-
1
-
-
34249018367
-
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
-
DOI 10.1016/j.cell.2007.05.018, PII S0092867407006551
-
Bos, J.L., Rehmann, H. & Wittinghofer, A. GEFs and GAPs: critical elements in the control of small G proteins. Cell 129, 865-877 (2007). (Pubitemid 46802708)
-
(2007)
Cell
, vol.129
, Issue.5
, pp. 865-877
-
-
Bos, J.L.1
Rehmann, H.2
Wittinghofer, A.3
-
2
-
-
0027304731
-
Human Sos1: A guanine nucleotide exchange factor for Ras that binds to GRB2
-
Chardin, P. et al. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 260, 1338-1343 (1993). (Pubitemid 23231980)
-
(1993)
Science
, vol.260
, Issue.5112
, pp. 1338-1343
-
-
Chardin, P.1
Camonis, J.H.2
Gale, N.W.3
Van Aelst, L.4
Schlessinger, J.5
Wigler, M.H.6
Bar-Sagi, D.7
-
3
-
-
0344885558
-
Structural evidence for feedback activation by Ras·GTP of the Ras-specific nucleotide exchange factor SOS
-
DOI 10.1016/S0092-8674(03)00149-1
-
Margarit, S.M. et al. Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell 112, 685-695 (2003). (Pubitemid 36331780)
-
(2003)
Cell
, vol.112
, Issue.5
, pp. 685-695
-
-
Margarit, S.M.1
Sondermann, H.2
Hall, B.E.3
Nagar, B.4
Hoelz, A.5
Pirruccello, M.6
Bar-Sagi, D.7
Kuriyan, J.8
-
4
-
-
7044226349
-
Structural analysis of autoinhibition in the Ras activator son of sevenless
-
DOI 10.1016/j.cell.2004.10.005, PII S0092867404009511
-
Sondermann, H. et al. Structural analysis of autoinhibition in the Ras activator Son ofsevenless. Cell 119, 393-405 (2004). (Pubitemid 39423841)
-
(2004)
Cell
, vol.119
, Issue.3
, pp. 393-405
-
-
Sondermann, H.1
Soisson, S.M.2
Boykevisch, S.3
Yang, S.-S.4
Bar-Sagi, D.5
Kuriyan, J.6
-
5
-
-
43249100633
-
Membrane-dependent signal integration by the Ras activator Son of sevenless
-
DOI 10.1038/nsmb.1418, PII NSMB1418
-
Gureasko, J. et al. Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct. Mol. Biol. 15, 452-461 (2008). (Pubitemid 351653589)
-
(2008)
Nature Structural and Molecular Biology
, vol.15
, Issue.5
, pp. 452-461
-
-
Gureasko, J.1
Galush, W.J.2
Boykevisch, S.3
Sondermann, H.4
Bar-Sagi, D.5
Groves, J.T.6
Kuriyan, J.7
-
6
-
-
0023221329
-
Activated H-ras transforms rat intestinal epithelial cells with expression of α-TGF
-
DOI 10.1016/0014-4827(87)90308-9
-
Buick, R.N., Filmus, J. & Quaroni, A. Activated H-ras transforms rat intestinal epithelial cells with expression of alpha-TGF. Exp. Cell. Res. 170, 300-309 (1987). (Pubitemid 17093682)
-
(1987)
Experimental Cell Research
, vol.170
, Issue.2
, pp. 300-309
-
-
Buick, R.N.1
Filmus, J.2
Quaroni, A.3
-
7
-
-
0025904660
-
Expression oftransforming growth factor alpha (TGF alpha) in breast cancer
-
Ciardiello, F. et al. Expression oftransforming growth factor alpha (TGF alpha) in breast cancer. Ann. Oncol. 2, 169-182 (1991).
-
(1991)
Ann. Oncol.
, vol.2
, pp. 169-182
-
-
Ciardiello, F.1
-
8
-
-
0028962318
-
Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: Potential involvement of alternate epidermal growth factor receptor ligands
-
Dlugosz, A.A. et al. Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands. Cancer Res. 55, 1883-1893 (1995).
-
(1995)
Cancer Res
, vol.55
, pp. 1883-1893
-
-
Dlugosz, A.A.1
-
9
-
-
0345275865
-
Epidermal Growth Factor Receptor Autocrine Signaling in RIE-1 Cells Transformed by the Ras Oncogene Enhances Radiation Resistance
-
Grana, T.M., Sartor, C.I. & Cox, A.D. Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance. Cancer Res. 63, 7807-7814 (2003). (Pubitemid 37466713)
-
(2003)
Cancer Research
, vol.63
, Issue.22
, pp. 7807-7814
-
-
Grana, T.M.1
Sartor, C.I.2
Cox, A.D.3
-
10
-
-
0026627960
-
Identification ofmurine homologues of the Drosophila son ofsevenless gene: Potential activators ofras
-
Bowtell, D., Fu, P., Simon, M. & Senior, P. Identification ofmurine homologues of the Drosophila son ofsevenless gene: potential activators ofras. Proc. Natl Acad. Sci. USA 89, 6511-6515 (1992).
