.1    Deeva, O.A.2    Gudasheva, T.A.3
  • 83
    • 0022374863 scopus 로고
    • Validation of open: closedarm entries in an elevated plus-maze as a measure of anxiety in the rat
    • Aug
    • S.Pellow, P.Chopin, S.E.File, et al. Validation of open:closedarm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods. 1985 Aug;14(3):149–167.
    • (1985) J Neurosci Methods , vol.14 , Issue.3 , pp. 149-167
    • Pellow, S.1    Chopin, P.2    File, S.E.3
  • 86
    • 0033548505 scopus 로고    scopus 로고
    • Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106
    • S.Okuyama, S.Chaki, R.Yoshikawa, et al. Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106. Life Sci. 1999;64(16):1455–1464.
    • (1999) Life Sci , vol.64 , Issue.16 , pp. 1455-1464
    • Okuyama, S.1    Chaki, S.2    Yoshikawa, R.3
  • 88
    • 0346690184 scopus 로고    scopus 로고
    • Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands
    • Jan
    • T.Okubo, R.Yoshikawa, S.Chaki, et al. Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands. Bioorg Med Chem. 2004 Jan 15;12(2):423–438.
    • (2004) Bioorg Med Chem , vol.12 , Issue.2 , pp. 423-438
    • Okubo, T.1    Yoshikawa, R.2    Chaki, S.3
  • 90
    • 79953660905 scopus 로고    scopus 로고
    • Structural requirements to obtain highly potent and selective 18 kDa translocator protein (TSPO) ligands
    • S.Taliani, I.Pugliesi, F.Da Settimo. Structural requirements to obtain highly potent and selective 18 kDa translocator protein (TSPO) ligands. Curr Top Med Chem. 2011;11(7):860–886.
    • (2011) Curr Top Med Chem , vol.11 , Issue.7 , pp. 860-886
    • Taliani, S.1    Pugliesi, I.2    Da Settimo, F.3
  • 91
    • 37849053628 scopus 로고    scopus 로고
    • Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo
    • Jan
    • E.Briard, S.S.Zoghbi, M.Imaizumi, et al. Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo. J Med Chem. 2008 Jan 10;51(1):17–30.
    • (2008) J Med Chem , vol.51 , Issue.1 , pp. 17-30
    • Briard, E.1    Zoghbi, S.S.2    Imaizumi, M.3
  • 92
    • 79851499878 scopus 로고    scopus 로고
    • Quantitative, preclinical PET of translocator protein expression in glioma using F-18-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline
    • Jan
    • J.R.Buck, E.T.McKinley, M.R.Hight, et al. Quantitative, preclinical PET of translocator protein expression in glioma using F-18-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline. J Nucl Med. 2011 Jan 1;52(1):107–114.
    • (2011) J Nucl Med , vol.52 , Issue.1 , pp. 107-114
    • Buck, J.R.1    McKinley, E.T.2    Hight, M.R.3
  • 93
    • 80052707691 scopus 로고    scopus 로고
    • Synthesis of [C-11]PBR06 and [F-18]PBR06 as agents for positron emission tomographic (PET) imaging of the translocator protein (TSPO)
    • Nov
    • M.Wang, M.Z.Gao, K.D.Miller, et al. Synthesis of [C-11]PBR06 and [F-18]PBR06 as agents for positron emission tomographic (PET) imaging of the translocator protein (TSPO). Steroids. 2011 Nov;76(12):1331–1340.
    • (2011) Steroids , vol.76 , Issue.12 , pp. 1331-1340
    • Wang, M.1    Gao, M.Z.2    Miller, K.D.3
  • 94
    • 0037212103 scopus 로고    scopus 로고
    • [18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR)
    • Jan
    • M.R.Zhang, J.Maeda, K.Furutsuka, et al. [18F]FMDAA1106 and [18F]FEDAA1106:two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR). Bioorg Med Chem Lett. 2003 Jan 20;13(2):201–204.
