Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 11, 2008, Pages 6145-6155

  Yu, Weiping ^a   Wang, Eric ^a   Voll, Ronald J ^a   Miller, Andrew H ^a   Goodman, Mark M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fluorine 18; Inflammation; Peripheral benzodiazepine receptor; PK11195; Positron emission tomography

Indexed keywords

1 (2 IODOPHENYL) N METHYL N (3 FLUOROPROPYL) 3 ISOQUINOLINE CARBOXAMIDE; 4' CHLORODIAZEPAM; 7 CHLORO N,N,5 TRIMETHYL 4 OXO 3 PHENYL 3,5 DIHYDRO 4H PYRIDAZINO[4,5 B]INDOLE 1 ACETAMIDE; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; DIAZEPAM; FGIN 1 27; FLUORINE 18; ISOQUINOLINE DERIVATIVE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N,N DI N HEXYL 2 (4 FLUOROPHENYL)INDOLE 3 ACETAMIDE; RADIOLIGAND; RO 54864; SSR 180575;

ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ISOTOPE LABELING; MITOCHONDRIAL MEMBRANE; POSITRON EMISSION TOMOGRAPHY;

ANIMALS; BINDING, COMPETITIVE; FLUORINE RADIOISOTOPES; ISOQUINOLINES; KIDNEY; LIGANDS; MITOCHONDRIAL MEMBRANES; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RATS; RECEPTORS, GABA-A;

PRIMATES; RATTUS;

EID: 44449123579     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.04.046     Document Type: Article

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