메뉴 건너뛰기




Volumn 63, Issue 8, 2014, Pages 1333-1344

Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TAMOXIFEN; YELLOW FLUORESCENT PROTEIN;

EID: 84904060793     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2013-305962     Document Type: Article
Times cited : (99)

References (58)
  • 1
    • 73949091032 scopus 로고    scopus 로고
    • Liver regeneration after partial hepatectomy: Critical analysis of mechanistic dilemmas
    • Michalopoulos GK. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol 2010;176:2-13.
    • (2010) Am J Pathol , vol.176 , pp. 2-13
    • Michalopoulos, G.K.1
  • 2
    • 0025050821 scopus 로고
    • Transforming growth factor-α1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver
    • Nakatsukasa H, Evarts RP, Hsia CC, et al. Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver. Lab Invest 1990;63:171-80. (Pubitemid 20262132)
    • (1990) Laboratory Investigation , vol.63 , Issue.2 , pp. 171-180
    • Nakatsukasa, H.1    Evarts, R.P.2    Hsia, C.3    Thorgeirsson, S.S.4
  • 3
    • 0026182911 scopus 로고
    • Transforming growth factor-beta (TGF-beta) isoforms in rat liver regeneration: Messenger RNA expression and activation of latent TGF-beta
    • Jakowlew SB, Mead JE, Danielpour D, et al. Transforming growth factor-beta (TGF-beta) isoforms in rat liver regeneration: messenger RNA expression and activation of latent TGF-beta. Cell Regul 1991;2:535-48.
    • (1991) Cell Regul , vol.2 , pp. 535-548
    • Jakowlew, S.B.1    Mead, J.E.2    Danielpour, D.3
  • 4
    • 78751585439 scopus 로고    scopus 로고
    • Hedgehog signaling in the liver
    • Omenetti A, Choi S, Michelotti G, et al. Hedgehog signaling in the liver. J Hepatol 2011;54:366-73.
    • (2011) J Hepatol , vol.54 , pp. 366-373
    • Omenetti, A.1    Choi, S.2    Michelotti, G.3
  • 5
    • 84878527104 scopus 로고    scopus 로고
    • Smoothened is a master regulator of adult liver repair
    • Michelotti GA, Xie G, Swiderska M, et al. Smoothened is a master regulator of adult liver repair. J Clin Invest 2013;123:2380-94.
    • (2013) J Clin Invest , vol.123 , pp. 2380-2394
    • Michelotti, G.A.1    Xie, G.2    Swiderska, M.3
  • 6
    • 0035691559 scopus 로고    scopus 로고
    • Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
    • Long F, Zhang XM, Karp S, et al. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 2001;128:5099-108. (Pubitemid 34086893)
    • (2001) Development , vol.128 , Issue.24 , pp. 5099-5108
    • Long, F.1    Zhang, X.M.2    Karp, S.3    Yang, Y.4    McMahon, A.P.5
  • 7
    • 77951436593 scopus 로고    scopus 로고
    • Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice
    • Ochoa B, Syn WK, Delgado I, et al. Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice. Hepatology 2010;51:1712-23.
    • (2010) Hepatology , vol.51 , pp. 1712-1723
    • Ochoa, B.1    Syn, W.K.2    Delgado, I.3
  • 8
    • 78651426961 scopus 로고    scopus 로고
    • The role of hedgehog signaling in fibrogenic liver repair
    • Choi SS, Omenetti A, Syn WK, et al. The role of Hedgehog signaling in fibrogenic liver repair. Int J Biochem Cell Biol 2011;43:238-44.
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 238-244
    • Choi, S.S.1    Omenetti, A.2    Syn, W.K.3
  • 9
    • 84883218984 scopus 로고    scopus 로고
    • Cellular basis of hepatic fibrosis and its role in inflammation and cancer
    • Kocabayoglu P, Friedman SL. Cellular basis of hepatic fibrosis and its role in inflammation and cancer. Front Biosci (Schol Ed) 2013;5:217-30.
    • (2013) Front Biosci (Schol Ed) , vol.5 , pp. 217-230
    • Kocabayoglu, P.1    Friedman, S.L.2
  • 10
    • 78751479915 scopus 로고    scopus 로고
    • Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis
    • Syn WK, Choi SS, Liaskou E, et al. Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. Hepatology 2011;53:106-15.
