Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific 'peripheral-type' benzodiazepine receptor ligands

Journal of Medicinal Chemistry

Volumn 39, Issue 18, 1996, Pages 3435-3450

  Campiani, Giuseppe ^a   Nacci, Vito ^a   Fiorini, Isabella ^a   De Filippis, Maria P ^a   Garofalo, Antonio ^a   Ciani, Silvia M ^a   Greco, Giovanni ^b   Novellino, Ettore ^b   Williams, D Clive ^c   Zisterer, Daniela M ^c   Woods, Margaret J ^c   Mihai, Camelia ^c   Manzoni, Cristina ^d   Mennini, Tiziana ^d  

^a UNIVERSITY OF SIENA   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c TRINITY COLLEGE DUBLIN   (Ireland)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4' CHLORODIAZEPAM; BENZODIAZEPINE RECEPTOR; BENZYL DERIVATIVE; LIGAND; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; OXAZEPINE DERIVATIVE; PYRROLE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; HYDROGEN BOND; LIGAND BINDING; MOLECULAR MODEL; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY; RECEPTOR OCCUPANCY; STEROIDOGENESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZODIAZEPINONES; BINDING SITES; CEREBRAL CORTEX; ISOQUINOLINES; LIGANDS; MICE; RATS; RATS, WISTAR; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 9544219672     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960251b     Document Type: Article

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