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Volumn 65, Issue 4, 2016, Pages 798-808

Role of epithelial to mesenchymal transition in hepatocellular carcinoma

Author keywords

Cell invasion; EMT; Epithelial plasticity; HCC; MET; Patient survival; Therapy; Tumor heterogeneity

Indexed keywords

GALUNISERTIB; KALININ; MICRORNA; SCATTER FACTOR RECEPTOR; TIVANTINIB; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E12; TRANSCRIPTION FACTOR E47; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR TWIST1; TRANSCRIPTION FACTOR TWIST2; TRANSCRIPTION FACTOR ZEB1; TRANSCRIPTION FACTOR ZEB2; TRANSFORMING GROWTH FACTOR BETA; TUMOR MARKER; UNCLASSIFIED DRUG; CADHERIN;

EID: 84991736278     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2016.05.007     Document Type: Review
Times cited : (500)

References (115)
  • 1
    • 84918815964 scopus 로고    scopus 로고
    • Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012
    • [1] Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136 (2015), E359–E386.
    • (2015) Int J Cancer , vol.136 , pp. E359-E386
    • Ferlay, J.1    Soerjomataram, I.2    Dikshit, R.3    Eser, S.4    Mathers, C.5    Rebelo, M.6
  • 2
    • 84859212951 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • [2] Forner, A., Llovet, J.M., Bruix, J., Hepatocellular carcinoma. Lancet 379 (2012), 1245–1255.
    • (2012) Lancet , vol.379 , pp. 1245-1255
    • Forner, A.1    Llovet, J.M.2    Bruix, J.3
  • 3
    • 84944906098 scopus 로고    scopus 로고
    • Functional and genetic deconstruction of the cellular origin in liver cancer
    • [3] Marquardt, J.U., Andersen, J.B., Thorgeirsson, S.S., Functional and genetic deconstruction of the cellular origin in liver cancer. Nat Rev Cancer 15 (2015), 653–667.
    • (2015) Nat Rev Cancer , vol.15 , pp. 653-667
    • Marquardt, J.U.1    Andersen, J.B.2    Thorgeirsson, S.S.3
  • 4
    • 84964744244 scopus 로고    scopus 로고
    • Deciphering cancer heterogeneity: the biological space
    • [4] Roessler, S., Budhu, A., Wang, X.W., Deciphering cancer heterogeneity: the biological space. Front Cell Dev Biol, 2, 2014, 12.
    • (2014) Front Cell Dev Biol , vol.2 , pp. 12
    • Roessler, S.1    Budhu, A.2    Wang, X.W.3
  • 5
    • 84926156421 scopus 로고    scopus 로고
    • Multiple carcinogenesis contributes to the heterogeneity of HCC
    • [5] Gao, Q., Wang, X.Y., Zhou, J., Fan, J., Multiple carcinogenesis contributes to the heterogeneity of HCC. Nat Rev Gastroenterol Hepatol, 12, 2015, 13.
    • (2015) Nat Rev Gastroenterol Hepatol , vol.12 , pp. 13
    • Gao, Q.1    Wang, X.Y.2    Zhou, J.3    Fan, J.4
  • 6
    • 33747029250 scopus 로고    scopus 로고
    • Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    • [6] Budhu, A., Forgues, M., Ye, Q.H., Jia, H.L., He, P., Zanetti, K.A., et al. Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 10 (2006), 99–111.
    • (2006) Cancer Cell , vol.10 , pp. 99-111
    • Budhu, A.1    Forgues, M.2    Ye, Q.H.3    Jia, H.L.4    He, P.5    Zanetti, K.A.6
  • 7
    • 78650361904 scopus 로고    scopus 로고
    • A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients
    • [7] Roessler, S., Jia, H.L., Budhu, A., Forgues, M., Ye, Q.H., Lee, J.S., et al. A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients. Cancer Res 70 (2010), 10202–10212.
    • (2010) Cancer Res , vol.70 , pp. 10202-10212
    • Roessler, S.1    Jia, H.L.2    Budhu, A.3    Forgues, M.4    Ye, Q.H.5    Lee, J.S.6
  • 9
    • 84890346941 scopus 로고    scopus 로고
    • Evidence for and against epithelial-to-mesenchymal transition in the liver
    • [9] Xie, G., Diehl, A.M., Evidence for and against epithelial-to-mesenchymal transition in the liver. Am J Physiol Gastrointest Liver Physiol 305 (2013), G881–G890.
    • (2013) Am J Physiol Gastrointest Liver Physiol , vol.305 , pp. G881-G890
    • Xie, G.1    Diehl, A.M.2
  • 10
    • 84861527239 scopus 로고    scopus 로고
    • To differentiate or not–routes towards metastasis
    • [10] Brabletz, T., To differentiate or not–routes towards metastasis. Nat Rev Cancer 12 (2012), 425–436.
    • (2012) Nat Rev Cancer , vol.12 , pp. 425-436
    • Brabletz, T.1
  • 11
    • 84887273608 scopus 로고    scopus 로고
    • Epithelial plasticity: a common theme in embryonic and cancer cells
    • [11] Nieto, M.A., Epithelial plasticity: a common theme in embryonic and cancer cells. Science, 342, 2013, 1234850.
    • (2013) Science , vol.342
    • Nieto, M.A.1
  • 12
    • 84948407218 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
    • [12]X. Zheng, J.L. Carstens, Kim, J., Scheible, M., Kaye, J., Sugimoto, H., et al. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature 527 (2015), 525–530.
    • (2015) Nature , vol.527 , pp. 525-530
    • Zheng, B.1    Carstens, B.L.2    Kim, J.3    Scheible, M.4    Kaye, J.5    Sugimoto, H.6
  • 13
    • 73149101056 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transitions in the liver
    • [13] Choi, S.S., Diehl, A.M., Epithelial-to-mesenchymal transitions in the liver. Hepatology 50 (2009), 2007–2013.
    • (2009) Hepatology , vol.50 , pp. 2007-2013
    • Choi, S.S.1    Diehl, A.M.2
  • 15
    • 84904060793 scopus 로고    scopus 로고
    • Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy
    • [15] Swiderska-Syn, M., Syn, W.K., Xie, G., Kruger, L., Machado, M.V., Karaca, G., et al. Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy. Gut 63 (2014), 1333–1344.
    • (2014) Gut , vol.63 , pp. 1333-1344
    • Swiderska-Syn, M.1    Syn, W.K.2    Xie, G.3    Kruger, L.4    Machado, M.V.5    Karaca, G.6
  • 16
    • 78649920691 scopus 로고    scopus 로고
    • The pathogenesis of idiopathic pulmonary fibrosis
    • [16] Coward, W.R., Saini, G., Jenkins, G., The pathogenesis of idiopathic pulmonary fibrosis. Ther Adv Respir Dis 4 (2010), 367–388.
    • (2010) Ther Adv Respir Dis , vol.4 , pp. 367-388
    • Coward, W.R.1    Saini, G.2    Jenkins, G.3
  • 17
    • 79551521517 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
    • [17] Kriz, W., Kaissling, B., Le Hir, M., Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?. J Clin Invest 121 (2011), 468–474.
