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Volumn 305, Issue 12, 2013, Pages

Evidence for and against epithelial-to-mesenchymal transition in the liver

Author keywords

Cholangiocytes; Fibrosis; Hepatic stellate cell; Hepatocytes; Progenitors; Regeneration

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; BETA GALACTOSIDASE; CALVASCULIN; COLLAGEN 1 ALPHA 1; COLLAGEN TYPE 1; CYTOKERATIN; CYTOKERATIN 19; CYTOKERATIN 7; DESMIN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; GOOSECOID PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 8; NERVE CELL ADHESION MOLECULE; NOTCH RECEPTOR; PLATELET DERIVED GROWTH FACTOR; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR FOXC2; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAI1; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UNINDEXED DRUG; UVOMORULIN; VIMENTIN; WNT PROTEIN;

EID: 84890346941     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00289.2013     Document Type: Review
Times cited : (95)

References (104)
  • 1
    • 67650996280 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: The importance of changing cell state in development and disease
    • Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA. Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 119: 1438-1449, 2009.
    • (2009) J Clin Invest , vol.119 , pp. 1438-1449
    • Acloque, H.1    Adams, M.S.2    Fishwick, K.3    Bronner-Fraser, M.4    Nieto, M.A.5
  • 3
    • 63349109309 scopus 로고    scopus 로고
    • Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development
    • Asahina K, Tsai SY, Li P, Ishii M, Maxson RE Jr, Sucov HM, Tsukamoto H. Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology 49: 998-1011, 2009.
    • (2009) Hepatology , vol.49 , pp. 998-1011
    • Asahina, K.1    Tsai, S.Y.2    Li, P.3    Ishii, M.4    Maxson Jr., R.E.5    Sucov, H.M.6    Tsukamoto, H.7
  • 4
    • 79952240154 scopus 로고    scopus 로고
    • Septum transversumderived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver
    • Asahina K, Zhou B, Pu WT, Tsukamoto H. Septum transversumderived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology 53: 983-995, 2011.
    • (2011) Hepatology , vol.53 , pp. 983-995
    • Asahina, K.1    Zhou, B.2    Pu, W.T.3    Tsukamoto, H.4
  • 6
    • 84888286377 scopus 로고    scopus 로고
    • Overactivation of the TGF-beta pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells
    • Jun 28. doi: 10.1002/hep.26597. [Epub ahead of print]
    • Bertran E, Crosas-Molist E, Sancho P, Caja L, Lopez-Luque J, Navarro E, Egea G, Lastra R, Serrano T, Ramos E, Fabregat I. Overactivation of the TGF-beta pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells. Hepatology 2013 Jun 28. doi: 10.1002/hep.26597. [Epub ahead of print]
    • (2013) Hepatology
    • Bertran, E.1    Crosas-Molist, E.2    Sancho, P.3    Caja, L.4    Lopez-Luque, J.5    Navarro, E.6    Egea, G.7    Lastra, R.8    Serrano, T.9    Ramos, E.10    Fabregat, I.11
  • 9
    • 79951797048 scopus 로고    scopus 로고
    • The transforming growth factor-beta (TGF-beta) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells
    • Caja L, Bertran E, Campbell J, Fausto N, Fabregat I. The transforming growth factor-beta (TGF-beta) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells. J Cell Physiol 226: 1214-1223, 2011.
    • (2011) J Cell Physiol , vol.226 , pp. 1214-1223
    • Caja, L.1    Bertran, E.2    Campbell, J.3    Fausto, N.4    Fabregat, I.5
  • 12
    • 80052947064 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations
    • Chen X, Lingala S, Khoobyari S, Nolta J, Zern MA, Wu J. Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations. J Hepatol 55: 838-845, 2011.
    • (2011) J Hepatol , vol.55 , pp. 838-845
    • Chen, X.1    Lingala, S.2    Khoobyari, S.3    Nolta, J.4    Zern, M.A.5    Wu, J.6
  • 13
    • 84867068023 scopus 로고    scopus 로고
    • Inhibition of Notch signaling by a gamma-secretase inhibitor attenuates hepatic fibrosis in rats
    • Chen Y, Zheng S, Qi D, Zheng S, Guo J, Zhang S, Weng Z. Inhibition of Notch signaling by a gamma-secretase inhibitor attenuates hepatic fibrosis in rats. PLoS One 7: e46512, 2012.
