메뉴 건너뛰기




Volumn 58, Issue , 2016, Pages 60-69

The role of wild type RAS isoforms in cancer

Author keywords

Cancer; Isoform; Mutant; RAS; RASGAP; Wild type

Indexed keywords

DUAL SPECIFICITY PHOSPHATASE; GUANOSINE TRIPHOSPHATASE; RAS PROTEIN; SPROUTY PROTEIN; TUMOR PROMOTER; TUMOR SUPPRESSOR PROTEIN; ISOPROTEIN;

EID: 84991087049     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2016.07.012     Document Type: Review
Times cited : (103)

References (98)
  • 1
    • 16844387479 scopus 로고    scopus 로고
    • The Ras superfamily at a glance
    • [1] Wennerberg, K., Rossman, K.L., Der, C.J., The Ras superfamily at a glance. J. Cell Sci. 118:Pt 5 (2005), 843–846.
    • (2005) J. Cell Sci. , vol.118 , pp. 843-846
    • Wennerberg, K.1    Rossman, K.L.2    Der, C.J.3
  • 2
    • 78649474147 scopus 로고    scopus 로고
    • Ras history: the saga continues
    • [2] Cox, A.D., Der, C.J., Ras history: the saga continues. Small GTPases 1:1 (2010), 2–27.
    • (2010) Small GTPases , vol.1 , Issue.1 , pp. 2-27
    • Cox, A.D.1    Der, C.J.2
  • 6
    • 78649487698 scopus 로고    scopus 로고
    • Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
    • [6] Vigil, D., Cherfils, J., Rossman, K.L., Der, C.J., Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?. Nat. Rev. Cancer 10:12 (2010), 842–857.
    • (2010) Nat. Rev. Cancer , vol.10 , Issue.12 , pp. 842-857
    • Vigil, D.1    Cherfils, J.2    Rossman, K.L.3    Der, C.J.4
  • 7
    • 84901433444 scopus 로고    scopus 로고
    • An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer
    • [7] Maertens, O., Cichowski, K., An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer. Adv. Biol. Regul. 55 (2014), 1–14.
    • (2014) Adv. Biol. Regul. , vol.55 , pp. 1-14
    • Maertens, O.1    Cichowski, K.2
  • 9
    • 84927620483 scopus 로고    scopus 로고
    • Targeting RAS membrane association: back to the future for anti-RAS drug discovery?
    • [9] Cox, A.D., Der, C.J., Philips, M.R., Targeting RAS membrane association: back to the future for anti-RAS drug discovery?. Clin. Cancer Res. 21:8 (2015), 1819–1827.
    • (2015) Clin. Cancer Res. , vol.21 , Issue.8 , pp. 1819-1827
    • Cox, A.D.1    Der, C.J.2    Philips, M.R.3
  • 10
    • 84858796808 scopus 로고    scopus 로고
    • Ras trafficking, localization and compartmentalized signalling
    • [10] Prior, I.A., Hancock, J.F., Ras trafficking, localization and compartmentalized signalling. Semin. Cell Dev. Biol. 23:2 (2012), 145–153.
    • (2012) Semin. Cell Dev. Biol. , vol.23 , Issue.2 , pp. 145-153
    • Prior, I.A.1    Hancock, J.F.2
  • 11
    • 62149129986 scopus 로고    scopus 로고
    • Compartmentalized signalling: ras proteins and signalling nanoclusters
    • [11] Omerovic, J., Prior, I.A., Compartmentalized signalling: ras proteins and signalling nanoclusters. FEBS J. 276:7 (2009), 1817–1825.
    • (2009) FEBS J. , vol.276 , Issue.7 , pp. 1817-1825
    • Omerovic, J.1    Prior, I.A.2
  • 12
    • 27344456331 scopus 로고    scopus 로고
    • membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton
    • [12] Plowman, S.J., Muncke, C., Parton, R.G., Hancock, J.F., K-ras, H-ras, plasma, inner, membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton. Proc. Natl. Acad. Sci. U. S. A. 102:43 (2005), 15500–15505.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , Issue.43 , pp. 15500-15505
    • Plowman, S.J.1    Muncke, C.2    Parton, R.G.3    Hancock, J.F.4    K-ras, H.-R.5
  • 13
    • 1642553461 scopus 로고    scopus 로고
    • The dark side of Ras: regulation of apoptosis
    • [13] Cox, A.D., Der, C.J., The dark side of Ras: regulation of apoptosis. Oncogene 22:56 (2003), 8999–9006.
