Protein-ligand and membrane-ligand interactions in pharmacology: The case of the translocator protein (TSPO)

Pharmacological Research

Volumn 100, Issue , 2015, Pages 58-63

  Hatty, Claire R ^a   Banati, Richard B ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

Author keywords

TSPO Membrane Lipid PK11195 Cholesterol

Indexed keywords

ACETYLSALICYLIC ACID; CARRIER PROTEIN; IBUPROFEN; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; TRANSLOCATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; LIGAND;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL MEMBRANE; CELL ORGANELLE; CELL PROLIFERATION; DRUG INTERACTION; DRUG PROTEIN INTERACTION; HUMAN; LIPID BILAYER; LIPID MEMBRANE; MEMBRANE BINDING; MITOCHONDRIAL MEMBRANE; PASSIVE TRANSPORT; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN TARGETING; ANIMAL; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; HUMANS; LIGANDS; MEMBRANE PROTEINS; PROTEIN TRANSPORT; RECEPTORS, GABA;

EID: 84939161869     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2015.07.029     Document Type: Review

References (57)

1. P. Ehrlich Address in pathology, on chemiotherapy: delivered before the seventeenth international congress of medicine Br. Med. J. 2 1913 353 359
2. H.P. Rang The receptor concept: Pharmacology's big idea Br. J. Pharmacol. 147 2006 S9 16
3. J.K. Seydel, E.A. Coats, H.P. Cordes, and M. Wiese Drug membrane interaction and the importance for drug transport, distribution, accumulation, efficacy and resistance Archiv. der Pharmazie. 327 1994 601 610
4. M. Deleu, J.M. Crowet, M.N. Nasir, and L. Lins Complementary biophysical tools to investigate lipid specificity in the interaction between bioactive molecules and the plasma membrane: a review Biochim. Biophys. Acta 1838 2014 3171 3190
5. W. Kopec, J. Telenius, and H. Khandelia Molecular dynamics simulations of the interactions of medicinal plant extracts and drugs with lipid bilayer membranes FEBS J. 280 2013 2785 2805
6. C.R. Hatty The 18 kda translocator protein in model membranes in: Facultyof Health Sciences, University of Sydney Sydney, Australia 2013 157
7. S.J. Singer, and G.L. Nicolson The fluid mosaic model of the structure of cell membranes Science (New York, NY) 175 1972 720 731
8. M. van, G. eer, D.R. Voelker, and G.W. Feigenson Membrane lipids: where they are and how they behave Nat. Rev. Mol. Cell Biol. 9 2008 112 124
9. M.P. Boland, C.R. Hatty, F. Separovic, A.F. Hill, D.J. Tew, K.J. Barnham, C.L. Haigh, M. James, C.L. Masters, and S.J. Collins Anionic phospholipid interactions of the prion protein n terminus are minimally perturbing and not driven solely by the octapeptide repeat domain J. Biol. Chem. 285 2010 32282 32292
10. A. Mechler, S. Praporski, K. Atmuri, M. Boland, F. Separovic, and L.L. Martin Specific and selective peptide-membrane interactions revealed using quartz crystal microbalance Biophys. J. 93 2007 3907 3916
11. V.A. Fadok, D.L. Bratton, S.C. Frasch, M.L. Warner, and P.M. Henson The role of phosphatidylserine in recognition of apoptotic cells by phagocytes Cell Death Differ. 5 1998 551 562
12. T.K. Ray, V.P. Skipski, M. Barclay, E. Essner, and F.M. Archibald Lipid composition of rat liver plasma membranes J. Biol. Chem. 244 1969 5528 5536
13. S.E. Horvath, and G. Daum Lipids of mitochondria Prog. Lipid Res. 52 2013 590 614
14. M. Lucio, J.L. Lima, and S. Reis Drug-membrane interactions: significance for medicinal chemistry Curr. Med. Chem. 17 2010 1795 1809
15. O.G. Mouritsen, and K. Jorgensen A new look at lipid-membrane structure in relation to drug research Pharm. Res. 15 1998 1507 1519
16. A.M. Seddon, D. Casey, R.V. Law, A. Gee, R.H. Templer, and O. Ces Drug interactions with lipid membranes Chem. Soc. Rev. 38 2009 2509 2519
17. C. Bourgaux, and P. Couvreur Interactions of anticancer drugs with biomembranes: what can we learn from model membranes J. Control. Release 190 2014 127 138
18. C. Peetla, S. Vijayaraghavalu, and V. Labhasetwar Biophysics of cell membrane lipids in cancer drug resistance: implications for drug transport and drug delivery with nanoparticles Adv. Drug Deliv. Rev. 65 2013 1686 1698
