메뉴 건너뛰기




Volumn 4, Issue 6, 2010, Pages 367-388

The pathogenesis of idiopathic pulmonary fibrosis

Author keywords

epithelium; idiopathic pulmonary fibrosis; myofibroblast; transforming growth factor

Indexed keywords

ALPHAVBETA6 INTEGRIN; CHEMOKINE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 78649920691     PISSN: 17534658     EISSN: None     Source Type: Journal    
DOI: 10.1177/1753465810379801     Document Type: Review
Times cited : (248)

References (216)
  • 6
    • 2942653435 scopus 로고    scopus 로고
    • Integrin alphavbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1
    • Annes, J.P., Chen, Y., Munger, J.S. and Rifkin, D.B. ( 2004) Integrin alphavbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol 165: 723-734.
    • (2004) J Cell Biol , vol.165 , pp. 723-734
    • Annes, J.P.1    Chen, Y.2    Munger, J.S.3    Rifkin, D.B.4
  • 8
    • 6744240499 scopus 로고    scopus 로고
    • Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo
    • Arai, T., Abe, K., Matsuoka, H., Yoshida, M., Mori, M., Goya, S. et al. (2000) Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo. Am J Physiol Lung Cell Mol Physiol 278: L914-L922.
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.278 , pp. L914-L922
    • Arai, T.1    Abe, K.2    Matsuoka, H.3    Yoshida, M.4    Mori, M.5    Goya, S.6
  • 9
    • 36048937539 scopus 로고    scopus 로고
    • Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients
    • Araya, J., Cambier, S., Markovics, J.A., Wolters, P., Jablons, D., Hill, A. et al. (2007) Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest 117: 3551-3562.
    • (2007) J Clin Invest , vol.117 , pp. 3551-3562
    • Araya, J.1    Cambier, S.2    Markovics, J.A.3    Wolters, P.4    Jablons, D.5    Hill, A.6
  • 10
    • 67650079362 scopus 로고    scopus 로고
    • Syndromes of telomere shortening
    • Armanios, M. ( 2009) Syndromes of telomere shortening. Annu Rev Genomics Hum Genet 10: 45-61.
    • (2009) Annu Rev Genomics Hum Genet , vol.10 , pp. 45-61
    • Armanios, M.1
  • 12
    • 28244449083 scopus 로고    scopus 로고
    • Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts
    • Asano, Y., Ihn, H., Yamane, K., Jinnin, M., Mimura, Y. and Tamaki, K. ( 2005) Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts. J Immunol 175: 7708-7718.
    • (2005) J Immunol , vol.175 , pp. 7708-7718
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 13
    • 33144458448 scopus 로고    scopus 로고
    • Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts
    • Asano, Y., Ihn, H., Yamane, K., Jinnin, M. and Tamaki, K. ( 2006) Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts. Am J Pathol 168: 499-510.
    • (2006) Am J Pathol , vol.168 , pp. 499-510
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Tamaki, K.5
  • 14
    • 72849117761 scopus 로고    scopus 로고
    • (2009) MFGE8 Diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages
    • et al
    • Atabai, K., Jame, S., Azhar, N., Kuo, A., Lam, M., McKleroy, W. et al. (2009) MFGE8 Diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. J Clin Invest 119: 3713-3722.
    • J Clin Invest , vol.119 , pp. 3713-3722
    • Atabai, K.1    Jame, S.2    Azhar, N.3    Kuo, A.4    Lam, M.5    McKleroy, W.6
  • 16
    • 34447260697 scopus 로고    scopus 로고
    • Important roles for macrophage colony-stimulating factor, Cc chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis
    • Baran, C.P., Opalek, J.M., McMaken, S., Newland, C.A., O–Brien Jr, J.M., Hunter, M.G. et al. (2007) Important roles for macrophage colony-stimulating factor, Cc chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med 176: 78-89.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 78-89
    • Baran, C.P.1    Opalek, J.M.2    McMaken, S.3    Newland, C.A.4    O–Brien, J.M.5    Hunter, M.G.6
  • 18
    • 14944348752 scopus 로고    scopus 로고
    • Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
    • Bates, R.C., Bellovin, D.I., Brown, C., Maynard, E., Wu, B., Kawakatsu, H. et al. (2005) Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest 115: 339-347.
    • (2005) J Clin Invest , vol.115 , pp. 339-347
    • Bates, R.C.1    Bellovin, D.I.2    Brown, C.3    Maynard, E.4    Wu, B.5    Kawakatsu, H.6
  • 19
    • 15544369388 scopus 로고    scopus 로고
    • Surfactant protein C biosynthesis and its emerging role in conformational lung disease
    • Beers, M.F. and Mulugeta, S. ( 2005) Surfactant protein C biosynthesis and its emerging role in conformational lung disease. Annu Rev Physiol 67: 663-696.
    • (2005) Annu Rev Physiol , vol.67 , pp. 663-696
    • Beers, M.F.1    Mulugeta, S.2
  • 20
    • 0036787916 scopus 로고    scopus 로고
    • Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis
    • Belperio, J.A., Dy, M., Burdick, M.D., Xue, Y.Y., Li, K., Elias, J.A. et al. (2002) Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 27: 419-427.
    • (2002) Am J Respir Cell Mol Biol , vol.27 , pp. 419-427
    • Belperio, J.A.1    Dy, M.2    Burdick, M.D.3    Xue, Y.Y.4    Li, K.5    Elias, J.A.6
  • 21
    • 0025318632 scopus 로고
    • Depressed Bronchoalveolar Urokinase Activity in Patients with Adult Respiratory Distress Syndrome
    • Bertozzi, P., Astedt, B., Zenzius, L., Lynch, K., Lemaire, F., Zapol, W. et al. (1990) Depressed Bronchoalveolar Urokinase Activity in Patients with Adult Respiratory Distress Syndrome. N Engl J Med 322: 890-897.
    • (1990) N Engl J Med , vol.322 , pp. 890-897
    • Bertozzi, P.1    Astedt, B.2    Zenzius, L.3    Lynch, K.4    Lemaire, F.5    Zapol, W.6
  • 22
    • 2942682928 scopus 로고    scopus 로고
    • Regulation of Pdgf and Its Receptors in Fibrotic Diseases
    • Bonner, J.C. ( 2004) Regulation of Pdgf and Its Receptors in Fibrotic Diseases. Cytokine Growth Factor Rev 15: 255-273.
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 255-273
    • Bonner, J.C.1
  • 23
    • 20244383986 scopus 로고    scopus 로고
    • Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active Alk5 kinase inhibitor
    • Bonniaud, P., Margetts, P.J., Kolb, M., Schroeder, J.A., Kapoun, A.M., Damm, D. et al. (2005) Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active Alk5 kinase inhibitor. Am J Respir Crit Care Med 171: 889-898.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 889-898
    • Bonniaud, P.1    Margetts, P.J.2    Kolb, M.3    Schroeder, J.A.4    Kapoun, A.M.5    Damm, D.6
  • 24
    • 0026010305 scopus 로고
    • Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis
    • Broekelmann, T.J., Limper, A.H., Colby, T.V. and McDonald, J.A. ( 1991) Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci U S A 88: 6642-6646.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 6642-6646
    • Broekelmann, T.J.1    Limper, A.H.2    Colby, T.V.3    McDonald, J.A.4
  • 25
    • 0028535872 scopus 로고
    • Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair
    • Bucala, R., Spiegel, L.A., Chesney, J., Hogan, M. and Cerami, A. ( 1994) Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1: 71-81.
    • (1994) Mol Med , vol.1 , pp. 71-81
    • Bucala, R.1    Spiegel, L.A.2    Chesney, J.3    Hogan, M.4    Cerami, A.5
  • 27
    • 0028325256 scopus 로고
    • Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis
    • Car, B.D., Meloni, F., Luisetti, M., Semenzato, G., Gialdroni-Grassi, G. and Walz, A. ( 1994) Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Am J Respir Crit Care Med 149: 655-659.
    • (1994) Am J Respir Crit Care Med , vol.149 , pp. 655-659
    • Car, B.D.1    Meloni, F.2    Luisetti, M.3    Semenzato, G.4    Gialdroni-Grassi, G.5    Walz, A.6
  • 28
    • 43049175154 scopus 로고    scopus 로고
    • TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts
    • Caraci, F., Gili, E., Calafiore, M., Failla, M., La Rosa, C., Crimi, N. et al. (2008) TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts. Pharmacol Res 57: 274-282.
    • (2008) Pharmacol Res , vol.57 , pp. 274-282
    • Caraci, F.1    Gili, E.2    Calafiore, M.3    Failla, M.4    La Rosa, C.5    Crimi, N.6
  • 29
    • 0141753083 scopus 로고    scopus 로고
    • Role of coagulation cascade proteases in lung repair and fibrosis
    • Chambers, R.C. ( 2003) Role of coagulation cascade proteases in lung repair and fibrosis. Eur Respir J Suppl 44: 33s-35s.
    • (2003) Eur Respir J Suppl , vol.44 , pp. 33s-35s
    • Chambers, R.C.1
  • 30
    • 77950896262 scopus 로고    scopus 로고
    • (2010) SPARC suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts through constitutive activation of beta-catenin
    • Chang, W., Wei, K., Jacobs, S.S., Upadhyay, D., Weill, D. and Rosen, G.D. (2010) SPARC suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts through constitutive activation of beta-catenin. J Biol Chem 285: 8196-8206.
    • J Biol Chem , vol.285 , pp. 8196-8206
    • Chang, W.1    Wei, K.2    Jacobs, S.S.3    Upadhyay, D.4    Weill, D.5    Rosen, G.D.6
  • 31
    • 0022623669 scopus 로고
    • Abnormalities in pathways of alveolar fibrin turnover among patients with interstitial lung disease
    • Chapman, H.A., Allen, C.L. and Stone, O.L. ( 1986) Abnormalities in pathways of alveolar fibrin turnover among patients with interstitial lung disease. Am Rev Respir Dis 133: 437-443.
    • (1986) Am Rev Respir Dis , vol.133 , pp. 437-443
    • Chapman, H.A.1    Allen, C.L.2    Stone, O.L.3
  • 32
    • 0242500879 scopus 로고    scopus 로고
    • Aberrant WNT/ beta-catenin pathway activation in idiopathic pulmonary fibrosis
    • Chilosi, M., Poletti, V., Zamo, A., Lestani, M., Montagna, L., Piccoli, P. et al. (2003) Aberrant WNT/ beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol 162: 1495-1502.
    • (2003) Am J Pathol , vol.162 , pp. 1495-1502
    • Chilosi, M.1    Poletti, V.2    Zamo, A.3    Lestani, M.4    Montagna, L.5    Piccoli, P.6
  • 33
    • 33847051344 scopus 로고    scopus 로고
    • Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis
    • Chua, F., Dunsmore, S.E., Clingen, P.H., Mutsaers, S.E., Shapiro, S.D., Segal, A.W. et al. (2007) Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis. Am J Pathol 170: 65-74.