    • (2012) PLoS One , vol.7
    • Chen, Y.1    Zheng, S.2    Qi, D.3    Zheng, S.4    Guo, J.5    Zhang, S.6    Weng, Z.7
  • 14
    • 79955087925 scopus 로고    scopus 로고
    • Sorafenib inhibits transforming growth factor beta1-mediated epithelial-mesenchymal transition and apoptosis in mouse hepatocytes
    • Chen YL, Lv J, Ye XL, Sun MY, Xu Q, Liu CH, Min LH, Li HP, Liu P, Ding X. Sorafenib inhibits transforming growth factor beta1-mediated epithelial-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology 53: 1708-1718, 2011.
    • (2011) Hepatology , vol.53 , pp. 1708-1718
    • Chen, Y.L.1    Lv, J.2    Ye, X.L.3    Sun, M.Y.4    Xu, Q.5    Liu, C.H.6    Min, L.H.7    Li, H.P.8    Liu, P.9    Ding, X.10
  • 15
    • 73149101056 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transitions in the liver
    • Choi SS, Diehl AM. Epithelial-to-mesenchymal transitions in the liver. Hepatology 50: 2007-2013, 2009.
    • (2009) Hepatology , vol.50 , pp. 2007-2013
    • Choi, S.S.1    Diehl, A.M.2
  • 18
    • 79955123951 scopus 로고    scopus 로고
    • Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis
    • Chu AS, Diaz R, Hui JJ, Yanger K, Zong Y, Alpini G, Stanger BZ, Wells RG. Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis. Hepatology 53: 1685-1695, 2011.
    • (2011) Hepatology , vol.53 , pp. 1685-1695
    • Chu, A.S.1    Diaz, R.2    Hui, J.J.3    Yanger, K.4    Zong, Y.5    Alpini, G.6    Stanger, B.Z.7    Wells, R.G.8
  • 24
    • 79954581525 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition as a biomarker in renal fibrosis: Are we ready for the bedside?
    • Galichon P, Hertig A. Epithelial to mesenchymal transition as a biomarker in renal fibrosis: are we ready for the bedside? Fibrogenesis Tissue Repair 4: 11, 2011.
    • (2011) Fibrogenesis Tissue Repair , vol.4 , pp. 11
    • Galichon, P.1    Hertig, A.2
  • 27
    • 34547599359 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro
    • Kaimori A, Potter J, Kaimori JY, Wang C, Mezey E, Koteish A. Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem 282: 22089-22101, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 22089-22101
    • Kaimori, A.1    Potter, J.2    Kaimori, J.Y.3    Wang, C.4    Mezey, E.5    Koteish, A.6
  • 28
    • 67651005404 scopus 로고    scopus 로고
    • EMT: When epithelial cells decide to become mesenchymallike cells
    • Kalluri R. EMT: when epithelial cells decide to become mesenchymallike cells. J Clin Invest 119: 1417-1419, 2009.
    • (2009) J Clin Invest , vol.119 , pp. 1417-1419
    • Kalluri, R.1
  • 29
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428, 2009.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 30
    • 84884567357 scopus 로고    scopus 로고
    • Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines
    • Kang J, Kim E, Kim W, Seong KM, Youn H, Kim JW, Kim J, Youn B. Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines. J Biol Chem 288: 27343-27357, 2013.
    • (2013) J Biol Chem , vol.288 , pp. 27343-27357
    • Kang, J.1    Kim, E.2    Kim, W.3    Seong, K.M.4    Youn, H.5    Kim, J.W.6    Kim, J.7    Youn, B.8
  • 31
    • 84864987692 scopus 로고    scopus 로고
    • Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition- like phenomenon
    • Kim HM, Haraguchi N, Ishii H, Ohkuma M, Okano M, Mimori K, Eguchi H, Yamamoto H, Nagano H, Sekimoto M, Doki Y, Mori M. Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition- like phenomenon. Ann Surg Oncol 19, Suppl 3: S539-S548, 2012.
    • (2012) Ann Surg Oncol , vol.19 , Issue.SUPPL. 3
    • Kim, H.M.1    Haraguchi, N.2    Ishii, H.3    Ohkuma, M.4    Okano, M.5    Mimori, K.6    Eguchi, H.7    Yamamoto, H.8    Nagano, H.9    Sekimoto, M.10    Doki, Y.11    Mori, M.12
  • 33
    • 79955120145 scopus 로고    scopus 로고
    • Is it the end of the line for the EMT?
