-
1
-
-
0036000275
-
Modulation of the Ras/Raf/MEK/ERK pathway by Ca(2+), and calmodulin
-
Agell N., Bachs O., Rocamora N., Villalonga P. Modulation of the Ras/Raf/MEK/ERK pathway by Ca(2+), and calmodulin. Cell. Signal. 14:2002;649-654.
-
(2002)
Cell. Signal.
, vol.14
, pp. 649-654
-
-
Agell, N.1
Bachs, O.2
Rocamora, N.3
Villalonga, P.4
-
2
-
-
0024292722
-
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
-
Almoguera C., Shibata D., Forrester K., Martin J., Arnheim N., Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 53:1988;549-554.
-
(1988)
Cell
, vol.53
, pp. 549-554
-
-
Almoguera, C.1
Shibata, D.2
Forrester, K.3
Martin, J.4
Arnheim, N.5
Perucho, M.6
-
3
-
-
0033587009
-
Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells
-
Balmanno K., Cook S.J. Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells. Oncogene. 18:1999;3085-3097.
-
(1999)
Oncogene
, vol.18
, pp. 3085-3097
-
-
Balmanno, K.1
Cook, S.J.2
-
4
-
-
0036059249
-
Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence
-
Barradas M., Gonos E.S., Zebedee Z., Kolettas E., Petropoulou C., Delgado M.D., Leon J., Hara E., Serrano M. Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence. Exp. Cell Res. 273:2002;127-137.
-
(2002)
Exp. Cell Res.
, vol.273
, pp. 127-137
-
-
Barradas, M.1
Gonos, E.S.2
Zebedee, Z.3
Kolettas, E.4
Petropoulou, C.5
Delgado, M.D.6
Leon, J.7
Hara, E.8
Serrano, M.9
-
5
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
Bos J.L. ras oncogenes in human cancer. a review Cancer Res. 49:1989;4682-4689.
-
(1989)
Cancer Res.
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
6
-
-
0031473544
-
Spatio-temporally controlled site-specific somatic mutagenesis in the mouse
-
Brocard J., Warot X., Wendling O., Messaddeq N., Vonesch J.L., Chambon P., Metzger D. Spatio-temporally controlled site-specific somatic mutagenesis in the mouse. Proc. Natl. Acad. Sci. USA. 94:1997;14559-14563.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 14559-14563
-
-
Brocard, J.1
Warot, X.2
Wendling, O.3
Messaddeq, N.4
Vonesch, J.L.5
Chambon, P.6
Metzger, D.7
-
7
-
-
0028228616
-
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
-
Cowley S., Paterson H., Kemp P., Marshall C.J. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell. 77:1994;841-852.
-
(1994)
Cell
, vol.77
, pp. 841-852
-
-
Cowley, S.1
Paterson, H.2
Kemp, P.3
Marshall, C.J.4
-
8
-
-
0021871141
-
Histogenesis of pancreatic carcinomas: A study based on 248 cases
-
Chen J., Baithun S.I., Ramsay M.A. Histogenesis of pancreatic carcinomas. a study based on 248 cases J. Pathol. 146:1985;65-76.
-
(1985)
J. Pathol.
, vol.146
, pp. 65-76
-
-
Chen, J.1
Baithun, S.I.2
Ramsay, M.A.3
-
9
-
-
0037264633
-
Targeting Ras signalling pathways in cancer therapy
-
Downward J. Targeting Ras signalling pathways in cancer therapy. Nat. Rev. Cancer. 3:2003;11-22.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
10
-
-
0035893318
-
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
-
Fisher G.H., Wellen S.L., Klimstra D., Lenczowski J.M., Tichelaar J.W., Lizak M.J., Whitsett J.A., Koretsky A., Varmus H.E. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev. 15:2001;3249-3262.
-
(2001)
Genes Dev.
, vol.15
, pp. 3249-3262
-
-
Fisher, G.H.1
Wellen, S.L.2
Klimstra, D.3
Lenczowski, J.M.4
Tichelaar, J.W.5
Lizak, M.J.6
Whitsett, J.A.7
Koretsky, A.8
Varmus, H.E.9
-
11
-
-
0025992469
-
Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice
-
Friedrich G., Soriano P. Promoter traps in embryonic stem cells. a genetic screen to identify and mutate developmental genes in mice Genes Dev. 5:1991;1513-1523.
-
(1991)
Genes Dev.
, vol.5
, pp. 1513-1523
-
-
Friedrich, G.1
Soriano, P.2
-
12
-
-
0003799070
-
-
Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
-
Hogan B., Beddington R., Costantini F., Lacy E. Manipulating the Mouse Embryo. A Laboratory Manual Second edition:1994;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
-
(1994)
Manipulating the Mouse Embryo: A Laboratory Manual Second edition
-
-
Hogan, B.1
Beddington, R.2
Costantini, F.3
Lacy, E.4
-
13
-
-
0035893252
-
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
-
Jackson E.L., Willis N., Mercer K., Bronson R.T., Crowley D., Montoya R., Jacks T., Tuveson D.A. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 15:2001;3243-3248.