    • (2003) Bioorg Med Chem Lett , vol.13 , Issue.2 , pp. 201-204
    • Zhang, M.R.1    Maeda, J.2    Furutsuka, K.3
  • 95
    • 84878784892 scopus 로고    scopus 로고
    • In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [18F]FEDAA1106
    • A.Takano, F.Piehl, J.Hillert, et al. In vivo TSPO imaging in patients with multiple sclerosis:a brain PET study with [18F]FEDAA1106. EJNMMI Res. 2013;3(1):30.
    • (2013) EJNMMI Res , vol.3 , Issue.1 , pp. 30
    • Takano, A.1    Piehl, F.2    Hillert, J.3
  • 96
    • 84891702940 scopus 로고    scopus 로고
    • In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer’s disease patients
    • Jun
    • A.Varrone, P.Mattsson, A.Forsberg, et al. In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer’s disease patients. Eur J Nucl Med Mol Imaging. 2013 Jun;40(6):921–931.
    • (2013) Eur J Nucl Med Mol Imaging , vol.40 , Issue.6 , pp. 921-931
    • Varrone, A.1    Mattsson, P.2    Forsberg, A.3
  • 97
    • 84937763794 scopus 로고    scopus 로고
    • (11)C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas
    • Jun
    • E.Park, J.-D.Gallezot, A.Delgadillo, et al. (11)C-PBR28 imaging in multiple sclerosis patients and healthy controls:test-retest reproducibility and focal visualization of active white matter areas. Eur J Nucl Med Mol Imaging. 2015 Jun;42(7):1081–1092.
    • (2015) Eur J Nucl Med Mol Imaging , vol.42 , Issue.7 , pp. 1081-1092
    • Park, E.1    Gallezot, J.-D.2    Delgadillo, A.3
  • 100
    • 40749142849 scopus 로고    scopus 로고
    • Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors
    • Apr
    • A.A.Wilson, A.Garcia, J.Parkes, et al. Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors. Nucl Med Biol. 2008 Apr;35(3):305–314.
    • (2008) Nucl Med Biol , vol.35 , Issue.3 , pp. 305-314
    • Wilson, A.A.1    Garcia, A.2    Parkes, J.3
  • 101
    • 84885710671 scopus 로고    scopus 로고
    • Neuroinflammation in healthy aging: a PET study using a novel translocator protein 18kDa (TSPO) radioligand, [(18)F]-FEPPA
    • Jan
    • I.Suridjan, P.M.Rusjan, A.N.Voineskos, et al. Neuroinflammation in healthy aging:a PET study using a novel translocator protein 18kDa (TSPO) radioligand, [(18)F]-FEPPA. NeuroImage. 2014 Jan 1;84:868–875.
    • (2014) NeuroImage , vol.84 , pp. 868-875
    • Suridjan, I.1    Rusjan, P.M.2    Voineskos, A.N.3
  • 102
    • 84908510509 scopus 로고    scopus 로고
    • Quantitative imaging of neuroinflammation in human white matter: a positron emission tomography study with translocator protein 18 kDa radioligand, [18F]-FEPPA
    • Nov
    • I.Suridjan, P.M.Rusjan, M.Kenk, et al. Quantitative imaging of neuroinflammation in human white matter:a positron emission tomography study with translocator protein 18 kDa radioligand, [18F]-FEPPA. Synapse. 2014 Nov;68(11):536–547.
    • (2014) Synapse , vol.68 , Issue.11 , pp. 536-547
    • Suridjan, I.1    Rusjan, P.M.2    Kenk, M.3
  • 103
    • 84947615776 scopus 로고    scopus 로고
    • In-vivo imaging of grey and white matter neuroinflammation in Alzheimer’s disease: a positron emission tomography study with a novel radioligand, [18F]-FEPPA
    • Feb
    • I.Suridjan, B.G.Pollock, N.P.Verhoeff, et al. In-vivo imaging of grey and white matter neuroinflammation in Alzheimer’s disease:a positron emission tomography study with a novel radioligand, [18F]-FEPPA. Mol Psychiatry. 2015 Feb 24;20(12):1579–1587.
