2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands

Bioorganic and Medicinal Chemistry

Volumn 9, Issue 10, 2001, Pages 2661-2671

  Selleri, Silvia ^a   Bruni, Fabrizio ^a   Costagli, Camilla ^a   Costanzo, Annarella ^a   Guerrini, Gabriella ^a   Ciciani, Giovanna ^a   Costa, Barbara ^b   Martini, Claudia ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

7 CHLORO 2 (3 PYRIDYL) ALPHA TETRALONE; ALPIDEM; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR; CLONAZEPAM; DAA 1097; DAA 1106; FGIN 127; FLUMAZENIL; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N,N DIETHYL(2 PHENYL 5 METHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL)ACETAMIDE; N,N DIETHYL(2 PHENYL 5,7 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL)ACETAMIDE; N,N DIETHYL(2 PHENYL 7 METHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL)ACETAMIDE; N,N DIETHYL(2 PHENYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL)ACETAMIDE; N,N DIETHYL(PYRAZOLO[1,5 A]PYRIMIDIN 3 YL)ACETAMIDE DERIVATIVE; N,N DIETHYL[2 (4 CHLOROPHENYL) 5,7 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE; N,N DIETHYL[2 (4 CHLOROPHENYL) 7 METHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE; N,N DIETHYL[2 (4 FLUOROPHENYL) 5 METHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE; N,N DIETHYL[2 (4 FLUOROPHENYL) 5,7 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE; N,N DIETHYL[2 (4 METHOXYPHENYL) 5,7 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE; N,N DIETHYL[2 (4 METHYLPHENYL) 5 METHYL 7 TRIFLUOROMETHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE; N,N DIETHYL[2 (4 METHYLPHENYL) 5 TRIFLUOROMETHYL 7 METHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE; N,N DIETHYL[2 (4 METHYLPHENYL) 5,7 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE; PYRAZOLO[1,5 A]PYRIMIDIN 3 YLACETAMIDE DERIVATIVE; RADIOLIGAND; RO 54864; TRILOSTANE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL TISSUE; BINDING AFFINITY; BIOASSAY; BIOSYNTHESIS; CHEMICAL REACTION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GLIOMA CELL; NONHUMAN; RAT; REACTION ANALYSIS; STIMULATION; TISSUE DISTRIBUTION;

ACETAMIDES; ANIMALS; BENZODIAZEPINONES; BINDING SITES; CEREBRAL CORTEX; CLONAZEPAM; FLUMAZENIL; GLIOMA; INTRACELLULAR MEMBRANES; ISOQUINOLINES; KIDNEY; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PYRAZOLES; PYRIMIDINES; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TUMOR CELLS, CULTURED;

EID: 0034846643     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00192-4     Document Type: Article

References (60)