Genomic Classification of Cutaneous Melanoma

Cell

Volumn 161, Issue 7, 2015, Pages 1681-1696

  Akbani, Rehan ^a   Akdemir, Kadir C ^a   Aksoy, B Arman ^a   Albert, Monique ^a   Ally, Adrian ^a   Amin, Samirkumar B ^a   Arachchi, Harindra ^a   Arora, Arshi ^a   Auman, J Todd ^a   Ayala, Brenda ^a   Baboud, Julien ^a   Balasundaram, Miruna ^a   Balu, Saianand ^a   Barnabas, Nandita ^a   Bartlett, John ^a   Bartlett, Pam ^a   Bastian, Boris C ^a   Baylin, Stephen B ^a   Behera, Madhusmita ^a   Belyaev, Dmitry ^a   Benz, Christopher ^a   Bernard, Brady ^a   Beroukhim, Rameen ^a   Bir, Natalie ^a   Black, Aaron D ^a   Bodenheimer, Tom ^a   Boice, Lori ^a   Boland, Genevieve M ^a   Bono, Riccardo ^a   Bootwalla, Moiz S ^a   Bosenberg, Marcus ^a   Bowen, Jay ^a   Bowlby, Reanne ^a   Bristow, Christopher A ^a   Brockway Lunardi, Laura ^a   Brooks, Denise ^a   Brzezinski, Jakub ^a   Bshara, Wiam ^a   Buda, Elizabeth ^a   Burns, William R ^a   Butterfield, Yaron S N ^a   Button, Michael ^a   Calderone, Tiffany ^a   Cappellini, Giancarlo Antonini ^a   Carter, Candace ^a   Carter, Scott L ^a   Cherney, Lynn ^a   Cherniack, Andrew D ^a   Chevalier, Aaron ^a   Chin, Lynda ^a   Cho, Juok ^a   Cho, Raymond J ^a   Choi, Yoon La ^a   Chu, Andy ^a   Chudamani, Sudha ^a   Cibulskis, Kristian ^a   Ciriello, Giovanni ^a   Clarke, Amanda ^a   Coons, Stephen ^a   Cope, Leslie ^a   Crain, Daniel ^a   Curley, Erin ^a   Danilova, Ludmila ^a   D'Atri, Stefania ^a   Davidsen, Tanja ^a   Davies, Michael A ^a   Delman, Keith A ^a   Demchok, John A ^a   Deng, Qixia A ^a   Deribe, Yonathan Lissanu ^a   Dhalla, Noreen ^a   Dhir, Rajiv ^a   Dicara, Daniel ^a   Dinikin, Michael ^a   Dubina, Michael ^a   Ebrom, J Stephen ^a   Egea, Sophie ^a   Eley, Greg ^a   Engel, Jay ^a   Eschbacher, Jennifer M ^a   Fedosenko, Konstantin V ^a   Felau, Ina ^a   Fennell, Timothy ^a   Ferguson, Martin L ^a   Fisher, Sheila ^a   Flaherty, Keith T ^a   Frazer, Scott ^a   Frick, Jessica ^a   Fulidou, Victoria ^a   Gabriel, Stacey B ^a   Gao, Jianjiong ^a   Gardner, Johanna ^a   Garraway, Levi A ^a   Gastier Foster, Julie M ^a   Gaudioso, Carmelo ^a   Gehlenborg, Nils ^a   Genovese, Giannicola ^a   Gerken, Mark ^a   Gershenwald, Jeffrey E ^a   Getz, Gad ^a   Gomez Fernandez, Carmen ^a   Gribbin, Thomas ^a   Grimsby, Jonna ^a   Gross, Benjamin ^a   Guin, Ranabir ^a   Gutschner, Tony ^a   Hadjipanayis, Angela ^a   Halaban, Ruth ^a   Hanf, Benjamin ^a   Haussler, David ^a   Haydu, Lauren E ^a   Hayes, D Neil ^a   Hayward, Nicholas K ^a   Heiman, David I ^a   Herbert, Lynn ^a   Herman, James G ^a   Hersey, Peter ^a   Hoadley, Katherine A ^a   Hodis, Eran ^a   Holt, Robert A ^a   Hoon, Dave Sb ^a   Hoppough, Susan ^a   Hoyle, Alan P ^a   Huang, Franklin W ^a   Huang, Mei ^a   Huang, Sharon ^a   Hutter, Carolyn M ^a   Ibbs, Matthew ^a   Iype, Lisa ^a   Jacobsen, Anders ^a   Jakrot, Valerie ^a   Janning, Alyssa ^a   Jeck, William R ^a   Jefferys, Stuart R ^a   Jensen, Mark A ^a   Jones, Corbin D ^a   Jones, Steven J M ^a   Ju, Zhenlin ^a   Kakavand, Hojabr ^a   Kang, Hyojin ^a   Kefford, Richard F ^a   Khuri, Fadlo R ^a   Kim, Jaegil ^a   Kirkwood, John M ^a   Klode, Joachim ^a   Korkut, Anil ^a   Korski, Konstanty ^a   Krauthammer, Michael ^a   Kucherlapati, Raju ^a   Kwong, Lawrence N ^a   Kycler, Witold ^a   Ladanyi, Marc ^a   Lai, Phillip H ^a   Laird, Peter W ^a   Lander, Eric ^a   Lawrence, Michael S ^a   Lazar, Alexander J ^a   Łaźniak, Radoslaw ^a   Lee, Darlene ^a   Lee, Jeffrey E ^a   Lee, Junehawk ^a   Lee, Kenneth ^a   Lee, Semin ^a   Lee, William ^a   Leporowska, Ewa ^a   Leraas, Kristen M ^a   Li, Haiyan I ^a   Lichtenberg, Tara M ^a   Lichtenstein, Lee ^a   Lin, Pei ^a   Ling, Shiyun ^a   Liu, Jia ^a   Liu, Ouida ^a   Liu, Wenbin ^a   Long, Georgina V ^a   Lu, Yiling ^a   Ma, Singer ^a   Ma, Yussanne ^a   Mackiewicz, Andrzej ^a   Mahadeshwar, Harshad S ^a   Malke, Jared ^a   Mallery, David ^a   Manikhas, Georgy M ^a   Mann, Graham J ^a   Marra, Marco A ^a   Matejka, Brenna ^a   Mayo, Michael ^a   Mehrabi, Sousan ^a   Meng, Shaowu ^a   Meyerson, Matthew ^a   Mieczkowski, Piotr A ^a   Miller, John P ^a   Miller, Martin L ^a   Mills, Gordon B ^a   Moiseenko, Fedor ^a   Moore, Richard A ^a   Morris, Scott ^a   Morrison, Carl ^a   Morton, Donald ^a   Moschos, Stergios ^a   Mose, Lisle E ^a   Muller, Florian L ^a   Mungall, Andrew J ^a   Murawa, Dawid ^a   Murawa, Pawel ^a   Murray, Bradley A ^a   Nezi, Luigi ^a   Ng, Sam ^a   Nicholson, Dana ^a   Noble, Michael S ^a   Osunkoya, Adeboye ^a   Owonikoko, Taofeek K ^a   Ozenberger, Bradley A ^a   Pagani, Elena ^a   Paklina, Oxana V ^a   Pantazi, Angeliki ^a   Parfenov, Michael ^a   Parfitt, Jeremy ^a   Park, Peter J ^a   Park, Woong Yang ^a   Parker, Joel S ^a   Passarelli, Francesca ^a   Penny, Robert ^a   Perou, Charles M ^a   Pihl, Todd D ^a   Potapova, Olga ^a   Prieto, Victor G ^a   Protopopov, Alexei ^a   Quinn, Michael J ^a   Radenbaugh, Amie ^a   Rai, Kunal ^a   Ramalingam, Suresh S ^a   Raman, Ayush