19. F.J. Sharom Complex interplay between the p-glycoprotein multidrug efflux pump and the membrane: its role in modulating protein function Front. Oncol. 4 2014 41
20. C. Pereira-Leite, C. Nunes, and S. Reis Interaction of nonsteroidal anti-inflammatory drugs with membranes: in vitro assessment and relevance for their biological actions Prog. Lipid Res. 52 2013 571 584
21. M.A. Barrett, S. Zheng, G. Roshankar, R.J. Alsop, R.K. Belanger, C. Huynh, N. Kucerka, and M.C. Rheinstadter Interaction of aspirin (acetylsalicylic acid) with lipid membranes PloS One 7 2012 e34357
22. M.B. Boggara, and R. Krishnamoorti Partitioning of nonsteroidal antiinflammatory drugs in lipid membranes: a molecular dynamics simulation study Biophys. J. 98 2010 586 595
23. M.B. Boggara, M. Mihailescu, and R. Krishnamoorti Structural association of nonsteroidal anti-inflammatory drugs with lipid membranes J. Am. Chem. Soc. 134 2012 19669 19676
24. L.M. Lichtenberger, Y. Zhou, V. Jayaraman, J.R. Doyen, R.G. O'Neil, E.J. Dial, D.E. Volk, D.G. Gorenstein, M.B. Boggara, and R. Krishnamoorti Insight into nsaid-induced membrane alterations, pathogenesis and therapeutics: characterization of interaction of nsaids with phosphatidylcholine Biochim. Biophys. Acta 1821 2012 994 1002
25. C. Nunes, G. Brezesinski, D. Lopes, J.L. Lima, S. Reis, and M. Lucio Lipid-drug interaction: biophysical effects of tolmetin on membrane mimetic systems of different dimensionality J. Phys. Chem. B 115 2011 12615 12623
26. C. Nunes, D. Lopes, M. Pinheiro, C. Pereira-Leite, and S. Reis In vitro assessment of nsaids-membrane interactions: significance for pharmacological actions Pharm. Res. 30 2013 2097 2107
27. M. Suwalsky, J. Belmar, F. Villena, M.J. Gallardo, M. Jemiola-Rzeminska, and K. Strzalka Acetylsalicylic acid (aspirin) and salicylic acid interaction with the human erythrocyte membrane bilayer induce in vitro changes in the morphology of erythrocytes Arch. Biochem. Biophys. 539 2013 9 19
28. A. Mocsai, L. Kovacs, and P. Gergely What is the future of targeted therapy in rheumatology: biologics or small molecules BMC Med. 12 2014 43
29. T. Morrow, and L.H. Felcone Defining the difference: what makes biologics unique Biotechnol. Healthcare 1 2004 24 29
30. T. Uhlig, T. Kyprianou, F.G. Martinelli, C.A. Oppici, D. Heiligers, D. Hills, X.R. Calvo, and P. Verhaert The emergence of peptides in the pharmaceutical business: from exploration to exploitation EuPA Open Proteom. 4 2014 58 69
31. K. Morohaku, S.H. Pelton, D.J. Daugherty, W.R. Butler, W. Deng, and V. Selvaraj Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis Endocrinology 155 2014 89 97
32. V. Papadopoulos On the role of the translocator protein (18-kda) tspo in steroid hormone biosynthesis Endocrinology 155 2014 15 20
33. D.M. Stocco The role of pbr/tspo in steroid biosynthesis challenged Endocrinology 155 2014 6 9
34. J.J. Lacapere, and V. Papadopoulos Peripheral-type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis Steroids 68 2003 569 585
35. S. Taketani, H. Kohno, T. Furukawa, and R. Tokunaga Involvement of peripheral-type benzodiazepine receptors in the intracellular transport of heme and porphyrins J. Biochem. 117 1995 875 880
36. H. Alho, V. Varga, and K.E. Krueger Expression of mitochondrial benzodiazepine receptor and its putative endogenous ligand diazepam binding inhibitor in cultured primary astrocytes and c-6 cells: relation to cell growth Cell Growth Differ.: Mol. Biol. J. Am. Assoc. Cancer Res. 5 1994 1005 1014
37. S. Zeno, M. Zaaroor, S. Leschiner, L. Veenman, and M. Gavish Cocl(2) induces apoptosis via the 18 kda translocator protein in u118mg human glioblastoma cells Biochemistry 48 2009 4652 4661
38. A. Klegeris, E.G. McGeer, and P.L. McGeer Inhibitory action of 1-(2-chlorophenyl)-n-methyl-n-(1-methylpropyl)-3-isoquinolinecarboxam ide (pk 11195) on some mononuclear phagocyte functions Biochem. Pharmacol. 59 2000 1305 1314
39. F. Zavala, and M. Lenfant Benzodiazepines and pk11195 exert immunomodulating activities by binding on a specific receptor on macrophages Ann. N. Y. Acad. Sci. 496 1987 240 249
40. J. Gatliff, D. East, J. Crosby, R. Abeti, R. Harvey, W. Craigen, P. Parker, and M. Campanella Tspo interacts with vdac1 and triggers a ros-mediated inhibition of mitochondrial quality control Autophagy 10 2014 2279 2296