    • Kisseleva T, Brenner DA. Is it the end of the line for the EMT? Hepatology 53: 1433-1435, 2011.
    • (2011) Hepatology , vol.53 , pp. 1433-1435
    • Kisseleva, T.1    Brenner, D.A.2
  • 34
    • 64249172203 scopus 로고    scopus 로고
    • The canonical Notch signaling pathway: Unfolding the activation mechanism
    • Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137: 216-233, 2009.
    • (2009) Cell , vol.137 , pp. 216-233
    • Kopan, R.1    Ilagan, M.X.2
  • 35
    • 84874799703 scopus 로고    scopus 로고
    • Hepatic stellate cells support hematopoiesis and are liver-resident mesenchymal stem cells
    • Kordes C, Sawitza I, Gotze S, Haussinger D. Hepatic stellate cells support hematopoiesis and are liver-resident mesenchymal stem cells. Cell Physiol Biochem 31: 290-304, 2013.
    • (2013) Cell Physiol Biochem , vol.31 , pp. 290-304
    • Kordes, C.1    Sawitza, I.2    Gotze, S.3    Haussinger, D.4
  • 37
    • 84856090845 scopus 로고    scopus 로고
    • Lineage tracing
    • Kretzschmar K, Watt FM. Lineage tracing. Cell 148: 33-45, 2012.
    • (2012) Cell , vol.148 , pp. 33-45
    • Kretzschmar, K.1    Watt, F.M.2
  • 38
    • 79551521517 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) in kidney fibrosis: Fact or fantasy?
    • Kriz W, Kaissling B, Le Hir M. Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy? J Clin Invest 121: 468-474, 2011.
    • (2011) J Clin Invest , vol.121 , pp. 468-474
    • Kriz, W.1    Kaissling, B.2    Le Hir, M.3
  • 39
    • 84877928478 scopus 로고    scopus 로고
    • Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs
    • Lamouille S, Subramanyam D, Blelloch R, Derynck R. Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr Opin Cell Biol 25: 200-207, 2013.
    • (2013) Curr Opin Cell Biol , vol.25 , pp. 200-207
    • Lamouille, S.1    Subramanyam, D.2    Blelloch, R.3    Derynck, R.4
  • 41
    • 84873461095 scopus 로고    scopus 로고
    • Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury
    • Li Y, Wang J, Asahina K. Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc Natl Acad Sci USA 110: 2324-2329, 2013.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 2324-2329
    • Li, Y.1    Wang, J.2    Asahina, K.3
  • 42
    • 84870862301 scopus 로고    scopus 로고
    • Col1A1 production and apoptotic resistance in TGF-beta1-induced epithelial-to-mesenchymal transitionlike phenotype of 603B cells
    • Liu J, Eischeid AN, Chen XM. Col1A1 production and apoptotic resistance in TGF-beta1-induced epithelial-to-mesenchymal transitionlike phenotype of 603B cells. PLoS One 7: e51371, 2012.
    • (2012) PLoS One , vol.7
    • Liu, J.1    Eischeid, A.N.2    Chen, X.M.3
  • 43
    • 84866745071 scopus 로고    scopus 로고
    • Notch-dependent expression of epithelial-mesenchymal transition markers in cholangiocytes after liver transplantation
    • Liu X, Li J, Xiong J, Li M, Zhang Y, Zheng Q. Notch-dependent expression of epithelial-mesenchymal transition markers in cholangiocytes after liver transplantation. Hepatol Res 42: 1024-1038, 2012.
    • (2012) Hepatol Res , vol.42 , pp. 1024-1038
    • Liu, X.1    Li, J.2    Xiong, J.3    Li, M.4    Zhang, Y.5    Zheng, Q.6
  • 44
    • 54049111838 scopus 로고    scopus 로고
    • Origin of stellate cells from submesothelial cells in a developing human liver
    • Loo CK, Wu XJ. Origin of stellate cells from submesothelial cells in a developing human liver. Liver Int 28: 1437-1445, 2008.
    • (2008) Liver Int , vol.28 , pp. 1437-1445
    • Loo, C.K.1    Wu, X.J.2
  • 45
    • 7044284840 scopus 로고    scopus 로고
    • A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations
    • Magness ST, Bataller R, Yang L, Brenner DA. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology 40: 1151-1159, 2004.