    • (2011) Hepatology , vol.53 , pp. 106-115
    • Syn, W.K.1    Choi, S.S.2    Liaskou, E.3
  • 11
    • 34547885530 scopus 로고    scopus 로고
    • An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma
    • DOI 10.1038/sj.onc.1210463, PII 1210463
    • Takafuji V, Forgues M, Unsworth E, et al. An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma. Oncogene 2007;26:6361-71. (Pubitemid 47494216)
    • (2007) Oncogene , vol.26 , Issue.44 , pp. 6361-6371
    • Takafuji, V.1    Forgues, M.2    Unsworth, E.3    Goldsmith, P.4    Wang, X.W.5
  • 13
    • 84878304558 scopus 로고    scopus 로고
    • Lgr proteins in epithelial stem cell biology
    • Barker N, Tan S, Clevers H. Lgr proteins in epithelial stem cell biology. Development 2013;140:2484-94.
    • (2013) Development , vol.140 , pp. 2484-2494
    • Barker, N.1    Tan, S.2    Clevers, H.3
  • 14
    • 84880249396 scopus 로고    scopus 로고
    • Lgr5 (+) liver stem cells, hepatic organoids and regenerative medicine
    • Huch M, Boj SF, Clevers H. Lgr5 (+) liver stem cells, hepatic organoids and regenerative medicine. Regen Med 2013;8:385-7.
    • (2013) Regen Med , vol.8 , pp. 385-387
    • Huch, M.1    Boj, S.F.2    Clevers, H.3
  • 15
    • 78651228289 scopus 로고    scopus 로고
    • Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
    • Furuyama K, Kawaguchi Y, Akiyama H, et al. Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet 2011;43:34-41.
    • (2011) Nat Genet , vol.43 , pp. 34-41
    • Furuyama, K.1    Kawaguchi, Y.2    Akiyama, H.3
  • 16
    • 82455188301 scopus 로고    scopus 로고
    • CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells
    • Qiu Q, Hernandez JC, Dean AM, et al. CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells. Stem Cells Dev 2011;20:2177-88.
    • (2011) Stem Cells Dev , vol.20 , pp. 2177-2188
    • Qiu, Q.1    Hernandez, J.C.2    Dean, A.M.3
  • 17
    • 84868192680 scopus 로고    scopus 로고
    • The mesenchymal- To-epithelial transition in somatic cell reprogramming
    • Esteban MA, Bao X, Zhuang Q, et al. The mesenchymal- To-epithelial transition in somatic cell reprogramming. Curr Opin Genet Dev 2012;22:423-8.
    • (2012) Curr Opin Genet Dev , vol.22 , pp. 423-428
    • Esteban, M.A.1    Bao, X.2    Zhuang, Q.3
  • 18
    • 84870745374 scopus 로고    scopus 로고
    • Epigenetic control of epithelial- To-mesenchymal transition and cancer metastasis
    • Wang Y, Shang Y. Epigenetic control of epithelial- To-mesenchymal transition and cancer metastasis. Exp Cell Res 2013;319:160-9.
    • (2013) Exp Cell Res , vol.319 , pp. 160-169
    • Wang, Y.1    Shang, Y.2
  • 19
    • 77956158103 scopus 로고    scopus 로고
    • Genetic labeling does not detect epithelial- To-mesenchymal transition of cholangiocytes in liver fibrosis in mice
    • Scholten D, Osterreicher CH, Scholten A, et al. Genetic labeling does not detect epithelial- To-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology 2010;139:987-98.
    • (2010) Gastroenterology , vol.139 , pp. 987-998
    • Scholten, D.1    Osterreicher, C.H.2    Scholten, A.3
  • 20
    • 77950597707 scopus 로고    scopus 로고
    • Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice
    • Taura K, Miura K, Iwaisako K, et al. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology 2010;51:1027-36.
    • (2010) Hepatology , vol.51 , pp. 1027-1036
    • Taura, K.1    Miura, K.2    Iwaisako, K.3
  • 21
    • 84879432007 scopus 로고    scopus 로고
    • Principles of liver regeneration and growth homeostasis
    • Michalopoulos GK. Principles of liver regeneration and growth homeostasis. Compr Physiol 2013;3:485-513.
    • (2013) Compr Physiol , vol.3 , pp. 485-513
    • Michalopoulos, G.K.1
  • 22
    • 84055199890 scopus 로고    scopus 로고
    • Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration
    • Malato Y, Naqvi S, Schurmann N, et al. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest 2011;121:4850-60.
    • (2011) J Clin Invest , vol.121 , pp. 4850-4860
    • Malato, Y.1    Naqvi, S.2    Schurmann, N.3
  • 23
    • 84883672073 scopus 로고    scopus 로고
    • Polyinosinic acid blocks adeno- Associated virus macrophage endocytosis in vitro and enhances adeno- Associated virus liver-directed gene therapy in vivo
    • van Dijk, R, Montenegro-Miranda PS, Riviere C, et al. Polyinosinic Acid blocks adeno- Associated virus macrophage endocytosis in vitro and enhances adeno- Associated virus liver-directed gene therapy in vivo. Hum Gene Ther 2013;24:807-13.
