-
1
-
-
50849107378
-
Mechanisms of Ras membrane organization and signaling: Ras on a rocker
-
Abankwa, D., Gorfe, A. A. and Hancock, J. F. (2008). Mechanisms of Ras membrane organization and signaling: Ras on a rocker. Cell Cycle 7, 2667-2673.
-
(2008)
Cell Cycle
, vol.7
, pp. 2667-2673
-
-
Abankwa, D.1
Gorfe, A.A.2
Hancock, J.F.3
-
2
-
-
75749150934
-
Ras membrane orientation and nanodomain localization generate isoform diversity
-
Abankwa, D., Gorfe, A. A., Inder, K. and Hancock, J. F. (2010). Ras membrane orientation and nanodomain localization generate isoform diversity. Proc. Natl. Acad. Sci. USA 107, 1130-1135.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 1130-1135
-
-
Abankwa, D.1
Gorfe, A.A.2
Inder, K.3
Hancock, J.F.4
-
3
-
-
84255195028
-
Regulating the regulator: post-translational modification of RAS
-
Ahearn, I. M., Haigis, K., Bar-Sagi, D. and Philips, M. R. (2012). Regulating the regulator: post-translational modification of RAS. Nat. Rev. Mol. Cell Biol. 13, 39-51.
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 39-51
-
-
Ahearn, I.M.1
Haigis, K.2
Bar-Sagi, D.3
Philips, M.R.4
-
4
-
-
65349189958
-
American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
-
Allegra, C. J., Jessup, J. M., Somerfield, M. R., Hamilton, S. R., Hammond, E. H., Hayes, D. F., McAllister, P. K., Morton, R. F. and Schilsky, R. L. (2009). American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J. Clin. Oncol. 27, 2091-2096.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 2091-2096
-
-
Allegra, C.J.1
Jessup, J.M.2
Somerfield, M.R.3
Hamilton, S.R.4
Hammond, E.H.5
Hayes, D.F.6
McAllister, P.K.7
Morton, R.F.8
Schilsky, R.L.9
-
5
-
-
84872027352
-
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function
-
Baker, R., Lewis, S. M., Sasaki, A. T., Wilkerson, E. M., Locasale, J.W., Cantley, L. C., Kuhlman, B., Dohlman, H. G. and Campbell, S. L. (2013a). Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. Nat. Struct. Mol. Biol. 20, 46-52.
-
(2013)
Nat. Struct. Mol. Biol.
, vol.20
, pp. 46-52
-
-
Baker, R.1
Lewis, S.M.2
Sasaki, A.T.3
Wilkerson, E.M.4
Locasale, J.W.5
Cantley, L.C.6
Kuhlman, B.7
Dohlman, H.G.8
Campbell, S.L.9
-
6
-
-
84891459348
-
Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination
-
Baker, R., Wilkerson, E. M., Sumita, K., Isom, D. G., Sasaki, A. T., Dohlman, H. G. and Campbell, S. L. (2013b). Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination. J. Biol. Chem. 288, 36856-36862.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 36856-36862
-
-
Baker, R.1
Wilkerson, E.M.2
Sumita, K.3
Isom, D.G.4
Sasaki, A.T.5
Dohlman, H.G.6
Campbell, S.L.7
-
7
-
-
70449091786
-
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
-
Barbie, D. A., Tamayo, P., Boehm, J. S., Kim, S. Y., Moody, S. E., Dunn, I. F., Schinzel, A. C., Sandy, P., Meylan, E., Scholl, C. et al. (2009). Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 462, 108-112.
-
(2009)
Nature
, vol.462
, pp. 108-112
-
-
Barbie, D.A.1
Tamayo, P.2
Boehm, J.S.3
Kim, S.Y.4
Moody, S.E.5
Dunn, I.F.6
Schinzel, A.C.7
Sandy, P.8
Meylan, E.9
Scholl, C.10
-
8
-
-
84894236975
-
Phosphorylation at Ser-181 of oncogenic KRAS is required for tumor growth
-
Barcelo, C., Paco, N., Morell, M., Alvarez-Moya, B., Bota-Rabassedas, N., Jaumot, M., Vilardell, F., Capella, G. and Agell, N. (2014). Phosphorylation at Ser-181 of oncogenic KRAS is required for tumor growth. Cancer Res. 74, 1190-1199.
-
(2014)
Cancer Res.
, vol.74
, pp. 1190-1199
-
-
Barcelo, C.1
Paco, N.2
Morell, M.3
Alvarez-Moya, B.4
Bota-Rabassedas, N.5
Jaumot, M.6
Vilardell, F.7
Capella, G.8
Agell, N.9
-
9
-
-
0025365140
-
Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7
-
Bremner, R. and Balmain, A. (1990). Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell 61, 407-417.
-
(1990)
Cell
, vol.61
, pp. 407-417
-
-
Bremner, R.1
Balmain, A.2
-
10
-
-
84892861646
-
KRAS: feeding pancreatic cancer proliferation
-
Bryant, K. L., Mancias, J. D., Kimmelman, A. C. and Der, C. J. (2014). KRAS: feeding pancreatic cancer proliferation. Trends Biochem. Sci. 39, 91-100.
-
(2014)
Trends Biochem. Sci.
, vol.39
, pp. 91-100
-
-
Bryant, K.L.1
Mancias, J.D.2
Kimmelman, A.C.3
Der, C.J.4
-
11
-
-
36749036721
-
Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf
-
Buhrman, G., Wink, G. and Mattos, C. (2007). Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf. Structure 15, 1618-1629.
