메뉴 건너뛰기




Volumn 517, Issue 7535, 2015, Pages 489-492

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CBL PROTEIN; JANUS KINASE 2; K RAS PROTEIN; METHYLNITROSOUREA; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR PAX5; CARCINOGEN; KRAS2 PROTEIN, MOUSE; PROTEIN P21; URETHAN;

EID: 84925536961     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13898     Document Type: Article
Times cited : (267)

References (42)
  • 1
    • 84884997982 scopus 로고    scopus 로고
    • Emerging landscape of oncogenic signatures across human cancers
    • Ciriello, G. et al. Emerging landscape of oncogenic signatures across human cancers. Nature Genet. 45, 1127-1133 (2013).
    • (2013) Nature Genet. , vol.45 , pp. 1127-1133
    • Ciriello, G.1
  • 3
    • 84882837534 scopus 로고    scopus 로고
    • Signatures ofmutational processes in humancancer
    • Alexandrov, L. B. et al. Signatures ofmutational processes in humancancer. Nature 500, 415-421 (2013).
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1
  • 4
    • 84880507665 scopus 로고    scopus 로고
    • Mutational heterogeneity in cancer and the search for new cancer-associated genes
    • Lawrence, M. S. et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 499, 214-218 (2013).
    • (2013) Nature , vol.499 , pp. 214-218
    • Lawrence, M.S.1
  • 5
    • 0035953550 scopus 로고    scopus 로고
    • Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
    • Johnson, L. et al. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410, 1111-1116 (2001).
    • (2001) Nature , vol.410 , pp. 1111-1116
    • Johnson, L.1
  • 6
    • 0007142725 scopus 로고
    • Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumours of the strain A mouse
    • You, M., Candrian, U., Maronpot, R. R., Stoner, G. D. & Anderson, M. W. Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumours of the strain A mouse. Proc. Natl Acad. Sci. USA 86, 3070-3074 (1989).
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 3070-3074
    • You, M.1    Candrian, U.2    Maronpot, R.R.3    Stoner, G.D.4    Anderson, M.W.5
  • 7
    • 84861147473 scopus 로고    scopus 로고
    • A comprehensive survey of Ras mutations in cancer
    • Prior, I. A., Lewis, P. D. & Mattos, C. A comprehensive survey of Ras mutations in cancer. Cancer Res. 72, 2457-2467 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 2457-2467
    • Prior, I.A.1    Lewis, P.D.2    Mattos, C.3
  • 8
    • 0035893252 scopus 로고    scopus 로고
    • Analysis of lung tumour initiation and progression using conditional expression of oncogenic K-ras
    • Jackson, E. L. et al. Analysis of lung tumour initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 15, 3243-3248 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 3243-3248
    • Jackson, E.L.1
  • 9
    • 17944369909 scopus 로고    scopus 로고
    • Wildtype Kras2 can inhibit lung carcinogenesis in mice
    • Zhang, Z. et al. Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nature Genet. 29, 25-33 (2001).
    • (2001) Nature Genet. , vol.29 , pp. 25-33
    • Zhang, Z.1
  • 10
    • 52949118488 scopus 로고    scopus 로고
    • Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
    • To, M. D. et al. Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nature Genet. 40, 1240-1244 (2008).
    • (2008) Nature Genet. , vol.40 , pp. 1240-1244
    • To, M.D.1
  • 11
    • 84866434919 scopus 로고    scopus 로고
    • Genomic landscape of non-small cell lung cancer in smokers and never-smokers
    • Govindan, R. et al. Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 150, 1121-1134 (2012).
    • (2012) Cell , vol.150 , pp. 1121-1134
    • Govindan, R.1
  • 12
    • 77951450917 scopus 로고    scopus 로고
    • Mechanisms of lung tumourigenesis by ethyl carbamate and vinyl carbamate
    • Forkert, P. G. Mechanisms of lung tumourigenesis by ethyl carbamate and vinyl carbamate. Drug Metab. Rev. 42, 355-378 (2010).
    • (2010) Drug Metab. Rev. , vol.42 , pp. 355-378
    • Forkert, P.G.1
  • 13
    • 84872271745 scopus 로고    scopus 로고
    • Molecular analysis of point mutations in a barley genome exposed to MNU and gamma rays
    • Kurowska, M., Labocha-Pawlowska, A., Gnizda, D., Maluszynski, M. & Szarejko, I. Molecular analysis of point mutations in a barley genome exposed to MNU and gamma rays. Mutat. Res. 738-739, 52-70 (2012).
    • (2012) Mutat. Res. , vol.738-739 , pp. 52-70
    • Kurowska, M.1    Labocha-Pawlowska, A.2    Gnizda, D.3    Maluszynski, M.4    Szarejko, I.5
  • 14
    • 29644436410 scopus 로고    scopus 로고
    • Mutagenesis at methylated CpG sequences
    • Pfeifer, G. P. Mutagenesis at methylated CpG sequences. Curr. Top. Microbiol. Immunol. 301, 259-281 (2006).
