-
1
-
-
84884997982
-
Emerging landscape of oncogenic signatures across human cancers
-
Ciriello, G. et al. Emerging landscape of oncogenic signatures across human cancers. Nature Genet. 45, 1127-1133 (2013).
-
(2013)
Nature Genet.
, vol.45
, pp. 1127-1133
-
-
Ciriello, G.1
-
2
-
-
64749094310
-
The cancer genome
-
Stratton, M. R., Campbell, P. J. & Futreal, P. A. The cancer genome. Nature 458, 719-724 (2009).
-
(2009)
Nature
, vol.458
, pp. 719-724
-
-
Stratton, M.R.1
Campbell, P.J.2
Futreal, P.A.3
-
3
-
-
84882837534
-
Signatures ofmutational processes in humancancer
-
Alexandrov, L. B. et al. Signatures ofmutational processes in humancancer. Nature 500, 415-421 (2013).
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
-
4
-
-
84880507665
-
Mutational heterogeneity in cancer and the search for new cancer-associated genes
-
Lawrence, M. S. et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 499, 214-218 (2013).
-
(2013)
Nature
, vol.499
, pp. 214-218
-
-
Lawrence, M.S.1
-
5
-
-
0035953550
-
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
-
Johnson, L. et al. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410, 1111-1116 (2001).
-
(2001)
Nature
, vol.410
, pp. 1111-1116
-
-
Johnson, L.1
-
6
-
-
0007142725
-
Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumours of the strain A mouse
-
You, M., Candrian, U., Maronpot, R. R., Stoner, G. D. & Anderson, M. W. Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumours of the strain A mouse. Proc. Natl Acad. Sci. USA 86, 3070-3074 (1989).
-
(1989)
Proc. Natl Acad. Sci. USA
, vol.86
, pp. 3070-3074
-
-
You, M.1
Candrian, U.2
Maronpot, R.R.3
Stoner, G.D.4
Anderson, M.W.5
-
7
-
-
84861147473
-
A comprehensive survey of Ras mutations in cancer
-
Prior, I. A., Lewis, P. D. & Mattos, C. A comprehensive survey of Ras mutations in cancer. Cancer Res. 72, 2457-2467 (2012).
-
(2012)
Cancer Res.
, vol.72
, pp. 2457-2467
-
-
Prior, I.A.1
Lewis, P.D.2
Mattos, C.3
-
8
-
-
0035893252
-
Analysis of lung tumour initiation and progression using conditional expression of oncogenic K-ras
-
Jackson, E. L. et al. Analysis of lung tumour initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 15, 3243-3248 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 3243-3248
-
-
Jackson, E.L.1
-
9
-
-
17944369909
-
Wildtype Kras2 can inhibit lung carcinogenesis in mice
-
Zhang, Z. et al. Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nature Genet. 29, 25-33 (2001).
-
(2001)
Nature Genet.
, vol.29
, pp. 25-33
-
-
Zhang, Z.1
-
10
-
-
52949118488
-
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
-
To, M. D. et al. Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nature Genet. 40, 1240-1244 (2008).
-
(2008)
Nature Genet.
, vol.40
, pp. 1240-1244
-
-
To, M.D.1
-
11
-
-
84866434919
-
Genomic landscape of non-small cell lung cancer in smokers and never-smokers
-
Govindan, R. et al. Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 150, 1121-1134 (2012).
-
(2012)
Cell
, vol.150
, pp. 1121-1134
-
-
Govindan, R.1
-
12
-
-
77951450917
-
Mechanisms of lung tumourigenesis by ethyl carbamate and vinyl carbamate
-
Forkert, P. G. Mechanisms of lung tumourigenesis by ethyl carbamate and vinyl carbamate. Drug Metab. Rev. 42, 355-378 (2010).
-
(2010)
Drug Metab. Rev.
, vol.42
, pp. 355-378
-
-
Forkert, P.G.1
-
13
-
-
84872271745
-
Molecular analysis of point mutations in a barley genome exposed to MNU and gamma rays
-
Kurowska, M., Labocha-Pawlowska, A., Gnizda, D., Maluszynski, M. & Szarejko, I. Molecular analysis of point mutations in a barley genome exposed to MNU and gamma rays. Mutat. Res. 738-739, 52-70 (2012).
-
(2012)
Mutat. Res.
, vol.738-739
, pp. 52-70
-
-
Kurowska, M.1
Labocha-Pawlowska, A.2
Gnizda, D.3
Maluszynski, M.4
Szarejko, I.5
-
14
-
-
29644436410
-
Mutagenesis at methylated CpG sequences
-
Pfeifer, G. P. Mutagenesis at methylated CpG sequences. Curr. Top. Microbiol. Immunol. 301, 259-281 (2006).