T ^a   Ramirez, Nilsa C ^a   Ramirez, Ricardo ^a   Rao, Uma ^a   Rathmell, W Kimryn ^a   Ren, Xiaojia ^a   Reynolds, Sheila M ^a   Roach, Jeffrey ^a   Robertson, A Gordon ^a   Ross, Merrick I ^a   Roszik, Jason ^a   Russo, Giandomenico ^a   Saksena, Gordon ^a   Saller, Charles ^a   Samuels, Yardena ^a   Sander, Chris ^a   Sander, Cindy ^a   Sandusky, George ^a   Santoso, Netty ^a   Saul, Melissa ^a   Saw, Robyn Pm ^a   Schadendorf, Dirk ^a   Schein, Jacqueline E ^a   Schultz, Nikolaus ^a   Schumacher, Steven E ^a   Schwallier, Charles ^a   Scolyer, Richard A ^a   Seidman, Jonathan ^a   Sekhar, Pedamallu Chandra ^a   Sekhon, Harmanjatinder S ^a   Senbabaoglu, Yasin ^a   Seth, Sahil ^a   Shannon, Kerwin F ^a   Sharpe, Samantha ^a   Sharpless, Norman E ^a   Shaw, Kenna R Mills ^a   Shelton, Candace ^a   Shelton, Troy ^a   Shen, Ronglai ^a   Sheth, Margi ^a   Shi, Yan ^a   Shiau, Carolyn J ^a   Shmulevich, Ilya ^a   Sica, Gabriel L ^a   Simons, Janae V ^a   Sinha, Rileen ^a   Sipahimalani, Payal ^a   Sofia, Heidi J ^a   Soloway, Matthew G ^a   Song, Xingzhi ^a   Sougnez, Carrie ^a   Spillane, Andrew J ^a   Spychała, Arkadiusz ^a   Stretch, Jonathan R ^a   Stuart, Joshua ^a   Suchorska, Wiktoria M ^a   Sucker, Antje ^a   Sumer, S Onur ^a   Sun, Yichao ^a   Synott, Maria ^a   Tabak, Barbara ^a   Tabler, Teresa R ^a   Tam, Angela ^a   Tan, Donghui ^a   Tang, Jiabin ^a   Tarnuzzer, Roy ^a   Tarvin, Katherine ^a   Tatka, Honorata ^a   Taylor, Barry S ^a   Teresiak, Marek ^a   Thiessen, Nina ^a   Thompson, John F ^a   Thorne, Leigh ^a   Thorsson, Vesteinn ^a   Trent, Jeffrey M ^a   Triche, Timothy J ^a   Tsai, Kenneth Y ^a   Tsou, Peiling ^a   Van Den Berg, David J ^a   Van Allen, Eliezer M ^a   Veluvolu, Umadevi ^a   Verhaak, Roeland G ^a   Voet, Douglas ^a   Voronina, Olga ^a   Walter, Vonn ^a   Walton, Jessica S ^a   Wan, Yunhu ^a   Wang, Yuling ^a   Wang, Zhining ^a   Waring, Scot ^a   Watson, Ian R ^a   Weinhold, Nils ^a   Weinstein, John N ^a   Weisenberger, Daniel J ^a   White, Peter ^a   Wilkerson, Matthew D ^a   Wilmott, James S ^a   Wise, Lisa ^a   Wiznerowicz, Maciej ^a   Woodman, Scott E ^a   Wu, Chang Jiun ^a   Wu, Chia Chin ^a   Wu, Junyuan ^a   Wu, Ye ^a   Xi, Ruibin ^a   Xu, Andrew Wei ^a   Yang, Da ^a   Yang, Liming ^a   Yang, Lixing ^a   Zack, Travis I ^a   Zenklusen, Jean C ^a   Zhang, Hailei ^a   Zhang, Jianhua ^a   Zhang, Wei ^a   Zhao, Xiaobei ^a   Zhu, Jingchun ^a   Zhu, Kelsey ^a   Zimmer, Lisa ^a   Zmuda, Erik ^a   Zou, Lihua ^a   more..