    • (2003) Oncogene , vol.22 , Issue.56 , pp. 8999-9006
    • Cox, A.D.1    Der, C.J.2
  • 14
    • 0032546232 scopus 로고    scopus 로고
    • Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo
    • [14] Hamilton, M., Wolfman, A., Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo. Oncogene 16:11 (1998), 1417–1428.
    • (1998) Oncogene , vol.16 , Issue.11 , pp. 1417-1428
    • Hamilton, M.1    Wolfman, A.2
  • 15
    • 0033546419 scopus 로고    scopus 로고
    • Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility
    • [15] Voice, J.K., Klemke, R.L., Le, A., Jackson, J.H., Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility. J. Biol. Chem. 274:24 (1999), 17164–17170.
    • (1999) J. Biol. Chem. , vol.274 , Issue.24 , pp. 17164-17170
    • Voice, J.K.1    Klemke, R.L.2    Le, A.3    Jackson, J.H.4
  • 16
    • 0032508517 scopus 로고    scopus 로고
    • Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase
    • [16] Yan, J., Roy, S., Apolloni, A., Lane, A., Hancock, J.F., Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. J. Biol. Chem. 273:37 (1998), 24052–24056.
    • (1998) J. Biol. Chem. , vol.273 , Issue.37 , pp. 24052-24056
    • Yan, J.1    Roy, S.2    Apolloni, A.3    Lane, A.4    Hancock, J.F.5
  • 17
    • 79960038169 scopus 로고    scopus 로고
    • Functional specificity of ras isoforms: so similar but so different
    • [17] Castellano, E., Santos, E., Functional specificity of ras isoforms: so similar but so different. Genes Cancer 2:3 (2011), 216–231.
    • (2011) Genes Cancer , vol.2 , Issue.3 , pp. 216-231
    • Castellano, E.1    Santos, E.2
  • 18
    • 34748908758 scopus 로고    scopus 로고
    • Wild-type NRas and KRas perform distinct functions during transformation
    • [18] Fotiadou, P.P., Takahashi, C., Rajabi, H.N., Ewen, M.E., Wild-type NRas and KRas perform distinct functions during transformation. Mol. Cell. Biol. 27:19 (2007), 6742–6755.
    • (2007) Mol. Cell. Biol. , vol.27 , Issue.19 , pp. 6742-6755
    • Fotiadou, P.P.1    Takahashi, C.2    Rajabi, H.N.3    Ewen, M.E.4
  • 21
    • 34547621066 scopus 로고    scopus 로고
    • Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice
    • [21] Parikh, C., Subrahmanyam, R., Ren, R., Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice. Cancer Res. 67:15 (2007), 7139–7146.
    • (2007) Cancer Res. , vol.67 , Issue.15 , pp. 7139-7146
    • Parikh, C.1    Subrahmanyam, R.2    Ren, R.3
  • 22
    • 65349150639 scopus 로고    scopus 로고
    • Isoform-specific ras functions in development and cancer
    • [22] Quinlan, M.P., Settleman, J., Isoform-specific ras functions in development and cancer. Future Oncol. 5:1 (2009), 105–116.
    • (2009) Future Oncol. , vol.5 , Issue.1 , pp. 105-116
    • Quinlan, M.P.1    Settleman, J.2
  • 31
    • 84964345721 scopus 로고    scopus 로고
    • RAS isoforms and mutations in cancer at a glance
    • [31] Hobbs, G.A., Der, C.J., Rossman, K.L., RAS isoforms and mutations in cancer at a glance. J. Cell Sci. 129:7 (2016), 1287–1292.
    • (2016) J. Cell Sci. , vol.129 , Issue.7 , pp. 1287-1292
    • Hobbs, G.A.1    Der, C.J.2    Rossman, K.L.3
  • 35
    • 84855270995 scopus 로고    scopus 로고
    • Ras-induced senescence and its physiological relevance in cancer
    • [35] Dimauro, T., David, G., Ras-induced senescence and its physiological relevance in cancer. Curr. Cancer Drug Targets 10:8 (2010), 869–876.