    • (2004) Hepatology , vol.40 , pp. 1151-1159
    • Magness, S.T.1    Bataller, R.2    Yang, L.3    Brenner, D.A.4
  • 51
    • 51349133312 scopus 로고    scopus 로고
    • Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways
    • Nitta T, Kim JS, Mohuczy D, Behrns KE. Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways. Hepatology 48: 909-919, 2008.
    • (2008) Hepatology , vol.48 , pp. 909-919
    • Nitta, T.1    Kim, J.S.2    Mohuczy, D.3    Behrns, K.E.4
  • 52
    • 84864911235 scopus 로고    scopus 로고
    • Therapeutic and prognostic importance of epithelial-mesenchymal transition in liver cancers: Insights from experimental models
    • Ogunwobi OO, Liu C. Therapeutic and prognostic importance of epithelial-mesenchymal transition in liver cancers: insights from experimental models. Crit Rev Oncol Hematol 83: 319-328, 2012.
    • (2012) Crit Rev Oncol Hematol , vol.83 , pp. 319-328
    • Ogunwobi, O.O.1    Liu, C.2
  • 57
    • 77954562833 scopus 로고    scopus 로고
    • Metastasis: Cancer cell's escape from oxidative stress
    • Pani G, Galeotti T, Chiarugi P. Metastasis: cancer cell's escape from oxidative stress. Cancer Metastasis Rev 29: 351-378, 2010.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 351-378
    • Pani, G.1    Galeotti, T.2    Chiarugi, P.3
  • 58
  • 60
    • 79960465979 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in chronic liver disease: Fibrogenesis or escape from death?
    • Pinzani M. Epithelial-mesenchymal transition in chronic liver disease: fibrogenesis or escape from death? J Hepatol 55: 459-465, 2011.
    • (2011) J Hepatol , vol.55 , pp. 459-465
    • Pinzani, M.1
  • 61
    • 34247334927 scopus 로고    scopus 로고
    • Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis
    • Robertson H, Kirby JA, Yip WW, Jones DE, Burt AD. Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis. Hepatology 45: 977-981, 2007.
    • (2007) Hepatology , vol.45 , pp. 977-981
    • Robertson, H.1    Kirby, J.A.2    Yip, W.W.3    Jones, D.E.4    Burt, A.D.5
  • 64
    • 77953541796 scopus 로고    scopus 로고
    • Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor
    • Saad S, Stanners SR, Yong R, Tang O, Pollock CA. Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor. Int J Biochem Cell Biol 42: 1115-1122, 2010.
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 1115-1122
    • Saad, S.1    Stanners, S.R.2    Yong, R.3    Tang, O.4    Pollock, C.A.5
  • 68
    • 80052964920 scopus 로고    scopus 로고
    • Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells?
    • Scheel C, Weinberg RA. Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Int J Cancer 129: 2310-2314, 2011.
    • (2011) Int J Cancer , vol.129 , pp. 2310-2314
    • Scheel, C.1    Weinberg, R.A.2
  • 71
    • 75449104452 scopus 로고    scopus 로고
    • Expression and functional significance of Twist1 in hepatocellular carcinoma: Its role in vasculogenic mimicry
    • Sun T, Zhao N, Zhao XL, Gu Q, Zhang SW, Che N, Wang XH, Du J, Liu YX, Sun BC. Expression and functional significance of Twist1 in hepatocellular carcinoma: its role in vasculogenic mimicry. Hepatology 51: 545-556, 2010.
    • (2010) Hepatology , vol.51 , pp. 545-556
    • Sun, T.1    Zhao, N.2    Zhao, X.L.3    Gu, Q.4    Zhang, S.W.5    Che, N.6    Wang, X.H.7    Du, J.8    Liu, Y.X.9    Sun, B.C.10
  • 72
    • 58149386485 scopus 로고    scopus 로고
    • Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver
    • Suzuki A, Sekiya S, Onishi M, Oshima N, Kiyonari H, Nakauchi H, Taniguchi H. Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver. Hepatology 48: 1964-1978, 2008.