-
(2007)
Structure
, vol.15
, pp. 1618-1629
-
-
Buhrman, G.1
Wink, G.2
Mattos, C.3
-
12
-
-
80054860512
-
Analysis of binding site hot spots on the surface of Ras GTPase
-
Buhrman, G., O'Connor, C., Zerbe, B., Kearney, B. M., Napoleon, R., Kovrigina, E. A., Vajda, S., Kozakov, D., Kovrigin, E. L. and Mattos, C. (2011). Analysis of binding site hot spots on the surface of Ras GTPase. J. Mol. Biol. 413, 773-789.
-
(2011)
J. Mol. Biol.
, vol.413
, pp. 773-789
-
-
Buhrman, G.1
O'Connor, C.2
Zerbe, B.3
Kearney, B.M.4
Napoleon, R.5
Kovrigina, E.A.6
Vajda, S.7
Kozakov, D.8
Kovrigin, E.L.9
Mattos, C.10
-
13
-
-
84907026904
-
Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation
-
Bunda, S., Heir, P., Srikumar, T., Cook, J. D., Burrell, K., Kano, Y., Lee, J. E., Zadeh, G., Raught, B. and Ohh, M. (2014). Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation. Proc. Natl. Acad. Sci. USA 111, E3785-E3794.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. E3785-E3794
-
-
Bunda, S.1
Heir, P.2
Srikumar, T.3
Cook, J.D.4
Burrell, K.5
Kano, Y.6
Lee, J.E.7
Zadeh, G.8
Raught, B.9
Ohh, M.10
-
14
-
-
84964315916
-
Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma
-
Burd, C. E., Liu, W., Huynh, M. V., Waqas, M. A., Gillahan, J. E., Clark, K. S., Fu, K., Martin, B. L., Jeck, W. R., Souroullas, G. P. et al. (2014). Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. Cancer Discov. 4, 1418-1429.
-
(2014)
Cancer Discov.
, vol.4
, pp. 1418-1429
-
-
Burd, C.E.1
Liu, W.2
Huynh, M.V.3
Waqas, M.A.4
Gillahan, J.E.5
Clark, K.S.6
Fu, K.7
Martin, B.L.8
Jeck, W.R.9
Souroullas, G.P.10
-
15
-
-
78649474147
-
Ras history: the saga continues
-
Cox, A. D. and Der, C. J. (2010). Ras history: the saga continues. Small GTPases 1, 2-27.
-
(2010)
Small GTPases
, vol.1
, pp. 2-27
-
-
Cox, A.D.1
Der, C.J.2
-
16
-
-
84908491115
-
Drugging the undruggable RAS: mission possible?
-
Cox, A. D., Fesik, S.W., Kimmelman, A. C., Luo, J. and Der, C. J. (2014). Drugging the undruggable RAS: mission possible? Nat. Rev. Drug Discov. 13, 828-851.
-
(2014)
Nat. Rev. Drug Discov.
, vol.13
, pp. 828-851
-
-
Cox, A.D.1
Fesik, S.W.2
Kimmelman, A.C.3
Luo, J.4
Der, C.J.5
-
17
-
-
84927620483
-
Targeting RAS membrane association: back to the future for anti-RAS drug discovery?
-
Cox, A. D., Der, C.J. and Philips, M. R. (2015). Targeting RAS membrane association: back to the future for anti-RAS drug discovery? Clin. Cancer Res. 21, 1819-1827.
-
(2015)
Clin. Cancer Res.
, vol.21
, pp. 1819-1827
-
-
Cox, A.D.1
Der, C.J.2
Philips, M.R.3
-
18
-
-
0022471217
-
Biological and biochemical properties of human rasH genes mutated at codon 61
-
Der, C. J., Finkel, T. and Cooper, G. M. (1986). Biological and biochemical properties of human rasH genes mutated at codon 61. Cell 44, 167-176.
-
(1986)
Cell
, vol.44
, pp. 167-176
-
-
Der, C.J.1
Finkel, T.2
Cooper, G.M.3
-
19
-
-
80053583350
-
Raft protein clustering alters N-Ras membrane interactions and activation pattern
-
Eisenberg, S., Beckett, A. J., Prior, I. A., Dekker, F. J., Hedberg, C., Waldmann, H., Ehrlich, M. and Henis, Y. I. (2011). Raft protein clustering alters N-Ras membrane interactions and activation pattern. Mol. Cell. Biol. 31, 3938-3952.
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 3938-3952
-
-
Eisenberg, S.1
Beckett, A.J.2
Prior, I.A.3
Dekker, F.J.4
Hedberg, C.5
Waldmann, H.6
Ehrlich, M.7
Henis, Y.I.8
-
20
-
-
84995891892
-
Effect of molecular genotyping to predict outcomes in patients with metastatic pancreatic cancer
-
Faris, J. E., Borger, D. R., Fernandez-del Castillo, C., Clark, J.W., Blaszkowsky, L. S., Zhu, A. X., Allen, J. N., Murphy, J. E., Ferrone, C., Goyal, L. et al. (2014). Effect of molecular genotyping to predict outcomes in patients with metastatic pancreatic cancer. J. Clin. Oncol. 32, 5s; abstract 4128.
-
(2014)
J. Clin. Oncol
, vol.32
, pp. 5s
-
-
Faris, J.E.1
Borger, D.R.2
Fernandez-del Castillo, C.3
Clark, J.W.4
Blaszkowsky, L.S.5
Zhu, A.X.6
Allen, J.N.7
Murphy, J.E.8
Ferrone, C.9
Goyal, L.10
-
21
-
-
84923853645
-
Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD
-
Fetics, S. K., Guterres, H., Kearney, B. M., Buhrman, G., Ma, B., Nussinov, R. and Mattos, C. (2015). Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD. Structure 23, 505-516.