    • (2010) Curr. Cancer Drug Targets , vol.10 , Issue.8 , pp. 869-876
    • Dimauro, T.1    David, G.2
  • 37
    • 0036675204 scopus 로고    scopus 로고
    • Normal ras genes: their onco-suppressor and pro-apoptotic functions (review)
    • [37] Spandidos, D.A., Sourvinos, G., Tsatsanis, C., Zafiropoulos, A., Normal ras genes: their onco-suppressor and pro-apoptotic functions (review). Int. J. Oncol. 21:2 (2002), 237–241.
    • (2002) Int. J. Oncol. , vol.21 , Issue.2 , pp. 237-241
    • Spandidos, D.A.1    Sourvinos, G.2    Tsatsanis, C.3    Zafiropoulos, A.4
  • 38
    • 33746555367 scopus 로고    scopus 로고
    • A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice
    • [38] To, M.D., Perez-Losada, J., Mao, J.H., Hsu, J., Jacks, T., Balmain, A., A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice. Nat. Genet. 38:8 (2006), 926–930.
    • (2006) Nat. Genet. , vol.38 , Issue.8 , pp. 926-930
    • To, M.D.1    Perez-Losada, J.2    Mao, J.H.3    Hsu, J.4    Jacks, T.5    Balmain, A.6
  • 42
    • 0024154082 scopus 로고
    • The normal human H-ras1 gene can act as an onco-suppressor
    • [42] Spandidos, A., Wilkie, N.M., The normal human H-ras1 gene can act as an onco-suppressor. Br. J. Cancer 9:Supplement (1988), 67–71.
    • (1988) Br. J. Cancer , vol.9 , pp. 67-71
    • Spandidos, A.1    Wilkie, N.M.2
  • 43
    • 0025520003 scopus 로고
    • Expression of the normal H-ras1 gene can suppress the transformed and tumorigenic phenotypes induced by mutant ras genes
    • [43] Spandidos, D.A., Frame, M., Wilkie, N.M., Expression of the normal H-ras1 gene can suppress the transformed and tumorigenic phenotypes induced by mutant ras genes. Anticancer Res. 10:6 (1990), 1543–1554.
    • (1990) Anticancer Res. , vol.10 , Issue.6 , pp. 1543-1554
    • Spandidos, D.A.1    Frame, M.2    Wilkie, N.M.3
  • 44
    • 0025365140 scopus 로고
    • Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7
    • [44] Bremner, R., Balmain, A., Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell 61:3 (1990), 407–417.
    • (1990) Cell , vol.61 , Issue.3 , pp. 407-417
    • Bremner, R.1    Balmain, A.2
  • 45
    • 0028138796 scopus 로고
    • Induction of different genetic changes by different classes of chemical carcinogens during progression of mouse skin tumors
    • [45] Bremner, R., Kemp, C.J., Balmain, A., Induction of different genetic changes by different classes of chemical carcinogens during progression of mouse skin tumors. Mol. Carcinog. 11:2 (1994), 90–97.
    • (1994) Mol. Carcinog. , vol.11 , Issue.2 , pp. 90-97
    • Bremner, R.1    Kemp, C.J.2    Balmain, A.3
  • 46
    • 0022366760 scopus 로고
    • Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen
    • [46] Guerrero, I., Villasante, A., Corces, V., Pellicer, A., Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen. Proc. Natl. Acad. Sci. U. S. A. 82:23 (1985), 7810–7814.
    • (1985) Proc. Natl. Acad. Sci. U. S. A. , vol.82 , Issue.23 , pp. 7810-7814
    • Guerrero, I.1    Villasante, A.2    Corces, V.3    Pellicer, A.4
  • 49
    • 84883186892 scopus 로고    scopus 로고
    • Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis
    • [49] To, M.D., Rosario, R.D., Westcott, P.M., Banta, K.L., Balmain, A., Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis. Oncogene 32:34 (2013), 4028–4033.