    • (2007) Am J Pathol , vol.170 , pp. 65-74
    • Chua, F.1    Dunsmore, S.E.2    Clingen, P.H.3    Mutsaers, S.E.4    Shapiro, S.D.5    Segal, A.W.6
  • 34
    • 0024588790 scopus 로고
    • Effects of interferon-gamma on expression of cell surface receptors for collagen and deposition of newly synthesized collagen by cultured human lung fibroblasts
    • Clark, J.G., Dedon, T.F., Wayner, E.A. and Carter, W.G. ( 1989) Effects of interferon-gamma on expression of cell surface receptors for collagen and deposition of newly synthesized collagen by cultured human lung fibroblasts. J Clin Invest 83: 1505-1511.
    • (1989) J Clin Invest , vol.83 , pp. 1505-1511
    • Clark, J.G.1    Dedon, T.F.2    Wayner, E.A.3    Carter, W.G.4
  • 35
    • 0019934293 scopus 로고
    • Bleomycin-induced pulmonary fibrosis in hamsters: effect of neutrophil depletion on lung collagen synthesis
    • Clark, J.G. and Kuhn III, C. ( 1982) Bleomycin-induced pulmonary fibrosis in hamsters: effect of neutrophil depletion on lung collagen synthesis. Am Rev Respir Dis 126: 737-739.
    • (1982) Am Rev Respir Dis , vol.126 , pp. 737-739
    • Clark, J.G.1    Kuhn, C.2
  • 36
    • 58149100136 scopus 로고    scopus 로고
    • Novel regulation of vascular endothelial growth factor-a (VEGF-a) by transforming growth factor (beta)1: requirement for SMADS, (beta)-catenin, and GSK3(beta)
    • Clifford, R.L., Deacon, K. and Knox, A.J. ( 2008) Novel regulation of vascular endothelial growth factor-a (VEGF-a) by transforming growth factor (beta)1: requirement for SMADS, (beta)-catenin, and GSK3(beta). J Biol Chem 283: 35337-35353.
    • (2008) J Biol Chem , vol.283 , pp. 35337-35353
    • Clifford, R.L.1    Deacon, K.2    Knox, A.J.3
  • 37
    • 0034960535 scopus 로고    scopus 로고
    • Localisation of transforming growth factor beta1 and beta3 MRNA transcripts in normal and fibrotic human lung
    • Coker, R.K., Laurent, G.J., Jeffery, P.K., Du Bois, R.M., Black, C.M. and McAnulty, R.J. ( 2001) Localisation of transforming growth factor beta1 and beta3 MRNA transcripts in normal and fibrotic human lung. Thorax 56: 549-556.
    • (2001) Thorax , vol.56 , pp. 549-556
    • Coker, R.K.1    Laurent, G.J.2    Jeffery, P.K.3    Du Bois, R.M.4    Black, C.M.5    McAnulty, R.J.6
  • 38
    • 0031059572 scopus 로고    scopus 로고
    • Transforming growth factors-beta 1-beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis
    • Coker, R.K., Laurent, G.J., Shahzeidi, S., Lympany, P.A., Du Bois, R.M., Jeffery, P.K. et al. (1997) Transforming growth factors-beta 1-beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis. Am J Pathol 150: 981-991.
    • (1997) Am J Pathol , vol.150 , pp. 981-991
    • Coker, R.K.1    Laurent, G.J.2    Shahzeidi, S.3    Lympany, P.A.4    Du Bois, R.M.5    Jeffery, P.K.6
  • 40
    • 77953449840 scopus 로고    scopus 로고
    • (2010) Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis
    • Coward, W.R., Watts, K., Feghali-Bostwick, C.A., Jenkins, G. and Pang, L. (2010) Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis. Mol Cell Biol 30: 2874-2886.
    • Mol Cell Biol , vol.30 , pp. 2874-2886
    • Coward, W.R.1    Watts, K.2    Feghali-Bostwick, C.A.3    Jenkins, G.4    Pang, L.5
  • 41
    • 67651232689 scopus 로고    scopus 로고
    • (2009) Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis
    • Coward, W.R., Watts, K., Feghali-Bostwick, C.A., Knox, A. and Pang, L. (2009) Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis. Mol Cell Biol 29: 4325-4339.
    • Mol Cell Biol , vol.29 , pp. 4325-4339
    • Coward, W.R.1    Watts, K.2    Feghali-Bostwick, C.A.3    Knox, A.4    Pang, L.5
  • 44
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumour suppression and cancer progression
    • Derynck, R., Akhurst, R.J. and Balmain, A. ( 2001) TGF-beta signaling in tumour suppression and cancer progression. Nat Genet 29: 117-129.
    • (2001) Nat Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 47
    • 73949141537 scopus 로고    scopus 로고
    • (2010) The quest for the initial lesion in idiopathic pulmonary fibrosis: gene expression differences in IPF fibroblasts
    • Eickelberg, O. and Laurent, G.J. (2010) The quest for the initial lesion in idiopathic pulmonary fibrosis: gene expression differences in IPF fibroblasts. Am J Respir Cell Mol Biol 42: 1-2.
    • Am J Respir Cell Mol Biol , vol.42 , pp. 1-2
    • Eickelberg, O.1    Laurent, G.J.2
  • 48
    • 0035085720 scopus 로고    scopus 로고
    • Molecular mechanisms of TGF-(beta) antagonism by interferon (gamma) and cyclosporine a in lung fibroblasts
    • Eickelberg, O., Pansky, A., Koehler, E., Bihl, M., Tamm, M., Hildebrand, P. et al. (2001) Molecular mechanisms of TGF-(beta) antagonism by interferon (gamma) and cyclosporine a in lung fibroblasts. FASEB J 15: 797-806.
    • (2001) FASEB J , vol.15 , pp. 797-806
    • Eickelberg, O.1    Pansky, A.2    Koehler, E.3    Bihl, M.4    Tamm, M.5    Hildebrand, P.6
  • 49
    • 0030054203 scopus 로고    scopus 로고
    • Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene
    • Eitzman, D.T., McCoy, R.D., Zheng, X., Fay, W.P., Shen, T., Ginsburg, D. et al. (1996) Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 97: 232-237.
    • (1996) J Clin Invest , vol.97 , pp. 232-237
    • Eitzman, D.T.1    McCoy, R.D.2    Zheng, X.3    Fay, W.P.4    Shen, T.5    Ginsburg, D.6
  • 50
    • 0023690417 scopus 로고
    • Tumor necrosis factor interacts with interleukin-1 and interferons to inhibit fibroblast proliferation via fibroblast prostaglandin-dependent and -independent mechanisms
    • Elias, J.A. ( 1988) Tumor necrosis factor interacts with interleukin-1 and interferons to inhibit fibroblast proliferation via fibroblast prostaglandin-dependent and -independent mechanisms. Am Rev Respir Dis 138: 652-658.
    • (1988) Am Rev Respir Dis , vol.138 , pp. 652-658
    • Elias, J.A.1
  • 51
    • 0025093211 scopus 로고
    • In vitro production of B cell growth factor and B cell differentiation factor by peripheral blood mononuclear cells and bronchoalveolar lavage T lymphocytes from patients with idiopathic pulmonary fibrosis
    • Emura, M., Nagai, S., Takeuchi, M., Kitaichi, M. and Izumi, T. ( 1990) In vitro production of B cell growth factor and B cell differentiation factor by peripheral blood mononuclear cells and bronchoalveolar lavage T lymphocytes from patients with idiopathic pulmonary fibrosis. Clin Exp Immunol 82: 133-139.
    • (1990) Clin Exp Immunol , vol.82 , pp. 133-139
    • Emura, M.1    Nagai, S.2    Takeuchi, M.3    Kitaichi, M.4    Izumi, T.5
  • 52
    • 72449162128 scopus 로고    scopus 로고
    • N-acetylcysteine inhibits alveolar epithelial-mesenchymal transition
    • Felton, V.M., Borok, Z. and Willis, B.C. ( 2009) N-acetylcysteine inhibits alveolar epithelial-mesenchymal transition. Am J Physiol Lung Cell Mol Physiol 297: L805-L812.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297 , pp. L805-L812
    • Felton, V.M.1    Borok, Z.2    Willis, B.C.3
  • 53
    • 17444434000 scopus 로고    scopus 로고
    • Predictive value of response to treatment of T-lymphocyte subpopulations in idiopathic pulmonary fibrosis
    • Fireman, E., Vardinon, N., Burke, M., Spizer, S., Levin, S., Endler, A. et al. (1998) Predictive value of response to treatment of T-lymphocyte subpopulations in idiopathic pulmonary fibrosis. Eur Respir J 11: 706-711.
    • (1998) Eur Respir J , vol.11 , pp. 706-711
    • Fireman, E.1    Vardinon, N.2    Burke, M.3    Spizer, S.4    Levin, S.5    Endler, A.6
  • 54
    • 0141929385 scopus 로고    scopus 로고
    • Binary switches and modification cassettes in histone biology and beyond
    • Fischle, W., Wang, Y. and David Allis, C. ( 2003) Binary switches and modification cassettes in histone biology and beyond. Nature 425: 475-479.
    • (2003) Nature , vol.425 , pp. 475-479
    • Fischle, W.1    Wang, Y.2    David Allis, C.3
  • 55
    • 0034661333 scopus 로고    scopus 로고
    • Relevance of tissue factor and tissue factor pathway inhibitor for hypercoagulable state in the lungs of patients with idiopathic pulmonary fibrosis
    • Fujii, M., Hayakawa, H., Urano, T., Sato, A., Chida, K., Nakamura, H. et al. (2000) Relevance of tissue factor and tissue factor pathway inhibitor for hypercoagulable state in the lungs of patients with idiopathic pulmonary fibrosis. Thromb Res 99: 111-117.
    • (2000) Thromb Res , vol.99 , pp. 111-117
    • Fujii, M.1    Hayakawa, H.2    Urano, T.3    Sato, A.4    Chida, K.5    Nakamura, H.6
  • 56
    • 77952489797 scopus 로고    scopus 로고
    • CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis
    • Gilani, S.R., Vuga, L.J., Lindell, K.O., Gibson, K.F., Xue, J., Kaminski, N. et al. (2010) CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis. PLoS One 5: e8959.
    • (2010) PLoS One , vol.5 , pp. e8959
    • Gilani, S.R.1    Vuga, L.J.2    Lindell, K.O.3    Gibson, K.F.4    Xue, J.5    Kaminski, N.6
  • 58
    • 0035798579 scopus 로고    scopus 로고
    • The transcription factor C/EBPbeta is essential for inducible expression of the COX-2 gene in macrophages but not in fibroblasts
    • Gorgoni, B., Caivano, M., Arizmendi, C. and Poli, V. ( 2001) The transcription factor C/EBPbeta is essential for inducible expression of the COX-2 gene in macrophages but not in fibroblasts. J Biol Chem 276: 40769-40777.
    • (2001) J Biol Chem , vol.276 , pp. 40769-40777
    • Gorgoni, B.1    Caivano, M.2    Arizmendi, C.3    Poli, V.4
  • 60
    • 44049094434 scopus 로고    scopus 로고
    • The effects of myostatin on adipogenic differentiation of human bone marrow-derived mesenchymal stem cells are mediated through cross-communication between SMAD3 and WNT/beta-catenin signaling pathways
    • Guo, W., Flanagan, J., Jasuja, R., Kirkland, J., Jiang, L. and Bhasin, S. ( 2008) The effects of myostatin on adipogenic differentiation of human bone marrow-derived mesenchymal stem cells are mediated through cross-communication between SMAD3 and WNT/beta-catenin signaling pathways. J Biol Chem 283: 9136-9145.