-
(2006)
Curr. Top. Microbiol. Immunol.
, vol.301
, pp. 259-281
-
-
Pfeifer, G.P.1
-
15
-
-
84864255882
-
The origin and evolution of mutations in acute myeloid leukemia
-
Welch, J. S. et al. The origin and evolution of mutations in acute myeloid leukemia. Cell 150, 264-278 (2012).
-
(2012)
Cell
, vol.150
, pp. 264-278
-
-
Welch, J.S.1
-
16
-
-
0030053105
-
Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation
-
Drugan, J. K. et al. Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation. J. Biol. Chem. 271, 233-237 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 233-237
-
-
Drugan, J.K.1
-
17
-
-
0035942247
-
Dynamic properties of the Ras switch i region and its importance for binding to effectors
-
Spoerner, M., Herrmann, C., Vetter, I. R., Kalbitzer, H. R. & Wittinghofer, A. Dynamic properties of the Ras switch I region and its importance for binding to effectors. Proc. Natl Acad. Sci. USA 98, 4944-4949 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 4944-4949
-
-
Spoerner, M.1
Herrmann, C.2
Vetter, I.R.3
Kalbitzer, H.R.4
Wittinghofer, A.5
-
18
-
-
84880677408
-
Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer
-
Fawdar, S. et al. Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer. Proc. Natl Acad. Sci. USA 110, 12426-12431 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 12426-12431
-
-
Fawdar, S.1
-
19
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein, B. et al. Cancer genome landscapes. Science 339, 1546-1558 (2013).
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
-
20
-
-
33745442180
-
Mutation analysis of the 8p22candidate tumour suppressor gene ATIP/MTUS1 in hepatocellular carcinoma
-
Di Benedetto, M. et al.Mutation analysis of the 8p22candidate tumour suppressor gene ATIP/MTUS1 in hepatocellular carcinoma. Mol. Cell. Endocrinol. 252, 207-215 (2006).
-
(2006)
Mol. Cell. Endocrinol.
, vol.252
, pp. 207-215
-
-
Di Benedetto, M.1
-
21
-
-
34547730931
-
Copy number variant in the candidate tumour suppressor gene MTUS1 and familial breast cancer risk
-
Frank, B. et al. Copy number variant in the candidate tumour suppressor gene MTUS1 and familial breast cancer risk. Carcinogenesis 28, 1442-1445 (2007).
-
(2007)
Carcinogenesis
, vol.28
, pp. 1442-1445
-
-
Frank, B.1
-
22
-
-
76049117945
-
Down-regulation of MTUS1 in human colon tumours
-
Zuern, C. et al. Down-regulation of MTUS1 in human colon tumours. Oncol. Rep. 23, 183-189 (2010).
-
(2010)
Oncol. Rep.
, vol.23
, pp. 183-189
-
-
Zuern, C.1
-
23
-
-
84861304588
-
Reduced expression of MTUS1 mRNA is correlated with poor prognosis in bladder cancer
-
Xiao, J. et al. Reduced expression of MTUS1 mRNA is correlated with poor prognosis in bladder cancer. Oncol Lett 4, 113-118 (2012).
-
(2012)
Oncol Lett
, vol.4
, pp. 113-118
-
-
Xiao, J.1
-
24
-
-
49149129916
-
Gene expression-based survival prediction in lung adenocarcinoma: A multi-site, blinded validation study
-
Shedden, K. et al. Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nature Med. 14, 822-827 (2008).
-
(2008)
Nature Med.
, vol.14
, pp. 822-827
-
-
Shedden, K.1
-
25
-
-
80054680116
-
Progressive genomic instability in the FVB/KrasLA2 mouse model of lung cancer
-
To, M. D. et al. Progressive genomic instability in the FVB/KrasLA2 mouse model of lung cancer. Mol. Cancer Res. 9, 1339-1345 (2011).
-
(2011)
Mol. Cancer Res.
, vol.9
, pp. 1339-1345
-
-
To, M.D.1
-
26
-
-
0030890933
-
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
-
Ahmed, N. N., Grimes, H. L., Bellacosa, A., Chan, T. O. & Tsichlis, P. N. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc. Natl Acad. Sci. USA 94, 3627-3632 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 3627-3632
-
-
Ahmed, N.N.1
Grimes, H.L.2
Bellacosa, A.3
Chan, T.O.4
Tsichlis, P.N.5
-
27
-
-
84896333670
-
Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing
-
McFadden, D. G. et al. Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing. Cell 156, 1298-1311 (2014).