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; MUTANT PROTEIN; NEUROFIBROMIN; PROTEIN KINASE LCK; RAS PROTEIN;

ADULT; ARTICLE; CANCER CLASSIFICATION; CANCER GENETICS; CANCER PROGNOSIS; CANCER SURVIVAL; CUTANEOUS MELANOMA; GENE AMPLIFICATION; GENE EXPRESSION; GENE MUTATION; GENE REARRANGEMENT; GENOMIC CLASSIFICATION; GENOMICS; HUMAN; HUMAN TISSUE; IMMUNOBIOLOGY; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REGIONAL METASTASIS; TRANSCRIPTOMICS; WILD TYPE; CLASSIFICATION; GENETIC DATABASE; GENETICS; MELANOMA; MUTATION; NATIONAL HEALTH ORGANIZATION; SKIN TUMOR; UNITED STATES;

DATABASES, GENETIC; HUMANS; MELANOMA; MUTATION; NATIONAL CANCER INSTITUTE (U.S.); SKIN NEOPLASMS; UNITED STATES;

EID: 84935009372     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2015.05.044     Document Type: Article

References (68)

1. L.B. Andersen, J.W. Fountain, D.H. Gutmann, S.A. Tarlé, T.W. Glover, N.C. Dracopoli, D.E. Housman, and F.S. Collins Mutations in the neurofibromatosis 1 gene in sporadic malignant melanoma cell lines Nat. Genet. 3 1993 118 121
2. P.A. Ascierto, E. Simeone, V.C. Sileni, J. Pigozzo, M. Maio, M. Altomonte, M. Del Vecchio, L. Di Guardo, P. Marchetti, and R. Ridolfi Clinical experience with ipilimumab 3 mg/kg: real-world efficacy and safety data from an expanded access programme cohort J. Transl. Med. 12 2014 116
3. F. Azimi, R.A. Scolyer, P. Rumcheva, M. Moncrieff, R. Murali, S.W. McCarthy, R.P. Saw, and J.F. Thompson Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma J. Clin. Oncol. 30 2012 2678 2683
4. P. Baade, X. Meng, D. Youlden, J. Aitken, and P. Youl Time trends and latitudinal differences in melanoma thickness distribution in Australia, 1990-2006 Int. J. Cancer 130 2012 170 178
5. C.M. Balch, J.E. Gershenwald, S.J. Soong, J.F. Thompson, M.B. Atkins, D.R. Byrd, A.C. Buzaid, A.J. Cochran, D.G. Coit, and S. Ding Final version of 2009 AJCC melanoma staging and classification J. Clin. Oncol. 27 2009 6199 6206
6. C.M. Balch, J.E. Gershenwald, S.J. Soong, J.F. Thompson, S. Ding, D.R. Byrd, N. Cascinelli, A.J. Cochran, D.G. Coit, and A.M. Eggermont Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: comparison of nodal micrometastases versus macrometastases J. Clin. Oncol. 28 2010 2452 2459
7. M.F. Berger, E. Hodis, T.P. Heffernan, Y.L. Deribe, M.S. Lawrence, A. Protopopov, E. Ivanova, I.R. Watson, E. Nickerson, and P. Ghosh Melanoma genome sequencing reveals frequent PREX2 mutations Nature 485 2012 502 506
8. D. Bogunovic, D.W. O'Neill, I. Belitskaya-Levy, V. Vacic, Y.L. Yu, S. Adams, F. Darvishian, R. Berman, R. Shapiro, and A.C. Pavlick Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival Proc. Natl. Acad. Sci. USA 106 2009 20429 20434
9. J.R. Brahmer, S.S. Tykodi, L.Q. Chow, W.J. Hwu, S.L. Topalian, P. Hwu, C.G. Drake, L.H. Camacho, J. Kauh, and K. Odunsi Safety and activity of anti-PD-L1 antibody in patients with advanced cancer N. Engl. J. Med. 366 2012 2455 2465
10. D.E. Brash UV signature mutations Photochem. Photobiol. 91 2015 15 26
11. C.W. Brennan, R.G. Verhaak, A. McKenna, B. Campos, H. Noushmehr, S.R. Salama, S. Zheng, D. Chakravarty, J.Z. Sanborn, S.H. Berman TCGA Research Network The somatic genomic landscape of glioblastoma Cell 155 2013 462 477