    • (2006) Curr. Top. Microbiol. Immunol. , vol.301 , pp. 259-281
    • Pfeifer, G.P.1
  • 15
    • 84864255882 scopus 로고    scopus 로고
    • The origin and evolution of mutations in acute myeloid leukemia
    • Welch, J. S. et al. The origin and evolution of mutations in acute myeloid leukemia. Cell 150, 264-278 (2012).
    • (2012) Cell , vol.150 , pp. 264-278
    • Welch, J.S.1
  • 16
    • 0030053105 scopus 로고    scopus 로고
    • Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation
    • Drugan, J. K. et al. Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation. J. Biol. Chem. 271, 233-237 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 233-237
    • Drugan, J.K.1
  • 18
    • 84880677408 scopus 로고    scopus 로고
    • Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer
    • Fawdar, S. et al. Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer. Proc. Natl Acad. Sci. USA 110, 12426-12431 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 12426-12431
    • Fawdar, S.1
  • 19
    • 84875490185 scopus 로고    scopus 로고
    • Cancer genome landscapes
    • Vogelstein, B. et al. Cancer genome landscapes. Science 339, 1546-1558 (2013).
    • (2013) Science , vol.339 , pp. 1546-1558
    • Vogelstein, B.1
  • 20
    • 33745442180 scopus 로고    scopus 로고
    • Mutation analysis of the 8p22candidate tumour suppressor gene ATIP/MTUS1 in hepatocellular carcinoma
    • Di Benedetto, M. et al.Mutation analysis of the 8p22candidate tumour suppressor gene ATIP/MTUS1 in hepatocellular carcinoma. Mol. Cell. Endocrinol. 252, 207-215 (2006).
    • (2006) Mol. Cell. Endocrinol. , vol.252 , pp. 207-215
    • Di Benedetto, M.1
  • 21
    • 34547730931 scopus 로고    scopus 로고
    • Copy number variant in the candidate tumour suppressor gene MTUS1 and familial breast cancer risk
    • Frank, B. et al. Copy number variant in the candidate tumour suppressor gene MTUS1 and familial breast cancer risk. Carcinogenesis 28, 1442-1445 (2007).
    • (2007) Carcinogenesis , vol.28 , pp. 1442-1445
    • Frank, B.1
  • 22
    • 76049117945 scopus 로고    scopus 로고
    • Down-regulation of MTUS1 in human colon tumours
    • Zuern, C. et al. Down-regulation of MTUS1 in human colon tumours. Oncol. Rep. 23, 183-189 (2010).
    • (2010) Oncol. Rep. , vol.23 , pp. 183-189
    • Zuern, C.1
  • 23
    • 84861304588 scopus 로고    scopus 로고
    • Reduced expression of MTUS1 mRNA is correlated with poor prognosis in bladder cancer
    • Xiao, J. et al. Reduced expression of MTUS1 mRNA is correlated with poor prognosis in bladder cancer. Oncol Lett 4, 113-118 (2012).
    • (2012) Oncol Lett , vol.4 , pp. 113-118
    • Xiao, J.1
  • 24
    • 49149129916 scopus 로고    scopus 로고
    • Gene expression-based survival prediction in lung adenocarcinoma: A multi-site, blinded validation study
    • Shedden, K. et al. Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nature Med. 14, 822-827 (2008).
    • (2008) Nature Med. , vol.14 , pp. 822-827
    • Shedden, K.1
  • 25
    • 80054680116 scopus 로고    scopus 로고
    • Progressive genomic instability in the FVB/KrasLA2 mouse model of lung cancer
    • To, M. D. et al. Progressive genomic instability in the FVB/KrasLA2 mouse model of lung cancer. Mol. Cancer Res. 9, 1339-1345 (2011).
    • (2011) Mol. Cancer Res. , vol.9 , pp. 1339-1345
    • To, M.D.1
  • 26
    • 0030890933 scopus 로고    scopus 로고
    • Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
    • Ahmed, N. N., Grimes, H. L., Bellacosa, A., Chan, T. O. & Tsichlis, P. N. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc. Natl Acad. Sci. USA 94, 3627-3632 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 3627-3632
    • Ahmed, N.N.1    Grimes, H.L.2    Bellacosa, A.3    Chan, T.O.4    Tsichlis, P.N.5
  • 27
    • 84896333670 scopus 로고    scopus 로고
    • Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing
    • McFadden, D. G. et al. Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing. Cell 156, 1298-1311 (2014).