    • (2013) Oncogene , vol.32 , Issue.34 , pp. 4028-4033
    • To, M.D.1    Rosario, R.D.2    Westcott, P.M.3    Banta, K.L.4    Balmain, A.5
  • 50
    • 52949118488 scopus 로고    scopus 로고
    • Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
    • [50] To, M.D., Wong, C.E., Karnezis, A.N., Del Rosario, R., Di Lauro, R., Balmain, A., Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nat. Genet. 40:10 (2008), 1240–1244.
    • (2008) Nat. Genet. , vol.40 , Issue.10 , pp. 1240-1244
    • To, M.D.1    Wong, C.E.2    Karnezis, A.N.3    Del Rosario, R.4    Di Lauro, R.5    Balmain, A.6
  • 51
    • 84929271544 scopus 로고    scopus 로고
    • Wild-type KRAS inhibits oncogenic KRAS-induced T-ALL in mice
    • [51] Staffas, A., Karlsson, C., Persson, M., Palmqvist, L., Bergo, M.O., Wild-type KRAS inhibits oncogenic KRAS-induced T-ALL in mice. Leukemia 29:5 (2015), 1032–1040.
    • (2015) Leukemia , vol.29 , Issue.5 , pp. 1032-1040
    • Staffas, A.1    Karlsson, C.2    Persson, M.3    Palmqvist, L.4    Bergo, M.O.5
  • 55
    • 0037468253 scopus 로고    scopus 로고
    • LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer
    • [55] Li, J., Zhang, Z., Dai, Z., Plass, C., Morrison, C., Wang, Y., Wiest, J.S., Anderson, M.W., You, M., LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer. Oncogene 22:8 (2003), 1243–1246.
    • (2003) Oncogene , vol.22 , Issue.8 , pp. 1243-1246
    • Li, J.1    Zhang, Z.2    Dai, Z.3    Plass, C.4    Morrison, C.5    Wang, Y.6    Wiest, J.S.7    Anderson, M.W.8    You, M.9
  • 57
    • 33645099287 scopus 로고    scopus 로고
    • Loss of heterozygosity of Kras2 gene on 12p 12–13 in Chinese colon carcinoma patients
    • [57] Wan, J., Li, H., Li, Y., Zhu, M.L., Zhao, P., Loss of heterozygosity of Kras2 gene on 12p 12–13 in Chinese colon carcinoma patients. World J. Gastroenterol. 12:7 (2006), 1033–1037.
    • (2006) World J. Gastroenterol. , vol.12 , Issue.7 , pp. 1033-1037
    • Wan, J.1    Li, H.2    Li, Y.3    Zhu, M.L.4    Zhao, P.5
  • 59
    • 84957591339 scopus 로고    scopus 로고
    • The significance of ras activity in pancreatic cancer initiation
    • [59] Logsdon, C.D., Lu, W., The significance of ras activity in pancreatic cancer initiation. Int. J. Biol. Sci. 12:3 (2016), 338–346.
    • (2016) Int. J. Biol. Sci. , vol.12 , Issue.3 , pp. 338-346
    • Logsdon, C.D.1    Lu, W.2
  • 63
    • 34247245135 scopus 로고    scopus 로고
    • Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells
    • [63] Cengel, K.A., Voong, K.R., Chandrasekaran, S., Maggiorella, L., Brunner, T.B., Stanbridge, E., Kao, G.D., McKenna, W.G., Bernhard, E.J., Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells. Neoplasia 9:4 (2007), 341–348.
    • (2007) Neoplasia , vol.9 , Issue.4 , pp. 341-348
    • Cengel, K.A.1    Voong, K.R.2    Chandrasekaran, S.3    Maggiorella, L.4    Brunner, T.B.5    Stanbridge, E.6    Kao, G.D.7    McKenna, W.G.8    Bernhard, E.J.9
  • 64
    • 84865563871 scopus 로고    scopus 로고
    • Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation
    • [64] Ikonomou, G., Kostourou, V., Shirasawa, S., Sasazuki, T., Samiotaki, M., Panayotou, G., Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation. J. Proteom. 75:17 (2012), 5356–5369.
    • (2012) J. Proteom. , vol.75 , Issue.17 , pp. 5356-5369
    • Ikonomou, G.1    Kostourou, V.2    Shirasawa, S.3    Sasazuki, T.4    Samiotaki, M.5    Panayotou, G.6
  • 65
    • 34248324359 scopus 로고    scopus 로고
    • Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex
    • [65] Keller, J.W., Haigis, K.M., Franklin, J.L., Whitehead, R.H., Jacks, T., Coffey, R.J., Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex. Oncogene 26:21 (2007), 3051–3059.