12. S.L. Carter, K. Cibulskis, E. Helman, A. McKenna, H. Shen, T. Zack, P.W. Laird, R.C. Onofrio, W. Winckler, and B.A. Weir Absolute quantification of somatic DNA alterations in human cancer Nat. Biotechnol. 30 2012 413 421
13. R.D. Carvajal, C.R. Antonescu, J.D. Wolchok, P.B. Chapman, R.A. Roman, J. Teitcher, K.S. Panageas, K.J. Busam, B. Chmielowski, and J. Lutzky KIT as a therapeutic target in metastatic melanoma JAMA 305 2011 2327 2334
14. V.D. Criscione, and M.A. Weinstock Melanoma thickness trends in the United States, 1988-2006 J. Invest. Dermatol. 130 2010 793 797
15. J.A. Curtin, J. Fridlyand, T. Kageshita, H.N. Patel, K.J. Busam, H. Kutzner, K.H. Cho, S. Aiba, E.B. Bröcker, and P.E. LeBoit Distinct sets of genetic alterations in melanoma N. Engl. J. Med. 353 2005 2135 2147
16. T. Dasgupta, L. Bowden, and J.W. Berg Malignant Melanoma of Unknown Primary Origin Surg. Gynecol. Obstet. 117 1963 341 345
17. G.J. Draper, B.M. Sanders, and J.E. Kingston Second primary neoplasms in patients with retinoblastoma Br. J. Cancer 53 1986 661 671
18. K. Dutton-Regester, J.J. Gartner, R. Emmanuel, N. Qutob, M.A. Davies, J.E. Gershenwald, W. Robinson, S. Robinson, S.A. Rosenberg, and R.A. Scolyer A highly recurrent RPS27 5′UTR mutation in melanoma Oncotarget 5 2014 2912 2917
19. A.M. Eggermont, S. Suciu, M. Santinami, A. Testori, W.H. Kruit, J. Marsden, C.J. Punt, F. Salès, M. Gore, R. Mackie EORTC Melanoma Group Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial Lancet 372 2008 117 126
20. G. Erdag, J.T. Schaefer, M.E. Smolkin, D.H. Deacon, S.M. Shea, L.T. Dengel, J.W. Patterson, and C.L. Slingluff Jr. Immunotype and immunohistologic characteristics of tumor-infiltrating immune cells are associated with clinical outcome in metastatic melanoma Cancer Res. 72 2012 1070 1080
21. M.G. Field, and J.W. Harbour Recent developments in prognostic and predictive testing in uveal melanoma Curr. Opin. Ophthalmol. 25 2014 234 239
22. D.T. Frederick, R.A. Salas Fragomeni, A. Schalck, I. Ferreiro-Neira, T. Hoff, Z.A. Cooper, R. Haq, D.J. Panka, L.N. Kwong, and M.A. Davies Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics PLoS ONE 9 2014 e101286
23. J.E. Gershenwald, and M.I. Ross Sentinel-lymph-node biopsy for cutaneous melanoma N. Engl. J. Med. 364 2011 1738 1745
24. H.L. Gold, J. Wengrod, E.V. de Miera, D. Wang, N. Fleming, L. Sikkema, T. Kirchhoff, T. Hochman, J.D. Goldberg, I. Osman, and L.B. Gardner PP6C hotspot mutations in melanoma display sensitivity to Aurora kinase inhibition Mol. Cancer Res. 12 2014 433 439
25. O. Hamid, C. Robert, A. Daud, F.S. Hodi, W.J. Hwu, R. Kefford, J.D. Wolchok, P. Hersey, R.W. Joseph, and J.S. Weber Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma N. Engl. J. Med. 369 2013 134 144
26. K.C. Helming, X. Wang, B.G. Wilson, F. Vazquez, J.R. Haswell, H.E. Manchester, Y. Kim, G.V. Kryukov, M. Ghandi, and A.J. Aguirre ARID1B is a specific vulnerability in ARID1A-mutant cancers Nat. Med. 20 2014 251 254
27. F.S. Hodi, P. Friedlander, C.L. Corless, M.C. Heinrich, S. Mac Rae, A. Kruse, J. Jagannathan, A.D. Van den Abbeele, E.F. Velazquez, G.D. Demetri, and D.E. Fisher Major response to imatinib mesylate in KIT-mutated melanoma J. Clin. Oncol. 26 2008 2046 2051