    • (2008) Hepatology , vol.48 , pp. 1964-1978
    • Suzuki, A.1    Sekiya, S.2    Onishi, M.3    Oshima, N.4    Kiyonari, H.5    Nakauchi, H.6    Taniguchi, H.7
  • 78
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890, 2009.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 79
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142, 2006.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 83
    • 84878504160 scopus 로고    scopus 로고
    • Regulation of hepatocarcinogenesis by microRNAs
    • Wong CM, Kai AK, Tsang FH, Ng IO. Regulation of hepatocarcinogenesis by microRNAs. Front Biosci 5: 49-60, 2013.
    • (2013) Front Biosci , vol.5 , pp. 49-60
    • Wong, C.M.1    Kai, A.K.2    Tsang, F.H.3    Ng, I.O.4
  • 84
    • 80055051887 scopus 로고    scopus 로고
    • HAb18G/CD147 promotes epithelial-mesenchymal transition through TGF-beta signaling and is transcriptionally regulated by Slug
    • Wu J, Ru NY, Zhang Y, Li Y, Wei D, Ren Z, Huang XF, Chen ZN, Bian H. HAb18G/CD147 promotes epithelial-mesenchymal transition through TGF-beta signaling and is transcriptionally regulated by Slug. Oncogene 30: 4410-4427, 2011.
    • (2011) Oncogene , vol.30 , pp. 4410-4427
    • Wu, J.1    Ru, N.Y.2    Zhang, Y.3    Li, Y.4    Wei, D.5    Ren, Z.6    Huang, X.F.7    Chen, Z.N.8    Bian, H.9
  • 85
    • 84881028557 scopus 로고    scopus 로고
    • MicroRNA-216a/217-induced epithelialmesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer
    • Xia H, Ooi LL, Hui KM. MicroRNA-216a/217-induced epithelialmesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer. Hepatology 58: 629-641, 2013.
    • (2013) Hepatology , vol.58 , pp. 629-641
    • Xia, H.1    Ooi, L.L.2    Hui, K.M.3
  • 87
    • 59449090107 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial to mesenchymal transition
    • Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res 19: 156-172, 2009.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 88
    • 84860879220 scopus 로고    scopus 로고
    • Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1) in epithelial cell lines
    • Xu Q, Isaji T, Lu Y, Gu W, Kondo M, Fukuda T, Du Y, Gu J. Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1) in epithelial cell lines. J Biol Chem 287: 16563-16574, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 16563-16574
    • Xu, Q.1    Isaji, T.2    Lu, Y.3    Gu, W.4    Kondo, M.5    Fukuda, T.6    Du, Y.7    Gu, J.8
  • 89
    • 64049102268 scopus 로고    scopus 로고
    • PI3 kinase/Akt signaling mediates epithelial-mesenchymal transition in hypoxic hepatocellular carcinoma cells
    • Yan W, Fu Y, Tian D, Liao J, Liu M, Wang B, Xia L, Zhu Q, Luo M. PI3 kinase/Akt signaling mediates epithelial-mesenchymal transition in hypoxic hepatocellular carcinoma cells. Biochem Biophys Res Commun 382: 631-636, 2009.
    • (2009) Biochem Biophys Res Commun , vol.382 , pp. 631-636
    • Yan, W.1    Fu, Y.2    Tian, D.3    Liao, J.4    Liu, M.5    Wang, B.6    Xia, L.7    Zhu, Q.8    Luo, M.9
  • 90
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 14: 818-829, 2008.
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 92
    • 72949120827 scopus 로고    scopus 로고
    • Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma
    • Yang MH, Chen CL, Chau GY, Chiou SH, Su CW, Chou TY, Peng WL, Wu JC. Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology 50: 1464-1474, 2009.
    • (2009) Hepatology , vol.50 , pp. 1464-1474
    • Yang, M.H.1    Chen, C.L.2    Chau, G.Y.3    Chiou, S.H.4    Su, C.W.5    Chou, T.Y.6    Peng, W.L.7    Wu, J.C.8
  • 93
    • 39549111466 scopus 로고    scopus 로고
    • Identification of adult hepatic progenitor cells capable of repopulating injured rat liver
    • Yovchev MI, Grozdanov PN, Zhou H, Racherla H, Guha C, Dabeva MD. Identification of adult hepatic progenitor cells capable of repopulating injured rat liver. Hepatology 47: 636-647, 2008.
    • (2008) Hepatology , vol.47 , pp. 636-647
    • Yovchev, M.I.1    Grozdanov, P.N.2    Zhou, H.3    Racherla, H.4    Guha, C.5    Dabeva, M.D.6
  • 94
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • Zavadil J, Bottinger EP. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 24: 5764-5774, 2005.