    • (2015) Mol Psychiatry
    • Suridjan, I.1    Pollock, B.G.2    Verhoeff, N.P.3
  • 104
    • 84920171026 scopus 로고    scopus 로고
    • Image derived input function for [18F]-FEPPA: application to quantify translocator protein (18 kDa) in the human brain
    • R.Mabrouk, P.M.Rusjan, R.Mizrahi, et al. Image derived input function for [18F]-FEPPA:application to quantify translocator protein (18 kDa) in the human brain. PLoS One. 2014;9(12):e115768.
    • (2014) PLoS One , vol.9 , Issue.12 , pp. e115768
    • Mabrouk, R.1    Rusjan, P.M.2    Mizrahi, R.3
  • 105
    • 84928798486 scopus 로고    scopus 로고
    • Imaging neuroinflammation in gray and white matter in schizophrenia: an in-vivo PET study with [18F]-FEPPA
    • Jan
    • M.Kenk, T.Selvanathan, N.Rao, et al. Imaging neuroinflammation in gray and white matter in schizophrenia:an in-vivo PET study with [18F]-FEPPA. Schizophr Bull. 2015 Jan;41(1):85–93.
    • (2015) Schizophr Bull , vol.41 , Issue.1 , pp. 85-93
    • Kenk, M.1    Selvanathan, T.2    Rao, N.3
  • 108
    • 17744386969 scopus 로고    scopus 로고
    • Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity
    • Apr
    • S.Veiga, I.Azcoitia, L.M.Garcia-Segura. Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity. J Neurosci Res. 2005 Apr 1;80(1):129–137.
    • (2005) J Neurosci Res , vol.80 , Issue.1 , pp. 129-137
    • Veiga, S.1    Azcoitia, I.2    Garcia-Segura, L.M.3
  • 109
    • 56749175080 scopus 로고    scopus 로고
    • Neuroprotective effect of Ro5-4864 following brain injury
    • Dec
    • J.F.Soustiel, M.Zaaroor, E.Vlodavsky, et al. Neuroprotective effect of Ro5-4864 following brain injury. Exp Neurol. 2008 Dec;214(2):201–208.
    • (2008) Exp Neurol , vol.214 , Issue.2 , pp. 201-208
    • Soustiel, J.F.1    Zaaroor, M.2    Vlodavsky, E.3
  • 111
    • 9544219672 scopus 로고    scopus 로고
    • Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific “peripheral-type” benzodiazepine receptor ligands
    • Aug
    • G.Campiani, V.Nacci, I.Fiorini, et al. Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific “peripheral-type” benzodiazepine receptor ligands. J Med Chem. 1996 Aug 30;39(18):3435–3450.
    • (1996) J Med Chem , vol.39 , Issue.18 , pp. 3435-3450
    • Campiani, G.1    Nacci, V.2    Fiorini, I.3
  • 112
    • 0037068436 scopus 로고    scopus 로고
    • Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR)
    • Sep
    • G.Campiani, A.Ramunno, I.Fiorini, et al. Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR). J Med Chem. 2002 Sep 12;45(19):4276–4281.
    • (2002) J Med Chem , vol.45 , Issue.19 , pp. 4276-4281
    • Campiani, G.1    Ramunno, A.2    Fiorini, I.3
  • 115
    • 33745596837 scopus 로고    scopus 로고
    • 5-aryl-imidazo[2,1-c][1,4]benzodiazepine derivatives as tricyclic constrained analogues of diazepam and Ro5-4864. Synthesis and binding properties at peripheral and central benzodiazepine receptors
    • Jun
    • E.Rizzetto, S.Castellano, C.Florio, et al. 5-aryl-imidazo[2,1-c][1,4]benzodiazepine derivatives as tricyclic constrained analogues of diazepam and Ro5-4864. Synthesis and binding properties at peripheral and central benzodiazepine receptors. Die Pharmazie. 2006 Jun;61(6):505–510.
