Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold

Journal of Medicinal Chemistry

Volumn 54, Issue 20, 2011, Pages 7165-7175

  Cappelli, Andrea ^a   Bini, Giulia ^a   Valenti, Salvatore ^a   Giuliani, Germano ^a   Paolino, Marco ^a   Anzini, Maurizio ^a   Vomero, Salvatore ^a   Giorgi, Gianluca ^a   Giordani, Antonio ^b   Stasi, Luigi Piero ^b   Makovec, Francesco ^b   Ghelardini, Carla ^c   Di Cesare Mannelli, Lorenzo ^c   Concas, Alessandra ^d   Porcu, Patrizia ^d   Biggio, Giovanni ^d  

^a UNIVERSITY OF SIENA   (Italy)

^b Rotta Research Laboratorium   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 METHYL 3 OXO 2 PHENYL 2,3 DIHYDRO 1H PYRAZOLO [3,4 B] QUINOLIN 1 YL) ACETAMIDE DERIVATIVE; 2 (4 METHYL 3 OXO 2 PHENYL 2H PYRAZOLO [3,4 B] QUINOLIN 9(3H) YL) ACETAMIDE DERIVATIVE; 4 METHYL 2 PHENYL 1H PYRAZOLO [3,4 B] QUINOLIN 3(2H) ONE DERIVATIVE; ACETAMIDE DERIVATIVE; BROMOACETAMIDE DERIVATIVE; CARRIER PROTEIN; EMAPUNIL; MOLECULAR SCAFFOLD; N (4 CHLOROPHENYL) 2[2(4 CHLOROPHENYL) 4 METHYL 3 OXO 2,3 DIHYDRO 1H PYRAZOLO [3,4 B] QUINOLIN 1 YL] N METHYLACETAMIDE; N (4 CHLOROPHENYL) 2[2(4 FLUOROPHENYL) 4 METHYL 3 OXO 2,3 DIHYDRO 1H PYRAZOLO [3,4 B] QUINOLIN 1 YL) N METHYLACETAMIDE; N (4 CHLOROPHENYL) N METHYL 2 (4 METHYL 3 OXO 2 PHENYL 2,3 DIHYDRO H PYRAZOLO [3,4 B] QUINOLIN 1 YL) ACETAMIDE; N BUTYL N METHYL 2 (4 METHYL 3 OXO 2 PHENYL 2H PYRAZOLO [3,4 B] QUINOLIN 9(3H) YL) ACETAMIDE; PYRAZOLO [3,4 B] QUINOLINE; QUINOLINE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG ISOLATION; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-ANXIETY AGENTS; CARRIER PROTEINS; CEREBRAL CORTEX; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGANDS; MALE; MICE; MODELS, MOLECULAR; MONONEUROPATHIES; PYRAZOLES; QUINOLINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80054954224     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200770f     Document Type: Article

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