    • (2008) J Biol Chem , vol.283 , pp. 9136-9145
    • Guo, W.1    Flanagan, J.2    Jasuja, R.3    Kirkland, J.4    Jiang, L.5    Bhasin, S.6
  • 61
    • 72449139586 scopus 로고    scopus 로고
    • (2009) Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition
    • Guo, W., Shan, B., Klingsberg, R.C., Qin, X. and Lasky, J.A. (2009) Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. Am J Physiol Lung Cell Mol Physiol 297: L864-L870.
    • Am J Physiol Lung Cell Mol Physiol , vol.297 , pp. L864-L870
    • Guo, W.1    Shan, B.2    Klingsberg, R.C.3    Qin, X.4    Lasky, J.A.5
  • 62
    • 0029124143 scopus 로고
    • Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expression
    • Gurujeyalakshmi, G. and Giri, S.N. ( 1995) Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expression. Exp Lung Res 21: 791-808.
    • (1995) Exp Lung Res , vol.21 , pp. 791-808
    • Gurujeyalakshmi, G.1    Giri, S.N.2
  • 63
    • 35548976126 scopus 로고    scopus 로고
    • Expression of the immunomodulator IL-10 in type I pneumocytes of the rat: alterations of IL-10 expression in radiation-induced lung damage
    • Haase, M.G., Klawitter, A., Geyer, P. and Baretton, G.B. ( 2007) Expression of the immunomodulator IL-10 in type I pneumocytes of the rat: alterations of IL-10 expression in radiation-induced lung damage. J Histochem Cytochem 55: 1167-1172.
    • (2007) J Histochem Cytochem , vol.55 , pp. 1167-1172
    • Haase, M.G.1    Klawitter, A.2    Geyer, P.3    Baretton, G.B.4
  • 64
    • 0037097680 scopus 로고    scopus 로고
    • TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells
    • Hagimoto, N., Kuwano, K., Inoshima, I., Yoshimi, M., Nakamura, N., Fujita, M. et al. (2002) TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells. J Immunol 168: 6470-6478.
    • (2002) J Immunol , vol.168 , pp. 6470-6478
    • Hagimoto, N.1    Kuwano, K.2    Inoshima, I.3    Yoshimi, M.4    Nakamura, N.5    Fujita, M.6
  • 65
    • 77950442739 scopus 로고    scopus 로고
    • (2010) IPF: new insight on pathogenesis and treatment
    • Harari, S. and Caminati, A. (2010) IPF: new insight on pathogenesis and treatment. Allergy 65: 537-553.
    • Allergy , vol.65 , pp. 537-553
    • Harari, S.1    Caminati, A.2
  • 66
    • 1342268310 scopus 로고    scopus 로고
    • Bone marrow-derived progenitor cells in pulmonary fibrosis
    • Hashimoto, N., Jin, H., Liu, T., Chensue, S.W. and Phan, S.H. ( 2004) Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest 113: 243-252.
    • (2004) J Clin Invest , vol.113 , pp. 243-252
    • Hashimoto, N.1    Jin, H.2    Liu, T.3    Chensue, S.W.4    Phan, S.H.5
  • 67
    • 0033585441 scopus 로고    scopus 로고
    • Upregulation of fibrinolysis by adenovirus-mediated transfer of urokinase-type plasminogen activator genes to lung cells in vitro and in vivo
    • Hattori, N., Sisson, T.H., Xu, Y. and Simon, R.H. ( 1999) Upregulation of fibrinolysis by adenovirus-mediated transfer of urokinase-type plasminogen activator genes to lung cells in vitro and in vivo. Hum Gene Ther 10: 215-222.
    • (1999) Hum Gene Ther , vol.10 , pp. 215-222
    • Hattori, N.1    Sisson, T.H.2    Xu, Y.3    Simon, R.H.4
  • 69
    • 72149111953 scopus 로고    scopus 로고
    • The myofibroblast: paradigm for a mechanically active cell
    • Hinz, B. ( 2010) The myofibroblast: paradigm for a mechanically active cell. J Biomech 43: 146-155.
    • (2010) J Biomech , vol.43 , pp. 146-155
    • Hinz, B.1
  • 70
    • 0026098618 scopus 로고
    • Prognosis of idiopathic pulmonary fibrosis in patients with mucous hypersecretion
    • Hiwatari, N., Shimura, S., Sasaki, T., Aikawa, T., Ando, Y., Ishihara, H. et al. (1991) Prognosis of idiopathic pulmonary fibrosis in patients with mucous hypersecretion. Am Rev Respir Dis 143: 182-185.
    • (1991) Am Rev Respir Dis , vol.143 , pp. 182-185
    • Hiwatari, N.1    Shimura, S.2    Sasaki, T.3    Aikawa, T.4    Ando, Y.5    Ishihara, H.6
  • 71
    • 7244227766 scopus 로고    scopus 로고
    • Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E(2) production
    • Hodges, R.J., Jenkins, R.G., Wheeler-Jones, C.P., Copeman, D.M., Bottoms, S.E., Bellingan, G.J. et al. (2004) Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E(2) production. Am J Pathol 165: 1663-1676.
    • (2004) Am J Pathol , vol.165 , pp. 1663-1676
    • Hodges, R.J.1    Jenkins, R.G.2    Wheeler-Jones, C.P.3    Copeman, D.M.4    Bottoms, S.E.5    Bellingan, G.J.6
  • 72
    • 34547956524 scopus 로고    scopus 로고
    • Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma
    • Hong, K.M., Belperio, J.A., Keane, M.P., Burdick, M.D. and Strieter, R.M. ( 2007) Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma. J Biol Chem 282: 22910-22920.
    • (2007) J Biol Chem , vol.282 , pp. 22910-22920
    • Hong, K.M.1    Belperio, J.A.2    Keane, M.P.3    Burdick, M.D.4    Strieter, R.M.5
  • 73
    • 38049002642 scopus 로고    scopus 로고
    • Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation
    • Horan, G.S., Wood, S., Ona, V., Li, D.J., Lukashev, M.E., Weinreb, P.H. et al. (2008) Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med 177: 56-65.
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 56-65
    • Horan, G.S.1    Wood, S.2    Ona, V.3    Li, D.J.4    Lukashev, M.E.5    Weinreb, P.H.6
  • 74
    • 0034795622 scopus 로고    scopus 로고
    • Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor MRNA levels in bleomycin-induced pulmonary fibrosis
    • Howell, D.C., Goldsack, N.R., Marshall, R.P., McAnulty, R.J., Starke, R., Purdy, G. et al. (2001) Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor MRNA levels in bleomycin-induced pulmonary fibrosis. Am J Pathol 159: 1383-1395.
    • (2001) Am J Pathol , vol.159 , pp. 1383-1395
    • Howell, D.C.1    Goldsack, N.R.2    Marshall, R.P.3    McAnulty, R.J.4    Starke, R.5    Purdy, G.6
  • 75
    • 17844399243 scopus 로고    scopus 로고
    • Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis
    • Howell, D.C., Johns, R.H., Lasky, J.A., Shan, B., Scotton, C.J., Laurent, G.J. et al. (2005) Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol 166: 1353-1365.
    • (2005) Am J Pathol , vol.166 , pp. 1353-1365
    • Howell, D.C.1    Johns, R.H.2    Lasky, J.A.3    Shan, B.4    Scotton, C.J.5    Laurent, G.J.6
  • 76
    • 0036549805 scopus 로고    scopus 로고
    • Role of thrombin and its major cellular receptor, protease-activated receptor-1
    • in, pulmonary fibrosis
    • Howell, D.C., Laurent, G.J. and Chambers, R.C. ( 2002) Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis. Biochem Soc Trans 30: 211-216.
    • (2002) Biochem Soc Trans , vol.30 , pp. 211-216
    • Howell, D.C.1    Laurent, G.J.2    Chambers, R.C.3
  • 77
    • 0032186263 scopus 로고    scopus 로고
    • Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice
    • Huang, X., Wu, J., Zhu, W., Pytela, R. and Sheppard, D. ( 1998) Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice. Am J Respir Cell Mol Biol 19: 636-642.
    • (1998) Am J Respir Cell Mol Biol , vol.19 , pp. 636-642
    • Huang, X.1    Wu, J.2    Zhu, W.3    Pytela, R.4    Sheppard, D.5
  • 78
    • 0031934999 scopus 로고    scopus 로고
    • Survival in patients with cryptogenic fibrosing alveolitis: a population-based cohort study
    • Hubbard, R., Johnston, I. and Britton, J. ( 1998) Survival in patients with cryptogenic fibrosing alveolitis: a population-based cohort study. Chest 113: 396-400.
    • (1998) Chest , vol.113 , pp. 396-400
    • Hubbard, R.1    Johnston, I.2    Britton, J.3
  • 79
    • 0030034711 scopus 로고    scopus 로고
    • Occupational exposure to metal or wood dust and aetiology of cryptogenic fibrosing alveolitis
    • Hubbard, R., Lewis, S., Richards, K., Johnston, I. and Britton, J. ( 1996) Occupational exposure to metal or wood dust and aetiology of cryptogenic fibrosing alveolitis. Lancet 347: 284-289.
    • (1996) Lancet , vol.347 , pp. 284-289
    • Hubbard, R.1    Lewis, S.2    Richards, K.3    Johnston, I.4    Britton, J.5
  • 81
    • 0032473355 scopus 로고    scopus 로고
    • Axin, a negative regulator of the WNT signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    • Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S. and Kikuchi, A. ( 1998) Axin, a negative regulator of the WNT signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J 17: 1371-1384.
    • (1998) EMBO J , vol.17 , pp. 1371-1384
    • Ikeda, S.1    Kishida, S.2    Yamamoto, H.3    Murai, H.4    Koyama, S.5    Kikuchi, A.6
  • 82
    • 0030791559 scopus 로고    scopus 로고
    • Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis
    • Imokawa, S., Sato, A., Hayakawa, H., Kotani, M., Urano, T. and Takada, A. ( 1997) Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis. Am J Respir Crit Care Med 156: 631-636.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 631-636
    • Imokawa, S.1    Sato, A.2    Hayakawa, H.3    Kotani, M.4    Urano, T.5    Takada, A.6
  • 83
    • 9444299027 scopus 로고    scopus 로고
    • IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-Aa and PDGF-Ralpha
    • Ingram, J.L., Rice, A.B., Geisenhoffer, K., Madtes, D.K. and Bonner, J.C. ( 2004) IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-Aa and PDGF-Ralpha. FASEB J 18: 1132-1134.
    • (2004) FASEB J , vol.18 , pp. 1132-1134
    • Ingram, J.L.1    Rice, A.B.2    Geisenhoffer, K.3    Madtes, D.K.4    Bonner, J.C.5
  • 85
    • 0032489318 scopus 로고    scopus 로고
    • Transcriptional role of the nuclear factor kappa B site in the induction by lipopolysaccharide and suppression by dexamethasone of cyclooxygenase-2 in U937 cells
    • Inoue, H. and Tanabe, T. ( 1998) Transcriptional role of the nuclear factor kappa B site in the induction by lipopolysaccharide and suppression by dexamethasone of cyclooxygenase-2 in U937 cells. Biochem Biophys Res Commun 244: 143-148.