    • (2006) Die Pharmazie , vol.61 , Issue.6 , pp. 505-510
    • Rizzetto, E.1    Castellano, S.2    Florio, C.3
  • 116
    • 0029793981 scopus 로고    scopus 로고
    • Molecular basis of peripheral vs central benzodiazepine receptor selectivity in a new class of peripheral benzodiazepine receptor ligands related to alpidem
    • Oct
    • M.Anzini, A.Cappelli, S.Vomero, et al. Molecular basis of peripheral vs central benzodiazepine receptor selectivity in a new class of peripheral benzodiazepine receptor ligands related to alpidem. J Med Chem. 1996 Oct 11;39(21):4275–4284.
    • (1996) J Med Chem , vol.39 , Issue.21 , pp. 4275-4284
    • Anzini, M.1    Cappelli, A.2    Vomero, S.3
  • 117
    • 84930209686 scopus 로고    scopus 로고
    • 2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line
    • Aug
    • A.Midzak, N.Denora, V.Laquintana, et al. 2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line. Eur J Pharm Sci. 2015 Aug 30;76:231–237.
    • (2015) Eur J Pharm Sci , vol.76 , pp. 231-237
    • Midzak, A.1    Denora, N.2    Laquintana, V.3
  • 118
    • 56249143493 scopus 로고    scopus 로고
    • 2-Phenyl-imidazo[1,2-a]pyridine compounds containing hydrophilic groups as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity and electrophysiological studies
    • Nov
    • N.Denora, V.Laquintana, M.G.Pisu, et al. 2-Phenyl-imidazo[1,2-a]pyridine compounds containing hydrophilic groups as potent and selective ligands for peripheral benzodiazepine receptors:synthesis, binding affinity and electrophysiological studies. J Med Chem. 2008 Nov 13;51(21):6876–6888.
    • (2008) J Med Chem , vol.51 , Issue.21 , pp. 6876-6888
    • Denora, N.1    Laquintana, V.2    Pisu, M.G.3
  • 119
    • 84866743619 scopus 로고    scopus 로고
    • Novel codrugs with GABAergic activity for dopamine delivery in the brain
    • Nov
    • N.Denora, T.Cassano, V.Laquintana, et al. Novel codrugs with GABAergic activity for dopamine delivery in the brain. Int J Pharm. 2012 Nov 1;437(1–2):221–231.
    • (2012) Int J Pharm , vol.437 , Issue.1-2 , pp. 221-231
    • Denora, N.1    Cassano, T.2    Laquintana, V.3
  • 120
    • 84957818686 scopus 로고    scopus 로고
    • A novel PET imaging probe for the detection and monitoring of translocator protein 18 kDa expression in pathological disorders
    • M.Perrone, B.S.Moon, H.S.Park, et al. A novel PET imaging probe for the detection and monitoring of translocator protein 18 kDa expression in pathological disorders. Sci Rep. 2016;6:20422.
    • (2016) Sci Rep , vol.6 , pp. 20422
    • Perrone, M.1    Moon, B.S.2    Park, H.S.3
  • 121
    • 40949117086 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationship studies in peripheral benzodiazepine receptor ligands related to alpidem
    • Mar
    • A.Cappelli, G.Giuliani, S.Valenti, et al. Synthesis and structure-activity relationship studies in peripheral benzodiazepine receptor ligands related to alpidem. Bioorg Med Chem. 2008 Mar 15;16(6):3428–3437.
    • (2008) Bioorg Med Chem , vol.16 , Issue.6 , pp. 3428-3437
    • Cappelli, A.1    Giuliani, G.2    Valenti, S.3
  • 122
    • 80054954224 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold
    • Oct
    • A.Cappelli, G.Bini, S.Valenti, et al. Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold. J Med Chem. 2011 Oct 27;54(20):7165–7175.