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Bottinger, E.P.2
  • 95
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119: 1429-1437, 2009.
    • (2009) J Clin Invest , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 96
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H, Kalluri R. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 282: 23337-23347, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 23337-23347
    • Zeisberg, M.1    Yang, C.2    Martino, M.3    Duncan, M.B.4    Rieder, F.5    Tanjore, H.6    Kalluri, R.7
  • 97
  • 98
    • 84883227969 scopus 로고    scopus 로고
    • Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor- 1alpha in hepatocellular carcinoma
    • Zhang L, Huang G, Li X, Zhang Y, Jiang Y, Shen J, Liu J, Wang Q, Zhu J, Feng X, Dong J, Qian C. Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor- 1alpha in hepatocellular carcinoma. BMC Cancer 13: 108, 2013.
    • (2013) BMC Cancer , vol.13 , pp. 108
    • Zhang, L.1    Huang, G.2    Li, X.3    Zhang, Y.4    Jiang, Y.5    Shen, J.6    Liu, J.7    Wang, Q.8    Zhu, J.9    Feng, X.10    Dong, J.11    Qian, C.12
  • 99
    • 84877157115 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1alpha signaling
    • Zhang Q, Bai X, Chen W, Ma T, Hu Q, Liang C, Xie S, Chen C, Hu L, Xu S, Liang T. Wnt/beta-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1alpha signaling. Carcinogenesis 34: 962-973, 2013.
    • (2013) Carcinogenesis , vol.34 , pp. 962-973
    • Zhang, Q.1    Bai, X.2    Chen, W.3    Ma, T.4    Hu, Q.5    Liang, C.6    Xie, S.7    Chen, C.8    Hu, L.9    Xu, S.10    Liang, T.11
  • 101
    • 84877843218 scopus 로고    scopus 로고
    • The roles of Notch1 expression in the migration of intrahepatic cholangiocarcinoma
    • Zhou Q, Wang Y, Peng B, Liang L, Li J. The roles of Notch1 expression in the migration of intrahepatic cholangiocarcinoma. BMC Cancer 13: 244, 2013.
    • (2013) BMC Cancer , vol.13 , pp. 244
    • Zhou, Q.1    Wang, Y.2    Peng, B.3    Liang, L.4    Li, J.5
  • 102
    • 84881550133 scopus 로고    scopus 로고
    • MicroRNA-491 is involved in metastasis of hepatocellular carcinoma by inhibitions of matrix metalloproteinase and epithelial to mesenchymal transition
    • Zhou Y, Li Y, Ye J, Jiang R, Yan H, Yang X, Liu Q, Zhang J. MicroRNA-491 is involved in metastasis of hepatocellular carcinoma by inhibitions of matrix metalloproteinase and epithelial to mesenchymal transition. Liver Int 33: 1271-1280, 2013.
    • (2013) Liver Int , vol.33 , pp. 1271-1280
    • Zhou, Y.1    Li, Y.2    Ye, J.3    Jiang, R.4    Yan, H.5    Yang, X.6    Liu, Q.7    Zhang, J.8
  • 103
    • 79952254584 scopus 로고    scopus 로고
    • Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury
    • Zhu L, Wang L, Wang X, Luo X, Yang L, Zhang R, Yin H, Xie D, Pan Y, Chen Y. Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury. PLoS One 6: e17415, 2011.
    • (2011) PLoS One , vol.6
    • Zhu, L.1    Wang, L.2    Wang, X.3    Luo, X.4    Yang, L.5    Zhang, R.6    Yin, H.7    Xie, D.8    Pan, Y.9    Chen, Y.10
  • 104
    • 84866156191 scopus 로고    scopus 로고
    • Organochlorine pesticides induce epithelial to mesenchymal transition of human primary cultured hepatocytes
    • Zucchini-Pascal N, Peyre L, de Sousa G, Rahmani R. Organochlorine pesticides induce epithelial to mesenchymal transition of human primary cultured hepatocytes. Food Chem Toxicol 50: 3963-3970, 2012.
    • (2012) Food Chem Toxicol , vol.50 , pp. 3963-3970
    • Zucchini-Pascal, N.1    Peyre, L.2    de Sousa, G.3    Rahmani, R.4


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