    • (2013) Hum Gene Ther , vol.24 , pp. 807-813
    • Montenegro-Miranda, P.S.1    Riviere, C.2    Van Dijk, R.3
  • 25
    • 69749103204 scopus 로고    scopus 로고
    • Adeno-associated virus vector-mediated production of hepatocyte growth factor attenuates liver fibrosis in mice
    • DOI 10.1007/s12072-007-9042-1
    • Suzumura K, Hirano T, Son G, et al. Adeno- Associated virus vector-mediated production of hepatocyte growth factor attenuates liver fibrosis in mice. Hepatol Int 2008;2:80-8. (Pubitemid 351250406)
    • (2008) Hepatology International , vol.2 , Issue.1 , pp. 80-88
    • Suzumura, K.1    Hirano, T.2    Son, G.3    Iimuro, Y.4    Mizukami, H.5    Ozawa, K.6    Fujimoto, J.7
  • 26
    • 70350770695 scopus 로고    scopus 로고
    • Suppression of tissue inhibitor of metalloproteinase-1 by recombinant adeno- Associated viruses carrying Si RNAs in hepatic stellate cells
    • Cong M, Liu T, Wang P, et al. Suppression of tissue inhibitor of metalloproteinase-1 by recombinant adeno- Associated viruses carrying siRNAs in hepatic stellate cells. Int J Mol Med 2009;24:685-92.
    • (2009) Int J Mol Med , vol.24 , pp. 685-692
    • Cong, M.1    Liu, T.2    Wang, P.3
  • 28
    • 34247619364 scopus 로고    scopus 로고
    • Gene Expression Profiles During Hepatic Stellate Cell Activation in Culture and In Vivo
    • DOI 10.1053/j.gastro.2007.02.033, PII S0016508507003903
    • De Minicis S, Seki E, Uchinami H, et al. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology 2007;132: 1937-46. (Pubitemid 46677935)
    • (2007) Gastroenterology , vol.132 , Issue.5 , pp. 1937-1946
    • De Minicis, S.1    Seki, E.2    Uchinami, H.3    Kluwe, J.4    Zhang, Y.5    Brenner, D.A.6    Schwabe, R.F.7
  • 29
    • 84869751765 scopus 로고    scopus 로고
    • Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice
    • Espanol-Suner R, Carpentier R, Van Hul N, et al. Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. Gastroenterology 2012;143:1564-75.
    • (2012) Gastroenterology , vol.143 , pp. 1564-1575
    • Espanol-Suner, R.1    Carpentier, R.2    Van, H.N.3
  • 30
    • 84865041500 scopus 로고    scopus 로고
    • NKT- Associated hedgehog and osteopontin drive fibrogenesis in non- Alcoholic fatty liver disease
    • Syn WK, Agboola KM, Swiderska M, et al. NKT- Associated hedgehog and osteopontin drive fibrogenesis in non- Alcoholic fatty liver disease. Gut 2012;61:1323-9.
    • (2012) Gut , vol.61 , pp. 1323-1329
    • Syn, W.K.1    Agboola, K.M.2    Swiderska, M.3
  • 31
    • 84871622308 scopus 로고    scopus 로고
    • Osteopontin contributes to TGF-beta1 mediated hepatic stellate cell activation
    • Xiao X, Gang Y, Gu Y, et al. Osteopontin contributes to TGF-beta1 mediated hepatic stellate cell activation. Dig Dis Sci 2012;57:2883-91.
    • (2012) Dig Dis Sci , vol.57 , pp. 2883-2891
    • Xiao, X.1    Gang, Y.2    Gu, Y.3
  • 32
    • 84876022474 scopus 로고    scopus 로고
    • Collagenolytic potential of rat liver myofibroblasts
    • Jiroutova A, Peterova E, Bittnerova L, et al. Collagenolytic potential of rat liver myofibroblasts. Physiol Res 2013;62:15-25.
    • (2013) Physiol Res , vol.62 , pp. 15-25
    • Jiroutova, A.1    Peterova, E.2    Bittnerova, L.3
  • 33
    • 84879497079 scopus 로고    scopus 로고
    • Utility of osteopontin in lineage tracing experiments
    • Coombes J, Syn WK. Utility of osteopontin in lineage tracing experiments. Gastroenterology 2013;145:254-5.
