메뉴 건너뛰기




Volumn 129, Issue 7, 2016, Pages 1287-1292

RAS isoforms and mutations in cancer at a glance

Author keywords

GTPase; Oncogene; PI3K; Rac; Raf; Ral

Indexed keywords

H RAS PROTEIN; K RAS PROTEIN; N RAS PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG; ISOPROTEIN; PROTEIN P21; STOP CODON;

EID: 84964345721     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.182873     Document Type: Article
Times cited : (676)

References (76)
  • 1
    • 50849107378 scopus 로고    scopus 로고
    • Mechanisms of Ras membrane organization and signaling: Ras on a rocker
    • Abankwa, D., Gorfe, A. A. and Hancock, J. F. (2008). Mechanisms of Ras membrane organization and signaling: Ras on a rocker. Cell Cycle 7, 2667-2673.
    • (2008) Cell Cycle , vol.7 , pp. 2667-2673
    • Abankwa, D.1    Gorfe, A.A.2    Hancock, J.F.3
  • 2
    • 75749150934 scopus 로고    scopus 로고
    • Ras membrane orientation and nanodomain localization generate isoform diversity
    • Abankwa, D., Gorfe, A. A., Inder, K. and Hancock, J. F. (2010). Ras membrane orientation and nanodomain localization generate isoform diversity. Proc. Natl. Acad. Sci. USA 107, 1130-1135.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 1130-1135
    • Abankwa, D.1    Gorfe, A.A.2    Inder, K.3    Hancock, J.F.4
  • 4
    • 65349189958 scopus 로고    scopus 로고
    • American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
    • Allegra, C. J., Jessup, J. M., Somerfield, M. R., Hamilton, S. R., Hammond, E. H., Hayes, D. F., McAllister, P. K., Morton, R. F. and Schilsky, R. L. (2009). American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J. Clin. Oncol. 27, 2091-2096.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2091-2096
    • Allegra, C.J.1    Jessup, J.M.2    Somerfield, M.R.3    Hamilton, S.R.4    Hammond, E.H.5    Hayes, D.F.6    McAllister, P.K.7    Morton, R.F.8    Schilsky, R.L.9
  • 9
    • 0025365140 scopus 로고
    • Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7
    • Bremner, R. and Balmain, A. (1990). Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell 61, 407-417.
    • (1990) Cell , vol.61 , pp. 407-417
    • Bremner, R.1    Balmain, A.2
  • 11
    • 36749036721 scopus 로고    scopus 로고
    • Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf
    • Buhrman, G., Wink, G. and Mattos, C. (2007). Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf. Structure 15, 1618-1629.
    • (2007) Structure , vol.15 , pp. 1618-1629
    • Buhrman, G.1    Wink, G.2    Mattos, C.3
  • 15
    • 78649474147 scopus 로고    scopus 로고
    • Ras history: the saga continues
    • Cox, A. D. and Der, C. J. (2010). Ras history: the saga continues. Small GTPases 1, 2-27.
    • (2010) Small GTPases , vol.1 , pp. 2-27
    • Cox, A.D.1    Der, C.J.2
  • 17
    • 84927620483 scopus 로고    scopus 로고
    • Targeting RAS membrane association: back to the future for anti-RAS drug discovery?
    • Cox, A. D., Der, C.J. and Philips, M. R. (2015). Targeting RAS membrane association: back to the future for anti-RAS drug discovery? Clin. Cancer Res. 21, 1819-1827.
    • (2015) Clin. Cancer Res. , vol.21 , pp. 1819-1827
    • Cox, A.D.1    Der, C.J.2    Philips, M.R.3
  • 18
    • 0022471217 scopus 로고
    • Biological and biochemical properties of human rasH genes mutated at codon 61
