In vivo imaging and characterization of [18F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET

Nuclear Medicine and Biology

Volumn 42, Issue 3, 2015, Pages 309-316

  Vicidomini, Caterina ^a,c   Panico, Mariarosaria ^a,c   Greco, Adelaide ^b,c   Gargiulo, Sara ^a,c   Coda, Anna Rita Daniela ^a,c   Zannetti, Antonella ^a,c   Gramanzini, Matteo ^a,c   Roviello, Giovanni N ^a   Quarantelli, Mario ^a   Alfano, Bruno ^a   Tavitian, Bertrand ^d,e   Dollé, Frederic ^e   Salvatore, Marco ^b   Brunetti, Arturo ^b,c   Pappatà, Sabina ^a  

^a CNR   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^d PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

^e SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

Author keywords

Biodistribution; Microglia; Neuroinflammation; PET; TSPO; 18F DPA 714

Indexed keywords

BENZODIAZEPINE RECEPTOR; N,N DIETHYL 2 [2 [4 (2 FLUOROETHOXY)PHENYL] 5,7 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE F 18; RADIOPHARMACEUTICAL AGENT; TRANSLOCATOR PROTEIN 18; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; BZRP PROTEIN, MOUSE; FLUORINE; ISOQUINOLINE DERIVATIVE; LIGAND; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N,N-DIETHYL-2-(2-(4-(2-FLUOROETHOXY)PHENYL)-5,7-DIMETHYLPYRAZOLO(1,5-A)PYRIMIDIN-3-YL)ACETAMIDE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; COMPETITIVE INHIBITION; CONTROLLED STUDY; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; LUNG; MALE; MOUSE; NONHUMAN; PET-CT SCANNER; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; SPLEEN; TISSUE DISTRIBUTION; ANIMAL; BINDING COMPETITION; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC USE; DRUG EFFECTS; METABOLISM; RADIOGRAPHY; SCINTISCANNING;

ANIMALS; BINDING, COMPETITIVE; BRAIN; FLUORINE RADIOISOTOPES; ISOQUINOLINES; LIGANDS; MALE; MICE; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; PYRIMIDINES; RECEPTORS, GABA; TISSUE DISTRIBUTION; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84922883622     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2014.11.009     Document Type: Article

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