-
(2015)
Structure
, vol.23
, pp. 505-516
-
-
Fetics, S.K.1
Guterres, H.2
Kearney, B.M.3
Buhrman, G.4
Ma, B.5
Nussinov, R.6
Mattos, C.7
-
22
-
-
84893249799
-
PI3K and cancer: lessons, challenges and opportunities
-
Fruman, D. A. and Rommel, C. (2014). PI3K and cancer: lessons, challenges and opportunities. Nat. Rev. Drug Discov. 13, 140-156.
-
(2014)
Nat. Rev. Drug Discov.
, vol.13
, pp. 140-156
-
-
Fruman, D.A.1
Rommel, C.2
-
23
-
-
84903714133
-
Dynamics of KRas on endosomes: involvement of acidic phospholipids in its association
-
Gelabert-Baldrich, M., Soriano-Castell, D., Calvo, M., Lu, A., Vina-Vilaseca, A., Rentero, C., Pol, A., Grinstein, S., Enrich, C. and Tebar, F. (2014). Dynamics of KRas on endosomes: involvement of acidic phospholipids in its association. FASEB J. 28, 3023-3037.
-
(2014)
FASEB J.
, vol.28
, pp. 3023-3037
-
-
Gelabert-Baldrich, M.1
Soriano-Castell, D.2
Calvo, M.3
Lu, A.4
Vina-Vilaseca, A.5
Rentero, C.6
Pol, A.7
Grinstein, S.8
Enrich, C.9
Tebar, F.10
-
24
-
-
84893622205
-
Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response
-
Grabocka, E., Pylayeva-Gupta, Y., Jones, M. J. K., Lubkov, V., Yemanaberhan, E., Taylor, L., Jeng, H. H. and Bar-Sagi, D. (2014). Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response. Cancer Cell 25, 243-256.
-
(2014)
Cancer Cell
, vol.25
, pp. 243-256
-
-
Grabocka, E.1
Pylayeva-Gupta, Y.2
Jones, M.J.K.3
Lubkov, V.4
Yemanaberhan, E.5
Taylor, L.6
Jeng, H.H.7
Bar-Sagi, D.8
-
25
-
-
42649125571
-
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
-
Haigis, K. M., Kendall, K. R., Wang, Y., Cheung, A., Haigis, M. C., Glickman, J. N., Niwa-Kawakita, M., Sweet-Cordero, A., Sebolt-Leopold, J., Shannon, K. M. et al. (2008). Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat. Genet. 40, 600-608.
-
(2008)
Nat. Genet.
, vol.40
, pp. 600-608
-
-
Haigis, K.M.1
Kendall, K.R.2
Wang, Y.3
Cheung, A.4
Haigis, M.C.5
Glickman, J.N.6
Niwa-Kawakita, M.7
Sweet-Cordero, A.8
Sebolt-Leopold, J.9
Shannon, K.M.10
-
26
-
-
84924359443
-
Differential reprogramming of isogenic colorectal cancercells by distinct activating KRAS mutations
-
Hammond, D. E., Mageean, C. J., Rusilowicz, E.V., Wickenden, J. A., Clague, M. J. and Prior, I.A. (2015). Differential reprogramming of isogenic colorectal cancercells by distinct activating KRAS mutations. J. Proteome Res. 14, 1535-1546.
-
(2015)
J. Proteome Res.
, vol.14
, pp. 1535-1546
-
-
Hammond, D.E.1
Mageean, C.J.2
Rusilowicz, E.V.3
Wickenden, J.A.4
Clague, M.J.5
Prior, I.A.6
-
27
-
-
84902603270
-
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C
-
Hunter, J. C., Gurbani, D., Ficarro, S. B., Carrasco, M. A., Lim, S. M., Choi, H. G., Xie, T., Marto, J. A., Chen, Z., Gray, N. S. et al. (2014). In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc. Natl. Acad. Sci. USA 111, 8895-8900.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 8895-8900
-
-
Hunter, J.C.1
Gurbani, D.2
Ficarro, S.B.3
Carrasco, M.A.4
Lim, S.M.5
Choi, H.G.6
Xie, T.7
Marto, J.A.8
Chen, Z.9
Gray, N.S.10
-
28
-
-
84942319192
-
Biochemical and structural analysis of common cancerassociated KRAS mutations
-
Hunter, J. C., Manandhar, A., Carrasco, M. A., Gurbani, D., Gondi, S. and Westover, K. D. (2015). Biochemical and structural analysis of common cancerassociated KRAS mutations. Mol. Cancer Res. 13, 1325-1335.
-
(2015)
Mol. Cancer Res.
, vol.13
, pp. 1325-1335
-
-
Hunter, J.C.1
Manandhar, A.2
Carrasco, M.A.3
Gurbani, D.4
Gondi, S.5
Westover, K.D.6
-
29
-
-
84863116014
-
Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome
-
Ihle, N. T., Byers, L. A., Kim, E. S., Saintigny, P., Lee, J. J., Blumenschein, G. R., Tsao, A., Liu, S., Larsen, J. E., Wang, J. et al. (2012). Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome. J. Natl. Cancer Inst. 104, 228-239.