    • (2007) Oncogene , vol.26 , Issue.21 , pp. 3051-3059
    • Keller, J.W.1    Haigis, K.M.2    Franklin, J.L.3    Whitehead, R.H.4    Jacks, T.5    Coffey, R.J.6
  • 66
    • 0034705598 scopus 로고    scopus 로고
    • Endogenous c-N-Ras provides a steady-state anti-apoptotic signal
    • [66] Wolfman, J.C., Wolfman, A., Endogenous c-N-Ras provides a steady-state anti-apoptotic signal. J. Biol. Chem. 275:25 (2000), 19315–19323.
    • (2000) J. Biol. Chem. , vol.275 , Issue.25 , pp. 19315-19323
    • Wolfman, J.C.1    Wolfman, A.2
  • 67
    • 41649108639 scopus 로고    scopus 로고
    • Tumour maintenance is mediated by eNOS
    • [67] Lim, K.H., Ancrile, B.B., Kashatus, D.F., Counter, C.M., Tumour maintenance is mediated by eNOS. Nature 452:7187 (2008), 646–649.
    • (2008) Nature , vol.452 , Issue.7187 , pp. 646-649
    • Lim, K.H.1    Ancrile, B.B.2    Kashatus, D.F.3    Counter, C.M.4
  • 68
    • 84869447282 scopus 로고    scopus 로고
    • Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis
    • [68] Jeng, H.H., Taylor, L.J., Bar-Sagi, D., Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis. Nat. Commun., 3, 2012, 1168.
    • (2012) Nat. Commun. , vol.3 , pp. 1168
    • Jeng, H.H.1    Taylor, L.J.2    Bar-Sagi, D.3
  • 70
    • 84872853570 scopus 로고    scopus 로고
    • Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling
    • [70] Young, A., Lou, D., McCormick, F., Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling. Cancer Discov. 3:1 (2013), 112–123.
    • (2013) Cancer Discov. , vol.3 , Issue.1 , pp. 112-123
    • Young, A.1    Lou, D.2    McCormick, F.3
  • 73
    • 84946195510 scopus 로고    scopus 로고
    • The molecular taxonomy of primary prostate cancer
    • [73] Cancer Genome Atlas Research Network, The molecular taxonomy of primary prostate cancer. Cell 163:4 (2015), 1011–1025.
    • (2015) Cell , vol.163 , Issue.4 , pp. 1011-1025
    • Cancer Genome Atlas Research Network1
  • 74
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • [74] Cancer Genome Atlas Research Network, Integrated genomic analyses of ovarian carcinoma. Nature 474:7353 (2011), 609–615.
    • (2011) Nature , vol.474 , Issue.7353 , pp. 609-615
    • Cancer Genome Atlas Research Network1
  • 76
    • 84918592372 scopus 로고    scopus 로고
    • Genomic rearrangements in prostate cancer
    • [76] Barbieri, C.E., Rubin, M.A., Genomic rearrangements in prostate cancer. Curr. Opin. Urol. 25:1 (2015), 71–76.
    • (2015) Curr. Opin. Urol. , vol.25 , Issue.1 , pp. 71-76
    • Barbieri, C.E.1    Rubin, M.A.2
  • 78
    • 78751566393 scopus 로고    scopus 로고
    • Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer
    • [78] Calvisi, D.F., Ladu, S., Conner, E.A., Seo, D., Hsieh, J.T., Factor, V.M., Thorgeirsson, S.S., Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer. J. Hepatol. 54:2 (2011), 311–319.
    • (2011) J. Hepatol. , vol.54 , Issue.2 , pp. 311-319
    • Calvisi, D.F.1    Ladu, S.2    Conner, E.A.3    Seo, D.4    Hsieh, J.T.5    Factor, V.M.6    Thorgeirsson, S.S.7
  • 80
    • 84935009372 scopus 로고    scopus 로고
    • Genomic Classification of Cutaneous MelanomaGenomic classification of cutaneous melanoma
    • [80] Cancer Genome Atlas Network, Genomic Classification of Cutaneous MelanomaGenomic classification of cutaneous melanoma. Cell 161:7 (2015), 1681–1696.