    • (2011) J Clin Invest , vol.121 , pp. 468-474
    • Kriz, W.1    Kaissling, B.2    Le Hir, M.3
  • 18
    • 79951797048 scopus 로고    scopus 로고
    • The transforming growth factor-beta (TGF-beta) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells
    • [18] Caja, L., Bertran, E., Campbell, J., Fausto, N., Fabregat, I., The transforming growth factor-beta (TGF-beta) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells. J Cell Physiol 226 (2011), 1214–1223.
    • (2011) J Cell Physiol , vol.226 , pp. 1214-1223
    • Caja, L.1    Bertran, E.2    Campbell, J.3    Fausto, N.4    Fabregat, I.5
  • 19
    • 48549084059 scopus 로고    scopus 로고
    • Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage
    • [19] Dooley, S., Hamzavi, J., Ciuclan, L., Godoy, P., Ilkavets, I., Ehnert, S., et al. Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage. Gastroenterology 135 (2008), 642–659.
    • (2008) Gastroenterology , vol.135 , pp. 642-659
    • Dooley, S.1    Hamzavi, J.2    Ciuclan, L.3    Godoy, P.4    Ilkavets, I.5    Ehnert, S.6
  • 20
    • 55849135600 scopus 로고    scopus 로고
    • Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans
    • [20] Omenetti, A., Porrello, A., Jung, Y., Yang, L., Popov, Y., Choi, S.S., et al. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest 118 (2008), 3331–3342.
    • (2008) J Clin Invest , vol.118 , pp. 3331-3342
    • Omenetti, A.1    Porrello, A.2    Jung, Y.3    Yang, L.4    Popov, Y.5    Choi, S.S.6
  • 21
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • [21] M. Zeisberg, C. Yang, Martino, M., Duncan, M.B., Rieder, F., Tanjore, H., et al. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 282 (2007), 23337–23347.
    • (2007) J Biol Chem , vol.282 , pp. 23337-23347
    • Zeisberg, B.1    Yang, B.2    Martino, M.3    Duncan, M.B.4    Rieder, F.5    Tanjore, H.6
  • 22
    • 77950597707 scopus 로고    scopus 로고
    • Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice
    • [22]K. Taura, K. Miura, Iwaisako, K., Osterreicher, C.H., Kodama, Y., Penz-Osterreicher, M., et al. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology 51 (2010), 1027–1036.
    • (2010) Hepatology , vol.51 , pp. 1027-1036
    • Taura, B.1    Miura, B.2    Iwaisako, K.3    Osterreicher, C.H.4    Kodama, Y.5    Penz-Osterreicher, M.6
  • 23
    • 77956158103 scopus 로고    scopus 로고
    • Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice
    • [23] Scholten, D., Osterreicher, C.H., Scholten, A., Iwaisako, K., Gu, G., Brenner, D.A., et al. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology 139 (2010), 987–998.
    • (2010) Gastroenterology , vol.139 , pp. 987-998
    • Scholten, D.1    Osterreicher, C.H.2    Scholten, A.3    Iwaisako, K.4    Gu, G.5    Brenner, D.A.6
  • 24
    • 79955123951 scopus 로고    scopus 로고
    • Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis
    • [24] Chu, A.S., Diaz, R., Hui, J.J., Yanger, K., Zong, Y., Alpini, G., et al. Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis. Hepatology 53 (2011), 1685–1695.
    • (2011) Hepatology , vol.53 , pp. 1685-1695
    • Chu, A.S.1    Diaz, R.2    Hui, J.J.3    Yanger, K.4    Zong, Y.5    Alpini, G.6
  • 26
    • 84856976151 scopus 로고    scopus 로고
    • What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis
    • [26] Iwaisako, K., Brenner, D.A., Kisseleva, T., What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis. J Gastroenterol Hepatol 27 (2012), 65–68.
    • (2012) J Gastroenterol Hepatol , vol.27 , pp. 65-68
    • Iwaisako, K.1    Brenner, D.A.2    Kisseleva, T.3
  • 28
    • 79960465979 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in chronic liver disease: fibrogenesis or escape from death?
    • [28] Pinzani, M., Epithelial-mesenchymal transition in chronic liver disease: fibrogenesis or escape from death?. J Hepatol 55 (2011), 459–465.
    • (2011) J Hepatol , vol.55 , pp. 459-465
    • Pinzani, M.1
  • 29
    • 77954562833 scopus 로고    scopus 로고
    • Metastasis: cancer cell's escape from oxidative stress
    • [29] Pani, G., Galeotti, T., Chiarugi, P., Metastasis: cancer cell's escape from oxidative stress. Cancer Metastasis Rev 29 (2010), 351–378.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 351-378
    • Pani, G.1    Galeotti, T.2    Chiarugi, P.3
  • 30
    • 77951156738 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions and hepatocarcinogenesis
    • [30] Jou, J., Diehl, A.M., Epithelial-mesenchymal transitions and hepatocarcinogenesis. J Clin Invest 120 (2010), 1031–1034.
    • (2010) J Clin Invest , vol.120 , pp. 1031-1034
    • Jou, J.1    Diehl, A.M.2
  • 31
    • 34249028607 scopus 로고    scopus 로고
    • PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression
    • [31] A.N. Fischer, E. Fuchs, M. Mikula, Huber, H., Beug, H., Mikulits, W., PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene 26 (2007), 3395–3405.
    • (2007) Oncogene , vol.26 , pp. 3395-3405
    • Fischer, B.N.1    Fuchs, B.2    Mikula, B.3    Huber, H.4    Beug, H.5    Mikulits, W.6
  • 32
    • 0037087507 scopus 로고    scopus 로고
    • Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness
    • [32] Gotzmann, J., Huber, H., Thallinger, C., Wolschek, M., Jansen, B., Schulte-Hermann, R., et al. Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness. J Cell Sci 115 (2002), 1189–1202.
    • (2002) J Cell Sci , vol.115 , pp. 1189-1202
    • Gotzmann, J.1    Huber, H.2    Thallinger, C.3    Wolschek, M.4    Jansen, B.5    Schulte-Hermann, R.6
  • 33
    • 84868094204 scopus 로고    scopus 로고
    • PDGF enhances IRES-mediated translation of Laminin B1 by cytoplasmic accumulation of La during epithelial to mesenchymal transition
    • [33] Petz, M., Them, N.C., Huber, H., Mikulits, W., PDGF enhances IRES-mediated translation of Laminin B1 by cytoplasmic accumulation of La during epithelial to mesenchymal transition. Nucleic Acids Res 40 (2012), 9738–9749.
    • (2012) Nucleic Acids Res , vol.40 , pp. 9738-9749
    • Petz, M.1    Them, N.C.2    Huber, H.3    Mikulits, W.4
  • 34
    • 70449636444 scopus 로고    scopus 로고
    • Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge
    • [34] van Zijl, F., Mair, M., Csiszar, A., Schneller, D., Zulehner, G., Huber, H., et al. Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge. Oncogene 28 (2009), 4022–4033.
    • (2009) Oncogene , vol.28 , pp. 4022-4033
    • van Zijl, F.1    Mair, M.2    Csiszar, A.3    Schneller, D.4    Zulehner, G.5    Huber, H.6
  • 35
    • 27744527762 scopus 로고    scopus 로고
    • Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma
    • [35] Giannelli, G., Bergamini, C., Fransvea, E., Sgarra, C., Antonaci, S., Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma. Gastroenterology 129 (2005), 1375–1383.
