Epithelial-mesenchymal transition expression profiles as a prognostic factor for disease-free survival in hepatocellular carcinoma: Clinical significance of transforming growth factor-β signaling

Oncology Letters

Volumn 5, Issue 1, 2012, Pages 149-154

  Mima, Kosuke ^a   Hayashi, Hiromitsu ^a   Kuroki, Hideyuki ^a   Nakagawa, Shigeki ^a   Okabe, Hirohisa ^a   Chikamoto, Akira ^a   Watanabe, Masayuki ^a   Beppu, Toru ^a   Baba, Hideo ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Epithelial mesenchymal transition; Hepatocellular carcinoma; Smad2; TGF

Indexed keywords

SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; VIMENTIN;

ADULT; ARTICLE; CANCER INVASION; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; DISEASE FREE SURVIVAL; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR DIFFERENTIATION;

EID: 84869050035     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2012.954     Document Type: Article

References (27)

1. El-Serag HB: Hepatocellular carcinoma. N Engl J Med 365: 1118-1127, 2011.
2. Thiery JP, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890, 2009.
3. Moody SE, Perez D, Pan TC, et al: The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell 8: 197-209, 2005.
4. Shioiri M, Shida T, Koda K, et al: Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients. Br J Cancer 94: 1816-1822, 2006.
5. Yang MH, Chen CL, Chau GY, et al: Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology 50: 1464-1474, 2009.
6. Zhou YM, Cao L, Li B, et al: Clinicopathological significance of ZEB1 protein in patients with hepatocellular carcinoma. Ann Surg Oncol 19: 1700-1706, 2011.
7. Siegel PM and Massagué J: Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 3: 807-821, 2003.
8. Mima K, Okabe H, Ishimoto T, et al: CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma. Cancer Res 72: 3414-3423, 2012.
9. Liver Cancer Study Group of Japan: The General Rules for the Clinical and Pathological Study of Primary Liver Cancer. Kanehara, Tokyo, 2009.
10. Minagawa M, Ikai I, Matsuyama Y, Yamaoka Y and Makuuchi M: Staging of hepatocellular carcinoma: assessment of the Japanese TNM and AJCC/UICC TNM systems in a cohort of 13,772 patients in Japan. Ann Surg 245: 909-922, 2007.
11. Vauthey JN, Lauwers GY, Esnaola NF, et al: Simplified staging for hepatocellular carcinoma. J Clin Oncol 20: 1527-1536, 2002.
12. Okabe H, Beppu T, Hayashi H, et al: Hepatic stellate cells accelerate the malignant behavior of cholangiocarcinoma cells. Ann Surg Oncol 18: 1175-1184, 2011.
13. Yang MH, Hsu DS, Wang HW, et al: Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat Cell Biol12: 982-992, 2010.
14. Iwatsuki M, Mimori K, Fukagawa T, et al: The clinical significance of vimentin-expressing gastric cancer cells in bone marrow. Ann Surg Oncol 17: 2526-2533, 2010.
15. Vora HH, Patel NA, Rajvik KN, et al: Cytokeratin and vimentin expression in breast cancer. Int J Biol Markers 24: 38-46, 2009.
16. Padua D, Zhang XH, Wang Q, et al: TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133: 66-77, 2008.
17. Yin JJ, Selander K, Chirgwin JM, et al: TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J Clin Invest 103: 197-206, 1999.
18. Bedossa P, Peltier E, Terris B, Franco D and Poynard T: Transforming growth factor-beta 1 (TGF-beta 1) and TGF-beta1 receptors in normal, cirrhotic, and neoplastic human livers. Hepatology 21: 760-766, 1995.
19. Abou-Shady M, Baer HU, Friess H, et al: Transforming growth factor betas and their signaling receptors in human hepatocellular carcinoma. Am J Surg 177: 209-215, 1999.
20. Lee TK, Man K, Poon RT, et al: Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition. Cancer Res 66: 9948-9956, 2006.
21. Chen L, Chan TH, Yuan YF, et al: CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. J Clin Invest120: 1178-1191, 2010.
22. Chung KY, Cheng IK, Ching AK, Chu JH, Lai PB and Wong N: Block of proliferation 1 (BOP1) plays an oncogenic role in hepatocellular carcinoma by promoting epithelial-to-mesenchymal transition. Hepatology 54: 307-318, 2011.
23. Fu J, Chen Y, Cao J, et al: p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1alpha pathways. Hepatology 53: 181-192, 2011.
24. Kim H, Choi GH, Na DC, et al: Human hepatocellular carcinomas with "stemness"-related marker expression: keratin 19 expression and a poor prognosis. Hepatology 54: 1707-1717, 2011.
25. Wang J, Chen L, Li Y and Guan XY: Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. PLoS One 6: e24967, 2011.
26. Yokomizo C, Yamaguchi K, Itoh Y, et al: High expression of p300 in HCC predicts shortened overall survival in association with enhanced epithelial mesenchymal transition of HCC cells. Cancer Lett 310: 140-147, 2011.
27. Zhu K, Dai Z, Pan Q, et al: Metadherin promotes hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin Cancer Res 17: 7294-7302, 2011.