    • Der, C. J., Finkel, T. and Cooper, G. M. (1986). Biological and biochemical properties of human rasH genes mutated at codon 61. Cell 44, 167-176.
    • (1986) Cell , vol.44 , pp. 167-176
    • Der, C.J.1    Finkel, T.2    Cooper, G.M.3
  • 22
    • 84893249799 scopus 로고    scopus 로고
    • PI3K and cancer: lessons, challenges and opportunities
    • Fruman, D. A. and Rommel, C. (2014). PI3K and cancer: lessons, challenges and opportunities. Nat. Rev. Drug Discov. 13, 140-156.
    • (2014) Nat. Rev. Drug Discov. , vol.13 , pp. 140-156
    • Fruman, D.A.1    Rommel, C.2
  • 26
    • 84924359443 scopus 로고    scopus 로고
    • Differential reprogramming of isogenic colorectal cancercells by distinct activating KRAS mutations
    • Hammond, D. E., Mageean, C. J., Rusilowicz, E.V., Wickenden, J. A., Clague, M. J. and Prior, I.A. (2015). Differential reprogramming of isogenic colorectal cancercells by distinct activating KRAS mutations. J. Proteome Res. 14, 1535-1546.
    • (2015) J. Proteome Res. , vol.14 , pp. 1535-1546
    • Hammond, D.E.1    Mageean, C.J.2    Rusilowicz, E.V.3    Wickenden, J.A.4    Clague, M.J.5    Prior, I.A.6
  • 31
    • 33344475413 scopus 로고    scopus 로고
    • Differential modification of Ras proteins by ubiquitination
    • Jura, N., Scotto-Lavino, E., Sobczyk, A. and Bar-Sagi, D. (2006). Differential modification of Ras proteins by ubiquitination. Mol. Cell 21, 679-687.
    • (2006) Mol. Cell , vol.21 , pp. 679-687
    • Jura, N.1    Scotto-Lavino, E.2    Sobczyk, A.3    Bar-Sagi, D.4
  • 32
    • 84910635300 scopus 로고    scopus 로고
    • Modeling the role of G12V and G13V Ras mutations in the Ras-GAP-catalyzed hydrolysis reaction of guanosine triphosphate
    • Khrenova, M. G., Mironov, V. A., Grigorenko, B. L. and Nemukhin, A. V. (2014). Modeling the role of G12V and G13V Ras mutations in the Ras-GAP-catalyzed hydrolysis reaction of guanosine triphosphate. Biochemistry 53, 7093-7099.
    • (2014) Biochemistry , vol.53 , pp. 7093-7099
    • Khrenova, M.G.1    Mironov, V.A.2    Grigorenko, B.L.3    Nemukhin, A.V.4
  • 33
    • 13844293072 scopus 로고    scopus 로고
    • Recognizing and defining true Ras binding domains II: in silico prediction based on homology modelling and energy calculations
    • Kiel, C., Wohlgemuth, S., Rousseau, F., Schymkowitz, J., Ferkinghoff-Borg, J., Wittinghofer, F. and Serrano, L. (2005). Recognizing and defining true Ras binding domains II: in silico prediction based on homology modelling and energy calculations. J. Mol. Biol. 348, 759-775.
    • (2005) J. Mol. Biol. , vol.348 , pp. 759-775
    • Kiel, C.1    Wohlgemuth, S.2    Rousseau, F.3    Schymkowitz, J.4    Ferkinghoff-Borg, J.5    Wittinghofer, F.6    Serrano, L.7
  • 36
    • 84928394480 scopus 로고    scopus 로고
    • Cancer: the Ras renaissance
    • Ledford, H. (2015). Cancer: the Ras renaissance. Nature 520, 278-280.
    • (2015) Nature , vol.520 , pp. 278-280
    • Ledford, H.1
  • 39
    • 84920911274 scopus 로고    scopus 로고
    • The differential palmitoylation states of N-Ras and H-Ras determine their distinct golgi subcompartment localizations
    • Lynch, S. J., Snitkin, H., Gumper, I., Philips, M. R., Sabatini, D. and Pellicer, A. (2015). The differential palmitoylation states of N-Ras and H-Ras determine their distinct golgi subcompartment localizations. J. Cell. Physiol. 230, 610-619.