    • (2011) J Med Chem , vol.54 , Issue.20 , pp. 7165-7175
    • Cappelli, A.1    Bini, G.2    Valenti, S.3
  • 125
    • 0034846643 scopus 로고    scopus 로고
    • 2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands
    • Oct
    • S.Selleri, F.Bruni, C.Costagli, et al. 2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands. Bioorg Med Chem. 2001 Oct;9(10):2661–2671.
    • (2001) Bioorg Med Chem , vol.9 , Issue.10 , pp. 2661-2671
    • Selleri, S.1    Bruni, F.2    Costagli, C.3
  • 126
    • 44149118198 scopus 로고    scopus 로고
    • DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization
    • May
    • M.L.James, R.R.Fulton, J.Vercoullie, et al. DPA-714, a new translocator protein-specific ligand:synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med. 2008 May;49(5):814–822.
    • (2008) J Nucl Med , vol.49 , Issue.5 , pp. 814-822
    • James, M.L.1    Fulton, R.R.2    Vercoullie, J.3
  • 128
    • 84922883622 scopus 로고    scopus 로고
    • In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET
    • Mar
    • C.Vicidomini, M.Panico, A.Greco, et al. In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET. Nucl Med Biol. 2015 Mar;42(3):309–316.
    • (2015) Nucl Med Biol , vol.42 , Issue.3 , pp. 309-316
    • Vicidomini, C.1    Panico, M.2    Greco, A.3
  • 129
    • 84895829890 scopus 로고    scopus 로고
    • Preparation and evaluation of novel pyrazolo[1,5-a]pyrimidine acetamides, closely related to DPA-714, as potent ligands for imaging the TSPO 18kDa with PET
    • Mar
    • V.Médran-Navarrete, A.Damont, M.-A.Peyronneau, et al. Preparation and evaluation of novel pyrazolo[1,5-a]pyrimidine acetamides, closely related to DPA-714, as potent ligands for imaging the TSPO 18kDa with PET. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1550–1556.
    • (2014) Bioorg Med Chem Lett , vol.24 , Issue.6 , pp. 1550-1556
    • Médran-Navarrete, V.1    Damont, A.2    Peyronneau, M.-A.3
  • 130
    • 84925490787 scopus 로고    scopus 로고
    • [18F]DPA-714 PET imaging of translocator protein TSPO (18 kDa) in the normal and excitotoxically-lesioned nonhuman primate brain
    • Mar
    • S.Lavisse, K.Inoue, C.Jan, et al. [18F]DPA-714 PET imaging of translocator protein TSPO (18 kDa) in the normal and excitotoxically-lesioned nonhuman primate brain. Eur J Nucl Med Mol Imaging. 2015 Mar;42(3):478–494.
    • (2015) Eur J Nucl Med Mol Imaging , vol.42 , Issue.3 , pp. 478-494
    • Lavisse, S.1    Inoue, K.2    Jan, C.3
  • 131
    • 84876883279 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging
    • Apr
    • D.Tang, E.T.McKinley, M.R.Hight, et al. Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines:discovery of a novel TSPO PET ligand for cancer imaging. J Med Chem. 2013 Apr 25;56(8):3429–3433.
    • (2013) J Med Chem , vol.56 , Issue.8 , pp. 3429-3433
    • Tang, D.1    McKinley, E.T.2    Hight, M.R.3
  • 132
    • 84923556920 scopus 로고    scopus 로고
    • Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO)
    • Mar
    • S.D.Banister, C.Beinat, S.M.Wilkinson, et al. Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO). Eur J Med Chem. 2015 Mar 26;93:392–400.