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 6511-6515
-
-
Bowtell, D.1
Fu, P.2
Simon, M.3
Senior, P.4
-
11
-
-
0030666849
-
The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1
-
Nielsen, K.H., Papageorge, A.G., Vass, W.C., Willumsen, B.M. & Lowy, D.R. The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1. Mol. CellBiol. 17, 7132-7138 (1997). (Pubitemid 27505943)
-
(1997)
Molecular and Cellular Biology
, vol.17
, Issue.12
, pp. 7132-7138
-
-
Nielsen, K.H.1
Papageorge, A.G.2
Vass, W.C.3
Willumsen, B.M.4
Lowy, D.R.5
-
12
-
-
77958513576
-
Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK
-
Kamioka, Y., Yasuda, S., Fujita, Y., Aoki, K. & Matsuda, M. Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK. J. Biol. Chem. 285, 33540-33548 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 33540-33548
-
-
Kamioka, Y.1
Yasuda, S.2
Fujita, Y.3
Aoki, K.4
Matsuda, M.5
-
13
-
-
0027153103
-
Epidermal growth factor regulates p21(ras) through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
-
DOI 10.1016/0092-8674(93)90146-H
-
Buday, L. & Downward, J. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73, 611-620 (1993). (Pubitemid 23143358)
-
(1993)
Cell
, vol.73
, Issue.3
, pp. 611-620
-
-
Buday, L.1
Downward, J.2
-
14
-
-
0027229556
-
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras
-
Gale, N.W., Kaplan, S., Lowenstein, E.J., Schlessinger, J. & Bar-Sagi, D. Grb2 mediates the EGF-dependent activation ofguanine nucleotide exchange on Ras. Nature 363, 88-92 (1993). (Pubitemid 23144969)
-
(1993)
Nature
, vol.362
, Issue.6424
, pp. 88-92
-
-
Gale, N.W.1
Kaplan, S.2
Lowenstein, E.J.3
Schlessinger, J.4
Bar-Sagi, D.5
-
15
-
-
0027312272
-
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
-
Li, N. et al. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature 363, 85-88 (1993). (Pubitemid 23144968)
-
(1993)
Nature
, vol.362
, Issue.6424
, pp. 85-88
-
-
Li, N.1
Batzer, A.2
Daly, R.3
Yajnik, V.4
Skolnik, E.5
Chardin, P.6
Bar-Sagi, D.7
Margolis, B.8
Schlessinger, J.9
-
16
-
-
0027910431
-
Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
-
Egan, S.E. et al. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363, 45-51 (1993). (Pubitemid 23144959)
-
(1993)
Nature
, vol.362
, Issue.6424
, pp. 45-51
-
-
Egan, S.E.1
Giddings, B.W.2
Brooks, M.W.3
Buday, L.4
Sizeland, A.M.5
Weinberg, R.A.6
-
17
-
-
0032546232
-
Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo
-
Hamilton, M. & Wolfman, A. Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo. Oncogene 16, 1417-1428 (1998). (Pubitemid 28151849)
-
(1998)
Oncogene
, vol.16
, Issue.11
, pp. 1417-1428
-
-
Hamilton, M.1
Wolfman, A.2
-
18
-
-
41649108639
-
Tumour maintenance is mediated by eNOS
-
DOI 10.1038/nature06778, PII NATURE06778
-
Lim, K.H., Ancrile, B.B., Kashatus, D.F. & Counter, C.M. Tumour maintenance is mediated by eNOS. Nature 452, 646-649 (2008). (Pubitemid 351483359)
-
(2008)
Nature
, vol.452
, Issue.7187
, pp. 646-649
-
-
Lim, K.-H.1
Ancrile, B.B.2
Kashatus, D.F.3
Counter, C.M.4
-
19
-
-
0024376173
-
Ras Oncogenes in human cancer: A review
-
Bos, J.L. Ras oncogenes in human cancer: a review. CancerRes. 49, 4682-4689 (1989). (Pubitemid 19213607)
-
(1989)
Cancer Research
, vol.49
, Issue.17
, pp. 4682-4689
-
-
Bos, J.L.1
-
20
-
-
0035920116
-
Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange
-
Hall, B.E., Yang, S.S., Boriack-Sjodin, P.A., Kuriyan, J. & Bar-Sagi, D. Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange. J. Biol. Chem. 276, 27629-27637 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 27629-27637
-
-
Hall, B.E.1
Yang, S.S.2
Boriack-Sjodin, P.A.3
Kuriyan, J.4
Bar-Sagi, D.5
-
21
-
-
34547209343
-
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance
-
DOI 10.1016/j.bbamcr.2006.10.001, PII S0167488906003156
-
McCubrey, J.A. et al. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim. Biophys. Acta. 1773, 1263-1284 (2007). (Pubitemid 47125967)
-
(2007)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1773
, Issue.8
, pp. 1263-1284
-
-
McCubrey, J.A.1
Steelman, L.S.2
Chappell, W.H.3
Abrams, S.L.4
Wong, E.W.T.5
Chang, F.6
Lehmann, B.7
Terrian, D.M.8
Milella, M.9
Tafuri, A.10
Stivala, F.11
Libra, M.12
Basecke, J.13
Evangelisti, C.14
Martelli, A.M.15
Franklin, R.A.16
-
22
-
-
67749122122
-
Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
-
Engelman, J.A. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev. Cancer 9, 550-562 (2009).