-
(2001)
Genes Dev.
, vol.15
, pp. 3243-3248
-
-
Jackson, E.L.1
Willis, N.2
Mercer, K.3
Bronson, R.T.4
Crowley, D.5
Montoya, R.6
Jacks, T.7
Tuveson, D.A.8
-
14
-
-
0345135149
-
K-ras is an essential gene in the mouse with partial functional overlap with N-ras
-
Johnson L., Greenbaum D., Cichowski K., Mercer K., Murphy E., Schmitt E., Bronson R.T., Umanoff H., Edelmann W., Kucherlapati R., Jacks T. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 11:1997;2468-2481.
-
(1997)
Genes Dev.
, vol.11
, pp. 2468-2481
-
-
Johnson, L.1
Greenbaum, D.2
Cichowski, K.3
Mercer, K.4
Murphy, E.5
Schmitt, E.6
Bronson, R.T.7
Umanoff, H.8
Edelmann, W.9
Kucherlapati, R.10
Jacks, T.11
-
15
-
-
0035953550
-
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
-
Johnson L., Mercer K., Greenbaum D., Bronson R.T., Crowley D., Tuveson D.A., Jacks T. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature. 410:2001;1111-1116.
-
(2001)
Nature
, vol.410
, pp. 1111-1116
-
-
Johnson, L.1
Mercer, K.2
Greenbaum, D.3
Bronson, R.T.4
Crowley, D.5
Tuveson, D.A.6
Jacks, T.7
-
16
-
-
0026743899
-
Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains
-
Kraus V.B., Moran E., Nevins J.R. Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains. Mol. Cell. Biol. 12:1992;4391-4399.
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 4391-4399
-
-
Kraus, V.B.1
Moran, E.2
Nevins, J.R.3
-
17
-
-
0026638820
-
Targeted oncogene activation by site-specific recombination in transgenic mice
-
Lakso M., Sauer B., Mosinger B. Jr., Lee E.J., Manning R.W., Yu S.H., Mulder K.L., Westphal H. Targeted oncogene activation by site-specific recombination in transgenic mice. Proc. Natl. Acad. Sci. USA. 89:1992;6232-6236.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 6232-6236
-
-
Lakso, M.1
Sauer, B.2
Mosinger B., Jr.3
Lee, E.J.4
Manning, R.W.5
Yu, S.H.6
Mulder, K.L.7
Westphal, H.8
-
18
-
-
0023098381
-
Differential expression of the ras gene family in mice
-
Leon J., Guerrero I., Pellicer A. Differential expression of the ras gene family in mice. Mol. Cell. Biol. 7:1987;1535-1540.
-
(1987)
Mol. Cell. Biol.
, vol.7
, pp. 1535-1540
-
-
Leon, J.1
Guerrero, I.2
Pellicer, A.3
-
19
-
-
0035979247
-
Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
-
Loonstra A., Vooijs M., Beverloo H.B., Allak B.A., van Drunen E., Kanaar R., Berns A., Jonkers J. Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc. Natl. Acad. Sci. USA. 98:2001;9209-9214.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9209-9214
-
-
Loonstra, A.1
Vooijs, M.2
Beverloo, H.B.3
Allak, B.A.4
Van Drunen, E.5
Kanaar, R.6
Berns, A.7
Jonkers, J.8
-
20
-
-
0028872649
-
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
-
Marshall C.J. Specificity of receptor tyrosine kinase signaling. transient versus sustained extracellular signal-regulated kinase activation Cell. 80:1995;179-185.
-
(1995)
Cell
, vol.80
, pp. 179-185
-
-
Marshall, C.J.1
-
21
-
-
0035807255
-
Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene
-
Meuwissen R., Linn S.C., van der Valk M., Mooi W.J., Berns A. Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene. Oncogene. 20:2001;6551-6558.