-
(2012)
J. Natl. Cancer Inst.
, vol.104
, pp. 228-239
-
-
Ihle, N.T.1
Byers, L.A.2
Kim, E.S.3
Saintigny, P.4
Lee, J.J.5
Blumenschein, G.R.6
Tsao, A.7
Liu, S.8
Larsen, J.E.9
Wang, J.10
-
30
-
-
84927144988
-
Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region
-
Jang, H., Abraham, S. J., Chavan, T. S., Hitchinson, B., Khavrutskii, L., Tarasova, N. I., Nussinov, R. and Gaponenko, V. (2015). Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region. J. Biol. Chem. 290, 9465-9477.
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 9465-9477
-
-
Jang, H.1
Abraham, S.J.2
Chavan, T.S.3
Hitchinson, B.4
Khavrutskii, L.5
Tarasova, N.I.6
Nussinov, R.7
Gaponenko, V.8
-
31
-
-
33344475413
-
Differential modification of Ras proteins by ubiquitination
-
Jura, N., Scotto-Lavino, E., Sobczyk, A. and Bar-Sagi, D. (2006). Differential modification of Ras proteins by ubiquitination. Mol. Cell 21, 679-687.
-
(2006)
Mol. Cell
, vol.21
, pp. 679-687
-
-
Jura, N.1
Scotto-Lavino, E.2
Sobczyk, A.3
Bar-Sagi, D.4
-
32
-
-
84910635300
-
Modeling the role of G12V and G13V Ras mutations in the Ras-GAP-catalyzed hydrolysis reaction of guanosine triphosphate
-
Khrenova, M. G., Mironov, V. A., Grigorenko, B. L. and Nemukhin, A. V. (2014). Modeling the role of G12V and G13V Ras mutations in the Ras-GAP-catalyzed hydrolysis reaction of guanosine triphosphate. Biochemistry 53, 7093-7099.
-
(2014)
Biochemistry
, vol.53
, pp. 7093-7099
-
-
Khrenova, M.G.1
Mironov, V.A.2
Grigorenko, B.L.3
Nemukhin, A.V.4
-
33
-
-
13844293072
-
Recognizing and defining true Ras binding domains II: in silico prediction based on homology modelling and energy calculations
-
Kiel, C., Wohlgemuth, S., Rousseau, F., Schymkowitz, J., Ferkinghoff-Borg, J., Wittinghofer, F. and Serrano, L. (2005). Recognizing and defining true Ras binding domains II: in silico prediction based on homology modelling and energy calculations. J. Mol. Biol. 348, 759-775.
-
(2005)
J. Mol. Biol.
, vol.348
, pp. 759-775
-
-
Kiel, C.1
Wohlgemuth, S.2
Rousseau, F.3
Schymkowitz, J.4
Ferkinghoff-Borg, J.5
Wittinghofer, F.6
Serrano, L.7
-
34
-
-
84860319361
-
The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer
-
Kumar, M. S., Hancock, D. C., Molina-Arcas, M., Steckel, M., East, P., Diefenbacher, M., Armenteros-Monterroso, E., Lassailly, F., Matthews, N., Nye, E. et al. (2012). The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer. Cell 149, 642-655.
-
(2012)
Cell
, vol.149
, pp. 642-655
-
-
Kumar, M.S.1
Hancock, D.C.2
Molina-Arcas, M.3
Steckel, M.4
East, P.5
Diefenbacher, M.6
Armenteros-Monterroso, E.7
Lassailly, F.8
Matthews, N.9
Nye, E.10
-
35
-
-
84872107552
-
Rare codons regulate KRas oncogenesis
-
Lampson, B. L., Pershing, N. L. K., Prinz, J. A., Lacsina, J. R., Marzluff, W. F., Nicchitta, C. V., MacAlpine, D. M. and Counter, C. M. (2013). Rare codons regulate KRas oncogenesis. Curr. Biol. 23, 70-75.
-
(2013)
Curr. Biol.
, vol.23
, pp. 70-75
-
-
Lampson, B.L.1
Pershing, N.L.K.2
Prinz, J.A.3
Lacsina, J.R.4
Marzluff, W.F.5
Nicchitta, C.V.6
MacAlpine, D.M.7
Counter, C.M.8
-
36
-
-
84928394480
-
Cancer: the Ras renaissance
-
Ledford, H. (2015). Cancer: the Ras renaissance. Nature 520, 278-280.
-
(2015)
Nature
, vol.520
, pp. 278-280
-
-
Ledford, H.1
-
37
-
-
41649108639
-
Tumour maintenance is mediated by eNOS
-
Lim, K.-H., Ancrile, B. B., Kashatus, D. F. and Counter, C. M. (2008). Tumour maintenance is mediated by eNOS. Nature 452, 646-649.
-
(2008)
Nature
, vol.452
, pp. 646-649
-
-
Lim, K.-H.1
Ancrile, B.B.2
Kashatus, D.F.3
Counter, C.M.4
-
38
-
-
66149091940
-
Agenome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
-
Luo, J., Emanuele, M. J., Li, D., Creighton, C. J., Schlabach, M. R., Westbrook, T. F., Wong, K.-K. and Elledge, S. J. (2009). Agenome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 137, 835-848.
-
(2009)
Cell
, vol.137
, pp. 835-848
-
-
Luo, J.1
Emanuele, M.J.2
Li, D.3
Creighton, C.J.4
Schlabach, M.R.5
Westbrook, T.F.6
Wong, K.-K.7
Elledge, S.J.8
-
39
-
-
84920911274
-
The differential palmitoylation states of N-Ras and H-Ras determine their distinct golgi subcompartment localizations
-
Lynch, S. J., Snitkin, H., Gumper, I., Philips, M. R., Sabatini, D. and Pellicer, A. (2015). The differential palmitoylation states of N-Ras and H-Ras determine their distinct golgi subcompartment localizations. J. Cell. Physiol. 230, 610-619.
