Overexpression of human H-ras transgene is responsible for tumors induced by chemical carcinogens in mice

Oncology Reports

Volumn 8, Issue 2, 2001, Pages 233-237

  Ueyama, Yoshito ^a  

^a TOKAI UNIVERSITY   (Japan)

Author keywords

H ras; Ovcrexprcssion; Point mutation; Transgene; Transgenic mouse

Indexed keywords

CARCINOGEN; ETHYLNITROSOUREA; METHYLNITROSOUREA; PROTEIN P21;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; GENE AMPLIFICATION; GENETICS; MOUSE; MOUSE STRAIN; ONCOGENE RAS; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH TUMOR; TRANSGENIC MOUSE;

ANIMALS; CARCINOGENS; ETHYLNITROSOUREA; GENE AMPLIFICATION; GENES, RAS; METHYLNITROSOUREA; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS P21(RAS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS;

EID: 0035286222     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (3)

1. Spalding JW, Momma J, Elwcll MR and Tennant RW: Chemically induced skin carcinogenesis in a transgenic mouse line (TO.AC) carrying a v-Ha-ras gene. Carcinogenesis 14: 1335-1341, 1993.
2. Donehowcr LA, Harvey M, Slagle BL, McArthur ML, Montgomery CA, Butel JS and Bradley A: Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356: 215-221, 1992.
3. Storer RD, Cartwright ME, Cook WO, Soper KA and Nicois WW: Short-term carcinogenesis bioassay of gcnotoxic procarcinogens in PIM transgenic mice. Carcinogenesis 16: 285-293, 1995.