    • (2015) Eur J Med Chem , vol.93 , pp. 392-400
    • Banister, S.D.1    Beinat, C.2    Wilkinson, S.M.3
  • 133
    • 84942284228 scopus 로고    scopus 로고
    • Novel pyrazolo[1,5-a]pyrimidines as translocator protein 18 kDa (TSPO) ligands: synthesis, in vitro biological evaluation, [(18)F]-labeling, and in vivo neuroinflammation PET images
    • Sep
    • A.Damont, V.Médran-Navarrete, F.Cacheux, et al. Novel pyrazolo[1,5-a]pyrimidines as translocator protein 18 kDa (TSPO) ligands:synthesis, in vitro biological evaluation, [(18)F]-labeling, and in vivo neuroinflammation PET images. J Med Chem. 2015 Sep 24;58(18):7449–7464.
    • (2015) J Med Chem , vol.58 , Issue.18 , pp. 7449-7464
    • Damont, A.1    Médran-Navarrete, V.2    Cacheux, F.3
  • 135
    • 0036184049 scopus 로고    scopus 로고
    • Tay-Sachs and Sandhoff diseases: enzymatic diagnosis in dried blood spots on filter paper: retrospective diagnoses in newborn-screening cards
    • Apr
    • N.A.Chamoles, M.Blanco, D.Gaggioli, et al. Tay-Sachs and Sandhoff diseases:enzymatic diagnosis in dried blood spots on filter paper:retrospective diagnoses in newborn-screening cards. Clin Chim Acta. 2002 Apr;318(1–2):133–137.
    • (2002) Clin Chim Acta , vol.318 , Issue.1-2 , pp. 133-137
    • Chamoles, N.A.1    Blanco, M.2    Gaggioli, D.3
  • 139
    • 84926671031 scopus 로고    scopus 로고
    • Anxiolytic-like effects of translocator protein (TSPO) ligand ZBD-2 in an animal model of chronic pain
    • D.-S.Wang, Z.Tian, -Y.-Y.Guo, et al. Anxiolytic-like effects of translocator protein (TSPO) ligand ZBD-2 in an animal model of chronic pain. Mol Pain. 2015;11:16.
    • (2015) Mol Pain , vol.11 , pp. 16
    • Wang, D.-S.1    Tian, Z.2    Guo, -Y.-Y.3
  • 141
    • 84866240889 scopus 로고    scopus 로고
    • Design, synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands
    • Sep
    • T.Fukaya, T.Kodo, T.Ishiyama, et al. Design, synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands. Bioorg Med Chem. 2012 Sep 15;20(18):5568–5582.
    • (2012) Bioorg Med Chem , vol.20 , Issue.18 , pp. 5568-5582
    • Fukaya, T.1    Kodo, T.2    Ishiyama, T.3
  • 142
    • 84886552984 scopus 로고    scopus 로고
    • Identification of a novel benzoxazolone derivative as a selective, orally active 18 kDa translocator protein (TSPO) ligand
    • Oct
    • T.Fukaya, T.Ishiyama, S.Baba, et al. Identification of a novel benzoxazolone derivative as a selective, orally active 18 kDa translocator protein (TSPO) ligand. J Med Chem. 2013 Oct 24;56(20):8191–8195.
    • (2013) J Med Chem , vol.56 , Issue.20 , pp. 8191-8195
    • Fukaya, T.1    Ishiyama, T.2    Baba, S.3
  • 143
    • 84873721829 scopus 로고    scopus 로고
    • Design, synthesis and structure-activity relationship of novel tricyclic benzimidazolone derivatives as potent 18 kDa translocator protein (TSPO) ligands
    • Mar
    • T.Fukaya, T.Kodo, T.Ishiyama, et al. Design, synthesis and structure-activity relationship of novel tricyclic benzimidazolone derivatives as potent 18 kDa translocator protein (TSPO) ligands. Bioorg Med Chem. 2013 Mar 1;21(5):1257–1267.