41. V. Papadopoulos, H. Amri, N. Boujrad, C. Cascio, M. Culty, M. Garnier, M. Hardwick, H. Li, B. Vidic, A.S. Brown, J.L. Reversa, J.M. Bernassau, and K. Drieu Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis Steroids 62 1997 21 28
42. V. Papadopoulos, H. Amri, H. Li, N. Boujrad, B. Vidic, and M. Garnier Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the r2c leydig tumor cell line J. Biol. Chem. 272 1997 32129 32135
43. L.N. Tu, K. Morohaku, P.R. Manna, S.H. Pelton, W.R. Butler, D.M. Stocco, and V. Selvaraj Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis J. Biol. Chem. 289 2014 27444 27454
44. L.N. Tu, A.H. Zhao, D.M. Stocco, and V. Selvaraj Pk11195 effect on steroidogenesis is not mediated through the translocator protein (tspo) Endocrinology 2014 en 20141707
45. R.B. Banati, R.J. Middleton, R. Chan, C.R. Hatty, W.W. Kam, C. Quin, M.B. Graeber, A. Parmar, D. Zahra, P. Callaghan, S. Fok, N.R. Howell, M. Gregoire, A. Szabo, T. Pham, E. Davis, and G.J. Liu Positron emission tomography and functional characterization of a complete pbr/tspo knockout Nat. Commun. 5 2014 5452
46. L. Veenman, V. Papadopoulos, and M. Gavish Channel-like functions of the 18-kda translocator protein (tspo): regulation of apoptosis and steroidogenesis as part of the host-defense response Curr. Pharm. Des. 13 2007 2385 2405
47. A.M. Scarf, C. Luus, P. Da, E. ozzo, S. Selleri, C. Guarino, C. Martini, L.M. Ittner, and M. Kassiou Evidence for complex binding profiles and species differences at the translocator protein (tspo) (18 kda) Curr. Mol. Med. 12 2012 488 493
48. R.A. Gonzalez-Polo, G. Carvalho, T. Braun, D. Decaudin, C. Fabre, N. Larochette, J.L. Perfettini, M. Djavaheri-Mergny, I. Youlyouz-Marfak, P. Codogno, M. Raphael, J. Feuillard, and G. Kroemer Pk11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor Oncogene 24 2005 7503 7513
49. D. Kletsas, W. Li, Z. Han, and V. Papadopoulos Peripheral-type benzodiazepine receptor (pbr) and pbr drug ligands in fibroblast and fibrosarcoma cell proliferation: role of erk, c-jun and ligand-activated pbr-independent pathways Biochem. Pharmacol. 67 2004 1927 1932
50. R.B. Walter, J.L. Pirga, M.R. Cronk, S. Mayer, F.R. Appelbaum, and D.E. Banker Pk11195, a peripheral benzodiazepine receptor (pbr) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pbr-independent, direct transporter-modulating mechanism Blood 106 2005 3584 3593
51. R.B. Walter, B.W. Raden, M.R. Cronk, I.D. Bernstein, F.R. Appelbaum, and D.E. Banker The peripheral benzodiazepine receptor ligand pk11195 overcomes different resistance mechanisms to sensitize aml cells to gemtuzumab ozogamicin Blood 103 2004 4276 4284
52. J. Šileikytė, E. Blachly-Dyson, R. Sewell, A. Carpi, R. Menabò, L. Di, F. isa, F. Ricchelli, P. Bernardi, and M. Forte Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (translocator protein of 18 kda (tspo)) J. Biol. Chem. 289 2014 13769 13781
53. C.R. Hatty, B. Le, A.P. run, V. Lake, L.A. Clifton, G.J. Liu, M. James, and R.B. Banati Investigating the interactions of the 18 kda translocator protein and its ligand pk11195 in planar lipid bilayers Biochim. Biophys. Acta 1838 2014 1019 1030
54. S. Drori, G.D. Eytan, and Y.G. Assaraf Potentiation of anticancer-drug cytotoxicity by multidrug-resistance chemosensitizers involves alterations in membrane fluidity leading to increased membrane permeability Eur. J. Biochem./FEBS 228 1995 1020 1029
55. L. Yeruva, J.A. Elegbede, and S.W. Carper Methyl jasmonate decreases membrane fluidity and induces apoptosis through tumor necrosis factor receptor 1 in breast cancer cells Anticancer Drugs 19 2008 766 776
56. C. Leneveu-Jenvrin, N. Connil, E. Bouffartigues, V. Papadopoulos, M.G. Feuilloley, and S. Chevalier Structure-to-function relationships of bacterial translocator protein (tspo): a focus on pseudomonas Front. Microbiol. 5 2014 631
57. A.M. Falchi, B. Battetta, F. Sanna, M. Piludu, V. Sogos, M. Serra, M. Melis, M. Putzolu, and G. Diaz Intracellular cholesterol changes induced by translocator protein (18 kda) tspo/pbr ligands Neuropharmacology 53 2007 318 329