-
(2015)
J. Cell. Physiol.
, vol.230
, pp. 610-619
-
-
Lynch, S.J.1
Snitkin, H.2
Gumper, I.3
Philips, M.R.4
Sabatini, D.5
Pellicer, A.6
-
40
-
-
84859463451
-
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
-
Maurer, T., Garrenton, L. S., Oh, A., Pitts, K., Anderson, D. J., Skelton, N. J., Fauber, B. P., Pan, B., Malek, S., Stokoe, D. et al. (2012). Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc. Natl. Acad. Sci. USA 109, 5299-5304.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 5299-5304
-
-
Maurer, T.1
Garrenton, L.S.2
Oh, A.3
Pitts, K.4
Anderson, D.J.5
Skelton, N.J.6
Fauber, B.P.7
Pan, B.8
Malek, S.9
Stokoe, D.10
-
41
-
-
84878110642
-
Prognostic value of K-rasmutation status and subtypes in endoscopic ultrasound-guided fine-needle aspiration specimens from patients with unresectable pancreatic cancer
-
Ogura, T., Yamao, K., Hara, K., Mizuno, N., Hijioka, S., Imaoka, H., Sawaki, A., Niwa, Y., Tajika, M., Kondo, S. et al. (2013). Prognostic value of K-rasmutation status and subtypes in endoscopic ultrasound-guided fine-needle aspiration specimens from patients with unresectable pancreatic cancer. J. Gastroenterol. 48, 640-646.
-
(2013)
J. Gastroenterol.
, vol.48
, pp. 640-646
-
-
Ogura, T.1
Yamao, K.2
Hara, K.3
Mizuno, N.4
Hijioka, S.5
Imaoka, H.6
Sawaki, A.7
Niwa, Y.8
Tajika, M.9
Kondo, S.10
-
42
-
-
84888639050
-
K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions
-
Ostrem, J. M., Peters, U., Sos, M. L., Wells, J. A. and Shokat, K. M. (2013). K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 503, 548-551.
-
(2013)
Nature
, vol.503
, pp. 548-551
-
-
Ostrem, J.M.1
Peters, U.2
Sos, M.L.3
Wells, J.A.4
Shokat, K.M.5
-
43
-
-
84927615339
-
The Ras-membrane interface: isoform-specific differences in the catalytic domain
-
Parker, J. A. and Mattos, C. (2015). The Ras-membrane interface: isoform-specific differences in the catalytic domain. Mol. Cancer Res. 13, 595.
-
(2015)
Mol. Cancer Res.
, vol.13
, pp. 595
-
-
Parker, J.A.1
Mattos, C.2
-
44
-
-
84918495709
-
Therapeutic silencing of KRAS using systemically delivered siRNAs
-
Pecot, C. V., Wu, S. Y., Bellister, S., Filant, J., Rupaimoole, R., Hisamatsu, T., Bhattacharya, R., Maharaj, A., Azam, S., Rodriguez-Aguayo, C. et al. (2014). Therapeutic silencing of KRAS using systemically delivered siRNAs. Mol. Cancer Ther. 13, 2876-2885.
-
(2014)
Mol. Cancer Ther.
, vol.13
, pp. 2876-2885
-
-
Pecot, C.V.1
Wu, S.Y.2
Bellister, S.3
Filant, J.4
Rupaimoole, R.5
Hisamatsu, T.6
Bhattacharya, R.7
Maharaj, A.8
Azam, S.9
Rodriguez-Aguayo, C.10
-
45
-
-
84920450418
-
Rare codons capacitate Kras-driven de novo tumorigenesis
-
Pershing, N. L. K., Lampson, B. L., Belsky, J. A., Kaltenbrun, E., MacAlpine, D. M. and Counter, C. M. (2015). Rare codons capacitate Kras-driven de novo tumorigenesis. J. Clin. Invest. 125, 222-233.
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 222-233
-
-
Pershing, N.L.K.1
Lampson, B.L.2
Belsky, J.A.3
Kaltenbrun, E.4
MacAlpine, D.M.5
Counter, C.M.6
-
46
-
-
84861147473
-
A comprehensive survey of Ras mutations in cancer
-
Prior, I. A., Lewis, P. D. and Mattos, C. (2012). A comprehensive survey of Ras mutations in cancer. Cancer Res. 72, 2457-2467.
-
(2012)
Cancer Res.
, vol.72
, pp. 2457-2467
-
-
Prior, I.A.1
Lewis, P.D.2
Mattos, C.3
-
47
-
-
84862833377
-
Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo
-
Qiu, W., Sahin, F., Iacobuzio-Donahue, C. A., Garcia-Carracedo, D., Wang, W. M., Kuo, C.-Y., Chen, D., Arking, D. E., Lowy, A. M., Hruban, R. H. et al. (2011). Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo. Oncotarget 2, 862-873.
-
(2011)
Oncotarget
, vol.2
, pp. 862-873
-
-
Qiu, W.1
Sahin, F.2
Iacobuzio-Donahue, C.A.3
Garcia-Carracedo, D.4
Wang, W.M.5
Kuo, C.-Y.6
Chen, D.7
Arking, D.E.8
Lowy, A.M.9
Hruban, R.H.10
-
48
-
-
45549094796
-
Analysis of K-Ras phosphorylation, translocation, and induction of apoptosis
-
Quatela, S. E., Sung, P. J., Ahearn, I. M., Bivona, T. G. and Philips, M. R. (2008). Analysis of K-Ras phosphorylation, translocation, and induction of apoptosis. Small Gtpases Dis. Pt. B 439, 87-102.