-
(2009)
Nat Rev. Cancer
, vol.9
, pp. 550-562
-
-
Engelman, J.A.1
-
23
-
-
17444431201
-
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
-
DOI 10.1016/j.cell.2005.02.031
-
Ma, L., Chen, Z., Erdjument-Bromage, H., Tempst, P. & Pandolfi, P.P. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121, 179-193 (2005). (Pubitemid 40546387)
-
(2005)
Cell
, vol.121
, Issue.2
, pp. 179-193
-
-
Ma, L.1
Chen, Z.2
Erdjument-Bromage, H.3
Tempst, P.4
Pandolfi, P.P.5
-
24
-
-
0032508517
-
Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase
-
DOI 10.1074/jbc.273.37.24052
-
Yan, J., Roy, S., Apolloni, A., Lane, A. & Hancock, J.F. Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. J. Biol. Chem. 273, 24052-24056 (1998). (Pubitemid 28435747)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.37
, pp. 24052-24056
-
-
Yan, J.1
Roy, S.2
Apolloni, A.3
Lane, A.4
Hancock, J.F.5
-
25
-
-
0033546419
-
Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility
-
Voice, J.K., Klemke, R.L., Le, A. & Jackson, J.H. Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility. J. Biol. Chem. 274, 17164-17170 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17164-17170
-
-
Voice, J.K.1
Klemke, R.L.2
Le, A.3
Jackson, J.H.4
-
26
-
-
34748908758
-
Wild-type NRas and KRas perform distinct functions during transformation
-
DOI 10.1128/MCB.00234-07
-
Fotiadou, P.P., Takahashi, C., Rajabi, H.N. & Ewen, M.E. Wild-type NRas and KRas perform distinct functions during transformation. Mol. Cell. Biol. 27, 6742-6755 (2007). (Pubitemid 47483626)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.19
, pp. 6742-6755
-
-
Fotiadou, P.P.1
Takahashi, C.2
Rajabi, H.N.3
Ewen, M.E.4
-
27
-
-
52949118488
-
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
-
To, M.D. et al. Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nat Genet. 40, 1240-1244 (2008).
-
(2008)
Nat Genet.
, vol.40
, pp. 1240-1244
-
-
To, M.D.1
-
28
-
-
84255187573
-
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras
-
Matallanas, D. et al. Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Mol. Cell 44, 893-906 (2011).
-
(2011)
Mol. Cell
, vol.44
, pp. 893-906
-
-
Matallanas, D.1
-
29
-
-
0036682167
-
The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene
-
Diaz, R. et al. The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene. CancerRes. 62, 4514-4518 (2002). (Pubitemid 34827316)
-
(2002)
Cancer Research
, vol.62
, Issue.15
, pp. 4514-4518
-
-
Diaz, R.1
Ahn, D.2
Lopez-Barcons, L.3
Malumbres, M.4
De Castro, I.P.5
Lue, J.6
Ferrer-Miralles, N.7
Mangues, R.8
Tsong, J.9
Garcia, R.10
Perez-Soler, R.11
Pellicer, A.12
-
30
-
-
33751102674
-
Regulation of Ras Signaling Dynamics by Sos-Mediated Positive Feedback
-
DOI 10.1016/j.cub.2006.09.033, PII S0960982206022263
-
Boykevisch, S. et al. Regulation of ras signalling dynamics by Sos-mediated positive feedback. Curr. Biol. 16, 2173-2179 (2006). (Pubitemid 44767628)
-
(2006)
Current Biology
, vol.16
, Issue.21
, pp. 2173-2179
-
-
Boykevisch, S.1
Zhao, C.2
Sondermann, H.3
Philippidou, P.4
Halegoua, S.5
Kuriyan, J.6
Bar-Sagi, D.7
|