    • (2015) J. Cell. Physiol. , vol.230 , pp. 610-619
    • Lynch, S.J.1    Snitkin, H.2    Gumper, I.3    Philips, M.R.4    Sabatini, D.5    Pellicer, A.6
  • 41
    • 84878110642 scopus 로고    scopus 로고
    • Prognostic value of K-rasmutation status and subtypes in endoscopic ultrasound-guided fine-needle aspiration specimens from patients with unresectable pancreatic cancer
    • Ogura, T., Yamao, K., Hara, K., Mizuno, N., Hijioka, S., Imaoka, H., Sawaki, A., Niwa, Y., Tajika, M., Kondo, S. et al. (2013). Prognostic value of K-rasmutation status and subtypes in endoscopic ultrasound-guided fine-needle aspiration specimens from patients with unresectable pancreatic cancer. J. Gastroenterol. 48, 640-646.
    • (2013) J. Gastroenterol. , vol.48 , pp. 640-646
    • Ogura, T.1    Yamao, K.2    Hara, K.3    Mizuno, N.4    Hijioka, S.5    Imaoka, H.6    Sawaki, A.7    Niwa, Y.8    Tajika, M.9    Kondo, S.10
  • 42
    • 84888639050 scopus 로고    scopus 로고
    • K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions
    • Ostrem, J. M., Peters, U., Sos, M. L., Wells, J. A. and Shokat, K. M. (2013). K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 503, 548-551.
    • (2013) Nature , vol.503 , pp. 548-551
    • Ostrem, J.M.1    Peters, U.2    Sos, M.L.3    Wells, J.A.4    Shokat, K.M.5
  • 43
    • 84927615339 scopus 로고    scopus 로고
    • The Ras-membrane interface: isoform-specific differences in the catalytic domain
    • Parker, J. A. and Mattos, C. (2015). The Ras-membrane interface: isoform-specific differences in the catalytic domain. Mol. Cancer Res. 13, 595.
    • (2015) Mol. Cancer Res. , vol.13 , pp. 595
    • Parker, J.A.1    Mattos, C.2
  • 46
    • 84861147473 scopus 로고    scopus 로고
    • A comprehensive survey of Ras mutations in cancer
    • Prior, I. A., Lewis, P. D. and Mattos, C. (2012). A comprehensive survey of Ras mutations in cancer. Cancer Res. 72, 2457-2467.
    • (2012) Cancer Res. , vol.72 , pp. 2457-2467
    • Prior, I.A.1    Lewis, P.D.2    Mattos, C.3
  • 49
    • 3242657115 scopus 로고    scopus 로고
    • Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane
    • Rotblat, B., Prior, I. A., Muncke, C., Parton, R. G., Kloog, Y., Henis, Y. I. and Hancock, J. F. (2004). Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane. Mol. Cell. Biol. 24, 6799-6810.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 6799-6810
    • Rotblat, B.1    Prior, I.A.2    Muncke, C.3    Parton, R.G.4    Kloog, Y.5    Henis, Y.I.6    Hancock, J.F.7
  • 50
    • 84921270388 scopus 로고    scopus 로고
    • Targeting RAS-ERK signalling in cancer: promises and challenges
    • Samatar, A. A. and Poulikakos, P. I. (2014). Targeting RAS-ERK signalling in cancer: promises and challenges. Nat. Rev. Drug Discov. 13, 928-942.
    • (2014) Nat. Rev. Drug Discov. , vol.13 , pp. 928-942
    • Samatar, A.A.1    Poulikakos, P.I.2
  • 54
    • 0021126650 scopus 로고
    • Biological properties of human c-Ha-ras1 genes mutated at codon 12
    • Seeburg, P. H., Colby, W. W., Capon, D. J., Goeddel, D. V. and Levinson, A. D. (1984). Biological properties of human c-Ha-ras1 genes mutated at codon 12. Nature 312, 71-75.
    • (1984) Nature , vol.312 , pp. 71-75
    • Seeburg, P.H.1    Colby, W.W.2    Capon, D.J.3    Goeddel, D.V.4    Levinson, A.D.5
  • 56
    • 84875233112 scopus 로고    scopus 로고