    • (1998) Biochem Biophys Res Commun , vol.244 , pp. 143-148
    • Inoue, H.1    Tanabe, T.2
  • 87
    • 34347228684 scopus 로고    scopus 로고
    • Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-beta1
    • Jain, R., Shaul, P.W., Borok, Z. and Willis, B.C. ( 2007) Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-beta1. Am J Respir Cell Mol Biol 37: 38-47.
    • (2007) Am J Respir Cell Mol Biol , vol.37 , pp. 38-47
    • Jain, R.1    Shaul, P.W.2    Borok, Z.3    Willis, B.C.4
  • 88
    • 0041427695 scopus 로고    scopus 로고
    • Therapeutic attenuation of pulmonary fibrosis via targeting of IL-4-and IL-13-responsive cells
    • Jakubzick, C., Choi, E.S., Joshi, B.H., Keane, M.P., Kunkel, S.L., Puri, R.K. et al. (2003) Therapeutic attenuation of pulmonary fibrosis via targeting of IL-4-and IL-13-responsive cells. J Immunol 171: 2684-2693.
    • (2003) J Immunol , vol.171 , pp. 2684-2693
    • Jakubzick, C.1    Choi, E.S.2    Joshi, B.H.3    Keane, M.P.4    Kunkel, S.L.5    Puri, R.K.6
  • 89
    • 33745183811 scopus 로고    scopus 로고
    • Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury
    • Jenkins, R.G., Su, X., Su, G., Scotton, C.J., Camerer, E., Laurent, G.J. et al. (2006) Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest 116: 1606-1614.
    • (2006) J Clin Invest , vol.116 , pp. 1606-1614
    • Jenkins, R.G.1    Su, X.2    Su, G.3    Scotton, C.J.4    Camerer, E.5    Laurent, G.J.6
  • 90
    • 33645007189 scopus 로고    scopus 로고
    • SMAD3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells
    • Jian, H., Shen, X., Liu, I., Semenov, M., He, X. and Wang, X.F. ( 2006) SMAD3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. Genes Dev 20: 666-674.
    • (2006) Genes Dev , vol.20 , pp. 666-674
    • Jian, H.1    Shen, X.2    Liu, I.3    Semenov, M.4    He, X.5    Wang, X.F.6
  • 91
    • 4043049618 scopus 로고    scopus 로고
    • Regulation of pulmonary fibrosis by chemokine receptor CXCR3
    • Jiang, D., Liang, J., Hodge, J., Lu, B., Zhu, Z., Yu, S. et al. (2004) Regulation of pulmonary fibrosis by chemokine receptor CXCR3. J Clin Invest 114: 291-299.
    • (2004) J Clin Invest , vol.114 , pp. 291-299
    • Jiang, D.1    Liang, J.2    Hodge, J.3    Lu, B.4    Zhu, Z.5    Yu, S.6
  • 92
    • 0037241720 scopus 로고    scopus 로고
    • N-COR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors
    • Jones, P.L. and Shi, Y.B. ( 2003) N-COR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors. Curr Top Microbiol Immunol 274: 237-268.
    • (2003) Curr Top Microbiol Immunol , vol.274 , pp. 237-268
    • Jones, P.L.1    Shi, Y.B.2
  • 93
    • 0037114003 scopus 로고    scopus 로고
    • Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis
    • Karsdal, M.A., Larsen, L., Engsig, M.T., Lou, H., Ferreras, M., Lochter, A. et al. (2002) Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. J Biol Chem 277: 44061-44067.
    • (2002) J Biol Chem , vol.277 , pp. 44061-44067
    • Karsdal, M.A.1    Larsen, L.2    Engsig, M.T.3    Lou, H.4    Ferreras, M.5    Lochter, A.6
  • 94
    • 0031965748 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification
    • Katzenstein, A.L. and Myers, J.L. ( 1998) Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification. Am J Respir Crit Care Med 157: 1301-1315.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 1301-1315
    • Katzenstein, A.L.1    Myers, J.L.2
  • 95
    • 0031201212 scopus 로고    scopus 로고
    • The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis
    • Keane, M.P., Arenberg, D.A., Lynch III, J.P., Whyte, R.I., Iannettoni, M.D., Burdick, M.D. et al. (1997) The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. J Immunol 159: 1437-1443.
    • (1997) J Immunol , vol.159 , pp. 1437-1443
    • Keane, M.P.1    Arenberg, D.A.2    Lynch, J.P.3    Whyte, R.I.4    Iannettoni, M.D.5    Burdick, M.D.6
  • 96
    • 0033571117 scopus 로고    scopus 로고
    • IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis
    • Keane, M.P., Belperio, J.A., Arenberg, D.A., Burdick, M.D., Xu, Z.J., Xue, Y.Y. et al. (1999) IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis. J Immunol 163: 5686-5692.
    • (1999) J Immunol , vol.163 , pp. 5686-5692
    • Keane, M.P.1    Belperio, J.A.2    Arenberg, D.A.3    Burdick, M.D.4    Xu, Z.J.5    Xue, Y.Y.6
  • 98
    • 0035070056 scopus 로고    scopus 로고
    • Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice
    • Keerthisingam, C.B., Jenkins, R.G., Harrison, N.K., Hernandez-Rodriguez, N.A., Booth, H., Laurent, G.J. et al. (2001) Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice. Am J Pathol 158: 1411-1422.
    • (2001) Am J Pathol , vol.158 , pp. 1411-1422
    • Keerthisingam, C.B.1    Jenkins, R.G.2    Harrison, N.K.3    Hernandez-Rodriguez, N.A.4    Booth, H.5    Laurent, G.J.6
  • 99
    • 0037102396 scopus 로고    scopus 로고
    • A rearranged form of Epstein-Barr virus DNA is associated with idiopathic pulmonary fibrosis
    • Kelly, B.G., Lok, S.S., Hasleton, P.S., Egan, J.J. and Stewart, J.P. ( 2002) A rearranged form of Epstein-Barr virus DNA is associated with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 166: 510-513.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 510-513
    • Kelly, B.G.1    Lok, S.S.2    Hasleton, P.S.3    Egan, J.J.4    Stewart, J.P.5
  • 100
    • 33847019563 scopus 로고    scopus 로고
    • Multiplicity of the interactions of WNT proteins and their receptors
    • Kikuchi, A., Yamamoto, H. and Kishida, S. ( 2007) Multiplicity of the interactions of WNT proteins and their receptors. Cell Signal 19: 659-671.
    • (2007) Cell Signal , vol.19 , pp. 659-671
    • Kikuchi, A.1    Yamamoto, H.2    Kishida, S.3
  • 101
    • 33748375828 scopus 로고    scopus 로고
    • Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    • Kim, K.K., Kugler, M.C., Wolters, P.J., Robillard, L., Galvez, M.G., Brumwell, A.N. et al. (2006) Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A 103: 13180-13185.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 13180-13185
    • Kim, K.K.1    Kugler, M.C.2    Wolters, P.J.3    Robillard, L.4    Galvez, M.G.5    Brumwell, A.N.6
  • 102
    • 61749102618 scopus 로고    scopus 로고
    • (2009) Epithelial cell alpha3beta1 integrin links beta-catenin and SMAD signaling to promote myofibroblast formation and pulmonary fibrosis
    • et al
    • Kim, K.K., Wei, Y., Szekeres, C., Kugler, M.C., Wolters, P.J., Hill, M.L. et al. (2009) Epithelial cell alpha3beta1 integrin links beta-catenin and SMAD signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119: 213-224.
    • J Clin Invest , vol.119 , pp. 213-224
    • Kim, K.K.1    Wei, Y.2    Szekeres, C.3    Kugler, M.C.4    Wolters, P.J.5    Hill, M.L.6
  • 103
    • 0035048449 scopus 로고    scopus 로고
    • Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
    • Kim, M.S., Kwon, H.J., Lee, Y.M., Baek, J.H., Jang, J.E., Lee, S.W. et al. (2001) Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat Med 7: 437-443.
    • (2001) Nat Med , vol.7 , pp. 437-443
    • Kim, M.S.1    Kwon, H.J.2    Lee, Y.M.3    Baek, J.H.4    Jang, J.E.5    Lee, S.W.6
  • 104
    • 67650349068 scopus 로고    scopus 로고
    • Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (Inspire): a multicentre, randomised, placebo-controlled trial
    • King Jr, T.E., Albera, C., Bradford, W.Z., Costabel, U., Hormel, P., Lancaster, L. et al. (2009) Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (Inspire): a multicentre, randomised, placebo-controlled trial. Lancet 374: 222-228.
    • (2009) Lancet , vol.374 , pp. 222-228
    • King, T.E.1    Albera, C.2    Bradford, W.Z.3    Costabel, U.4    Hormel, P.5    Lancaster, L.6
  • 105
    • 0033522491 scopus 로고    scopus 로고
    • An F-box protein, Fwd1, mediates ubiquitin-dependent proteolysis of beta-catenin
    • Kitagawa, M., Hatakeyama, S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K. et al. (1999) An F-box protein, Fwd1, mediates ubiquitin-dependent proteolysis of beta-catenin. EMBO J 18: 2401-2410.
    • (1999) EMBO J , vol.18 , pp. 2401-2410
    • Kitagawa, M.1    Hatakeyama, S.2    Shirane, M.3    Matsumoto, M.4    Ishida, N.5    Hattori, K.6
  • 107
    • 0242319836 scopus 로고    scopus 로고
    • Prostaglandin E2 inhibits fibroblast to myofibroblast transition via E. prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation
    • Kolodsick, J.E., Peters-Golden, M., Larios, J., Toews, G.B., Thannickal, V.J. and Moore, B.B. ( 2003) Prostaglandin E2 inhibits fibroblast to myofibroblast transition via E. prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation. Am J Respir Cell Mol Biol 29: 537-544.
    • (2003) Am J Respir Cell Mol Biol , vol.29 , pp. 537-544
    • Kolodsick, J.E.1    Peters-Golden, M.2    Larios, J.3    Toews, G.B.4    Thannickal, V.J.5    Moore, B.B.6
  • 108
    • 1642333177 scopus 로고    scopus 로고
    • Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts
    • Kolodsick, J.E., Toews, G.B., Jakubzick, C., Hogaboam, C., Moore, T.A., McKenzie, A. et al. (2004) Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts. J Immunol 172: 4068-4076.
    • (2004) J Immunol , vol.172 , pp. 4068-4076
    • Kolodsick, J.E.1    Toews, G.B.2    Jakubzick, C.3    Hogaboam, C.4    Moore, T.A.5    McKenzie, A.6
  • 109
  • 110
    • 73949090577 scopus 로고    scopus 로고
    • (2010) WNT signaling in lung disease: a failure or a regeneration signal?
    • Konigshoff, M. and Eickelberg, O. (2010) WNT signaling in lung disease: a failure or a regeneration signal? Am J Respir Cell Mol Biol 42: 21-31.