    • (2014) Cell , vol.156 , pp. 1298-1311
    • McFadden, D.G.1
  • 28
    • 0025670013 scopus 로고
    • Specific Ki-rascodon 61mutationsmay determine the development of urethan-induced mouse lung adenomas or adenocarcinomas
    • Nuzum,E. O.,Malkinson, A. M. & Beer, D. G.Specific Ki-rascodon 61mutationsmay determine the development of urethan-induced mouse lung adenomas or adenocarcinomas. Mol. Carcinog. 3, 287-295 (1990).
    • (1990) Mol. Carcinog. , vol.3 , pp. 287-295
    • Nuzum, E.O.1    Malkinson, A.M.2    Beer, D.G.3
  • 29
    • 80052244375 scopus 로고    scopus 로고
    • Identification of Fat4 and Tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas
    • Berndt, A. et al. Identification of Fat4 and Tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas. Cancer Res. 71, 5779-5791 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 5779-5791
    • Berndt, A.1
  • 30
    • 84883186892 scopus 로고    scopus 로고
    • Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis
    • To, M. D., Rosario, R. D., Westcott, P. M., Banta, K. L. & Balmain, A. Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis. Oncogene 32, 4028-4033 (2013).
    • (2013) Oncogene , vol.32 , pp. 4028-4033
    • To, M.D.1    Rosario, R.D.2    Westcott, P.M.3    Banta, K.L.4    Balmain, A.5
  • 31
    • 0345135149 scopus 로고    scopus 로고
    • K-ras is an essential gene in the mouse with partial functional overlap with N-ras
    • Johnson, L. et al. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 11, 2468-2481 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 2468-2481
    • Johnson, L.1
  • 32
    • 79251635938 scopus 로고    scopus 로고
    • Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
    • Varela, I. et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469, 539-542 (2011).
    • (2011) Nature , vol.469 , pp. 539-542
    • Varela, I.1
  • 33
    • 67649884743 scopus 로고    scopus 로고
    • And accurate short read alignment with Burrows-Wheeler transform
    • Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 1754-1760 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 1754-1760
    • Li, H.1    Fast, D.R.2
  • 34
    • 79955483667 scopus 로고    scopus 로고
    • A framework for variation discovery and genotyping using next-generation DNA sequencing data
    • DePristo, M. A. et al. A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nature Genet. 43, 491-498 (2011).
    • (2011) Nature Genet. , vol.43 , pp. 491-498
    • Depristo, M.A.1
  • 35
    • 84874025843 scopus 로고    scopus 로고
    • Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
    • Cibulskis, K. et al. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nature Biotechnol. 31, 213-219 (2013).
    • (2013) Nature Biotechnol. , vol.31 , pp. 213-219
    • Cibulskis, K.1
  • 36
    • 68549104404 scopus 로고    scopus 로고
    • The Sequence Alignment/Map format and SAMtools
    • Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078-2079 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 2078-2079
    • Li, H.1
  • 37
    • 77956534324 scopus 로고    scopus 로고
    • ANNOVAR: Functional annotation of genetic variants from high-throughput sequencing data
    • Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164 (2010).
    • (2010) Nucleic Acids Res. , vol.38 , pp. e164
    • Wang, K.1    Li, M.2    Hakonarson, H.3
  • 38
    • 78651330430 scopus 로고    scopus 로고
    • COSMIC: Mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
    • Forbes, S. A. et al. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res. 39, D945-D950 (2011).
    • (2011) Nucleic Acids Res. , vol.39 , pp. D945-D950
    • Forbes, S.A.1
  • 39
    • 80054078476 scopus 로고    scopus 로고
    • Fast, scalable generation of high-quality proteinmultiple sequence alignments using Clustal Omega
    • Sievers, F. et al. Fast, scalable generation of high-quality proteinmultiple sequence alignments using Clustal Omega. Mol. Syst. Biol. 7, 539 (2011).
    • (2011) Mol. Syst. Biol. , vol.7 , pp. 539
    • Sievers, F.1
  • 40
    • 84861541343 scopus 로고    scopus 로고
    • Mutational processes molding the genomes of 21 breast cancers
    • Nik-Zainal, S. et al. Mutational processes molding the genomes of 21 breast cancers. Cell 149, 979-993 (2012).
    • (2012) Cell , vol.149 , pp. 979-993
    • Nik-Zainal, S.1
  • 41
    • 78651430230 scopus 로고    scopus 로고
    • Control-free calling of copy number alterations in deep-sequencing data using GC-content normalization
    • Boeva, V. et al. Control-free calling of copy number alterations in deep-sequencing data using GC-content normalization. Bioinformatics 27, 268-269 (2011).
    • (2011) Bioinformatics , vol.27 , pp. 268-269
    • Boeva, V.1
  • 42
    • 33747878451 scopus 로고    scopus 로고
    • Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung
    • Raponi, M. et al. Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung. Cancer Res. 66, 7466-7472 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 7466-7472
    • Raponi, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.