    • NMR-based functional profiling of RASopathies and oncogenic RAS mutations
    • Smith, M. J., Neel, B. G. and Ikura, M. (2013). NMR-based functional profiling of RASopathies and oncogenic RAS mutations. Proc. Natl. Acad. Sci. USA 110, 4574-4579.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 4574-4579
    • Smith, M.J.1    Neel, B.G.2    Ikura, M.3
  • 58
    • 84867117207 scopus 로고    scopus 로고
    • Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab
    • Tejpar, S., Celik, I., Schlichting, M., Sartorius, U., Bokemeyer, C. and Van Cutsem, E. (2012). Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab. J. Clin. Oncol. 30, 3570-3577.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 3570-3577
    • Tejpar, S.1    Celik, I.2    Schlichting, M.3    Sartorius, U.4    Bokemeyer, C.5    Van Cutsem, E.6
  • 59
    • 84886745490 scopus 로고    scopus 로고
    • US National Cancer Institute's new Ras project targets an old foe
    • Thompson, H. (2013). US National Cancer Institute's new Ras project targets an old foe. Nat. Med. 19, 949-950.
    • (2013) Nat. Med. , vol.19 , pp. 949-950
    • Thompson, H.1
  • 60
    • 84942895072 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding
    • Ting, P. Y., Johnson, C. W., Fang, C., Cao, X., Graeber, T. G., Mattos, C. and Colicelli, J. (2015). Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding. FASEB J. 29, 3750-3761.
    • (2015) FASEB J. , vol.29 , pp. 3750-3761
    • Ting, P.Y.1    Johnson, C.W.2    Fang, C.3    Cao, X.4    Graeber, T.G.5    Mattos, C.6    Colicelli, J.7
  • 61
    • 84883186892 scopus 로고    scopus 로고
    • Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis
    • To, M. D., Rosario, R. D., Westcott, P. M. K., Banta, K. L. and Balmain, A. (2013). Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis. Oncogene 32, 4028-4033.
    • (2013) Oncogene , vol.32 , pp. 4028-4033
    • To, M.D.1    Rosario, R.D.2    Westcott, P.M.K.3    Banta, K.L.4    Balmain, A.5
  • 66
    • 78649487698 scopus 로고    scopus 로고
    • Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
    • Vigil, D., Cherfils, J., Rossman, K. L. and Der, C. J. (2010). Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat. Rev. Cancer 10, 842-857.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 842-857
    • Vigil, D.1    Cherfils, J.2    Rossman, K.L.3    Der, C.J.4
  • 68
    • 84948650504 scopus 로고    scopus 로고
    • Wild-type Hras suppresses the earliest stages of tumorigenesis in a genetically engineered mouse model of pancreatic cancer
    • Weyandt, J. D., Lampson, B. L., Tang, S., Mastrodomenico, M., Cardona, D. M. and Counter, C. M. (2015). Wild-type Hras suppresses the earliest stages of tumorigenesis in a genetically engineered mouse model of pancreatic cancer. PLoS ONE 10, e0140253.
    • (2015) PLoS ONE , vol.10
    • Weyandt, J.D.1    Lampson, B.L.2    Tang, S.3    Mastrodomenico, M.4    Cardona, D.M.5    Counter, C.M.6
  • 73
    • 84872853570 scopus 로고    scopus 로고
    • Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling
    • Young, A., Lou, D. and McCormick, F. (2013). Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling. Cancer Discov. 3, 112-123.
    • (2013) Cancer Discov. , vol.3 , pp. 112-123
    • Young, A.1    Lou, D.2    McCormick, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.