    • Am J Respir Cell Mol Biol , vol.42 , pp. 21-31
    • Konigshoff, M.1    Eickelberg, O.2
  • 111
    • 65249088418 scopus 로고    scopus 로고
    • (2009) WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
    • et al
    • Konigshoff, M., Kramer, M., Balsara, N., Wilhelm, J., Amarie, O.V., Jahn, A. et al. (2009) WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest 119: 772-787.
    • J Clin Invest , vol.119 , pp. 772-787
    • Konigshoff, M.1    Kramer, M.2    Balsara, N.3    Wilhelm, J.4    Amarie, O.V.5    Jahn, A.6
  • 112
    • 0028929665 scopus 로고
    • Increased procoagulant and antifibrinolytic activities in the lungs with idiopathic pulmonary fibrosis
    • Kotani, I., Sato, A., Hayakawa, H., Urano, T., Takada, Y. and Takada, A. ( 1995) Increased procoagulant and antifibrinolytic activities in the lungs with idiopathic pulmonary fibrosis. Thromb Res 77: 493-504.
    • (1995) Thromb Res , vol.77 , pp. 493-504
    • Kotani, I.1    Sato, A.2    Hayakawa, H.3    Urano, T.4    Takada, Y.5    Takada, A.6
  • 114
    • 24944467299 scopus 로고    scopus 로고
    • Anticoagulant therapy for idiopathic pulmonary fibrosis
    • Kubo, H., Nakayama, K., Yanai, M., Suzuki, T., Yamaya, M., Watanabe, M. et al. (2005) Anticoagulant therapy for idiopathic pulmonary fibrosis. Chest 128: 1475-1482.
    • (2005) Chest , vol.128 , pp. 1475-1482
    • Kubo, H.1    Nakayama, K.2    Yanai, M.3    Suzuki, T.4    Yamaya, M.5    Watanabe, M.6
  • 115
    • 8544245673 scopus 로고    scopus 로고
    • Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF
    • Lawson, W.E., Grant, S.W., Ambrosini, V., Womble, K.E., Dawson, E.P., Lane, K.B. et al. (2004) Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF. Thorax 59: 977-980.
    • (2004) Thorax , vol.59 , pp. 977-980
    • Lawson, W.E.1    Grant, S.W.2    Ambrosini, V.3    Womble, K.E.4    Dawson, E.P.5    Lane, K.B.6
  • 116
    • 33744935773 scopus 로고    scopus 로고
    • The genetic approach in pulmonary fibrosis: can it provide clues to this complex disease?
    • Lawson, W.E. and Loyd, J.E. ( 2006) The genetic approach in pulmonary fibrosis: can it provide clues to this complex disease? Proc Am Thorac Soc 3: 345-349.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 345-349
    • Lawson, W.E.1    Loyd, J.E.2
  • 117
    • 0442291674 scopus 로고    scopus 로고
    • The role of connective tissue growth factor, a multifunctional matricellular protein
    • in, fibroblast biology
    • Leask, A. and Abraham, D.J. ( 2003) The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology. Biochem Cell Biol 81: 355-363.
    • (2003) Biochem Cell Biol , vol.81 , pp. 355-363
    • Leask, A.1    Abraham, D.J.2
  • 118
    • 0035903306 scopus 로고    scopus 로고
    • Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1)
    • Lee, C.G., Homer, R.J., Zhu, Z., Lanone, S., Wang, X., Koteliansky, V. et al. (2001) Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med 194: 809-821.
    • (2001) J Exp Med , vol.194 , pp. 809-821
    • Lee, C.G.1    Homer, R.J.2    Zhu, Z.3    Lanone, S.4    Wang, X.5    Koteliansky, V.6
  • 119
    • 0037163049 scopus 로고    scopus 로고
    • Activation of the beta-catenin/LEF-TCF pathway is obligate for formation of primitive endoderm by mouse F9 totipotent teratocarcinoma cells in response to retinoic acid
    • Liu, T., Lee, Y.N., Malbon, C.C. and Wang, H.Y. ( 2002) Activation of the beta-catenin/LEF-TCF pathway is obligate for formation of primitive endoderm by mouse F9 totipotent teratocarcinoma cells in response to retinoic acid. J Biol Chem 277: 30887-30891.
    • (2002) J Biol Chem , vol.277 , pp. 30887-30891
    • Liu, T.1    Lee, Y.N.2    Malbon, C.C.3    Wang, H.Y.4
  • 120
    • 0141537244 scopus 로고    scopus 로고
    • Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) Mice
    • Ma, L.J., Yang, H., Gaspert, A., Carlesso, G., Barty, M.M., Davidson, J.M. et al. (2003) Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) Mice. Am J Pathol 163: 1261-1273.
    • (2003) Am J Pathol , vol.163 , pp. 1261-1273
    • Ma, L.J.1    Yang, H.2    Gaspert, A.3    Carlesso, G.4    Barty, M.M.5    Davidson, J.M.6
  • 121
    • 85047689270 scopus 로고    scopus 로고
    • The role of microvascular injury in the evolution of idiopathic pulmonary fibrosis
    • Magro, C.M., Allen, J., Pope-Harman, A., Waldman, W.J., Moh, P., Rothrauff, S. et al. (2003) The role of microvascular injury in the evolution of idiopathic pulmonary fibrosis. Am J Clin Pathol 119: 556-567.
    • (2003) Am J Clin Pathol , vol.119 , pp. 556-567
    • Magro, C.M.1    Allen, J.2    Pope-Harman, A.3    Waldman, W.J.4    Moh, P.5    Rothrauff, S.6
  • 122
    • 65749101004 scopus 로고    scopus 로고
    • (2009) CUX1/WNT signaling regulates epithelial mesenchymal transition in EBV infected epithelial cells
    • Malizia, A.P., Lacey, N., Walls, D., Egan, J.J. and Doran, P.P. (2009) CUX1/WNT signaling regulates epithelial mesenchymal transition in EBV infected epithelial cells. Exp Cell Res 315: 1819-1831.
    • Exp Cell Res , vol.315 , pp. 1819-1831
    • Malizia, A.P.1    Lacey, N.2    Walls, D.3    Egan, J.J.4    Doran, P.P.5
  • 123
    • 73549094456 scopus 로고    scopus 로고
    • Matrilysin (matrix metalloproteinase-7) regulates anti-inflammatory and antifibrotic pulmonary dendritic cells that express CD103 (alpha(e)beta(7)-integrin)
    • Manicone, A.M., Huizar, I. and McGuire, J.K. ( 2009) Matrilysin (matrix metalloproteinase-7) regulates anti-inflammatory and antifibrotic pulmonary dendritic cells that express CD103 (alpha(e)beta(7)-integrin). Am J Pathol 175: 2319-2331.
    • (2009) Am J Pathol , vol.175 , pp. 2319-2331
    • Manicone, A.M.1    Huizar, I.2    McGuire, J.K.3
  • 124
    • 75949103899 scopus 로고    scopus 로고
    • (2010) Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing
    • Margadant, C. and Sonnenberg, A. (2010) Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing. EMBO Rep 11: 97-105.
    • EMBO Rep , vol.11 , pp. 97-105
    • Margadant, C.1    Sonnenberg, A.2
  • 125
    • 0035845006 scopus 로고    scopus 로고
    • Structure and function of bromodomains in chromatin-regulating complexes
    • Marmorstein, R. and Berger, S.L. ( 2001) Structure and function of bromodomains in chromatin-regulating complexes. Gene 272: 1-9.
    • (2001) Gene , vol.272 , pp. 1-9
    • Marmorstein, R.1    Berger, S.L.2
  • 126
    • 0023266217 scopus 로고
    • Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis
    • Martinet, Y., Rom, W.N., Grotendorst, G.R., Martin, G.R. and Crystal, R.G. ( 1987) Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis. N Engl J Med 317: 202-209.
    • (1987) N Engl J Med , vol.317 , pp. 202-209
    • Martinet, Y.1    Rom, W.N.2    Grotendorst, G.R.3    Martin, G.R.4    Crystal, R.G.5
  • 127
    • 0037824660 scopus 로고    scopus 로고
    • Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies
    • Martinez-Pomares, L., Reid, D.M., Brown, G.D., Taylor, P.R., Stillion, R.J., Linehan, S.A. et al. (2003) Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies. J Leukoc Biol 73: 604-613.
    • (2003) J Leukoc Biol , vol.73 , pp. 604-613
    • Martinez-Pomares, L.1    Reid, D.M.2    Brown, G.D.3    Taylor, P.R.4    Stillion, R.J.5    Linehan, S.A.6
  • 128
    • 63349085645 scopus 로고    scopus 로고
    • (2009) Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis
    • et al
    • Mercer, P.F., Johns, R.H., Scotton, C.J., Krupiczojc, M.A., Konigshoff, M., Howell, D.C. et al. (2009) Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis. Am J Respir Crit Care Med 179: 414-425.
    • Am J Respir Crit Care Med , vol.179 , pp. 414-425
    • Mercer, P.F.1    Johns, R.H.2    Scotton, C.J.3    Krupiczojc, M.A.4    Konigshoff, M.5    Howell, D.C.6
  • 129
    • 65249098301 scopus 로고    scopus 로고
    • (2009) Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis
    • et al
    • Moeller, A., Gilpin, S.E., Ask, K., Cox, G., Cook, D., Gauldie, J. et al. (2009) Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 179: 588-594.
    • Am J Respir Crit Care Med , vol.179 , pp. 588-594
    • Moeller, A.1    Gilpin, S.E.2    Ask, K.3    Cox, G.4    Cook, D.5    Gauldie, J.6
  • 131
  • 132
    • 0037408422 scopus 로고    scopus 로고
    • WNT signaling and pulmonary fibrosis
    • Morrisey, E.E. ( 2003) WNT signaling and pulmonary fibrosis. Am J Pathol 162: 1393-1397.
    • (2003) Am J Pathol , vol.162 , pp. 1393-1397
    • Morrisey, E.E.1
  • 133
    • 34548175512 scopus 로고    scopus 로고
    • Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression
    • Moustakas, A. and Heldin, C.H. ( 2007) Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci 98: 1512-1520.
    • (2007) Cancer Sci , vol.98 , pp. 1512-1520
    • Moustakas, A.1    Heldin, C.H.2
  • 134
    • 0033524949 scopus 로고    scopus 로고
    • The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
    • Munger, J.S., Huang, X., Kawakatsu, H., Griffiths, M.J., Dalton, S.L., Wu, J. et al. (1999) The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96: 319-328.
    • (1999) Cell , vol.96 , pp. 319-328
    • Munger, J.S.1    Huang, X.2    Kawakatsu, H.3    Griffiths, M.J.4    Dalton, S.L.5    Wu, J.6
  • 135
    • 54049136464 scopus 로고    scopus 로고
    • A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis
    • Mushiroda, T., Wattanapokayakit, S., Takahashi, A., Nukiwa, T., Kudoh, S., Ogura, T. et al. (2008) A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis. J Med Genet 45: 654-656.