    • (2013) Bioorg Med Chem , vol.21 , Issue.5 , pp. 1257-1267
    • Fukaya, T.1    Kodo, T.2    Ishiyama, T.3
  • 144
    • 84899486540 scopus 로고    scopus 로고
    • Characterization of a novel acetamidobenzoxazolone-based PET ligand for translocator protein (18 kDa) imaging of neuroinflammation in the brain
    • May
    • A.K.Tiwari, J.Yui, M.Fujinaga, et al. Characterization of a novel acetamidobenzoxazolone-based PET ligand for translocator protein (18 kDa) imaging of neuroinflammation in the brain. J Neurochem. 2014 May;129(4):712–720.
    • (2014) J Neurochem , vol.129 , Issue.4 , pp. 712-720
    • Tiwari, A.K.1    Yui, J.2    Fujinaga, M.3
  • 145
    • 84910020373 scopus 로고    scopus 로고
    • Synthesis and evaluation of new (18)F-labelled acetamidobenzoxazolone-based radioligands for imaging of the translocator protein (18 kDa, TSPO) in the brain
    • Dec
    • A.K.Tiwari, M.Fujinaga, J.Yui, et al. Synthesis and evaluation of new (18)F-labelled acetamidobenzoxazolone-based radioligands for imaging of the translocator protein (18 kDa, TSPO) in the brain. Org Biomol Chem. 2014 Dec 21;12(47):9621–9630.
    • (2014) Org Biomol Chem , vol.12 , Issue.47 , pp. 9621-9630
    • Tiwari, A.K.1    Fujinaga, M.2    Yui, J.3
  • 146
    • 84945936058 scopus 로고    scopus 로고
    • [18F]FEBMP: positron emission tomography imaging of TSPO in a model of neuroinflammation in rats, and in vitro autoradiograms of the human brain
    • A.K.Tiwari, B.Ji, J.Yui, et al. [18F]FEBMP:positron emission tomography imaging of TSPO in a model of neuroinflammation in rats, and in vitro autoradiograms of the human brain. Theranostics. 2015;5(9):961–969.
    • (2015) Theranostics , vol.5 , Issue.9 , pp. 961-969
    • Tiwari, A.K.1    Ji, B.2    Yui, J.3
  • 148
    • 84971602793 scopus 로고    scopus 로고
    • Tetrapyrroles as endogenous TSPO ligands in eukaryotes and prokaryotes: comparisons with synthetic ligands
    • L.Veenman, A.Vainshtein, N.Yasin, et al. Tetrapyrroles as endogenous TSPO ligands in eukaryotes and prokaryotes:comparisons with synthetic ligands. Int J Mol Sci. 2016;17(6):880.
    • (2016) Int J Mol Sci , vol.17 , Issue.6
    • Veenman, L.1    Vainshtein, A.2    Yasin, N.3
  • 149
    • 84860303350 scopus 로고    scopus 로고
    • PK11195 inhibits mitophagy targeting the F1Fo-ATPsynthase in Bcl-2 knock-down cells
    • May
    • M.S.Seneviratne, D.Faccenda, V.De Biase, et al. PK11195 inhibits mitophagy targeting the F1Fo-ATPsynthase in Bcl-2 knock-down cells. Curr Mol Med. 2012 May;12(4):476–482.
    • (2012) Curr Mol Med , vol.12 , Issue.4 , pp. 476-482
    • Seneviratne, M.S.1    Faccenda, D.2    De Biase, V.3
  • 150
    • 84939161869 scopus 로고    scopus 로고
    • Protein-ligand and membrane-ligand interactions in pharmacology: the case of the translocator protein (TSPO)
    • Oct
    • C.R.Hatty, R.B.Banati. Protein-ligand and membrane-ligand interactions in pharmacology:the case of the translocator protein (TSPO). Pharmacol Res. 2015 Oct;100:58–63.
    • (2015) Pharmacol Res , vol.100 , pp. 58-63
    • Hatty, C.R.1    Banati, R.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.