-
(2008)
Small Gtpases Dis. Pt. B
, vol.439
, pp. 87-102
-
-
Quatela, S.E.1
Sung, P.J.2
Ahearn, I.M.3
Bivona, T.G.4
Philips, M.R.5
-
49
-
-
3242657115
-
Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane
-
Rotblat, B., Prior, I. A., Muncke, C., Parton, R. G., Kloog, Y., Henis, Y. I. and Hancock, J. F. (2004). Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane. Mol. Cell. Biol. 24, 6799-6810.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 6799-6810
-
-
Rotblat, B.1
Prior, I.A.2
Muncke, C.3
Parton, R.G.4
Kloog, Y.5
Henis, Y.I.6
Hancock, J.F.7
-
50
-
-
84921270388
-
Targeting RAS-ERK signalling in cancer: promises and challenges
-
Samatar, A. A. and Poulikakos, P. I. (2014). Targeting RAS-ERK signalling in cancer: promises and challenges. Nat. Rev. Drug Discov. 13, 928-942.
-
(2014)
Nat. Rev. Drug Discov.
, vol.13
, pp. 928-942
-
-
Samatar, A.A.1
Poulikakos, P.I.2
-
51
-
-
33846846261
-
Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells
-
Sarthy, A. V., Morgan-Lappe, S. E., Zakula, D., Vernetti, L., Schurdak, M., Packer, J. C. L., Anderson, M. G., Shirasawa, S., Sasazuki, T. and Fesik, S.W. (2007). Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells. Mol. Cancer Ther. 6, 269-276.
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 269-276
-
-
Sarthy, A.V.1
Morgan-Lappe, S.E.2
Zakula, D.3
Vernetti, L.4
Schurdak, M.5
Packer, J.C.L.6
Anderson, M.G.7
Shirasawa, S.8
Sasazuki, T.9
Fesik, S.W.10
-
52
-
-
79952551201
-
Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors
-
Sasaki, A. T., Carracedo, A., Locasale, J. W., Anastasiou, D., Takeuchi, K., Kahoud, E. R., Haviv, S., Asara, J. M., Pandolfi, P. P. and Cantley, L. C. (2011). Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. Sci. Signal. 4, ra13.
-
(2011)
Sci. Signal
, vol.4
-
-
Sasaki, A.T.1
Carracedo, A.2
Locasale, J.W.3
Anastasiou, D.4
Takeuchi, K.5
Kahoud, E.R.6
Haviv, S.7
Asara, J.M.8
Pandolfi, P.P.9
Cantley, L.C.10
-
53
-
-
65849111219
-
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells
-
Scholl, C., Fröhling, S., Dunn, I. F., Schinzel, A. C., Barbie, D. A., Kim, S. Y., Silver, S. J., Tamayo, P., Wadlow, R. C., Ramaswamy, S. et al. (2009). Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell 137, 821-834.
-
(2009)
Cell
, vol.137
, pp. 821-834
-
-
Scholl, C.1
Fröhling, S.2
Dunn, I.F.3
Schinzel, A.C.4
Barbie, D.A.5
Kim, S.Y.6
Silver, S.J.7
Tamayo, P.8
Wadlow, R.C.9
Ramaswamy, S.10
-
54
-
-
0021126650
-
Biological properties of human c-Ha-ras1 genes mutated at codon 12
-
Seeburg, P. H., Colby, W. W., Capon, D. J., Goeddel, D. V. and Levinson, A. D. (1984). Biological properties of human c-Ha-ras1 genes mutated at codon 12. Nature 312, 71-75.
-
(1984)
Nature
, vol.312
, pp. 71-75
-
-
Seeburg, P.H.1
Colby, W.W.2
Capon, D.J.3
Goeddel, D.V.4
Levinson, A.D.5
-
55
-
-
84877863454
-
In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction
-
Shima, F., Yoshikawa, Y., Ye, M., Araki, M., Matsumoto, S., Liao, J., Hu, L., Sugimoto, T., Ijiri, Y., Takeda, A. et al. (2013). In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc. Natl. Acad. Sci. USA 110, 8182-8187.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 8182-8187
-
-
Shima, F.1
Yoshikawa, Y.2
Ye, M.3
Araki, M.4
Matsumoto, S.5
Liao, J.6
Hu, L.7
Sugimoto, T.8
Ijiri, Y.9
Takeda, A.10
-
56
-
-
84875233112
-
NMR-based functional profiling of RASopathies and oncogenic RAS mutations
-
Smith, M. J., Neel, B. G. and Ikura, M. (2013). NMR-based functional profiling of RASopathies and oncogenic RAS mutations. Proc. Natl. Acad. Sci. USA 110, 4574-4579.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 4574-4579
-
-
Smith, M.J.1
Neel, B.G.2
Ikura, M.3
-
57
-
-
84862649997
-
Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation
-
Sun, Q., Burke, J. P., Phan, J., Burns, M. C., Olejniczak, E. T., Waterson, A. G., Lee, T., Rossanese, O.W. and Fesik, S.W. (2012). Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew. Chem. Int. Ed. Engl. 51, 6140-6143.
-
(2012)
Angew. Chem. Int. Ed. Engl.
