메뉴 건너뛰기




Volumn 12, Issue 3, 2016, Pages 338-346

The significance of ras activity in pancreatic cancer initiation

Author keywords

K Ras

Indexed keywords

PROTEIN P21;

EID: 84957591339     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.15020     Document Type: Review
Times cited : (54)

References (50)
  • 2
    • 78649474147 scopus 로고    scopus 로고
    • Ras history: The saga continues
    • Cox AD, Der CJ. Ras history: The saga continues. Small GTPases. 2010; 1: 2-27
    • (2010) Small Gtpases , vol.1 , pp. 2-27
    • Cox, A.D.1    Der, C.J.2
  • 3
  • 4
    • 22744445886 scopus 로고    scopus 로고
    • Signaling interplay in Ras superfamily function
    • Mitin N, Rossman KL, Der CJ. Signaling interplay in Ras superfamily function. Curr Biol. 2005; 15: R563-74
    • (2005) Curr Biol , vol.15 , pp. R563-R574
    • Mitin, N.1    Rossman, K.L.2    Der, C.J.3
  • 5
    • 78649487698 scopus 로고    scopus 로고
    • Ras superfamily GEFs and GAPs: Validated and tractable targets for cancer therapy?
    • Vigil D, Cherfils J, Rossman KL, Der CJ. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat Rev Cancer. 2010; 10: 842-57
    • (2010) Nat Rev Cancer , vol.10 , pp. 842-857
    • Vigil, D.1    Cherfils, J.2    Rossman, K.L.3    Der, C.J.4
  • 6
    • 84901433444 scopus 로고    scopus 로고
    • An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer
    • Maertens O, Cichowski K. An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer. Adv Biol Regul. 2014; 55: 1-14
    • (2014) Adv Biol Regul , vol.55 , pp. 1-14
    • Maertens, O.1    Cichowski, K.2
  • 7
  • 8
    • 0032911205 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of RasN17 inhibits specific CCK actions on pancreatic acinar cells
    • Nicke B, Tseng MJ, Fenrich M, Logsdon CD. Adenovirus-mediated gene transfer of RasN17 inhibits specific CCK actions on pancreatic acinar cells. Am J Physiol. 1999; 276: G499-506
    • (1999) Am J Physiol , vol.276 , pp. G499-G506
    • Nicke, B.1    Tseng, M.J.2    Fenrich, M.3    Logsdon, C.D.4
  • 12
    • 33847419143 scopus 로고    scopus 로고
    • Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
    • Guerra C, Schuhmacher AJ, Canamero M, Grippo PJ, Verdaguer L, Perez-Gallego L, et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell. 2007; 11: 291-302
    • (2007) Cancer Cell , vol.11 , pp. 291-302
    • Guerra, C.1    Schuhmacher, A.J.2    Canamero, M.3    Grippo, P.J.4    Verdaguer, L.5    Perez-Gallego, L.6
  • 13
    • 84859710888 scopus 로고    scopus 로고
    • An NF-kappaB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice
    • Daniluk J, Liu Y, Deng D, Chu J, Huang H, Gaiser S, et al. An NF-kappaB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. J Clin Invest. 2012; 122: 1519-28
    • (2012) J Clin Invest , vol.122 , pp. 1519-1528
    • Daniluk, J.1    Liu, Y.2    Deng, D.3    Chu, J.4    Huang, H.5    Gaiser, S.6
  • 14
    • 64049085356 scopus 로고    scopus 로고
    • Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic K-Ras
    • Carriere C, Young AL, Gunn JR, Longnecker DS, Korc M. Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic K-Ras. Biochem Biophys Res Commun. 2009; 382: 561-5
    • (2009) Biochem Biophys Res Commun , vol.382 , pp. 561-565
    • Carriere, C.1    Young, A.L.2    Gunn, J.R.3    Longnecker, D.S.4    Korc, M.5
  • 15
    • 84888267890 scopus 로고    scopus 로고
    • A High-Fat Diet Activates Oncogenic K-Ras and COX2 to Induce Development of Pancreatic Ductal Adenocarcinoma in Mice
    • Philip B, Roland CL, Daniluk J, Liu Y, Chatterjee D, Gomez SB, et al. A High-Fat Diet Activates Oncogenic K-Ras and COX2 to Induce Development of Pancreatic Ductal Adenocarcinoma in Mice. Gastroenterology. 2013
    • (2013) Gastroenterology
    • Philip, B.1    Roland, C.L.2    Daniluk, J.3    Liu, Y.4    Chatterjee, D.5    Gomez, S.B.6
  • 16
    • 20444475238 scopus 로고    scopus 로고
    • Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups
    • Yan L, McFaul C, Howes N, Leslie J, Lancaster G, Wong T, et al. Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups. Gastroenterology. 2005; 128: 2124-30
    • (2005) Gastroenterology , vol.128 , pp. 2124-2130
    • Yan, L.1    McFaul, C.2    Howes, N.3    Leslie, J.4    Lancaster, G.5    Wong, T.6
  • 17
    • 0036864180 scopus 로고    scopus 로고