-
(2014)
Cell
, vol.156
, pp. 1298-1311
-
-
McFadden, D.G.1
-
28
-
-
0025670013
-
Specific Ki-rascodon 61mutationsmay determine the development of urethan-induced mouse lung adenomas or adenocarcinomas
-
Nuzum,E. O.,Malkinson, A. M. & Beer, D. G.Specific Ki-rascodon 61mutationsmay determine the development of urethan-induced mouse lung adenomas or adenocarcinomas. Mol. Carcinog. 3, 287-295 (1990).
-
(1990)
Mol. Carcinog.
, vol.3
, pp. 287-295
-
-
Nuzum, E.O.1
Malkinson, A.M.2
Beer, D.G.3
-
29
-
-
80052244375
-
Identification of Fat4 and Tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas
-
Berndt, A. et al. Identification of Fat4 and Tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas. Cancer Res. 71, 5779-5791 (2011).
-
(2011)
Cancer Res.
, vol.71
, pp. 5779-5791
-
-
Berndt, A.1
-
30
-
-
84883186892
-
Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis
-
To, M. D., Rosario, R. D., Westcott, P. M., Banta, K. L. & Balmain, A. Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis. Oncogene 32, 4028-4033 (2013).
-
(2013)
Oncogene
, vol.32
, pp. 4028-4033
-
-
To, M.D.1
Rosario, R.D.2
Westcott, P.M.3
Banta, K.L.4
Balmain, A.5
-
31
-
-
0345135149
-
K-ras is an essential gene in the mouse with partial functional overlap with N-ras
-
Johnson, L. et al. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 11, 2468-2481 (1997).
-
(1997)
Genes Dev.
, vol.11
, pp. 2468-2481
-
-
Johnson, L.1
-
32
-
-
79251635938
-
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
-
Varela, I. et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469, 539-542 (2011).
-
(2011)
Nature
, vol.469
, pp. 539-542
-
-
Varela, I.1
-
33
-
-
67649884743
-
And accurate short read alignment with Burrows-Wheeler transform
-
Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 1754-1760 (2009).
-
(2009)
Bioinformatics
, vol.25
, pp. 1754-1760
-
-
Li, H.1
Fast, D.R.2
-
34
-
-
79955483667
-
A framework for variation discovery and genotyping using next-generation DNA sequencing data
-
DePristo, M. A. et al. A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nature Genet. 43, 491-498 (2011).
-
(2011)
Nature Genet.
, vol.43
, pp. 491-498
-
-
Depristo, M.A.1
-
35
-
-
84874025843
-
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
-
Cibulskis, K. et al. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nature Biotechnol. 31, 213-219 (2013).
-
(2013)
Nature Biotechnol.
, vol.31
, pp. 213-219
-
-
Cibulskis, K.1
-
36
-
-
68549104404
-
The Sequence Alignment/Map format and SAMtools
-
Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078-2079 (2009).
-
(2009)
Bioinformatics
, vol.25
, pp. 2078-2079
-
-
Li, H.1
-
37
-
-
77956534324
-
ANNOVAR: Functional annotation of genetic variants from high-throughput sequencing data
-
Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164 (2010).
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. e164
-
-
Wang, K.1
Li, M.2
Hakonarson, H.3
-
38
-
-
78651330430
-
COSMIC: Mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
-
Forbes, S. A. et al. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res. 39, D945-D950 (2011).
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. D945-D950
-
-
Forbes, S.A.1
-
39
-
-
80054078476
-
Fast, scalable generation of high-quality proteinmultiple sequence alignments using Clustal Omega
-
Sievers, F. et al. Fast, scalable generation of high-quality proteinmultiple sequence alignments using Clustal Omega. Mol. Syst. Biol. 7, 539 (2011).
-
(2011)
Mol. Syst. Biol.
, vol.7
, pp. 539
-
-
Sievers, F.1
-
40
-
-
84861541343
-
Mutational processes molding the genomes of 21 breast cancers
-
Nik-Zainal, S. et al. Mutational processes molding the genomes of 21 breast cancers. Cell 149, 979-993 (2012).
-
(2012)
Cell
, vol.149
, pp. 979-993
-
-
Nik-Zainal, S.1
-
41
-
-
78651430230
-
Control-free calling of copy number alterations in deep-sequencing data using GC-content normalization
-
Boeva, V. et al. Control-free calling of copy number alterations in deep-sequencing data using GC-content normalization. Bioinformatics 27, 268-269 (2011).
-
(2011)
Bioinformatics
, vol.27
, pp. 268-269
-
-
Boeva, V.1
-
42
-
-
33747878451
-
Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung
-
Raponi, M. et al. Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung. Cancer Res. 66, 7466-7472 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 7466-7472
-
-
Raponi, M.1
|