    • (2008) J Med Genet , vol.45 , pp. 654-656
    • Mushiroda, T.1    Wattanapokayakit, S.2    Takahashi, A.3    Nukiwa, T.4    Kudoh, S.5    Ogura, T.6
  • 136
    • 33750017364 scopus 로고    scopus 로고
    • In vivo IL-10 gene delivery attenuates bleomycin induced pulmonary fibrosis by inhibiting the production and activation of TGF-beta in the lung
    • Nakagome, K., Dohi, M., Okunishi, K., Tanaka, R., Miyazaki, J. and Yamamoto, K. ( 2006) In vivo IL-10 gene delivery attenuates bleomycin induced pulmonary fibrosis by inhibiting the production and activation of TGF-beta in the lung. Thorax 61: 886-894.
    • (2006) Thorax , vol.61 , pp. 886-894
    • Nakagome, K.1    Dohi, M.2    Okunishi, K.3    Tanaka, R.4    Miyazaki, J.5    Yamamoto, K.6
  • 137
    • 0026741726 scopus 로고
    • Effect of gamma-interferon on collagen synthesis by normal and fibrotic human lung fibroblasts
    • Narayanan, A.S., Whithey, J., Souza, A. and Raghu, G. ( 1992) Effect of gamma-interferon on collagen synthesis by normal and fibrotic human lung fibroblasts. Chest 101: 1326-1331.
    • (1992) Chest , vol.101 , pp. 1326-1331
    • Narayanan, A.S.1    Whithey, J.2    Souza, A.3    Raghu, G.4
  • 138
    • 0345491616 scopus 로고    scopus 로고
    • Transcriptional regulation of cyclooxygenase 2 by bradykinin and interleukin-1beta in human airway smooth muscle cells: involvement of different promoter elements, transcription factors, and histone H4 acetylation
    • Nie, M., Pang, L., Inoue, H. and Knox, A.J. ( 2003) Transcriptional regulation of cyclooxygenase 2 by bradykinin and interleukin-1beta in human airway smooth muscle cells: involvement of different promoter elements, transcription factors, and histone H4 acetylation. Mol Cell Biol 23: 9233-9244.
    • (2003) Mol Cell Biol , vol.23 , pp. 9233-9244
    • Nie, M.1    Pang, L.2    Inoue, H.3    Knox, A.J.4
  • 139
    • 0035931973 scopus 로고    scopus 로고
    • A mutation in the surfactant protein C gene associated with familial interstitial lung disease
    • Nogee, L.M., Dunbar III, A.E., Wert, S.E., Askin, F., Hamvas, A. and Whitsett, J.A. ( 2001) A mutation in the surfactant protein C gene associated with familial interstitial lung disease. N Engl J Med 344: 573-579.
    • (2001) N Engl J Med , vol.344 , pp. 573-579
    • Nogee, L.M.1    Dunbar, A.E.2    Wert, S.E.3    Askin, F.4    Hamvas, A.5    Whitsett, J.A.6
  • 140
    • 19644373254 scopus 로고    scopus 로고
    • WNT signaling in disease and in development
    • Nusse, R. ( 2005) WNT signaling in disease and in development. Cell Res 15: 28-32.
    • (2005) Cell Res , vol.15 , pp. 28-32
    • Nusse, R.1
  • 141
    • 0030694282 scopus 로고    scopus 로고
    • The role of neutrophils in the pathogenesis of idiopathic pulmonary fibrosis
    • Obayashi, Y., Yamadori, I., Fujita, J., Yoshinouchi, T., Ueda, N. and Takahara, J. ( 1997) The role of neutrophils in the pathogenesis of idiopathic pulmonary fibrosis. Chest 112: 1338-1343.
    • (1997) Chest , vol.112 , pp. 1338-1343
    • Obayashi, Y.1    Yamadori, I.2    Fujita, J.3    Yoshinouchi, T.4    Ueda, N.5    Takahara, J.6
  • 142
    • 0027225314 scopus 로고
    • Effects of gamma-interferon on collagen and histamine content in bleomycin-induced lung fibrosis in rats
    • Okada, T., Sugie, I. and Aisaka, K. ( 1993) Effects of gamma-interferon on collagen and histamine content in bleomycin-induced lung fibrosis in rats. Lymphokine Cytokine Res 12: 87-91.
    • (1993) Lymphokine Cytokine Res , vol.12 , pp. 87-91
    • Okada, T.1    Sugie, I.2    Aisaka, K.3
  • 143
    • 28144449401 scopus 로고    scopus 로고
    • Histopathologic features and outcome of patients with acute exacerbation of idiopathic pulmonary fibrosis undergoing surgical lung biopsy
    • Parambil, J.G., Myers, J.L. and Ryu, J.H. ( 2005) Histopathologic features and outcome of patients with acute exacerbation of idiopathic pulmonary fibrosis undergoing surgical lung biopsy. Chest 128: 3310-3315.
    • (2005) Chest , vol.128 , pp. 3310-3315
    • Parambil, J.G.1    Myers, J.L.2    Ryu, J.H.3
  • 144
    • 0028153694 scopus 로고
    • Neoformation of blood vessels in association with rat lung fibrosis induced by bleomycin
    • Peao, M.N., Aguas, A.P., De Sa, C.M. and Grande, N.R. ( 1994) Neoformation of blood vessels in association with rat lung fibrosis induced by bleomycin. Anat Rec 238: 57-67.
    • (1994) Anat Rec , vol.238 , pp. 57-67
    • Peao, M.N.1    Aguas, A.P.2    De Sa, C.M.3    Grande, N.R.4
  • 145
    • 0027404744 scopus 로고
    • Effective treatment of the pulmonary fibrosis elicited in mice by bleomycin or silica with anti-CD-11 antibodies
    • Piguet, P.F., Rosen, H., Vesin, C. and Grau, G.E. ( 1993) Effective treatment of the pulmonary fibrosis elicited in mice by bleomycin or silica with anti-CD-11 antibodies. Am Rev Respir Dis 147: 435-441.
    • (1993) Am Rev Respir Dis , vol.147 , pp. 435-441
    • Piguet, P.F.1    Rosen, H.2    Vesin, C.3    Grau, G.E.4
  • 146
  • 147
    • 37849008770 scopus 로고    scopus 로고
    • Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis
    • Puthawala, K., Hadjiangelis, N., Jacoby, S.C., Bayongan, E., Zhao, Z., Yang, Z. et al. (2008) Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. Am J Respir Crit Care Med 177: 82-90.
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 82-90
    • Puthawala, K.1    Hadjiangelis, N.2    Jacoby, S.C.3    Bayongan, E.4    Zhao, Z.5    Yang, Z.6
  • 148
    • 30744455313 scopus 로고    scopus 로고
    • High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis
    • Raghu, G., Freudenberger, T.D., Yang, S., Curtis, J.R., Spada, C., Hayes, J. et al. (2006b) High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis. Eur Respir J 27: 136-142.
    • (2006) Eur Respir J , vol.27 , pp. 136-142
    • Raghu, G.1    Freudenberger, T.D.2    Yang, S.3    Curtis, J.R.4    Spada, C.5    Hayes, J.6
  • 151
    • 0019403740 scopus 로고
    • Cryptogenic fibrosing alveolitis. Relationships of pulmonary physiology and bronchoalveolar lavage to response to treatment and prognosis
    • Rudd, R.M., Haslam, P.L. and Turner-Warwick, M. ( 1981) Cryptogenic fibrosing alveolitis. Relationships of pulmonary physiology and bronchoalveolar lavage to response to treatment and prognosis. Am Rev Respir Dis 124: 1-8.
    • (1981) Am Rev Respir Dis , vol.124 , pp. 1-8
    • Rudd, R.M.1    Haslam, P.L.2    Turner-Warwick, M.3
  • 152
    • 1542289674 scopus 로고    scopus 로고
    • SMAD3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury
    • Saika, S., Kono-Saika, S., Ohnishi, Y., Sato, M., Muragaki, Y., Ooshima, A. et al. (2004) SMAD3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury. Am J Pathol 164: 651-663.
    • (2004) Am J Pathol , vol.164 , pp. 651-663
    • Saika, S.1    Kono-Saika, S.2    Ohnishi, Y.3    Sato, M.4    Muragaki, Y.5    Ooshima, A.6
  • 153
    • 0035914297 scopus 로고    scopus 로고
    • Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression
    • Sánchez-Elsner, T., Botella, L.M., Velasco, B., Corbí, A., Attisano, L. and Bernabéu, C. ( 2001) Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression. J Biol Chem 276: 38527-35.
    • (2001) J Biol Chem , vol.276 , pp. 38527-38535
    • Sánchez-Elsner, T.1    Botella, L.M.2    Velasco, B.3    Corbí, A.4    Attisano, L.5    Bernabéu, C.6
  • 155
    • 0038544594 scopus 로고    scopus 로고
    • Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma
    • Schmidt, M., Sun, G., Stacey, M.A., Mori, L. and Mattoli, S. ( 2003) Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol 171: 380-389.
    • (2003) J Immunol , vol.171 , pp. 380-389
    • Schmidt, M.1    Sun, G.2    Stacey, M.A.3    Mori, L.4    Mattoli, S.5
  • 156
    • 0028823394 scopus 로고
    • Silencing is golden: negative regulation in the control of neuronal gene transcription
    • Schoenherr, C.J. and Anderson, D.J. ( 1995) Silencing is golden: negative regulation in the control of neuronal gene transcription. Curr Opin Neurobiol 5: 566-571.
    • (1995) Curr Opin Neurobiol , vol.5 , pp. 566-571
    • Schoenherr, C.J.1    Anderson, D.J.2
  • 157
    • 0020618189 scopus 로고
    • The effects of the nude (NU/NU) mutation on bleomycin-induced pulmonary fibrosis. A biochemical evaluation
    • Schrier, D.J., Phan, S.H. and McGarry, B.M. ( 1983) The effects of the nude (NU/NU) mutation on bleomycin-induced pulmonary fibrosis. A biochemical evaluation. Am Rev Respir Dis 127: 614-617.
    • (1983) Am Rev Respir Dis , vol.127 , pp. 614-617
    • Schrier, D.J.1    Phan, S.H.2    McGarry, B.M.3
  • 158
    • 35448988114 scopus 로고    scopus 로고
    • Molecular targets in pulmonary fibrosis: the myofibroblast in focus
    • Scotton, C.J. and Chambers, R.C. ( 2007) Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest 132: 1311-1321.
    • (2007) Chest , vol.132 , pp. 1311-1321
    • Scotton, C.J.1    Chambers, R.C.2
  • 159
    • 70349422341 scopus 로고    scopus 로고
    • (2009) Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury
    • et al
    • Scotton, C.J., Krupiczojc, M.A., Konigshoff, M., Mercer, P.F., Lee, Y.C., Kaminski, N. et al. (2009) Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest 119: 2550-2563.
    • J Clin Invest , vol.119 , pp. 2550-2563
    • Scotton, C.J.1    Krupiczojc, M.A.2    Konigshoff, M.3    Mercer, P.F.4    Lee, Y.C.5    Kaminski, N.6
  • 160
    • 31944436620 scopus 로고    scopus 로고
    • Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis
    • Selman, M., Pardo, A., Barrera, L., Estrada, A., Watson, S.R., Wilson, K. et al. (2006) Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis. Am J Respir Crit Care Med 173: 188-198.