    • (2005) Gastroenterology , vol.129 , pp. 1375-1383
    • Giannelli, G.1    Bergamini, C.2    Fransvea, E.3    Sgarra, C.4    Antonaci, S.5
  • 36
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • [36] Thiery, J.P., Acloque, H., Huang, R.Y., Nieto, M.A., Epithelial-mesenchymal transitions in development and disease. Cell 139 (2009), 871–890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 37
    • 79961208848 scopus 로고    scopus 로고
    • Initial steps of metastasis: cell invasion and endothelial transmigration
    • [37] van Zijl, F., Krupitza, G., Mikulits, W., Initial steps of metastasis: cell invasion and endothelial transmigration. Mutat Res 728 (2011), 23–34.
    • (2011) Mutat Res , vol.728 , pp. 23-34
    • van Zijl, F.1    Krupitza, G.2    Mikulits, W.3
  • 38
    • 84897450600 scopus 로고    scopus 로고
    • Transforming growth factor-beta as a therapeutic target in hepatocellular carcinoma
    • [38] Giannelli, G., Villa, E., Lahn, M., Transforming growth factor-beta as a therapeutic target in hepatocellular carcinoma. Cancer Res 74 (2014), 1890–1894.
    • (2014) Cancer Res , vol.74 , pp. 1890-1894
    • Giannelli, G.1    Villa, E.2    Lahn, M.3
  • 39
    • 84866338445 scopus 로고    scopus 로고
    • TGF-beta in epithelial to mesenchymal transition and metastasis of liver carcinoma
    • [39] P. Reichl, C. Haider, Grubinger, M., Mikulits, W., TGF-beta in epithelial to mesenchymal transition and metastasis of liver carcinoma. Curr Pharm Des 18 (2012), 4135–4147.
    • (2012) Curr Pharm Des , vol.18 , pp. 4135-4147
    • Reichl, B.1    Haider, B.2    Grubinger, M.3    Mikulits, W.4
  • 40
    • 84923523471 scopus 로고    scopus 로고
    • When good transforming growth factor-beta turns bad in hepatocellular carcinoma: Axl takes the stage
    • [40] Calvisi, D.F., When good transforming growth factor-beta turns bad in hepatocellular carcinoma: Axl takes the stage. Hepatology 61 (2015), 759–761.
    • (2015) Hepatology , vol.61 , pp. 759-761
    • Calvisi, D.F.1
  • 41
    • 70349739285 scopus 로고    scopus 로고
    • Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma
    • [41] Hoshida, Y., Nijman, S.M., Kobayashi, M., Chan, J.A., Brunet, J.P., Chiang, D.Y., et al. Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res 69 (2009), 7385–7392.
    • (2009) Cancer Res , vol.69 , pp. 7385-7392
    • Hoshida, Y.1    Nijman, S.M.2    Kobayashi, M.3    Chan, J.A.4    Brunet, J.P.5    Chiang, D.Y.6
  • 42
    • 46249085489 scopus 로고    scopus 로고
    • Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer
    • [42] Coulouarn, C., Factor, V.M., Thorgeirsson, S.S., Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer. Hepatology 47 (2008), 2059–2067.
    • (2008) Hepatology , vol.47 , pp. 2059-2067
    • Coulouarn, C.1    Factor, V.M.2    Thorgeirsson, S.S.3
  • 43
    • 84894593599 scopus 로고    scopus 로고
    • Molecular mechanisms of epithelial-mesenchymal transition
    • [43] Lamouille, S., Xu, J., Derynck, R., Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol 15 (2014), 178–196.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 178-196
    • Lamouille, S.1    Xu, J.2    Derynck, R.3
  • 44
    • 84894520335 scopus 로고    scopus 로고
    • Beyond E-cadherin: roles of other cadherin superfamily members in cancer
    • [44] van Roy, F., Beyond E-cadherin: roles of other cadherin superfamily members in cancer. Nat Rev Cancer 14 (2014), 121–134.
    • (2014) Nat Rev Cancer , vol.14 , pp. 121-134
    • van Roy, F.1
  • 45
    • 84896689295 scopus 로고    scopus 로고
    • Decreased TIP30 promotes Snail-mediated epithelial-mesenchymal transition and tumor-initiating properties in hepatocellular carcinoma
    • [45] Zhu, M., Yin, F., Fan, X., Jing, W., Chen, R., Liu, L., et al. Decreased TIP30 promotes Snail-mediated epithelial-mesenchymal transition and tumor-initiating properties in hepatocellular carcinoma. Oncogene 34 (2015), 1420–1431.
    • (2015) Oncogene , vol.34 , pp. 1420-1431
    • Zhu, M.1    Yin, F.2    Fan, X.3    Jing, W.4    Chen, R.5    Liu, L.6
  • 46
    • 84923296070 scopus 로고    scopus 로고
    • Axl activates autocrine transforming growth factor-beta signaling in hepatocellular carcinoma
    • [46] Reichl, P., Dengler, M., van Zijl, F., Huber, H., Fuhrlinger, G., Reichel, C., et al. Axl activates autocrine transforming growth factor-beta signaling in hepatocellular carcinoma. Hepatology 61 (2015), 930–941.
    • (2015) Hepatology , vol.61 , pp. 930-941
    • Reichl, P.1    Dengler, M.2    van Zijl, F.3    Huber, H.4    Fuhrlinger, G.5    Reichel, C.6
  • 47
    • 84901273062 scopus 로고    scopus 로고
    • HNRNPAB induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by transcriptionally activating SNAIL
    • [47] Z.J. Zhou, Z. Dai, S.L. Zhou, Hu, Z.Q., Chen, Q., Zhao, Y.M., et al. HNRNPAB induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by transcriptionally activating SNAIL. Cancer Res 74 (2014), 2750–2762.
    • (2014) Cancer Res , vol.74 , pp. 2750-2762
    • Zhou, B.J.1    Dai, B.2    Zhou, B.L.3    Hu, Z.Q.4    Chen, Q.5    Zhao, Y.M.6
  • 48
    • 84890499677 scopus 로고    scopus 로고
    • A double-negative feedback loop between Wnt-beta-catenin signaling and HNF4alpha regulates epithelial-mesenchymal transition in hepatocellular carcinoma
    • [48] Yang, M., Li, S.N., Anjum, K.M., Gui, L.X., Zhu, S.S., Liu, J., et al. A double-negative feedback loop between Wnt-beta-catenin signaling and HNF4alpha regulates epithelial-mesenchymal transition in hepatocellular carcinoma. J Cell Sci 126 (2013), 5692–5703.
    • (2013) J Cell Sci , vol.126 , pp. 5692-5703
    • Yang, M.1    Li, S.N.2    Anjum, K.M.3    Gui, L.X.4    Zhu, S.S.5    Liu, J.6
  • 49
    • 78751544628 scopus 로고    scopus 로고
    • P28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1alpha pathways
    • [49] J. Fu, Y. Chen, J. Cao, Luo, T., Qian, Y.W., Yang, W., et al. P28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1alpha pathways. Hepatology 53 (2011), 181–192.
    • (2011) Hepatology , vol.53 , pp. 181-192
    • Fu, B.1    Chen, B.2    Cao, B.3    Luo, T.4    Qian, Y.W.5    Yang, W.6
  • 50
    • 84867056874 scopus 로고    scopus 로고
    • Runt-related transcription factor 3 reverses epithelial-mesenchymal transition in hepatocellular carcinoma
    • [50] S. Tanaka, H. Shiraha, Nakanishi, Y., Nishina, S., Matsubara, M., Horiguchi, S., et al. Runt-related transcription factor 3 reverses epithelial-mesenchymal transition in hepatocellular carcinoma. Int J Cancer 131 (2012), 2537–2546.
    • (2012) Int J Cancer , vol.131 , pp. 2537-2546
    • Tanaka, B.1    Shiraha, B.2    Nakanishi, Y.3    Nishina, S.4    Matsubara, M.5    Horiguchi, S.6
  • 51
    • 84884979461 scopus 로고    scopus 로고
    • Lipocalin-2 negatively modulates the epithelial-to-mesenchymal transition in hepatocellular carcinoma through the epidermal growth factor (TGF-beta1)/Lcn2/Twist1 pathway
    • [51] Wang, Y.P., Yu, G.R., Lee, M.J., Lee, S.Y., Chu, I.S., Leem, S.H., et al. Lipocalin-2 negatively modulates the epithelial-to-mesenchymal transition in hepatocellular carcinoma through the epidermal growth factor (TGF-beta1)/Lcn2/Twist1 pathway. Hepatology 58 (2013), 1349–1361.
    • (2013) Hepatology , vol.58 , pp. 1349-1361
    • Wang, Y.P.1    Yu, G.R.2    Lee, M.J.3    Lee, S.Y.4    Chu, I.S.5    Leem, S.H.6
  • 52
    • 84927130210 scopus 로고    scopus 로고
    • The PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cells
    • [52] Wang, R., Li, Y., Hou, Y., Yang, Q., Chen, S., Wang, X., et al. The PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cells. Oncotarget 6 (2015), 7000–7010.
    • (2015) Oncotarget , vol.6 , pp. 7000-7010
    • Wang, R.1    Li, Y.2    Hou, Y.3    Yang, Q.4    Chen, S.5    Wang, X.6
  • 53
    • 84896850322 scopus 로고    scopus 로고
    • Forkhead box Q1 promotes hepatocellular carcinoma metastasis by transactivating ZEB2 and VersicanV1 expression
    • [53] L. Xia, W. Huang, Tian, D., Zhang, L., Qi, X., Chen, Z., et al. Forkhead box Q1 promotes hepatocellular carcinoma metastasis by transactivating ZEB2 and VersicanV1 expression. Hepatology 59 (2014), 958–973.
    • (2014) Hepatology , vol.59 , pp. 958-973
    • Xia, B.1    Huang, B.2    Tian, D.3    Zhang, L.4    Qi, X.5    Chen, Z.6
  • 54
    • 84900316922 scopus 로고    scopus 로고
    • A long noncoding RNA activated by TGF-beta promotes the invasion-metastasis cascade in hepatocellular carcinoma
    • [54] Yuan, J.H., Yang, F., Wang, F., Ma, J.Z., Guo, Y.J., Tao, Q.F., et al. A long noncoding RNA activated by TGF-beta promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell 25 (2014), 666–681.
    • (2014) Cancer Cell , vol.25 , pp. 666-681
    • Yuan, J.H.1    Yang, F.2    Wang, F.3    Ma, J.Z.4    Guo, Y.J.5    Tao, Q.F.6
  • 55
    • 84930999448 scopus 로고    scopus 로고
    • Upregulation of long noncoding RNA ZEB1-AS1 promotes tumor metastasis and predicts poor prognosis in hepatocellular carcinoma
    • [55] Li, T., Xie, J., Shen, C., Cheng, D., Shi, Y., Wu, Z., et al. Upregulation of long noncoding RNA ZEB1-AS1 promotes tumor metastasis and predicts poor prognosis in hepatocellular carcinoma. Oncogene 35 (2015), 1575–1584.
    • (2015) Oncogene , vol.35 , pp. 1575-1584
    • Li, T.1    Xie, J.2    Shen, C.3    Cheng, D.4    Shi, Y.5    Wu, Z.6
  • 56
    • 79956143950 scopus 로고    scopus 로고
    • P53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
    • [56] Kim, T., Veronese, A., Pichiorri, F., Lee, T.J., Jeon, Y.J., Volinia, S., et al. P53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J Exp Med 208 (2011), 875–883.
    • (2011) J Exp Med , vol.208 , pp. 875-883
    • Kim, T.1    Veronese, A.2    Pichiorri, F.3    Lee, T.J.4    Jeon, Y.J.5    Volinia, S.6
  • 57
    • 84881028557 scopus 로고    scopus 로고
    • MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer
    • [57] Xia, H., Ooi, L.L., Hui, K.M., MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer. Hepatology 58 (2013), 629–641.
    • (2013) Hepatology , vol.58 , pp. 629-641
    • Xia, H.1    Ooi, L.L.2    Hui, K.M.3
  • 58
    • 84878662313 scopus 로고    scopus 로고
    • MiR-612 suppresses the invasive-metastatic cascade in hepatocellular carcinoma
    • [58] Z.H. Tao, J.L. Wan, Zeng, L.Y., Xie, L., Sun, H.C., Qin, L.X., et al. MiR-612 suppresses the invasive-metastatic cascade in hepatocellular carcinoma. J Exp Med 210 (2013), 789–803.
    • (2013) J Exp Med , vol.210 , pp. 789-803
    • Tao, B.H.1    Wan, B.L.2    Zeng, L.Y.3    Xie, L.4    Sun, H.C.5    Qin, L.X.6
  • 59
    • 84905401527 scopus 로고    scopus 로고
    • MicroRNA-148a suppresses the epithelial-mesenchymal transition and metastasis of hepatoma cells by targeting Met/Snail signaling
    • [59] Zhang, J.P., Zeng, C., Xu, L., Gong, J., Fang, J.H., Zhuang, S.M., MicroRNA-148a suppresses the epithelial-mesenchymal transition and metastasis of hepatoma cells by targeting Met/Snail signaling. Oncogene 33 (2013), 4069–4076.
    • (2013) Oncogene , vol.33 , pp. 4069-4076
    • Zhang, J.P.1    Zeng, C.2    Xu, L.3    Gong, J.4    Fang, J.H.5    Zhuang, S.M.6
  • 60
    • 84938787433 scopus 로고    scopus 로고
    • MicroRNA-451: epithelial-mesenchymal transition inhibitor and prognostic biomarker of hepatocelluar carcinoma
    • [60] J.Y. Huang, K. Zhang, D.Q. Chen, Chen, J., Feng, B., Song, H., et al. MicroRNA-451: epithelial-mesenchymal transition inhibitor and prognostic biomarker of hepatocelluar carcinoma. Oncotarget 6 (2015), 18613–18630.
    • (2015) Oncotarget , vol.6 , pp. 18613-18630
    • Huang, B.Y.1    Zhang, B.2    Chen, B.Q.3    Chen, J.4    Feng, B.5    Song, H.6
  • 61
    • 84939651110 scopus 로고    scopus 로고
    • MicroRNA-125b attenuates epithelial-mesenchymal transitions and targets stem-like liver cancer cells through small mothers against decapentaplegic 2 and 4
    • [61] J.N. Zhou, Q. Zeng, Wang, H.Y., Zhang, B., Li, S.T., Nan, X., et al. MicroRNA-125b attenuates epithelial-mesenchymal transitions and targets stem-like liver cancer cells through small mothers against decapentaplegic 2 and 4. Hepatology 62 (2015), 801–815.
    • (2015) Hepatology , vol.62 , pp. 801-815
    • Zhou, B.N.1    Zeng, B.2    Wang, H.Y.3    Zhang, B.4    Li, S.T.5    Nan, X.6
  • 62
    • 84888268472 scopus 로고    scopus 로고
    • MUC15 inhibits dimerization of EGFR and PI3K-AKT signaling and is associated with aggressive hepatocellular carcinomas in patients
    • e1431–e1412
    • [62] R.Y. Wang, L. Chen, H.Y. Chen, Hu, L., Li, L., Sun, H.Y., et al. MUC15 inhibits dimerization of EGFR and PI3K-AKT signaling and is associated with aggressive hepatocellular carcinomas in patients. Gastroenterology 145 (2013), 1436–1448 e1431–e1412.
    • (2013) Gastroenterology , vol.145 , pp. 1436-1448
    • Wang, B.Y.1    Chen, B.2    Chen, B.Y.3    Hu, L.4    Li, L.5    Sun, H.Y.6
  • 63
    • 84879081348 scopus 로고    scopus 로고
    • SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3beta/beta-catenin signaling
    • [63] Chen, J., Chan, A.W., To, K.F., Chen, W., Zhang, Z., Ren, J., et al. SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3beta/beta-catenin signaling. Hepatology 57 (2013), 2287–2298.
    • (2013) Hepatology , vol.57 , pp. 2287-2298
    • Chen, J.1    Chan, A.W.2    To, K.F.3    Chen, W.4    Zhang, Z.5    Ren, J.6
  • 64
    • 84878997506 scopus 로고    scopus 로고
    • Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition
    • [64] J. Li, B. Yang, Q. Zhou, Y. Wu, D. Shang, Guo, Y., et al. Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition. Carcinogenesis 34 (2013), 1343–1351.
    • (2013) Carcinogenesis , vol.34 , pp. 1343-1351
    • Li, B.1    Yang, B.2    Zhou, B.3    Wu, B.4    Shang, B.5    Guo, Y.6
  • 65
    • 84941932708 scopus 로고    scopus 로고
    • EDIL3 is a novel regulator of epithelial-mesenchymal transition controlling early recurrence of hepatocellular carcinoma
    • [65] Xia, H., Chen, J., Shi, M., Gao, H., Sekar, K., Seshachalam, V.P., et al. EDIL3 is a novel regulator of epithelial-mesenchymal transition controlling early recurrence of hepatocellular carcinoma. J Hepatol 63 (2015), 863–873.
    • (2015) J Hepatol , vol.63 , pp. 863-873
    • Xia, H.1    Chen, J.2    Shi, M.3    Gao, H.4    Sekar, K.5    Seshachalam, V.P.6
  • 66
    • 84931070961 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces epithelial-mesenchymal transition in human hepatocytes by upregulating E12/E47 levels
    • [66] Tiwari, I., Yoon, M.H., Park, B.J., Jang, K.L., Hepatitis C virus core protein induces epithelial-mesenchymal transition in human hepatocytes by upregulating E12/E47 levels. Cancer Lett 362 (2015), 131–138.
    • (2015) Cancer Lett , vol.362 , pp. 131-138
    • Tiwari, I.1    Yoon, M.H.2    Park, B.J.3    Jang, K.L.4
  • 67
    • 4344665192 scopus 로고    scopus 로고
    • Disregulation of E-cadherin in transgenic mouse models of liver cancer
    • [67] D.F. Calvisi, S. Ladu, Conner, E.A., Factor, V.M., Thorgeirsson, S.S., Disregulation of E-cadherin in transgenic mouse models of liver cancer. Lab Invest 84 (2004), 1137–1147.
    • (2004) Lab Invest , vol.84 , pp. 1137-1147
    • Calvisi, B.F.1    Ladu, B.2    Conner, E.A.3    Factor, V.M.4    Thorgeirsson, S.S.5
  • 68
    • 0032789624 scopus 로고    scopus 로고
    • Correlation of E-cadherin expression and recurrence of hepatocellular carcinoma
    • [68] Huang, G.T., Lee, H.S., Chen, C.H., Sheu, J.C., Chiou, L.L., Chen, D.S., Correlation of E-cadherin expression and recurrence of hepatocellular carcinoma. Hepatogastroenterology 46 (1999), 1923–1927.
    • (1999) Hepatogastroenterology , vol.46 , pp. 1923-1927
    • Huang, G.T.1    Lee, H.S.2    Chen, C.H.3    Sheu, J.C.4    Chiou, L.L.5    Chen, D.S.6
  • 69
    • 0034905286 scopus 로고    scopus 로고
    • Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas
    • [69] Matsumura, T., Makino, R., Mitamura, K., Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas. Clin Cancer Res 7 (2001), 594–599.
    • (2001) Clin Cancer Res , vol.7 , pp. 594-599
    • Matsumura, T.1    Makino, R.2    Mitamura, K.3
  • 70
    • 1942469421 scopus 로고    scopus 로고
    • Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells
    • [70] Miyoshi, A., Kitajima, Y., Sumi, K., Sato, K., Hagiwara, A., Koga, Y., et al. Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. Br J Cancer 90 (2004), 1265–1273.
    • (2004) Br J Cancer , vol.90 , pp. 1265-1273
    • Miyoshi, A.1    Kitajima, Y.2    Sumi, K.3    Sato, K.4    Hagiwara, A.5    Koga, Y.6
  • 71
    • 14844297318 scopus 로고    scopus 로고
    • Snail accelerates cancer invasion by upregulating MMP expression and is associated with poor prognosis of hepatocellular carcinoma
    • [71] Miyoshi, A., Kitajima, Y., Kido, S., Shimonishi, T., Matsuyama, S., Kitahara, K., et al. Snail accelerates cancer invasion by upregulating MMP expression and is associated with poor prognosis of hepatocellular carcinoma. Br J Cancer 92 (2005), 252–258.
    • (2005) Br J Cancer , vol.92 , pp. 252-258
    • Miyoshi, A.1    Kitajima, Y.2    Kido, S.3    Shimonishi, T.4    Matsuyama, S.5    Kitahara, K.6
  • 72
    • 0036725378 scopus 로고    scopus 로고
    • Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, beta-catenin expression, and clinical features
    • [72] Wei, Y., Van Nhieu, J.T., Prigent, S., Srivatanakul, P., Tiollais, P., Buendia, M.A., Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, beta-catenin expression, and clinical features. Hepatology 36 (2002), 692–701.
    • (2002) Hepatology , vol.36 , pp. 692-701
    • Wei, Y.1    Van Nhieu, J.T.2    Prigent, S.3    Srivatanakul, P.4    Tiollais, P.5    Buendia, M.A.6
  • 73
    • 0141961143 scopus 로고    scopus 로고
    • Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes
    • [73] W. Prange, K. Breuhahn, Fischer, F., Zilkens, C., Pietsch, T., Petmecky, K., et al. Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes. J Pathol 201 (2003), 250–259.
    • (2003) J Pathol , vol.201 , pp. 250-259
    • Prange, B.1    Breuhahn, B.2    Fischer, F.3    Zilkens, C.4    Pietsch, T.5    Petmecky, K.6
  • 74
    • 82555173154 scopus 로고    scopus 로고
    • Metadherin promotes hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition
    • [74] K. Zhu, Z. Dai, Q. Pan, Wang, Z., Yang, G.H., Yu, L., et al. Metadherin promotes hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin Cancer Res 17 (2011), 7294–7302.
    • (2011) Clin Cancer Res , vol.17 , pp. 7294-7302
    • Zhu, B.1    Dai, B.2    Pan, B.3    Wang, Z.4    Yang, G.H.5    Yu, L.6
  • 75
    • 72949120827 scopus 로고    scopus 로고
    • Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma
    • [75] M.H. Yang, C.L. Chen, Chau, G.Y., Chiou, S.H., Su, C.W., Chou, T.Y., et al. Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology 50 (2009), 1464–1474.
    • (2009) Hepatology , vol.50 , pp. 1464-1474
    • Yang, B.H.1    Chen, B.L.2    Chau, G.Y.3    Chiou, S.H.4    Su, C.W.5    Chou, T.Y.6
  • 76
    • 84918828466 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is associated with shorter disease-free survival in hepatocellular carcinoma
    • [76] Yamada, S., Okumura, N., Wei, L., Fuchs, B.C., Fujii, T., Sugimoto, H., et al. Epithelial to mesenchymal transition is associated with shorter disease-free survival in hepatocellular carcinoma. Ann Surg Oncol 21 (2014), 3882–3890.
    • (2014) Ann Surg Oncol , vol.21 , pp. 3882-3890
    • Yamada, S.1    Okumura, N.2    Wei, L.3    Fuchs, B.C.4    Fujii, T.5    Sugimoto, H.6
  • 77
    • 84905485934 scopus 로고    scopus 로고
    • Abnormal expression of EMT-related proteins, S100A4, vimentin and E-cadherin, is correlated with clinicopathological features and prognosis in HCC
    • [77] Zhai, X., Zhu, H., Wang, W., Zhang, S., Zhang, Y., Mao, G., Abnormal expression of EMT-related proteins, S100A4, vimentin and E-cadherin, is correlated with clinicopathological features and prognosis in HCC. Med Oncol, 31, 2014, 970.
    • (2014) Med Oncol , vol.31 , pp. 970
    • Zhai, X.1    Zhu, H.2    Wang, W.3    Zhang, S.4    Zhang, Y.5    Mao, G.6
  • 78
    • 77954159670 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition gene signature to predict clinical outcome of hepatocellular carcinoma
    • [78] Kim, J., Hong, S.J., Park, J.Y., Park, J.H., Yu, Y.S., Park, S.Y., et al. Epithelial-mesenchymal transition gene signature to predict clinical outcome of hepatocellular carcinoma. Cancer Sci 101 (2010), 1521–1528.
    • (2010) Cancer Sci , vol.101 , pp. 1521-1528
    • Kim, J.1    Hong, S.J.2    Park, J.Y.3    Park, J.H.4    Yu, Y.S.5    Park, S.Y.6
  • 79
    • 84869050035 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition expression profiles as a prognostic factor for disease-free survival in hepatocellular carcinoma: Clinical significance of transforming growth factor-beta signaling
    • [79] Mima, K., Hayashi, H., Kuroki, H., Nakagawa, S., Okabe, H., Chikamoto, A., et al. Epithelial-mesenchymal transition expression profiles as a prognostic factor for disease-free survival in hepatocellular carcinoma: Clinical significance of transforming growth factor-beta signaling. Oncol Lett 5 (2013), 149–154.
    • (2013) Oncol Lett , vol.5 , pp. 149-154
    • Mima, K.1    Hayashi, H.2    Kuroki, H.3    Nakagawa, S.4    Okabe, H.5    Chikamoto, A.6
  • 80
    • 84887490152 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition markers expressed in circulating tumor cells in hepatocellular carcinoma patients with different stages of disease
    • [80] Li, Y.M., Xu, S.C., Li, J., Han, K.Q., Pi, H.F., Zheng, L., et al. Epithelial-mesenchymal transition markers expressed in circulating tumor cells in hepatocellular carcinoma patients with different stages of disease. Cell Death Dis, 4, 2013, e831.
    • (2013) Cell Death Dis , vol.4
    • Li, Y.M.1    Xu, S.C.2    Li, J.3    Han, K.Q.4    Pi, H.F.5    Zheng, L.6
  • 81
    • 0033305426 scopus 로고    scopus 로고
    • Potential mechanisms for the plasmin-mediated release and activation of latent transforming growth factor-beta1 from the extracellular matrix of growth plate chondrocytes
    • [81] Pedrozo, H.A., Schwartz, Z., Robinson, M., Gomes, R., Dean, D.D., Bonewald, L.F., et al. Potential mechanisms for the plasmin-mediated release and activation of latent transforming growth factor-beta1 from the extracellular matrix of growth plate chondrocytes. Endocrinology 140 (1999), 5806–5816.
    • (1999) Endocrinology , vol.140 , pp. 5806-5816
    • Pedrozo, H.A.1    Schwartz, Z.2    Robinson, M.3    Gomes, R.4    Dean, D.D.5    Bonewald, L.F.6
  • 82
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    • [82] Yu, Q., Stamenkovic, I., Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 14 (2000), 163–176.
    • (2000) Genes Dev , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 83
    • 0036317838 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 triggers hepatocellular carcinoma invasiveness via alpha3beta1 integrin
    • [83] G. Giannelli, E. Fransvea, Marinosci, F., Bergamini, C., Colucci, S., Schiraldi, O., et al. Transforming growth factor-beta1 triggers hepatocellular carcinoma invasiveness via alpha3beta1 integrin. Am J Pathol 161 (2002), 183–193.
    • (2002) Am J Pathol , vol.161 , pp. 183-193
    • Giannelli, B.1    Fransvea, B.2    Marinosci, F.3    Bergamini, C.4    Colucci, S.5    Schiraldi, O.6
  • 84
    • 79955432112 scopus 로고    scopus 로고
    • CD151 amplifies signaling by integrin alpha6beta1 to PI3K and induces the epithelial-mesenchymal transition in HCC cells
    • [84] Ke, A.W., Shi, G.M., Zhou, J., Huang, X.Y., Shi, Y.H., Ding, Z.B., et al. CD151 amplifies signaling by integrin alpha6beta1 to PI3K and induces the epithelial-mesenchymal transition in HCC cells. Gastroenterology, 140, 2011, e1615.
    • (2011) Gastroenterology , vol.140
    • Ke, A.W.1    Shi, G.M.2    Zhou, J.3    Huang, X.Y.4    Shi, Y.H.5    Ding, Z.B.6
  • 85
    • 70449703290 scopus 로고    scopus 로고
    • Defining the role of laminin-332 in carcinoma
    • [85] Guess, C.M., Quaranta, V., Defining the role of laminin-332 in carcinoma. Matrix Biol 28 (2009), 445–455.
    • (2009) Matrix Biol , vol.28 , pp. 445-455
    • Guess, C.M.1    Quaranta, V.2
  • 86
  • 87
    • 37749038909 scopus 로고    scopus 로고
    • Laminin-5 stimulates hepatocellular carcinoma growth through a different function of alpha6beta4 and alpha3beta1 integrins
    • [87] Bergamini, C., Sgarra, C., Trerotoli, P., Lupo, L., Azzariti, A., Antonaci, S., et al. Laminin-5 stimulates hepatocellular carcinoma growth through a different function of alpha6beta4 and alpha3beta1 integrins. Hepatology 46 (2007), 1801–1809.
    • (2007) Hepatology , vol.46 , pp. 1801-1809
    • Bergamini, C.1    Sgarra, C.2    Trerotoli, P.3    Lupo, L.4    Azzariti, A.5    Antonaci, S.6
  • 88
    • 84871948755 scopus 로고    scopus 로고
    • TGF-beta signaling and epithelial-mesenchymal transition in cancer progression
    • [88] Katsuno, Y., Lamouille, S., Derynck, R., TGF-beta signaling and epithelial-mesenchymal transition in cancer progression. Curr Opin Oncol 25 (2013), 76–84.
    • (2013) Curr Opin Oncol , vol.25 , pp. 76-84
    • Katsuno, Y.1    Lamouille, S.2    Derynck, R.3
  • 89
    • 84866312611 scopus 로고    scopus 로고
    • Context-dependent action of transforming growth factor beta family members on normal and cancer stem cells
    • [89] Caja, L., Kahata, K., Moustakas, A., Context-dependent action of transforming growth factor beta family members on normal and cancer stem cells. Curr Pharm Des 18 (2012), 4072–4086.
    • (2012) Curr Pharm Des , vol.18 , pp. 4072-4086
    • Caja, L.1    Kahata, K.2    Moustakas, A.3
  • 90
    • 74949090309 scopus 로고    scopus 로고
    • The therapeutic promise of the cancer stem cell concept
    • [90] Frank, N.Y., Schatton, T., Frank, M.H., The therapeutic promise of the cancer stem cell concept. J Clin Invest 120 (2010), 41–50.
    • (2010) J Clin Invest , vol.120 , pp. 41-50
    • Frank, N.Y.1    Schatton, T.2    Frank, M.H.3
  • 91
    • 84918815230 scopus 로고    scopus 로고
    • A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells
    • [91] Fernando, J., Malfettone, A., Cepeda, E.B., Vilarrasa-Blasi, R., Bertran, E., Raimondi, G., et al. A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells. Int J Cancer 136 (2015), E161–E172.
    • (2015) Int J Cancer , vol.136 , pp. E161-E172
    • Fernando, J.1    Malfettone, A.2    Cepeda, E.B.3    Vilarrasa-Blasi, R.4    Bertran, E.5    Raimondi, G.6
  • 92
    • 80055060696 scopus 로고    scopus 로고
    • Human hepatocellular carcinomas with “Stemness”-related marker expression: keratin 19 expression and a poor prognosis
    • [92] Kim, H., Choi, G.H., Na, D.C., Ahn, E.Y., Kim, G.I., Lee, J.E., et al. Human hepatocellular carcinomas with “Stemness”-related marker expression: keratin 19 expression and a poor prognosis. Hepatology 54 (2011), 1707–1717.
    • (2011) Hepatology , vol.54 , pp. 1707-1717
    • Kim, H.1    Choi, G.H.2    Na, D.C.3    Ahn, E.Y.4    Kim, G.I.5    Lee, J.E.6
  • 93
    • 79959845312 scopus 로고    scopus 로고
    • Expression of keratin 19 is related to high recurrence of hepatocellular carcinoma after radiofrequency ablation
    • [93] K. Tsuchiya, M. Komuta, Yasui, Y., Tamaki, N., Hosokawa, T., Ueda, K., et al. Expression of keratin 19 is related to high recurrence of hepatocellular carcinoma after radiofrequency ablation. Oncology 80 (2011), 278–288.
    • (2011) Oncology , vol.80 , pp. 278-288
    • Tsuchiya, B.1    Komuta, B.2    Yasui, Y.3    Tamaki, N.4    Hosokawa, T.5    Ueda, K.6
  • 94
    • 84895435815 scopus 로고    scopus 로고
    • Keratin 19: a key role player in the invasion of human hepatocellular carcinomas
    • [94] Govaere, O., Komuta, M., Berkers, J., Spee, B., Janssen, C., de Luca, F., et al. Keratin 19: a key role player in the invasion of human hepatocellular carcinomas. Gut 63 (2014), 674–685.
    • (2014) Gut , vol.63 , pp. 674-685
    • Govaere, O.1    Komuta, M.2    Berkers, J.3    Spee, B.4    Janssen, C.5    de Luca, F.6
  • 95
    • 0141679409 scopus 로고    scopus 로고
    • Laminin-5 chains are expressed differentially in metastatic and nonmetastatic hepatocellular carcinoma
    • [95] Giannelli, G., Fransvea, E., Bergamini, C., Marinosci, F., Antonaci, S., Laminin-5 chains are expressed differentially in metastatic and nonmetastatic hepatocellular carcinoma. Clin Cancer Res 9 (2003), 3684–3691.
    • (2003) Clin Cancer Res , vol.9 , pp. 3684-3691
    • Giannelli, G.1    Fransvea, E.2    Bergamini, C.3    Marinosci, F.4    Antonaci, S.5
  • 96
    • 84958849429 scopus 로고    scopus 로고
    • Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche
    • [96] Govaere, O., Wouters, J., Petz, M., Vandewynckel, Y.P., Van den Eynde, K., Van den Broeck, A., et al. Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche. J Hepatol 64 (2016), 609–617.
    • (2016) J Hepatol , vol.64 , pp. 609-617
    • Govaere, O.1    Wouters, J.2    Petz, M.3    Vandewynckel, Y.P.4    Van den Eynde, K.5    Van den Broeck, A.6
  • 97
    • 84888297095 scopus 로고    scopus 로고
    • Molecular profiling of stroma identifies osteopontin as an independent predictor of poor prognosis in intrahepatic cholangiocarcinoma
    • [97] Sulpice, L., Rayar, M., Desille, M., Turlin, B., Fautrel, A., Boucher, E., et al. Molecular profiling of stroma identifies osteopontin as an independent predictor of poor prognosis in intrahepatic cholangiocarcinoma. Hepatology 58 (2013), 1992–2000.
    • (2013) Hepatology , vol.58 , pp. 1992-2000
    • Sulpice, L.1    Rayar, M.2    Desille, M.3    Turlin, B.4    Fautrel, A.5    Boucher, E.6
  • 98
    • 71849114901 scopus 로고    scopus 로고
    • Influence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model: relevance of epithelial-mesenchymal transition
    • [98] Liu, L., Ren, Z.G., Shen, Y., Zhu, X.D., Zhang, W., Xiong, W., et al. Influence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model: relevance of epithelial-mesenchymal transition. Cancer Sci 101 (2010), 120–128.
    • (2010) Cancer Sci , vol.101 , pp. 120-128
    • Liu, L.1    Ren, Z.G.2    Shen, Y.3    Zhu, X.D.4    Zhang, W.5    Xiong, W.6
  • 100
    • 82355185942 scopus 로고    scopus 로고
    • Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways
    • [100] Ogunwobi, O.O., Liu, C., Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways. Clin Exp Metastasis 28 (2011), 721–731.
    • (2011) Clin Exp Metastasis , vol.28 , pp. 721-731
    • Ogunwobi, O.O.1    Liu, C.2
  • 101
    • 77956635530 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion
    • [101] Ding, W., You, H., Dang, H., LeBlanc, F., Galicia, V., Lu, S.C., et al. Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. Hepatology 52 (2010), 945–953.
    • (2010) Hepatology , vol.52 , pp. 945-953
    • Ding, W.1    You, H.2    Dang, H.3    LeBlanc, F.4    Galicia, V.5    Lu, S.C.6
  • 102
    • 0030951358 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor and its receptor c-met proto-oncogene in hepatocellular carcinoma
    • [102] Ueki, T., Fujimoto, J., Suzuki, T., Yamamoto, H., Okamoto, E., Expression of hepatocyte growth factor and its receptor c-met proto-oncogene in hepatocellular carcinoma. Hepatology 25 (1997), 862–866.
    • (1997) Hepatology , vol.25 , pp. 862-866
    • Ueki, T.1    Fujimoto, J.2    Suzuki, T.3    Yamamoto, H.4    Okamoto, E.5
  • 103
    • 33745220780 scopus 로고    scopus 로고
    • Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
    • [103] Kaposi-Novak, P., Lee, J.S., Gomez-Quiroz, L., Coulouarn, C., Factor, V.M., Thorgeirsson, S.S., Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J Clin Invest 116 (2006), 1582–1595.
    • (2006) J Clin Invest , vol.116 , pp. 1582-1595
    • Kaposi-Novak, P.1    Lee, J.S.2    Gomez-Quiroz, L.3    Coulouarn, C.4    Factor, V.M.5    Thorgeirsson, S.S.6
  • 104
    • 84871721240 scopus 로고    scopus 로고
    • Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study
    • [104] A. Santoro, L. Rimassa, Borbath, I., Daniele, B., Salvagni, S., Van Laethem, J.L., et al. Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study. Lancet Oncol 14 (2013), 55–63.
    • (2013) Lancet Oncol , vol.14 , pp. 55-63
    • Santoro, B.1    Rimassa, B.2    Borbath, I.3    Daniele, B.4    Salvagni, S.5    Van Laethem, J.L.6
  • 105
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • [105] Thiery, J.P., Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2 (2002), 442–454.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 106
    • 84879528782 scopus 로고    scopus 로고
    • Differential Inhibition of the TGF-beta Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-beta Receptor Type II
    • [106] Dituri, F., Mazzocca, A., Peidro, F.J., Papappicco, P., Fabregat, I., De Santis, F., et al. Differential Inhibition of the TGF-beta Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-beta Receptor Type II. PLoS One, 8, 2013, e67109.
    • (2013) PLoS One , vol.8
    • Dituri, F.1    Mazzocca, A.2    Peidro, F.J.3    Papappicco, P.4    Fabregat, I.5    De Santis, F.6
  • 108
    • 84908671704 scopus 로고    scopus 로고
    • Circulating TGF-beta1-related biomarkers in patients with hepatocellular carcinoma and their association with HCC staging scores
    • [108] Dituri, F., Serio, G., Filannino, D., Mascolo, A., Sacco, R., Villa, E., et al. Circulating TGF-beta1-related biomarkers in patients with hepatocellular carcinoma and their association with HCC staging scores. Cancer Lett 353 (2014), 264–271.
    • (2014) Cancer Lett , vol.353 , pp. 264-271
    • Dituri, F.1    Serio, G.2    Filannino, D.3    Mascolo, A.4    Sacco, R.5    Villa, E.6
  • 109
    • 84944879420 scopus 로고    scopus 로고
    • MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets
    • [109] S.P. Chen, B.X. Liu, J. Xu, Pei, X.F., Liao, Y.J., Yuan, F., et al. MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets. BMC Cancer, 15, 2015, 706.
    • (2015) BMC Cancer , vol.15 , pp. 706
    • Chen, B.P.1    Liu, B.X.2    Xu, B.3    Pei, X.F.4    Liao, Y.J.5    Yuan, F.6
  • 110
    • 84943663583 scopus 로고    scopus 로고
    • SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma
    • [110] Fan, L.C., Shiau, C.W., Tai, W.T., Hung, M.H., Chu, P.Y., Hsieh, F.S., et al. SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma. Oncogene 34 (2015), 5252–5263.
    • (2015) Oncogene , vol.34 , pp. 5252-5263
    • Fan, L.C.1    Shiau, C.W.2    Tai, W.T.3    Hung, M.H.4    Chu, P.Y.5    Hsieh, F.S.6
  • 111
    • 84942902954 scopus 로고    scopus 로고
    • Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma
    • [111] Nath, A., Li, I., Roberts, L.R., Chan, C., Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma. Sci Rep, 5, 2015, 14752.
    • (2015) Sci Rep , vol.5
    • Nath, A.1    Li, I.2    Roberts, L.R.3    Chan, C.4
  • 112
    • 84942553117 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor-induced epithelial-mesenchymal transition
    • [112] Z.C. Wang, Q. Gao, J.Y. Shi, W.J. Guo, Yang, L.X., Liu, X.Y., et al. Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor-induced epithelial-mesenchymal transition. Hepatology 62 (2015), 1201–1214.
    • (2015) Hepatology , vol.62 , pp. 1201-1214
    • Wang, B.C.1    Gao, B.2    Shi, B.Y.3    Guo, B.J.4    Yang, L.X.5    Liu, X.Y.6
  • 113
    • 84956627972 scopus 로고    scopus 로고
    • Actin-like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial-mesenchymal transition
    • [113] Xiao, S., Chang, R.M., Yang, M.Y., Lei, X., Liu, X., Gao, W.B., et al. Actin-like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial-mesenchymal transition. Hepatology 63 (2016), 1256–1271.
    • (2016) Hepatology , vol.63 , pp. 1256-1271
    • Xiao, S.1    Chang, R.M.2    Yang, M.Y.3    Lei, X.4    Liu, X.5    Gao, W.B.6
  • 114
    • 84971667932 scopus 로고    scopus 로고
    • FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3beta/beta- catenin signaling cascade via FGFR4 activation
    • [114] Zhao, H., Lv, F., Liang, G., Huang, X., Wu, G., Zhang, W., et al. FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3beta/beta- catenin signaling cascade via FGFR4 activation. Oncotarget 7 (2016), 13575–13586.
    • (2016) Oncotarget , vol.7 , pp. 13575-13586
    • Zhao, H.1    Lv, F.2    Liang, G.3    Huang, X.4    Wu, G.5    Zhang, W.6
  • 115
    • 84958063858 scopus 로고    scopus 로고
    • Protein kinase D2 contributes to TNF-alpha-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3beta/beta-catenin pathway in hepatocellular carcinoma
    • [115] Y. Zhu, Y. Cheng, Guo, Y., Chen, J., Chen, F., Luo, R., et al. Protein kinase D2 contributes to TNF-alpha-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3beta/beta-catenin pathway in hepatocellular carcinoma. Oncotarget 7 (2016), 5327–5341.
    • (2016) Oncotarget , vol.7 , pp. 5327-5341
    • Zhu, B.1    Cheng, B.2    Guo, Y.3    Chen, J.4    Chen, F.5    Luo, R.6


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