-
(2001)
Oncogene
, vol.20
, pp. 6551-6558
-
-
Meuwissen, R.1
Linn, S.C.2
Van Der Valk, M.3
Mooi, W.J.4
Berns, A.5
-
22
-
-
0028279829
-
Dicistronic targeting constructs: Reporters and modifiers of mammalian gene expression
-
Mountford P., Zevnik B., Duwel A., Nichols J., Li M., Dani C., Robertson M., Chambers I., Smith A. Dicistronic targeting constructs. reporters and modifiers of mammalian gene expression Proc. Natl. Acad. Sci. USA. 91:1994;4303-4307.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 4303-4307
-
-
Mountford, P.1
Zevnik, B.2
Duwel, A.3
Nichols, J.4
Li, M.5
Dani, C.6
Robertson, M.7
Chambers, I.8
Smith, A.9
-
23
-
-
0027321548
-
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
-
Nagy A., Rossant J., Nagy R., Abramow-Newerly W., Roder J.C. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA. 90:1993;8424-8428.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 8424-8428
-
-
Nagy, A.1
Rossant, J.2
Nagy, R.3
Abramow-Newerly, W.4
Roder, J.C.5
-
24
-
-
0025889018
-
Differential activation of ras genes by point mutation in human colon cancer with metastases to either lung or liver
-
Oudejans J.J., Slebos R.J., Zoetmulder F.A., Mooi W.J., Rodenhuis S. Differential activation of ras genes by point mutation in human colon cancer with metastases to either lung or liver. Int. J. Cancer. 49:1991;875-879.
-
(1991)
Int. J. Cancer
, vol.49
, pp. 875-879
-
-
Oudejans, J.J.1
Slebos, R.J.2
Zoetmulder, F.A.3
Mooi, W.J.4
Rodenhuis, S.5
-
25
-
-
0028173464
-
Use of fluorescein-di-beta-D-galactopyranoside (FDG) and C12-FDG as substrates for beta-galactosidase detection by flow cytometry in animal, bacterial, and yeast cells
-
Plovins A., Alvarez A.M., Ibañez M., Molina M., Nombela C. Use of fluorescein-di-beta-D-galactopyranoside (FDG) and C12-FDG as substrates for beta-galactosidase detection by flow cytometry in animal, bacterial, and yeast cells. Appl. Environ. Microbiol. 60:1994;4638-4641.
-
(1994)
Appl. Environ. Microbiol.
, vol.60
, pp. 4638-4641
-
-
Plovins, A.1
Alvarez, A.M.2
Ibañez, M.3
Molina, M.4
Nombela, C.5
-
26
-
-
0020520517
-
Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
-
Ruley H.E. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature. 304:1983;602-606.
-
(1983)
Nature
, vol.304
, pp. 602-606
-
-
Ruley, H.E.1
-
27
-
-
0029566108
-
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells
-
Schwenk F., Baron U., Rajewsky K. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23:1995;5080-5081.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 5080-5081
-
-
Schwenk, F.1
Baron, U.2
Rajewsky, K.3
-
28
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M., Lin A.W., McCurrach M.E., Beach D., Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 88:1997;593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
29
-
-
0035803395
-
Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors
-
Sotillo R., Dubus P., Martin J., de la Cueva E., Ortega S., Malumbres M., Barbacid M. Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. EMBO J. 20:2001;6637-6647.
-
(2001)
EMBO J.
, vol.20
, pp. 6637-6647
-
-
Sotillo, R.1
Dubus, P.2
Martin, J.3
De La Cueva, E.4
Ortega, S.5
Malumbres, M.6
Barbacid, M.7
-
30
-
-
84883840386
-
Quantitative studies of the growth of mouse embryo cells in culture and their development into stablish lines
-
Todaro G.J., Green H. Quantitative studies of the growth of mouse embryo cells in culture and their development into stablish lines. J. Cell Biol. 17:1963;299-313.
-
(1963)
J. Cell Biol.
, vol.17
, pp. 299-313
-
-
Todaro, G.J.1
Green, H.2
-
31
-
-
0035834388
-
The guanine nucleotide-binding switch in three dimensions
-
Vetter I.R., Wittinghofer A. The guanine nucleotide-binding switch in three dimensions. Science. 294:2001;1299-1304.
-
(2001)
Science
, vol.294
, pp. 1299-1304
-
-
Vetter, I.R.1
Wittinghofer, A.2
-
32
-
-
0027502624
-
Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation
-
Yanagisawa A., Ohtake K., Ohashi K., Hori M., Kitagawa T., Sugano H., Kato Y. Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation. Cancer Res. 53:1993;953-956.
-
(1993)
Cancer Res.
, vol.53
, pp. 953-956
-
-
Yanagisawa, A.1
Ohtake, K.2
Ohashi, K.3
Hori, M.4
Kitagawa, T.5
Sugano, H.6
Kato, Y.7
-
33
-
-
17944369909
-
Wildtype Kras2 can inhibit lung carcinogenesis in mice
-
Zhang Z., Wang Y., Vikis H.G., Johnson L., Liu G., Li J., Anderson M.W., Sills R.C., Hong H.L., Devereux T.R.et al. Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat. Med. 29:2001;25-33.
-
(2001)
Nat. Med.
, vol.29
, pp. 25-33
-
-
Zhang, Z.1
Wang, Y.2
Vikis, H.G.3
Johnson, L.4
Liu, G.5
Li, J.6
Anderson, M.W.7
Sills, R.C.8
Hong, H.L.9
Devereux, T.R.10
|