    • (2006) Am J Respir Crit Care Med , vol.173 , pp. 188-198
    • Selman, M.1    Pardo, A.2    Barrera, L.3    Estrada, A.4    Watson, S.R.5    Wilson, K.6
  • 161
    • 41549108935 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs?
    • Selman, M., Pardo, A. and Kaminski, N. ( 2008) Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs? PLoS Med 5: e62.
    • (2008) PLoS Med , vol.5 , pp. e62
    • Selman, M.1    Pardo, A.2    Kaminski, N.3
  • 162
    • 0028224194 scopus 로고
    • Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis
    • Sempowski, G.D., Beckmann, M.P., Derdak, S. and Phipps, R.P. ( 1994) Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis. J Immunol 152: 3606-3614.
    • (1994) J Immunol , vol.152 , pp. 3606-3614
    • Sempowski, G.D.1    Beckmann, M.P.2    Derdak, S.3    Phipps, R.P.4
  • 163
    • 0030800795 scopus 로고    scopus 로고
    • Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung
    • Sime, P.J., Xing, Z., Graham, F.L., Csaky, K.G. and Gauldie, J. ( 1997) Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest 100: 768-776.
    • (1997) J Clin Invest , vol.100 , pp. 768-776
    • Sime, P.J.1    Xing, Z.2    Graham, F.L.3    Csaky, K.G.4    Gauldie, J.5
  • 168
    • 0034051227 scopus 로고    scopus 로고
    • Acetylation of histones and transcription-related factors
    • Sterner, D.E. and Berger, S.L. ( 2000) Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev 64: 435-459.
    • (2000) Microbiol Mol Biol Rev , vol.64 , pp. 435-459
    • Sterner, D.E.1    Berger, S.L.2
  • 169
    • 0032958746 scopus 로고    scopus 로고
    • The detection of Epstein-Barr virus DNA in lung tissue from patients with idiopathic pulmonary fibrosis
    • Stewart, J.P., Egan, J.J., Ross, A.J., Kelly, B.G., Lok, S.S., Hasleton, P.S. et al. (1999) The detection of Epstein-Barr virus DNA in lung tissue from patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 159: 1336-1341.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1336-1341
    • Stewart, J.P.1    Egan, J.J.2    Ross, A.J.3    Kelly, B.G.4    Lok, S.S.5    Hasleton, P.S.6
  • 170
    • 4143052494 scopus 로고    scopus 로고
    • Innate immunity dictates cytokine polarization relevant to the development of pulmonary fibrosis
    • Strieter, R.M. and Keane, M.P. ( 2004) Innate immunity dictates cytokine polarization relevant to the development of pulmonary fibrosis. J Clin Invest 114: 165-168.
    • (2004) J Clin Invest , vol.114 , pp. 165-168
    • Strieter, R.M.1    Keane, M.P.2
  • 171
    • 70449440734 scopus 로고    scopus 로고
    • (2009) New mechanisms of pulmonary fibrosis
    • Strieter, R.M. and Mehrad, B. (2009) New mechanisms of pulmonary fibrosis. Chest 136: 1364-1370.
    • Chest , vol.136 , pp. 1364-1370
    • Strieter, R.M.1    Mehrad, B.2
  • 172
    • 0035853840 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. evidence for involvement of activator protein-1 and CREBbinding protein/P300
    • Subbaramaiah, K., Lin, D.T., Hart, J.C. and Dannenberg, A.J. ( 2001) Peroxisome proliferatoractivated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. evidence for involvement of activator protein-1 and CREBbinding protein/P300. J Biol Chem 276: 12440-12448.
    • (2001) J Biol Chem , vol.276 , pp. 12440-12448
    • Subbaramaiah, K.1    Lin, D.T.2    Hart, J.C.3    Dannenberg, A.J.4
  • 174
    • 38049091636 scopus 로고    scopus 로고
    • The lysophosphatidic acid receptor lpa1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
    • Tager, A.M., Lacamera, P., Shea, B.S., Campanella, G.S., Selman, M., Zhao, Z. et al. (2008) The lysophosphatidic acid receptor lpa1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med 14: 45-54.
    • (2008) Nat Med , vol.14 , pp. 45-54
    • Tager, A.M.1    Lacamera, P.2    Shea, B.S.3    Campanella, G.S.4    Selman, M.5    Zhao, Z.6
  • 175
    • 0026447801 scopus 로고
    • Release of transforming growth factor-beta 1 from the peri-cellular matrix of cultured fibroblasts and fibrosarcoma cells by plasmin and thrombin
    • Taipale, J., Koli, K. and Keski-Oja, J. ( 1992) Release of transforming growth factor-beta 1 from the peri-cellular matrix of cultured fibroblasts and fibrosarcoma cells by plasmin and thrombin. J Biol Chem 267: 25378-25384.
    • (1992) J Biol Chem , vol.267 , pp. 25378-25384
    • Taipale, J.1    Koli, K.2    Keski-Oja, J.3
  • 176
    • 70349441112 scopus 로고    scopus 로고
    • (2009) Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis
    • et al
    • Tanjore, H., Xu, X.C., Polosukhin, V.V., Degryse, A.L., Li, B., Han, W. et al. (2009) Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis. Am J Respir Crit Care Med 180: 657-665.
    • Am J Respir Crit Care Med , vol.180 , pp. 657-665
    • Tanjore, H.1    Xu, X.C.2    Polosukhin, V.V.3    Degryse, A.L.4    Li, B.5    Han, W.6
  • 177
    • 0030741005 scopus 로고    scopus 로고
    • Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice
    • Taooka, Y., Maeda, A., Hiyama, K., Ishioka, S. and Yamakido, M. ( 1997) Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 156: 260-265.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 260-265
    • Taooka, Y.1    Maeda, A.2    Hiyama, K.3    Ishioka, S.4    Yamakido, M.5
  • 178
    • 33744908816 scopus 로고    scopus 로고
    • Is idiopathic pulmonary fibrosis an environmental disease?
    • Taskar, V.S. and Coultas, D.B. ( 2006) Is idiopathic pulmonary fibrosis an environmental disease? Proc Am Thorac Soc 3: 293-298.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 293-298
    • Taskar, V.S.1    Coultas, D.B.2
  • 179
    • 42249092990 scopus 로고    scopus 로고
    • Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis
    • Tatler, A.L., Porte, J., Knox, A., Jenkins, G. and Pang, L. ( 2008) Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis. Biochem Biophys Res Commun 370: 239-242.
    • (2008) Biochem Biophys Res Commun , vol.370 , pp. 239-242
    • Tatler, A.L.1    Porte, J.2    Knox, A.3    Jenkins, G.4    Pang, L.5
  • 180
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery, J.P. and Sleeman, J.P. ( 2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 181
    • 0036570052 scopus 로고    scopus 로고
    • Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred
    • Thomas, A.Q., Lane, K., Phillips III, J., Prince, M., Markin, C., Speer, M. et al. (2002) Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred. Am J Respir Crit Care Med 165: 1322-1328.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 1322-1328
    • Thomas, A.Q.1    Lane, K.2    Phillips, J.3    Prince, M.4    Markin, C.5    Speer, M.6
  • 182
    • 0018354906 scopus 로고
    • Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin
    • Thrall, R.S., McCormick, J.R., Jack, R.M., McReynolds, R.A. and Ward, P.A. ( 1979) Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin. Am J Pathol 95: 117-130.
    • (1979) Am J Pathol , vol.95 , pp. 117-130
    • Thrall, R.S.1    McCormick, J.R.2    Jack, R.M.3    McReynolds, R.A.4    Ward, P.A.5
  • 183
    • 0019408568 scopus 로고
    • The development of bleomycin-induced pulmonary fibrosis in neutrophil-depleted and complement-depleted rats
    • Thrall, R.S., Phan, S.H., McCormick, J.R. and Ward, P.A. ( 1981) The development of bleomycin-induced pulmonary fibrosis in neutrophil-depleted and complement-depleted rats. Am J Pathol 105: 76-81.
    • (1981) Am J Pathol , vol.105 , pp. 76-81
    • Thrall, R.S.1    Phan, S.H.2    McCormick, J.R.3    Ward, P.A.4
  • 184
    • 33748704958 scopus 로고    scopus 로고
    • Relationship between histopathological features and the course of idiopathic pulmonary fibrosis/usual interstitial pneumonia
    • Tiitto, L., Bloigu, R., Heiskanen, U., Paakko, P., Kinnula, V.L. and Kaarteenaho-Wiik, R. ( 2006) Relationship between histopathological features and the course of idiopathic pulmonary fibrosis/usual interstitial pneumonia. Thorax 61: 1091-1095.
    • (2006) Thorax , vol.61 , pp. 1091-1095
    • Tiitto, L.1    Bloigu, R.2    Heiskanen, U.3    Paakko, P.4    Kinnula, V.L.5    Kaarteenaho-Wiik, R.6
  • 185
    • 1842531133 scopus 로고    scopus 로고
    • Butyrate suppresses COX-2 activation in colon cancer cells through HDAC inhibition
    • Tong, X., Yin, L. and Giardina, C. ( 2004) Butyrate suppresses COX-2 activation in colon cancer cells through HDAC inhibition. Biochem Biophys Res Commun 317: 463-471.
    • (2004) Biochem Biophys Res Commun , vol.317 , pp. 463-471
    • Tong, X.1    Yin, L.2    Giardina, C.3
  • 186
    • 11144354727 scopus 로고    scopus 로고
    • Mutation of SFTPC in infantile pulmonary alveolar proteinosis with or without fibrosing lung disease
    • Tredano, M., Griese, M., Brasch, F., Schumacher, S., De Blic, J., Marque, S. et al. (2004) Mutation of SFTPC in infantile pulmonary alveolar proteinosis with or without fibrosing lung disease. Am J Med Genet A 126A: 18-26.
    • (2004) Am J Med Genet A , vol.126A , pp. 18-26
    • Tredano, M.1    Griese, M.2    Brasch, F.3    Schumacher, S.4    De Blic, J.5    Marque, S.6
  • 188
    • 0003158779 scopus 로고
    • Systemic arterial patterns in the lung and clubbing of the fingers
    • Turner-Warwick, M. ( 1963) Systemic arterial patterns in the lung and clubbing of the fingers. Thorax 18: 238-250.
    • (1963) Thorax , vol.18 , pp. 238-250
    • Turner-Warwick, M.1
  • 189
    • 0035962646 scopus 로고    scopus 로고
    • Chromatin remodeling and transcriptional activation: the cast (in order of appearance)
    • Urnov, F.D. and Wolffe, A.P. ( 2001) Chromatin remodeling and transcriptional activation: the cast (in order of appearance). Oncogene 20: 2991-3006.
    • (2001) Oncogene , vol.20 , pp. 2991-3006
    • Urnov, F.D.1    Wolffe, A.P.2
  • 190
    • 77951176799 scopus 로고    scopus 로고
    • (2010) Idiopathic pulmonary fibrosis: a disease with similarities and links to cancer biology
    • Vancheri, C., Failla, M., Crimi, N. and Raghu, G. (2010) Idiopathic pulmonary fibrosis: a disease with similarities and links to cancer biology. Eur Respir J 35: 496-504.