    • (2013) Gastroenterology , vol.145 , pp. 254-255
    • Coombes, J.1    Syn, W.K.2
  • 34
    • 0026453596 scopus 로고
    • Secretion of 72 KDA type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity
    • Arthur MJ, Stanley A, Iredale JP, et al. Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity. Biochem J 1992;287 (Pt 3):701-7.
    • (1992) Biochem J , vol.287 , Issue.PART 3 , pp. 701-707
    • Arthur, M.J.1    Stanley, A.2    Iredale, J.P.3
  • 35
    • 0029055170 scopus 로고
    • Tissue inhibitor of metalloproteinase-I and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes
    • Iredale JP, Goddard S, Murphy G, et al. Tissue inhibitor of metalloproteinase-I and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes. Clin Sci (Lond) 1995;89:75-81.
    • (1995) Clin Sci (Lond) , vol.89 , pp. 75-81
    • Iredale, J.P.1    Goddard, S.2    Murphy, G.3
  • 36
    • 0032801286 scopus 로고    scopus 로고
    • Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy
    • DOI 10.1046/j.1440-1746.1999.01928.x
    • Li D, Friedman SL. Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy. J Gastroenterol Hepatol 1999;14:618-33. (Pubitemid 29350115)
    • (1999) Journal of Gastroenterology and Hepatology , vol.14 , Issue.7 , pp. 618-633
    • Li, D.1    Friedman, S.L.2
  • 37
    • 80053505418 scopus 로고    scopus 로고
    • Human hepatic stellate cell line (LX-2) exhibits characteristics of bone marrow-derived mesenchymal stem cells
    • Castilho-Fernandes A, de Almeida, DC, Fontes AM, et al. Human hepatic stellate cell line (LX-2) exhibits characteristics of bone marrow-derived mesenchymal stem cells. Exp Mol Pathol 2011;91:664-72.
    • (2011) Exp Mol Pathol , vol.91 , pp. 664-672
    • Castilho-Fernandes, A.1    Fontes, A.M.2    De Almeida, D.C.3
  • 38
    • 80053413477 scopus 로고    scopus 로고
    • The epigenetic regulation of stem cell factors in hepatic stellate cells
    • Reister S, Kordes C, Sawitza I, et al. The epigenetic regulation of stem cell factors in hepatic stellate cells. Stem Cells Dev 2011;20:1687-99.
    • (2011) Stem Cells Dev , vol.20 , pp. 1687-1699
    • Reister, S.1    Kordes, C.2    Sawitza, I.3
  • 40
    • 84874799703 scopus 로고    scopus 로고
    • Hepatic stellate cells support hematopoiesis and are liver-resident mesenchymal stem cells
    • Kordes C, Sawitza I, Gotze S, et al. Hepatic stellate cells support hematopoiesis and are liver-resident mesenchymal stem cells. Cell Physiol Biochem 2013;31:290-304.
    • (2013) Cell Physiol Biochem , vol.31 , pp. 290-304
    • Kordes, C.1    Sawitza, I.2    Gotze, S.3
  • 42
    • 53449092969 scopus 로고    scopus 로고
    • Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers
    • Yang L, Jung Y, Omenetti A, et al. Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells 2008;26: 2104-13.
    • (2008) Stem Cells , vol.26 , pp. 2104-2113
    • Yang, L.1    Jung, Y.2    Omenetti, A.3
  • 43
    • 84880320134 scopus 로고    scopus 로고
    • Evidence for a common progenitor of epithelial and mesenchymal components of the liver
    • Conigliaro A, Amicone L, Costa V, et al. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. Cell Death Differ 2013;20:1116-23.
    • (2013) Cell Death Differ , vol.20 , pp. 1116-1123
    • Conigliaro, A.1    Amicone, L.2    Costa, V.3
  • 44
    • 84856948234 scopus 로고    scopus 로고
    • Hepatic stellate cell progenitor cells
    • Asahina K. Hepatic stellate cell progenitor cells. J Gastroenterol Hepatol 2012;27 (Suppl 2):80-4.
    • (2012) J Gastroenterol Hepatol , vol.27 , Issue.SUPPL. 2 , pp. 80-84
    • Asahina, K.1
  • 45
    • 70349338010 scopus 로고    scopus 로고
    • Hepatic and pancreatic stellate cells in focus
    • Kordes C, Sawitza I, Haussinger D. Hepatic and pancreatic stellate cells in focus. Biol Chem 2009;390:1003-12.
    • (2009) Biol Chem , vol.390 , pp. 1003-1012
    • Kordes, C.1    Sawitza, I.2    Haussinger, D.3
  • 46
    • 84877139427 scopus 로고    scopus 로고
    • Hepatic stellate cells in liver development, regeneration, and cancer
    • Yin C, Evason KJ, Asahina K, et al. Hepatic stellate cells in liver development, regeneration, and cancer. J Clin Invest 2013;123:1902-10.
    • (2013) J Clin Invest , vol.123 , pp. 1902-1910
    • Yin, C.1    Evason, K.J.2    Asahina, K.3
  • 47
    • 84871298755 scopus 로고    scopus 로고
    • Stellate cells from rat pancreas are stem cells and can contribute to liver regeneration
    • Kordes C, Sawitza I, Gotze S, et al. Stellate cells from rat pancreas are stem cells and can contribute to liver regeneration. PLoS ONE 2012;7:51878.
    • (2012) PLoS ONE , vol.7 , pp. 51878
    • Kordes, C.1    Sawitza, I.2    Gotze, S.3
  • 48
    • 77957551870 scopus 로고    scopus 로고
    • A mesenchymal- To-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
    • Li R, Liang J, Ni S, et al. A mesenchymal- To-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 2010;7:51-63.
    • (2010) Cell Stem Cell , vol.7 , pp. 51-63
    • Li, R.1    Liang, J.2    Ni, S.3
  • 49
    • 84880330190 scopus 로고    scopus 로고
    • Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming
    • Liu X, Sun H, Qi J, et al. Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol 2013;15:829-38.
    • (2013) Nat Cell Biol , vol.15 , pp. 829-838
    • Liu, X.1    Sun, H.2    Qi, J.3
  • 51
    • 22344455913 scopus 로고    scopus 로고
    • Liver repair by intra- and extrahepatic progenitors
    • Dorrell C, Grompe M. Liver repair by intra- And extrahepatic progenitors. Stem Cell Rev 2005;1:61-4. (Pubitemid 41003465)
    • (2005) Stem Cell Reviews , vol.1 , Issue.1 , pp. 61-64
    • Dorrell, C.1    Grompe, M.2
  • 52
    • 84859614232 scopus 로고    scopus 로고
    • Macrophage-derived WNT opposes notch signaling to specify hepatic progenitor cell fate in chronic liver disease
    • Boulter L, Govaere O, Bird TG, et al. Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med 2012;18:572-9.
    • (2012) Nat Med , vol.18 , pp. 572-579
    • Boulter, L.1    Govaere, O.2    Bird, T.G.3
  • 53
    • 84876241811 scopus 로고    scopus 로고
    • Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling
    • Bird TG, Lu WY, Boulter L, et al. Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling. Proc Natl Acad Sci USA 2013;110:6542-7.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 6542-6547
    • Bird, T.G.1    Lu, W.Y.2    Boulter, L.3
  • 54
    • 82455168059 scopus 로고    scopus 로고
    • Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets
    • Cardinale V, Wang Y, Carpino G, et al. Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets. Hepatology 2011;54:2159-72.
    • (2011) Hepatology , vol.54 , pp. 2159-2172
    • Cardinale, V.1    Wang, Y.2    Carpino, G.3
  • 55
    • 63349106593 scopus 로고    scopus 로고
    • Foxl1 is a marker of bipotential hepatic progenitor cells in mice
    • Sackett SD, Li Z, Hurtt R, et al. Foxl1 is a marker of bipotential hepatic progenitor cells in mice. Hepatology 2009;49:920-9.
    • (2009) Hepatology , vol.49 , pp. 920-929
    • Sackett, S.D.1    Li, Z.2    Hurtt, R.3
  • 56
    • 84873712443 scopus 로고    scopus 로고
    • In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
    • Huch M, Dorrell C, Boj SF, et al. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature 2013;494:247-50.
    • (2013) Nature , vol.494 , pp. 247-250
    • Huch, M.1    Dorrell, C.2    Boj, S.F.3
  • 57
    • 84868102616 scopus 로고    scopus 로고
    • Hedgehog controls hepatic stellate cell fate by regulating metabolism
    • Chen Y, Choi SS, Michelotti GA, et al. Hedgehog controls hepatic stellate cell fate by regulating metabolism. Gastroenterology 2012;143:1319-29.
    • (2012) Gastroenterology , vol.143 , pp. 1319-1329
    • Chen, Y.1    Choi, S.S.2    Michelotti, G.A.3
  • 58
    • 84868208364 scopus 로고    scopus 로고
    • The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: Analysis of stellate cell entry into the developing liver
    • Yin C, Evason KJ, Maher JJ, et al. The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: Analysis of stellate cell entry into the developing liver. Hepatology 2012;56:1958-70.
    • (2012) Hepatology , vol.56 , pp. 1958-1970
    • Yin, C.1    Evason, K.J.2    Maher, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.