2-Phenyl-imidazo[1,2-a]pyridine compounds containing hydrophilic groups as potent and selective ligands for peripheral benzodiazepine receptors: Synthesis, binding affinity and electrophysiological studies

Journal of Medicinal Chemistry

Volumn 51, Issue 21, 2008, Pages 6876-6888

  Denora, Nunzio ^a   Laquintana, Valentino ^a   Pisu, Maria Giuseppina ^b,c   Dore, Riccardo ^b   Murru, Luca ^b   Latrofa, Andrea ^a   Trapani, Giuseppe ^a   Sanna, Enrico ^b  

^a UNIVERSITY OF BARI   (Italy)

^b Sezione di Neuroscienze   (Italy)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

(2 PHENYL IMIDAZO[1,2 A]PYRIDIN 3 YL)ACETAMIDE; (2 THIAZOLYL IMIDAZO[1,2 A]PYRIDIN 3 YL)ACETAMIDE; 2 [2 (3 AMINO 4 CHLOROPHENYL) 6,8 DICHLOROIMIDAZOL[1,2 A]PYRIDIN 3 YL]N BUTYL N METHYLACETAMIDE; 2 [2 (3 AMINO 4 CHLOROPHENYL) 6,8 DICHLOROIMIDAZOL[1,2 A]PYRIDIN 3 YL]N,N DIPROPYLACETAMIDE; 2 [2 (3 AMINO 4 CHLOROPHENYL) 8 CHLOROIMIDAZOL[1,2 A]PYRIDIN 3 YL]N BUTYL N METHYLACETAMIDE; 2 [2 (4 AMINOPHENYL) 6,8 DICHLOROIMIDAZOL[1,2 A]PYRIDIN 3 YL]N,N DIPROPYLACETAMIDE; 2 [6,8 DICHLORO 2 (4 CHLORO 3 NITROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]N,N DIPROPYLACETAMIDE; 2 [6,8 DICHLORO 2 (4 HYDROXYPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]N BUTYL N METHYLACETAMIDE; 2 [6,8 DICHLORO 2 (4 HYDROXYPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]N BUTYL N PHENYLACETAMIDE; 2 [6,8 DICHLORO 2 (4 HYDROXYPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]N,N DIPROPYLACETAMIDE; 2 [6,8 DICHLORO 2 (4 METHOXYPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]N METHYL N PHENYLACETAMIDE; 2 [6,8 DICHLORO 2 (4 METHOXYPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]N,N DIPROPYLACETAMIDE; 2 [6,8 DICHLORO 2 (4 NITROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]N,N DIPROPYLACETAMIDE; 2 [6,8 DICHLORO 2 (THIAZOL 2 YL)IMIDAZO[1,2 A]PYRIDIN 3 YL]N METHYL N PHENYLACETAMIDE; 2 [6,8 DICHLORO 3 [2 (DIPROPYLAMINO) 2 OXOETHYL]IMIDAZO[1,2 A]PYRIDIN 3 YL]PHENYL 2 AMINOACETATE; 2 [8 (2 AMINOACETAMIDO) 2 (4 CHLOROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]N,N DIPROPYLACETAMIDE; 3 [2 (4 CHLOROPHENYL) 3 [2 (DIPROPYLAMINO) 2 OXOETHYL]IMIDAZO[1,2 A]PYRIDIN 8 YLAMINO] 3 OXOPROPANOIC ACID; 4 [2 (4 CHLOROPHENYL) 3 [2 (DIPROPYLAMINO) 2 OXOETHYL]IMIDAZO[1,2 A]PYRIDIN 8 YLAMINO] 4 OXOBUTANOATE; 4 [2 (4 CHLOROPHENYL) 3 [2 (DIPROPYLAMINO) 2 OXOETHYL]IMIDAZO[1,2 A]PYRIDIN 8 YLAMINO] 4 OXOBUTANOIC ACID; 4 [2 CHLORO 5 [6,8 DICHLORO 3 [2 (DIPROPYLAMINO) 2 OXOETHYL]IMIDAZO[1,2 A]PYRIDIN 2 YL]PHENYLAMINO] 4 OXOBUTANOIC ACID; 4 [6,8 DICHLORO 3 [2 (DIPROPYLAMINO) 2 OXOETHYL]IMIDAZO[1,2 A]PYRIDIN 3 YL]PHENYL METHYL SUCCINATE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 5 [2 (4 CHLOROPHENYL) 3 [2 (DIPROPYLAMINO) 2 OXOETHYL]IMIDAZO[1,2 A]PYRIDIN 8 YLAMINO] 5 OXOPENTANOIC ACID; BENZODIAZEPINE RECEPTOR; CHLORIDE; N BUTYL 2 [6,8 DICHLORO 2 (4 CHLORO 3 NITROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]N METHYLACETAMIDE; N BUTYL 2 [6,8 DICHLORO 2 (4 METHOXYPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]N METHYLACETAMIDE; N BUTYL 2 [8 CHLORO 2 (4 CHLORO 3 NITROPHENYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]N METHYLACETAMIDE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; HIPPOCAMPUS; HYDROGEN BOND; HYDROPHILICITY; OOCYTE; PYRAMIDAL NERVE CELL; XENOPUS;

ACETAMIDES; ANIMALS; ELECTROPHYSIOLOGY; FEMALE; HUMANS; IMIDAZOLES; LIGANDS; MOLECULAR STRUCTURE; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PYRIDINES; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; WATER; XENOPUS;

EID: 56249143493     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8006728     Document Type: Article

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