    • Eur Respir J , vol.35 , pp. 496-504
    • Vancheri, C.1    Failla, M.2    Crimi, N.3    Raghu, G.4
  • 191
    • 1542344332 scopus 로고    scopus 로고
    • In vitro targeting reveals intrinsic histone tail specificity of the SIN3/histone deacetylase and N-COR/SMRT corepressor complexes
    • Vermeulen, M., Carrozza, M.J., Lasonder, E., Workman, J.L., Logie, C. and Stunnenberg, H.G. ( 2004) In vitro targeting reveals intrinsic histone tail specificity of the SIN3/histone deacetylase and N-COR/SMRT corepressor complexes. Mol Cell Biol 24: 2364-2372.
    • (2004) Mol Cell Biol , vol.24 , pp. 2364-2372
    • Vermeulen, M.1    Carrozza, M.J.2    Lasonder, E.3    Workman, J.L.4    Logie, C.5    Stunnenberg, H.G.6
  • 193
    • 75949125865 scopus 로고    scopus 로고
    • (2010) Abnormal expression of telomerase/apoptosis limits type II alveolar epithelial cell replication in the early remodeling of usual interstitial pneumonia/ idiopathic pulmonary fibrosis
    • et al
    • Waisberg, D.R., Barbas-Filho, J.V., Parra, E.R., Fernezlian, S., De Carvalho, C.R., Kairalla, R.A. et al. (2010) Abnormal expression of telomerase/apoptosis limits type II alveolar epithelial cell replication in the early remodeling of usual interstitial pneumonia/ idiopathic pulmonary fibrosis. Hum Pathol 41: 385-391.
    • Hum Pathol , vol.41 , pp. 385-391
    • Waisberg, D.R.1    Barbas-Filho, J.V.2    Parra, E.R.3    Fernezlian, S.4    De Carvalho, C.R.5    Kairalla, R.A.6
  • 194
    • 0029113474 scopus 로고
    • A type 2 (Th2-like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis (CFA)
    • Wallace, W.A., Ramage, E.A., Lamb, D. and Howie, S.E. ( 1995) A type 2 (Th2-like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis (CFA). Clin Exp Immunol 101: 436-441.
    • (1995) Clin Exp Immunol , vol.101 , pp. 436-441
    • Wallace, W.A.1    Ramage, E.A.2    Lamb, D.3    Howie, S.E.4
  • 196
    • 0032771311 scopus 로고    scopus 로고
    • Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters
    • Wang, Q., Wang, Y., Hyde, D.M., Gotwals, P.J., Koteliansky, V.E., Ryan, S.T. et al. (1999) Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters. Thorax 54: 805-812.
    • (1999) Thorax , vol.54 , pp. 805-812
    • Wang, Q.1    Wang, Y.2    Hyde, D.M.3    Gotwals, P.J.4    Koteliansky, V.E.5    Ryan, S.T.6
  • 197
    • 0023135833 scopus 로고
    • Idiopathic pulmonary fibrosis. pretreatment bronchoalveolar lavage cellular constituents and their relationships with lung histopathology and clinical response to therapy
    • Watters, L.C., Schwarz, M.I., Cherniack, R.M., Waldron, J.A., Dunn, T.L., Stanford, R.E. et al. (1987) Idiopathic pulmonary fibrosis. pretreatment bronchoalveolar lavage cellular constituents and their relationships with lung histopathology and clinical response to therapy. Am Rev Respir Dis 135: 696-704.
    • (1987) Am Rev Respir Dis , vol.135 , pp. 696-704
    • Watters, L.C.1    Schwarz, M.I.2    Cherniack, R.M.3    Waldron, J.A.4    Dunn, T.L.5    Stanford, R.E.6
  • 198
    • 0037180829 scopus 로고    scopus 로고
    • Hydrophobic surfactant proteins in lung function and disease
    • Whitsett, J.A. and Weaver, T.E. ( 2002) Hydrophobic surfactant proteins in lung function and disease. N Engl J Med 347: 2141-2148.
    • (2002) N Engl J Med , vol.347 , pp. 2141-2148
    • Whitsett, J.A.1    Weaver, T.E.2
  • 199
    • 17844384822 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis
    • Willis, B.C., Liebler, J.M., Luby-Phelps, K., Nicholson, A.G., Crandall, E.D., Du Bois, R.M. et al. (2005) Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol 166: 1321-1332.
    • (2005) Am J Pathol , vol.166 , pp. 1321-1332
    • Willis, B.C.1    Liebler, J.M.2    Luby-Phelps, K.3    Nicholson, A.G.4    Crandall, E.D.5    Du Bois, R.M.6
  • 201
    • 60649102339 scopus 로고    scopus 로고
    • (2009) Pulmonary fibrosis: pathogenesis, etiology and regulation
    • Wilson, M.S. and Wynn, T.A. (2009) Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol 2: 103-121.
    • Mucosal Immunol , vol.2 , pp. 103-121
    • Wilson, M.S.1    Wynn, T.A.2
  • 202
    • 37249044357 scopus 로고    scopus 로고
    • Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix
    • Wipff, P.J., Rifkin, D.B., Meister, J.J. and Hinz, B. ( 2007) Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol 179: 1311-1323.
    • (2007) J Cell Biol , vol.179 , pp. 1311-1323
    • Wipff, P.J.1    Rifkin, D.B.2    Meister, J.J.3    Hinz, B.4
  • 203
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Wynn, T.A. ( 2008) Cellular and molecular mechanisms of fibrosis. J Pathol 214: 199-210.
    • (2008) J Pathol , vol.214 , pp. 199-210
    • Wynn, T.A.1
  • 204
    • 0028170074 scopus 로고
    • V-SRC induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element
    • Xie, W., Fletcher, B.S., Andersen, R.D. and Herschman, H.R. ( 1994) V-SRC induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element. Mol Cell Biol 14: 6531-6539.
    • (1994) Mol Cell Biol , vol.14 , pp. 6531-6539
    • Xie, W.1    Fletcher, B.S.2    Andersen, R.D.3    Herschman, H.R.4
  • 205
    • 65349145784 scopus 로고    scopus 로고
    • (2009) Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(Q)
    • et al
    • Xu, M.Y., Porte, J., Knox, A.J., Weinreb, P.H., Maher, T.M., Violette, S.M. et al. (2009) Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(Q). Am J Pathol 174: 1264-1279.
    • Am J Pathol , vol.174 , pp. 1264-1279
    • Xu, M.Y.1    Porte, J.2    Knox, A.J.3    Weinreb, P.H.4    Maher, T.M.5    Violette, S.M.6
  • 207
    • 6344254484 scopus 로고    scopus 로고
    • TGF-beta1 induces alveolar epithelial to mesenchymal transition in vitro
    • Yao, H.W., Xie, Q.M., Chen, J.Q., Deng, Y.M. and Tang, H.F. ( 2004) TGF-beta1 induces alveolar epithelial to mesenchymal transition in vitro. Life Sci 76: 29-37.
    • (2004) Life Sci , vol.76 , pp. 29-37
    • Yao, H.W.1    Xie, Q.M.2    Chen, J.Q.3    Deng, Y.M.4    Tang, H.F.5
  • 208
    • 0034955797 scopus 로고    scopus 로고
    • Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse
    • Yasui, H., Gabazza, E.C., Tamaki, S., Kobayashi, T., Hataji, O., Yuda, H. et al. (2001) Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse. Am J Respir Crit Care Med 163: 1660-1668.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1660-1668
    • Yasui, H.1    Gabazza, E.C.2    Tamaki, S.3    Kobayashi, T.4    Hataji, O.5    Yuda, H.6
  • 209
    • 11144333630 scopus 로고    scopus 로고
    • Reading and function of a histone code involved in targeting corepressor complexes for repression
    • Yoon, H.-G., Choi, Y., Cole, P.A. and Wong, J. ( 2005) Reading and function of a histone code involved in targeting corepressor complexes for repression. Mol Cell Biol 25: 324-335.
    • (2005) Mol Cell Biol , vol.25 , pp. 324-335
    • Yoon, H.-G.1    Choi, Y.2    Cole, P.A.3    Wong, J.4
  • 210
    • 0035852637 scopus 로고    scopus 로고
    • CoREST is an integral component of the CoREST-human histone deacetylase complex
    • You, A., Tong, J.K., Grozinger, C.M. and Schreiber, S.L. ( 2001) CoREST is an integral component of the CoREST-human histone deacetylase complex. Proc Natl Acad Sci U S A 98: 1454-1458.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1454-1458
    • You, A.1    Tong, J.K.2    Grozinger, C.M.3    Schreiber, S.L.4
  • 211
    • 44949201593 scopus 로고    scopus 로고
    • Transgelin is a direct target of TGF-beta/SMAD3-dependent epithelial cell migration in lung fibrosis
    • Yu, H., Konigshoff, M., Jayachandran, A., Handley, D., Seeger, W., Kaminski, N. et al. (2008) Transgelin is a direct target of TGF-beta/SMAD3-dependent epithelial cell migration in lung fibrosis. FASEB J 22: 1778-1789.
    • (2008) FASEB J , vol.22 , pp. 1778-1789
    • Yu, H.1    Konigshoff, M.2    Jayachandran, A.3    Handley, D.4    Seeger, W.5    Kaminski, N.6
  • 212
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    • Yu, Q. and Stamenkovic, I. ( 2000) Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 14: 163-176.
    • (2000) Genes Dev , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 213
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • Zeisberg, M., Yang, C., Martino, M., Duncan, M.B., Rieder, F., Tanjore, H. et al. (2007) Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 282: 23337-23347.
    • (2007) J Biol Chem , vol.282 , pp. 23337-23347
    • Zeisberg, M.1    Yang, C.2    Martino, M.3    Duncan, M.B.4    Rieder, F.5    Tanjore, H.6
  • 214
    • 0036086293 scopus 로고    scopus 로고
    • SMAD3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice
    • e Zhao, J., Shi, W., Wang, Y.L., Chen, H., Bringas Jr, P., Datto, M.B. (2002) SMAD3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol 282: L585-L593.
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.282 , pp. L585-L593
  • 215
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Zhu, Z., Homer, R.J., Wang, Z., Chen, Q., Geba, G.P., Wang, J. et al. (1999) Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 103: 779-788.
    • (1999) J Clin Invest , vol.103 , pp. 779-788
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3    Chen, Q.4    Geba, G.P.5    Wang, J.6
  • 216
    • 0032084906 scopus 로고    scopus 로고
    • Increased expression of proinflammatory chemokines in bronchoalveolar lavage cells of patients with progressing idiopathic pulmonary fibrosis and sarcoidosis
    • Ziegenhagen, M.W., Schrum, S., Zissel, G., Zipfel, P.F., Schlaak, M. and Muller-Quernheim, J. ( 1998) Increased expression of proinflammatory chemokines in bronchoalveolar lavage cells of patients with progressing idiopathic pulmonary fibrosis and sarcoidosis. J Investig Med 46: 223-231.
    • (1998) J Investig Med , vol.46 , pp. 223-231
    • Ziegenhagen, M.W.1    Schrum, S.2    Zissel, G.3    Zipfel, P.F.4    Schlaak, M.5    Muller-Quernheim, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.