    • Detecting K-ras and p53 gene mutation from stool and pancreatic juice for diagnosis of early pancreatic cancer
    • Lu X, Xu T, Qian J, Wen X, Wu D. Detecting K-ras and p53 gene mutation from stool and pancreatic juice for diagnosis of early pancreatic cancer. Chin Med J (Engl). 2002; 115: 1632-6
    • (2002) Chin Med J (Engl) , vol.115 , pp. 1632-1636
    • Lu, X.1    Xu, T.2    Qian, J.3    Wen, X.4    Wu, D.5
  • 18
    • 0029642291 scopus 로고
    • High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer
    • Yakubovskaya MS, Spiegelman V, Luo FC, Malaev S, Salnev A, Zborovskaya I, et al. High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer. Int J Cancer. 1995; 63: 810-4
    • (1995) Int J Cancer , vol.63 , pp. 810-814
    • Yakubovskaya, M.S.1    Spiegelman, V.2    Luo, F.C.3    Malaev, S.4    Salnev, A.5    Zborovskaya, I.6
  • 19
    • 0030050945 scopus 로고    scopus 로고
    • Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease
    • Tada M, Ohashi M, Shiratori Y, Okudaira T, Komatsu Y, Kawabe T, et al. Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Gastroenterology. 1996; 110: 227-31
    • (1996) Gastroenterology , vol.110 , pp. 227-231
    • Tada, M.1    Ohashi, M.2    Shiratori, Y.3    Okudaira, T.4    Komatsu, Y.5    Kawabe, T.6
  • 20
    • 0142072036 scopus 로고    scopus 로고
    • Clinicopathological correlates of pancreatic intraepithelial neoplasia: A comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma
    • Andea A, Sarkar F, Adsay VN. Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma. Mod Pathol. 2003; 16: 996-1006
    • (2003) Mod Pathol , vol.16 , pp. 996-1006
    • Andea, A.1    Sarkar, F.2    Adsay, V.N.3
  • 21
    • 61349100218 scopus 로고    scopus 로고
    • K-RAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: Implications for the human pancreatic cancer cell of origin
    • Shi C, Hong SM, Lim P, Kamiyama H, Khan M, Anders RA, et al. K-RAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin. Mol Cancer Res. 2009; 7: 230-6
    • (2009) Mol Cancer Res , vol.7 , pp. 230-236
    • Shi, C.1    Hong, S.M.2    Lim, P.3    Kamiyama, H.4    Khan, M.5    Ers, R.A.6
  • 22
    • 84929501731 scopus 로고    scopus 로고
    • The Ras/MAPK pathway and hepatocarcinoma: Pathogenesis and therapeutic implications
    • Delire B, Starkel P. The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications. Eur J Clin Invest. 2015; 45: 609-23
    • (2015) Eur J Clin Invest , vol.45 , pp. 609-623
    • Delire, B.1    Starkel, P.2
  • 23
    • 78751566393 scopus 로고    scopus 로고
    • Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer
    • Calvisi DF, Ladu S, Conner EA, Seo D, Hsieh JT, Factor VM, et al. Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer. J Hepatol. 2011; 54: 311-9
    • (2011) J Hepatol , vol.54 , pp. 311-319
    • Calvisi, D.F.1    Ladu, S.2    Conner, E.A.3    Seo, D.4    Hsieh, J.T.5    Factor, V.M.6
  • 26
    • 0034690029 scopus 로고    scopus 로고
    • A dominant negative RAS-specific guanine nucleotide exchange factor reverses neoplastic phenotype in K-ras transformed mouse fibroblasts
    • Bossu P, Vanoni M, Wanke V, Cesaroni MP, Tropea F, Melillo G, et al. A dominant negative RAS-specific guanine nucleotide exchange factor reverses neoplastic phenotype in K-ras transformed mouse fibroblasts. Oncogene. 2000; 19: 2147-54
    • (2000) Oncogene , vol.19 , pp. 2147-2154
    • Bossu, P.1    Vanoni, M.2    Wanke, V.3    Cesaroni, M.P.4    Tropea, F.5    Melillo, G.6
  • 27
    • 78651279608 scopus 로고    scopus 로고
    • Tyrosine kinase receptor transactivation associated to G protein-coupled receptors
    • Almendro V, Garcia-Recio S, Gascon P. Tyrosine kinase receptor transactivation associated to G protein-coupled receptors. Curr Drug Targets. 2010; 11: 1169-80
    • (2010) Curr Drug Targets , vol.11 , pp. 1169-1180
    • Almendro, V.1    Garcia-Recio, S.2    Gascon, P.3
  • 32
    • 84870505131 scopus 로고    scopus 로고
    • Is there a future for prenyltransferase inhibitors in cancer therapy?
    • Holstein SA, Hohl RJ. Is there a future for prenyltransferase inhibitors in cancer therapy? Curr Opin Pharmacol. 2012; 12: 704-9
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 704-709
    • Holstein, S.A.1    Hohl, R.J.2
  • 33
    • 32444441115 scopus 로고    scopus 로고
    • PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis
    • Bivona TG, Quatela SE, Bodemann BO, Ahearn IM, Soskis MJ, Mor A, et al. PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Molecular cell. 2006; 21: 481-93
    • (2006) Molecular Cell , vol.21 , pp. 481-493
    • Bivona, T.G.1    Quatela, S.E.2    Bodemann, B.O.3    Ahearn, I.M.4    Soskis, M.J.5    Mor, A.6
  • 34
    • 84856595714 scopus 로고    scopus 로고
    • K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis
    • Hu Y, Lu W, Chen G, Wang P, Chen Z, Zhou Y, et al. K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis. Cell Res. 2012; 22: 399-412
    • (2012) Cell Res , vol.22 , pp. 399-412
    • Hu, Y.1    Lu, W.2    Chen, G.3    Wang, P.4    Chen, Z.5    Zhou, Y.6
  • 36
  • 37
    • 79952563237 scopus 로고    scopus 로고
    • Ubiquitin on ras: Warden or partner in crime?
    • Pfleger CM. Ubiquitin on ras: warden or partner in crime? Sci Signal. 2011; 4: pe12
    • (2011) Sci Signal , vol.4
    • Pfleger, C.M.1
  • 38
    • 84883555139 scopus 로고    scopus 로고
    • HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS
    • Yang MH, Laurent G, Bause AS, Spang R, German N, Haigis MC, et al. HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS. Mol Cancer Res. 2013; 11: 1072-7
    • (2013) Mol Cancer Res , vol.11 , pp. 1072-1077
    • Yang, M.H.1    Laurent, G.2    Bause, A.S.3    Spang, R.4    German, N.5    Haigis, M.C.6
  • 39
    • 0028982274 scopus 로고
    • Novogrodsky A. P21ras as a common signaling target of reactive free radicals and cellular redox stress
    • Lander HM, Ogiste JS, Teng KK, Novogrodsky A. p21ras as a common signaling target of reactive free radicals and cellular redox stress. J Biol Chem. 1995; 270: 21195-8
    • (1995) J Biol Chem , vol.270 , pp. 21195-21198
    • Lander, H.M.1    Ogiste, J.S.2    Teng, K.K.3
  • 41
    • 79251582896 scopus 로고    scopus 로고
    • Redox control of GTPases: From molecular mechanisms to functional significance in health and disease
    • Heo J. Redox control of GTPases: from molecular mechanisms to functional significance in health and disease. Antioxidants & redox signaling. 2011; 14: 689-724
    • (2011) Antioxidants & Redox Signaling , vol.14 , pp. 689-724
    • Heo, J.1
  • 42
    • 84874592389 scopus 로고    scopus 로고
    • The Interplay between ROS and Ras GTPases: Physiological and Pathological Implications
    • Ferro E, Goitre L, Retta SF, Trabalzini L. The Interplay between ROS and Ras GTPases: Physiological and Pathological Implications. J Signal Transduct. 2012: 365769
    • (2012) J Signal Transduct
    • Ferro, E.1    Goitre, L.2    Retta, S.F.3    Trabalzini, L.4
  • 43
    • 16844374922 scopus 로고    scopus 로고
    • Superoxide anion radical modulates the activity of Ras and Ras-related GTPases by a radical-based mechanism similar to that of nitric oxide
    • Heo J, Campbell SL. Superoxide anion radical modulates the activity of Ras and Ras-related GTPases by a radical-based mechanism similar to that of nitric oxide. The Journal of biological chemistry. 2005; 280: 12438-45
    • (2005) The Journal of Biological Chemistry , vol.280 , pp. 12438-12445
    • Heo, J.1    Campbell, S.L.2
  • 44
    • 0023676068 scopus 로고
    • Oligomeric structure of p21 ras proteins as determined by radiation inactivation
    • Santos E, Nebreda AR, Bryan T, Kempner ES. Oligomeric structure of p21 ras proteins as determined by radiation inactivation. J Biol Chem. 1988; 263: 9853-8
    • (1988) J Biol Chem , vol.263 , pp. 9853-9858
    • Santos, E.1    Nebreda, A.R.2    Bryan, T.3    Kempner, E.S.4
  • 47
    • 84886745490 scopus 로고    scopus 로고
    • US National Cancer Institute's new Ras project targets an old foe
    • Thompson H. US National Cancer Institute's new Ras project targets an old foe. Nat Med. 2013; 19: 949-50
    • (2013) Nat Med , vol.19 , pp. 949-950
    • Thompson, H.1
  • 49
    • 84891559641 scopus 로고    scopus 로고
    • High-dose aspirin consumption contributes to decreased risk for pancreatic cancer in a systematic review and meta-analysis
    • Cui XJ, He Q, Zhang JM, Fan HJ, Wen ZF, Qin YR. High-dose aspirin consumption contributes to decreased risk for pancreatic cancer in a systematic review and meta-analysis. Pancreas. 2014; 43: 135-40
    • (2014) Pancreas , vol.43 , pp. 135-140
    • Cui, X.J.1    He, Q.2    Zhang, J.M.3    Fan, H.J.4    Wen, Z.F.5    Qin, Y.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.