28. E. Hodis, I.R. Watson, G.V. Kryukov, S.T. Arold, M. Imielinski, J.P. Theurillat, E. Nickerson, D. Auclair, L. Li, and C. Place A landscape of driver mutations in melanoma Cell 150 2012 251 263
29. S. Horn, A. Figl, P.S. Rachakonda, C. Fischer, A. Sucker, A. Gast, S. Kadel, I. Moll, E. Nagore, and K. Hemminki TERT promoter mutations in familial and sporadic melanoma Science 339 2013 959 961
30. F.W. Huang, E. Hodis, M.J. Xu, G.V. Kryukov, L. Chin, and L.A. Garraway Highly recurrent TERT promoter mutations in human melanoma Science 339 2013 957 959
31. S.S. Jayaraman, D.J. Rayhan, S. Hazany, and M.S. Kolodney Mutational landscape of basal cell carcinomas by whole-exome sequencing J. Invest. Dermatol. 134 2014 213 220
32. Z. Ji, R. Kumar, M. Taylor, A. Rajadurai, A. Marzuka-Alcalá, Y.E. Chen, C.N. Njauw, K. Flaherty, G. Jönsson, and H. Tsao Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth Clin. Cancer Res. 19 2013 4383 4391
33. J.M. Kirkwood, M.H. Strawderman, M.S. Ernstoff, T.J. Smith, E.C. Borden, and R.H. Blum Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684 J. Clin. Oncol. 14 1996 7 17
34. M. Krauthammer, Y. Kong, B.H. Ha, P. Evans, A. Bacchiocchi, J.P. McCusker, E. Cheng, M.J. Davis, G. Goh, and M. Choi Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma Nat. Genet. 44 2012 1006 1014
35. H.V. Küsters-Vandevelde, A. Klaasen, B. Küsters, P.J. Groenen, I.A. van Engen-van Grunsven, M.R. van Dijk, G. Reifenberger, P. Wesseling, and W.A. Blokx Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system Acta Neuropathol. 119 2010 317 323
36. M.S. Lawrence, P. Stojanov, P. Polak, G.V. Kryukov, K. Cibulskis, A. Sivachenko, S.L. Carter, C. Stewart, C.H. Mermel, and S.A. Roberts Mutational heterogeneity in cancer and the search for new cancer-associated genes Nature 499 2013 214 218
37. M.S. Lawrence, P. Stojanov, C.H. Mermel, J.T. Robinson, L.A. Garraway, T.R. Golub, M. Meyerson, S.B. Gabriel, E.S. Lander, and G. Getz Discovery and saturation analysis of cancer genes across 21 tumour types Nature 505 2014 495 501
38. G.Y. Lopez, Z.J. Reitman, D. Solomon, T. Waldman, D.D. Bigner, R.E. McLendon, S.A. Rosenberg, Y. Samuels, and H. Yan IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain Biochem. Biophys. Res. Commun. 398 2010 585 587
39. J. Lutzky, J. Bauer, and B.C. Bastian Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation Pigment Cell Melanoma Res. 21 2008 492 493
40. O. Maertens, B. Johnson, P. Hollstein, D.T. Frederick, Z.A. Cooper, L. Messiaen, R.T. Bronson, M. McMahon, S. Granter, and K. Flaherty Elucidating distinct roles for NF1 in melanomagenesis Cancer Discov. 3 2013 338 349
41. G.J. Mann, G.M. Pupo, A.E. Campain, C.D. Carter, S.J. Schramm, S. Pianova, S.K. Gerega, C. De Silva, K. Lai, and J.S. Wilmott BRAF mutation, NRAS mutation, and the absence of an immune-related expressed gene profile predict poor outcome in patients with stage III melanoma J. Invest. Dermatol. 133 2013 509 517
42. G.A. McArthur, and A. Ribas Targeting oncogenic drivers and the immune system in melanoma J. Clin. Oncol. 31 2013 499 506
43. M.C. Mihm Jr., C.G. Clemente, and N. Cascinelli Tumor infiltrating lymphocytes in lymph node melanoma metastases: a histopathologic prognostic indicator and an expression of local immune response Lab. