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Volumn 31, Issue 6, 2014, Pages

Abnormal expression of EMT-related proteins, S100A4, vimentin and E-cadherin, is correlated with clinicopathological features and prognosis in HCC

Author keywords

E cadherin; Hepatocellular carcinoma; Immunohistochemistry; Prognosis; S100A4; Tissue microarray; Vimentin

Indexed keywords

ALPHA FETOPROTEIN; CALVASCULIN; UVOMORULIN; VIMENTIN; CADHERIN; MUC1 PROTEIN, HUMAN; MUCIN 1; PROTEIN S 100; S100A4 PROTEIN, HUMAN; TUMOR MARKER;

EID: 84905485934     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-014-0970-z     Document Type: Article
Times cited : (109)

References (49)
  • 1
    • 79952232216 scopus 로고    scopus 로고
    • Global cancer statistics
    • Jemal A, et al. Global cancer statistics. CA Cancer J Clin.2011;61(2):69-90.
    • (2011) CA Cancer J Clin , vol.61 , Issue.2 , pp. 69-90
    • Jemal, A.1
  • 3
    • 14744291909 scopus 로고    scopus 로고
    • Epidemiology and natural history of hepatocellular carcinoma
    • DOI 10.1016/j.bpg.2004.10.004, PII S1521691804001465
    • McGlynn KA, London WT. Epidemiology and natural history ofhepatocellular carcinoma. Best Pract Res Clin Gastroenterol.2005;19(1):3-23. (Pubitemid 40331495)
    • (2005) Best Practice and Research: Clinical Gastroenterology , vol.19 , Issue.1 SPEC. ISS. , pp. 3-23
    • McGlynn, K.A.1    London, W.T.2
  • 4
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: From genes to environment
    • DOI 10.1038/nrc1934, PII NRC1934
    • Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis:from genes to environment. Nat Rev Cancer. 2006;6(9):674-87. (Pubitemid 44286000)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.9 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 5
    • 78650825660 scopus 로고    scopus 로고
    • Novel molecular therapies inhepatocellular carcinoma
    • Faivre S, Bouattour M, Raymond E. Novel molecular therapies inhepatocellular carcinoma. Liver Int. 2011;31(Suppl 1):151-60.
    • (2011) Liver Int , vol.31 , Issue.SUPPL. 1 , pp. 151-160
    • Faivre, S.1    Bouattour, M.2    Raymond, E.3
  • 6
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of humanhepatocellular carcinoma
    • Thorgeirsson SS, Grisham JW. Molecular pathogenesis of humanhepatocellular carcinoma. Nat Genet. 2002;31(4):339-46.
    • (2002) Nat Genet , vol.31 , Issue.4 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 7
    • 79951555293 scopus 로고    scopus 로고
    • Transcription factors zeb1, twist and snai1 in breastcarcinoma
    • Soini Y, et al. Transcription factors zeb1, twist and snai1 in breastcarcinoma. BMC Cancer. 2011;11:73.
    • (2011) BMC Cancer , vol.11 , pp. 73
    • Soini, Y.1
  • 8
    • 79251474948 scopus 로고    scopus 로고
    • Subcellular proteomics revealed the epithelial-mesenchymaltransition phenotype in lung cancer
    • Li LP, et al. Subcellular proteomics revealed the epithelial- mesenchymaltransition phenotype in lung cancer. Proteomics. 2011;11(3):429-39.
    • (2011) Proteomics , vol.11 , Issue.3 , pp. 429-439
    • Li, L.P.1
  • 9
    • 58149335431 scopus 로고    scopus 로고
    • Prognostic significance of epithelial-mesenchymaland mesenchymal- epithelial transition protein expressionin non-small cell lung cancer
    • Soltermann A, et al. Prognostic significance of epithelial-mesenchymaland mesenchymal-epithelial transition protein expressionin non-small cell lung cancer. Clin Cancer Res. 2008;14(22):7430-7.
    • (2008) Clin Cancer Res , vol.14 , Issue.22 , pp. 7430-7437
    • Soltermann, A.1
  • 10
    • 79956007927 scopus 로고    scopus 로고
    • A human model of epithelial to mesenchymaltransition to monitor drug efficacy in hepatocellular carcinomaprogression
    • van Zijl F, et al. A human model of epithelial to mesenchymaltransition to monitor drug efficacy in hepatocellular carcinomaprogression. Mol Cancer Ther. 2011;10(5):850-60.
    • (2011) Mol Cancer Ther , vol.10 , Issue.5 , pp. 850-860
    • Van Zijl, F.1
  • 11
    • 79952054688 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1activation mediates epithelial to mesenchymal transition inhepatocellular carcinoma cells
    • Yi ZY, et al. Vascular endothelial growth factor receptor-1activation mediates epithelial to mesenchymal transition inhepatocellular carcinoma cells. J Invest Surg. 2011;24(2):67-76.
    • (2011) J Invest Surg , vol.24 , Issue.2 , pp. 67-76
    • Yi, Z.Y.1
  • 12
    • 77954159670 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition gene signature topredict clinical outcome of hepatocellular carcinoma
    • Kim J, et al. Epithelial-mesenchymal transition gene signature topredict clinical outcome of hepatocellular carcinoma. Cancer Sci.2010;101(6):1521-8.
    • (2010) Cancer Sci , vol.101 , Issue.6 , pp. 1521-1528
    • Kim, J.1
  • 13
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymaltransition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymaltransition. J Clin Invest. 2009;119(6):1420-8.
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 14
    • 0024383791 scopus 로고
    • Dissecting tumor cell invasion: Epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion
    • Behrens J, et al. Dissecting tumor cell invasion: epithelial cellsacquire invasive properties after the loss of uvomorulin-mediatedcell-cell adhesion. J Cell Biol. 1989;108(6):2435-47. (Pubitemid 19168932)
    • (1989) Journal of Cell Biology , vol.108 , Issue.6 , pp. 2435-2447
    • Behrens, J.1    Mareel, M.M.2    Van Roy, F.M.3    Birchmeier, W.4
  • 15
    • 67649385780 scopus 로고    scopus 로고
    • Mesenchymal to epithelial transition in thehuman ovarian surface epithelium focusing on inclusion cysts
    • Okamoto S, et al. Mesenchymal to epithelial transition in thehuman ovarian surface epithelium focusing on inclusion cysts.Oncol Rep. 2009;21(5):1209-14.
    • (2009) Oncol Rep , vol.21 , Issue.5 , pp. 1209-1214
    • Okamoto, S.1
  • 16
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in developmentand disease
    • Thiery JP, et al. Epithelial-mesenchymal transitions in developmentand disease. Cell. 2009;139(5):871-90.
    • (2009) Cell , vol.139 , Issue.5 , pp. 871-890
    • Thiery, J.P.1
  • 17
    • 84867870604 scopus 로고    scopus 로고
    • Loss of E-cadherin and acquisition of vimentin inepithelial-mesenchymal transition are noble indicators of uterinecervix cancer progression
    • Myong NH. Loss of E-cadherin and acquisition of vimentin inepithelial-mesenchymal transition are noble indicators of uterinecervix cancer progression. Korean J Pathol. 2012;46(4):341-8.
    • (2012) Korean J Pathol , vol.46 , Issue.4 , pp. 341-348
    • Myong, N.H.1
  • 18
    • 34547599359 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro
    • DOI 10.1074/jbc.M700998200
    • Kaimori A, et al. Transforming growth factor-beta1 induces anepithelial-to-mesenchymal transition state in mouse hepatocytesin vitro. J Biol Chem. 2007;282(30):22089-101. (Pubitemid 47195788)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.30 , pp. 22089-22101
    • Kaimori, A.1    Potter, J.2    Kaimori, J.-Y.3    Wang, C.4    Mezey, E.5    Koteish, A.6
  • 19
    • 66149101390 scopus 로고    scopus 로고
    • Specific glycosphingolipidsmediate epithelial-to-mesenchymal transition of human andmouse epithelial cell lines
    • Guan F, Handa K, Hakomori SI. Specific glycosphingolipidsmediate epithelial-to-mesenchymal transition of human andmouse epithelial cell lines. Proc Natl Acad Sci USA. 2009;106(18):7461-6.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.18 , pp. 7461-7466
    • Guan, F.1    Handa, K.2    Hakomori, S.I.3
  • 20
    • 79959620404 scopus 로고    scopus 로고
    • Grape seed proanthocyanidinsinhibit melanoma cell invasiveness by reduction of PGE2 synthesisand reversal of epithelial-to-mesenchymal transition
    • Vaid M, Singh T, Katiyar SK. Grape seed proanthocyanidinsinhibit melanoma cell invasiveness by reduction of PGE2 synthesisand reversal of epithelial-to-mesenchymal transition. PLoSONE. 2011;6(6):e21539.
    • (2011) PLoSONE , vol.6 , Issue.6
    • Vaid, M.1    Singh, T.2    Katiyar, S.K.3
  • 21
    • 77954586069 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition induced bytransforming growth factor-{beta}1/Snail activation aggravatesinvasive growth of cholangiocarcinoma
    • Sato Y, et al. Epithelial-mesenchymal transition induced bytransforming growth factor-{beta}1/Snail activation aggravatesinvasive growth of cholangiocarcinoma. Am J Pathol. 2010;177(1):141-52.
    • (2010) Am J Pathol , vol.177 , Issue.1 , pp. 141-152
    • Sato, Y.1
  • 22
    • 66249099232 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition and resistanceto ingenol 3-angelate, a novel protein kinase C modulator,in colon cancer cells
    • Ghoul A, et al. Epithelial-to-mesenchymal transition and resistanceto ingenol 3-angelate, a novel protein kinase C modulator,in colon cancer cells. Cancer Res. 2009;69(10):4260-9.
    • (2009) Cancer Res , vol.69 , Issue.10 , pp. 4260-4269
    • Ghoul, A.1
  • 23
    • 79952219736 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition mediatorS100A4 maintains cancer-initiating cells in head and neck cancers
    • Lo JF, et al. The epithelial-mesenchymal transition mediatorS100A4 maintains cancer-initiating cells in head and neck cancers.Cancer Res. 2011;71(5):1912-23.
    • (2011) Cancer Res , vol.71 , Issue.5 , pp. 1912-1923
    • Lo, J.F.1
  • 24
    • 78649320264 scopus 로고    scopus 로고
    • Potential role of mesenchymal stem cells(MSCs) in the breast tumour microenvironment: Stimulation ofepithelial to mesenchymal transition (EMT)
    • Martin FT, et al. Potential role of mesenchymal stem cells(MSCs) in the breast tumour microenvironment: stimulation ofepithelial to mesenchymal transition (EMT). Breast Cancer ResTreat. 2010;124(2):317-26.
    • (2010) Breast Cancer ResTreat , vol.124 , Issue.2 , pp. 317-326
    • Martin, F.T.1
  • 25
    • 75449104452 scopus 로고    scopus 로고
    • Expression and functional significance of Twist1 inhepatocellular carcinoma: Its role in vasculogenic mimicry
    • Sun T, et al. Expression and functional significance of Twist1 inhepatocellular carcinoma: its role in vasculogenic mimicry.Hepatology. 2010;51(2):545-56.
    • (2010) Hepatology , vol.51 , Issue.2 , pp. 545-556
    • Sun, T.1
  • 26
    • 72949120827 scopus 로고    scopus 로고
    • Comprehensive analysis of the independenteffect of twist and snail in promoting metastasis of hepatocellularcarcinoma
    • Yang MH, et al. Comprehensive analysis of the independenteffect of twist and snail in promoting metastasis of hepatocellularcarcinoma. Hepatology. 2009;50(5):1464-74.
    • (2009) Hepatology , vol.50 , Issue.5 , pp. 1464-1474
    • Yang, M.H.1
  • 27
    • 79955613190 scopus 로고    scopus 로고
    • A comparison of Twist and E-cadherin proteinexpression in primary non-small-cell lung carcinoma and correspondingmetastases
    • Wang G, et al. A comparison of Twist and E-cadherin proteinexpression in primary non-small-cell lung carcinoma and correspondingmetastases. Eur J Cardiothorac Surg. 2011;39(6):1028-32.
    • (2011) Eur J Cardiothorac Surg , vol.39 , Issue.6 , pp. 1028-1032
    • Wang, G.1
  • 28
    • 68449094056 scopus 로고    scopus 로고
    • Disruption of E-cadherin by matrix metalloproteinasedirectly mediates epithelial-mesenchymal transitiondownstream of transforming growth factor-beta1 in renal tubularepithelial cells
    • Zheng G, et al. Disruption of E-cadherin by matrix metalloproteinasedirectly mediates epithelial-mesenchymal transitiondownstream of transforming growth factor-beta1 in renal tubularepithelial cells. Am J Pathol. 2009;175(2):580-91.
    • (2009) Am J Pathol , vol.175 , Issue.2 , pp. 580-591
    • Zheng, G.1
  • 29
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression.Nat Rev Cancer. 2002;2(6):442-54.
    • (2002) Nat Rev Cancer , vol.2 , Issue.6 , pp. 442-454
    • Thiery, J.P.1
  • 32
    • 0038745381 scopus 로고    scopus 로고
    • The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis
    • Xue C, et al. The gatekeeper effect of epithelial-mesenchymaltransition regulates the frequency of breast cancer metastasis.Cancer Res. 2003;63(12):3386-94. (Pubitemid 36735899)
    • (2003) Cancer Research , vol.63 , Issue.12 , pp. 3386-3394
    • Xue, C.1    Plieth, D.2    Venkov, C.3    Xu, C.4    Neilson, E.G.5
  • 33
    • 34547120221 scopus 로고    scopus 로고
    • S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer
    • DOI 10.1158/0008-5472.CAN-07-0440
    • Mahon PC, et al. S100A4 contributes to the suppression ofBNIP3 expression, chemoresistance, and inhibition of apoptosisin pancreatic cancer. Cancer Res. 2007;67(14):6786-95. (Pubitemid 47105526)
    • (2007) Cancer Research , vol.67 , Issue.14 , pp. 6786-6795
    • Mahon, P.C.1    Baril, P.2    Bhakta, V.3    Chelala, C.4    Caulee, K.5    Harada, T.6    Lemoine, N.R.7
  • 34
    • 80052267874 scopus 로고    scopus 로고
    • Vimentin in cancer and its potential as amolecular target for cancer therapy
    • Satelli A, Li S. Vimentin in cancer and its potential as amolecular target for cancer therapy. Cell Mol Life Sci. 2011;68(18):3033-46.
    • (2011) Cell Mol Life Sci , vol.68 , Issue.18 , pp. 3033-3046
    • Satelli, A.1    Li, S.2
  • 35
    • 0347123435 scopus 로고    scopus 로고
    • Mucins in cancer: Protection and control of the cell surface
    • Hollingsworth MA, Swanson BJ. Mucins in cancer: protectionand control of the cell surface. Nat Rev Cancer. 2004;4(1):45-60. (Pubitemid 38082153)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.1 , pp. 45-60
    • Hollingsworth, M.A.1    Swanson, B.J.2
  • 37
    • 62149103291 scopus 로고    scopus 로고
    • Prognostic importance of epithelial-mesenchymaltransition-related protein expression in gastric carcinoma
    • Kim MA, et al. Prognostic importance of epithelial-mesenchymaltransition- related protein expression in gastric carcinoma. Histopathology.2009;54(4):442- 51.
    • (2009) Histopathology , vol.54 , Issue.4 , pp. 442-451
    • Kim, M.A.1
  • 38
    • 78651507080 scopus 로고    scopus 로고
    • S100A4 over-expression underlies lymph nodemetastasis and poor prognosis in colorectal cancer
    • Huang LY, et al. S100A4 over-expression underlies lymph nodemetastasis and poor prognosis in colorectal cancer. World JGastroenterol. 2011;17(1):69-78.
    • (2011) World JGastroenterol , vol.17 , Issue.1 , pp. 69-78
    • Huang, L.Y.1
  • 39
    • 84886996188 scopus 로고    scopus 로고
    • Increased expression of Slug and Vimentin asnovel predictive biomarkers for lymph node metastasis and poorprognosis in colorectal cancer
    • Toiyama Y, et al. Increased expression of Slug and Vimentin asnovel predictive biomarkers for lymph node metastasis and poorprognosis in colorectal cancer. Carcinogenesis. 2013;34(11):2548-57.
    • (2013) Carcinogenesis , vol.34 , Issue.11 , pp. 2548-2557
    • Toiyama, Y.1
  • 40
    • 84876295683 scopus 로고    scopus 로고
    • Vimentin as a poor prognostic factor fortriple-negative breast cancer
    • Yamashita N, et al. Vimentin as a poor prognostic factor fortriple-negative breast cancer. J Cancer Res Clin Oncol. 2013;139(5):739-46.
    • (2013) J Cancer Res Clin Oncol , vol.139 , Issue.5 , pp. 739-746
    • Yamashita, N.1
  • 41
    • 41149144519 scopus 로고    scopus 로고
    • Positive association of up-regulated Cripto-1and down-regulated E-cadherin with tumour progression andpoor prognosis in gastric cancer
    • Zhong XY, et al. Positive association of up-regulated Cripto-1and down-regulated E-cadherin with tumour progression andpoor prognosis in gastric cancer. Histopathology. 2008;52(5):560-8.
    • (2008) Histopathology , vol.52 , Issue.5 , pp. 560-568
    • Zhong, X.Y.1
  • 43
    • 68049099265 scopus 로고    scopus 로고
    • Prognostic significance of the expression of MUC1and collagen type IV in advanced gastric carcinoma
    • Ando H, et al. Prognostic significance of the expression of MUC1and collagen type IV in advanced gastric carcinoma. Br J Surg.2009;96(8):901-9.
    • (2009) Br J Surg , vol.96 , Issue.8 , pp. 901-909
    • Ando, H.1
  • 44
    • 84890310936 scopus 로고    scopus 로고
    • The role of tumour-associated MUC1 in epithelialovarian cancer metastasis and progression
    • Deng J, et al. The role of tumour-associated MUC1 in epithelialovarian cancer metastasis and progression. Cancer MetastasisRev. 2013;32(3-4):535-51.
    • (2013) Cancer MetastasisRev , vol.32 , Issue.3-4 , pp. 535-551
    • Deng, J.1
  • 45
    • 79961086826 scopus 로고    scopus 로고
    • The latest 2010 WHO classification of tumors ofdigestive system
    • Li ZS, Li Q. The latest 2010 WHO classification of tumors ofdigestive system. Zhonghua Bing Li Xue Za Zhi. 2011;40(5):351-4.
    • (2011) Zhonghua Bing Li Xue Za Zhi , vol.40 , Issue.5 , pp. 351-354
    • Li, Z.S.1    Li, Q.2
  • 46
    • 79953090713 scopus 로고    scopus 로고
    • Prognostic significance and potential therapeutictarget of VEGFR2 in hepatocellular carcinoma
    • Huang J, et al. Prognostic significance and potential therapeutictarget of VEGFR2 in hepatocellular carcinoma. J Clin Pathol.2011;64(4):343-8.
    • (2011) J Clin Pathol , vol.64 , Issue.4 , pp. 343-348
    • Huang, J.1
  • 47
    • 0034668172 scopus 로고    scopus 로고
    • Induction and regulation of epi-thelial-mesenchymal transitions
    • Boyer B, Valles AM, Edme N. Induction and regulation of epi-thelial-mesenchymal transitions. Biochem Pharmacol. 2000;60(8):1091-9.
    • (2000) Biochem Pharmacol , vol.60 , Issue.8 , pp. 1091-1099
    • Boyer, B.1    Valles, A.M.2    Edme, N.3
  • 48
    • 44449111555 scopus 로고    scopus 로고
    • Loss of E-cadherin promotes metastasis viamultiple downstream transcriptional pathways
    • Onder TT, et al. Loss of E-cadherin promotes metastasis viamultiple downstream transcriptional pathways. Cancer Res. 2008;68(10):3645-54.
    • (2008) Cancer Res , vol.68 , Issue.10 , pp. 3645-3654
    • Onder, T.T.1
  • 49
    • 76149146685 scopus 로고    scopus 로고
    • S100A4 and metastasis: A small actorplaying many roles
    • Boye K, Maelandsmo GM. S100A4 and metastasis: a small actorplaying many roles. Am J Pathol. 2010;176(2):528-35.
    • (2010) Am J Pathol , vol.176 , Issue.2 , pp. 528-535
    • Boye, K.1    Maelandsmo, G.M.2


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