, vol.51
, pp. 6140-6143
-
-
Sun, Q.1
Burke, J.P.2
Phan, J.3
Burns, M.C.4
Olejniczak, E.T.5
Waterson, A.G.6
Lee, T.7
Rossanese, O.W.8
Fesik, S.W.9
-
58
-
-
84867117207
-
Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab
-
Tejpar, S., Celik, I., Schlichting, M., Sartorius, U., Bokemeyer, C. and Van Cutsem, E. (2012). Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab. J. Clin. Oncol. 30, 3570-3577.
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 3570-3577
-
-
Tejpar, S.1
Celik, I.2
Schlichting, M.3
Sartorius, U.4
Bokemeyer, C.5
Van Cutsem, E.6
-
59
-
-
84886745490
-
US National Cancer Institute's new Ras project targets an old foe
-
Thompson, H. (2013). US National Cancer Institute's new Ras project targets an old foe. Nat. Med. 19, 949-950.
-
(2013)
Nat. Med.
, vol.19
, pp. 949-950
-
-
Thompson, H.1
-
60
-
-
84942895072
-
Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding
-
Ting, P. Y., Johnson, C. W., Fang, C., Cao, X., Graeber, T. G., Mattos, C. and Colicelli, J. (2015). Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding. FASEB J. 29, 3750-3761.
-
(2015)
FASEB J.
, vol.29
, pp. 3750-3761
-
-
Ting, P.Y.1
Johnson, C.W.2
Fang, C.3
Cao, X.4
Graeber, T.G.5
Mattos, C.6
Colicelli, J.7
-
61
-
-
84883186892
-
Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis
-
To, M. D., Rosario, R. D., Westcott, P. M. K., Banta, K. L. and Balmain, A. (2013). Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis. Oncogene 32, 4028-4033.
-
(2013)
Oncogene
, vol.32
, pp. 4028-4033
-
-
To, M.D.1
Rosario, R.D.2
Westcott, P.M.K.3
Banta, K.L.4
Balmain, A.5
-
62
-
-
84940194038
-
Precision medicine in colorectal cancer: the molecular profile alters treatment strategies
-
Tran, N. H., Cavalcante, L. L., Lubner, S. J., Mulkerin, D. L., LoConte, N. K., Clipson, L., Matkowskyj, K. A. and Deming, D. A. (2015). Precision medicine in colorectal cancer: the molecular profile alters treatment strategies. Ther. Adv. Med. Oncol. 7, 252-262.
-
(2015)
Ther. Adv. Med. Oncol.
, vol.7
, pp. 252-262
-
-
Tran, N.H.1
Cavalcante, L.L.2
Lubner, S.J.3
Mulkerin, D.L.4
LoConte, N.K.5
Clipson, L.6
Matkowskyj, K.A.7
Deming, D.A.8
-
63
-
-
84922287331
-
K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif
-
Tsai, F. D., Lopes, M. S., Zhou, M., Court, H., Ponce, O., Fiordalisi, J. J., Gierut, J. J., Cox, A. D., Haigis, K. M. and Philips, M. R. (2015). K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif. Proc. Natl. Acad. Sci. USA 112, 779-784.
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 779-784
-
-
Tsai, F.D.1
Lopes, M.S.2
Zhou, M.3
Court, H.4
Ponce, O.5
Fiordalisi, J.J.6
Gierut, J.J.7
Cox, A.D.8
Haigis, K.M.9
Philips, M.R.10
-
64
-
-
84925324704
-
Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer
-
Van Cutsem, E., Lenz, H.-J., Kohne, C.-H., Heinemann, V., Tejpar, S., Melezinek, I., Beier, F., Stroh, C., Rougier, P., van Krieken, J. H. et al. (2015). Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer. J. Clin. Oncol. 33, 692-700.
-
(2015)
J. Clin. Oncol.
, vol.33
, pp. 692-700
-
-
Van Cutsem, E.1
Lenz, H.-J.2
Kohne, C.-H.3
Heinemann, V.4
Tejpar, S.5
Melezinek, I.6
Beier, F.7
Stroh, C.8
Rougier, P.9
van Krieken, J.H.10
-
66
-
-
78649487698
-
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
-
Vigil, D., Cherfils, J., Rossman, K. L. and Der, C. J. (2010). Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat. Rev. Cancer 10, 842-857.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 842-857
-
-
Vigil, D.1
Cherfils, J.2
Rossman, K.L.3
Der, C.J.4
-
67
-
-
84925536961
-
The mutational landscapes of genetic and chemical models of Kras-driven lung cancer
-
Westcott, P. M. K., Halliwill, K. D., To, M. D., Rashid, M., Rust, A. G., Keane, T. M., Delrosario, R., Jen, K.-Y., Gurley, K. E., Kemp, C. J. et al. (2015). The mutational landscapes of genetic and chemical models of Kras-driven lung cancer. Nature 517, 489-492.
-
(2015)
Nature
, vol.517
, pp. 489-492
-
-
Westcott, P.M.K.1
Halliwill, K.D.2
To, M.D.3
Rashid, M.4
Rust, A.G.5
Keane, T.M.6
Delrosario, R.7
Jen, K.-Y.8
Gurley, K.E.9
Kemp, C.J.10
-
68
-
-
84948650504
-
Wild-type Hras suppresses the earliest stages of tumorigenesis in a genetically engineered mouse model of pancreatic cancer
-
Weyandt, J. D., Lampson, B. L., Tang, S., Mastrodomenico, M., Cardona, D. M. and Counter, C. M. (2015). Wild-type Hras suppresses the earliest stages of tumorigenesis in a genetically engineered mouse model of pancreatic cancer. PLoS ONE 10, e0140253.
-
(2015)
PLoS ONE
, vol.10
-
-
Weyandt, J.D.1
Lampson, B.L.2
Tang, S.3
Mastrodomenico, M.4
Cardona, D.M.5
Counter, C.M.6
-
69
-
-
84927144113
-
Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets
-
Witkiewicz, A. K., McMillan, E. A., Balaji, U., Baek, G., Lin, W.-C., Mansour, J., Mollaee, M., Wagner, K.-U., Koduru, P., Yopp, A. et al. (2015). Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets. Nat. Commun. 6, 6744.
-
(2015)
Nat. Commun.
, vol.6
, pp. 6744
-
-
Witkiewicz, A.K.1
McMillan, E.A.2
Balaji, U.3
Baek, G.4
Lin, W.-C.5
Mansour, J.6
Mollaee, M.7
Wagner, K.-U.8
Koduru, P.9
Yopp, A.10
-
70
-
-
17144384463
-
Recognizing and defining true Ras binding domains I: biochemical analysis
-
Wohlgemuth, S., Kiel, C., Krämer, A., Serrano, L., Wittinghofer, F. and Herrmann, C. (2005). Recognizing and defining true Ras binding domains I: biochemical analysis. J. Mol. Biol. 348, 741-758.
-
(2005)
J. Mol. Biol.
, vol.348
, pp. 741-758
-
-
Wohlgemuth, S.1
Kiel, C.2
Krämer, A.3
Serrano, L.4
Wittinghofer, F.5
Herrmann, C.6
-
71
-
-
84906706945
-
Small RNA combination therapy for lung cancer
-
Xue, W., Dahlman, J. E., Tammela, T., Khan, O. F., Sood, S., Dave, A., Cai, W., Chirino, L. M., Yang, G. R., Bronson, R. et al. (2014). Small RNA combination therapy for lung cancer. Proc. Natl. Acad. Sci. USA 111, E3553-E3561.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. E3553-E3561
-
-
Xue, W.1
Dahlman, J.E.2
Tammela, T.3
Khan, O.F.4
Sood, S.5
Dave, A.6
Cai, W.7
Chirino, L.M.8
Yang, G.R.9
Bronson, R.10
-
72
-
-
84863587306
-
Regulation of RAS oncogenicity by acetylation
-
Yang, M. H., Nickerson, S., Kim, E. T., Liot, C., Laurent, G., Spang, R., Philips, M. R., Shan, Y., Shaw, D. E., Bar-Sagi, D. et al. (2012). Regulation of RAS oncogenicity by acetylation. Proc. Natl. Acad. Sci. USA 109, 10843-10848.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 10843-10848
-
-
Yang, M.H.1
Nickerson, S.2
Kim, E.T.3
Liot, C.4
Laurent, G.5
Spang, R.6
Philips, M.R.7
Shan, Y.8
Shaw, D.E.9
Bar-Sagi, D.10
-
73
-
-
84872853570
-
Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling
-
Young, A., Lou, D. and McCormick, F. (2013). Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling. Cancer Discov. 3, 112-123.
-
(2013)
Cancer Discov.
, vol.3
, pp. 112-123
-
-
Young, A.1
Lou, D.2
McCormick, F.3
-
74
-
-
84907528772
-
Development of siRNA payloads to target KRAS-mutant cancer
-
Yuan, T. L., Fellmann, C., Lee, C.-S., Ritchie, C. D., Thapar, V., Lee, L. C., Hsu, D. J., Grace, D., Carver, J. O., Zuber, J. et al. (2014). Development of siRNA payloads to target KRAS-mutant cancer. Cancer Discov. 4, 1182-1197.
-
(2014)
Cancer Discov.
, vol.4
, pp. 1182-1197
-
-
Yuan, T.L.1
Fellmann, C.2
Lee, C.-S.3
Ritchie, C.D.4
Thapar, V.5
Lee, L.C.6
Hsu, D.J.7
Grace, D.8
Carver, J.O.9
Zuber, J.10
-
75
-
-
17944369909
-
Wildtype Kras2 can inhibit lung carcinogenesis in mice
-
Zhang, Z., Wang, Y., Vikis, H. G., Johnson, L., Liu, G., Li, J., Anderson, M. W., Sills, R. C., Hong, H. L., Devereux, T. R. et al. (2001). Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat. Genet. 29, 25-33.
-
(2001)
Nat. Genet.
, vol.29
, pp. 25-33
-
-
Zhang, Z.1
Wang, Y.2
Vikis, H.G.3
Johnson, L.4
Liu, G.5
Li, J.6
Anderson, M.W.7
Sills, R.C.8
Hong, H.L.9
Devereux, T.R.10
-
76
-
-
84878401236
-
Small molecule inhibition of the KRAS-PDEdelta interaction impairs oncogenic KRAS signalling
-
Zimmermann, G., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S. A., Triola, G., Wittinghofer, A., Bastiaens, P. I. et al. (2013). Small molecule inhibition of the KRAS-PDEdelta interaction impairs oncogenic KRAS signalling. Nature 497, 638-642.
-
(2013)
Nature
, vol.497
, pp. 638-642
-
-
Zimmermann, G.1
Papke, B.2
Ismail, S.3
Vartak, N.4
Chandra, A.5
Hoffmann, M.6
Hahn, S.A.7
Triola, G.8
Wittinghofer, A.9
Bastiaens, P.I.10
|