    • (2015) Cell , vol.161 , Issue.7 , pp. 1681-1696
    • Cancer Genome Atlas Network1
  • 83
    • 84905029258 scopus 로고    scopus 로고
    • Comprehensive molecular profiling of lung adenocarcinoma
    • [83] Comprehensive molecular profiling of lung adenocarcinoma. Nature 511:7511 (2014), 543–550.
    • (2014) Nature , vol.511 , Issue.7511 , pp. 543-550
  • 84
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • [84] Comprehensive genomic characterization of squamous cell lung cancers. Nature 489:7417 (2012), 519–525.
    • (2012) Nature , vol.489 , Issue.7417 , pp. 519-525
  • 88
    • 84966801131 scopus 로고    scopus 로고
    • Smurf1 regulation of DAB2IP controls cell proliferation and migration
    • In press, epub ahead of print
    • [88] Li, X., Dai, X., Wan, L., Inuzuka, H., Sun, L., North, B.J., Smurf1 regulation of DAB2IP controls cell proliferation and migration. Oncotarget, 2016, 10.18632/oncotarget.8424 In press, epub ahead of print.
    • (2016) Oncotarget
    • Li, X.1    Dai, X.2    Wan, L.3    Inuzuka, H.4    Sun, L.5    North, B.J.6
  • 89
    • 84959208170 scopus 로고    scopus 로고
    • The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs)
    • [89] Kidger, A.M., Keyse, S.M., The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs). Semin. Cell Dev. Biol. 50 (2016), 125–132.
    • (2016) Semin. Cell Dev. Biol. , vol.50 , pp. 125-132
    • Kidger, A.M.1    Keyse, S.M.2
  • 90
    • 77950877457 scopus 로고    scopus 로고
    • Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells
    • [90] Zhang, Z., Kobayashi, S., Borczuk, A.C., Leidner, R.S., Laframboise, T., Levine, A.D., Halmos, B., Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells. Carcinogenesis 31:4 (2010), 577–586.
    • (2010) Carcinogenesis , vol.31 , Issue.4 , pp. 577-586
    • Zhang, Z.1    Kobayashi, S.2    Borczuk, A.C.3    Leidner, R.S.4    Laframboise, T.5    Levine, A.D.6    Halmos, B.7
  • 92
    • 0036847930 scopus 로고    scopus 로고
    • Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
    • [92] Hanafusa, H., Torii, S., Yasunaga, T., Nishida, E., Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Nat. Cell Biol. 4:11 (2002), 850–858.
    • (2002) Nat. Cell Biol. , vol.4 , Issue.11 , pp. 850-858
    • Hanafusa, H.1    Torii, S.2    Yasunaga, T.3    Nishida, E.4
  • 93
    • 2942568167 scopus 로고    scopus 로고
    • Modulation of signalling by Sprouty: a developing story
    • [93] Kim, H.J., Bar-Sagi, D., Modulation of signalling by Sprouty: a developing story. Nat. Rev. Mol. Cell Biol. 5:6 (2004), 441–450.
    • (2004) Nat. Rev. Mol. Cell Biol. , vol.5 , Issue.6 , pp. 441-450
    • Kim, H.J.1    Bar-Sagi, D.2
  • 94
    • 84870583628 scopus 로고    scopus 로고
    • Sprouty genes function in suppression of prostate tumorigenesis
    • [94] Schutzman, J.L., Martin, G.R., Sprouty genes function in suppression of prostate tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 109:49 (2012), 20023–20028.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , Issue.49 , pp. 20023-20028
    • Schutzman, J.L.1    Martin, G.R.2
  • 97
    • 84884854171 scopus 로고    scopus 로고
    • RasGRP Ras guanine nucleotide exchange factors in cancer
    • [97] Ksionda, O., Limnander, A., Roose, J.P., RasGRP Ras guanine nucleotide exchange factors in cancer. Front. Biol. 8:5 (2013), 508–532.
    • (2013) Front. Biol. , vol.8 , Issue.5 , pp. 508-532
    • Ksionda, O.1    Limnander, A.2    Roose, J.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.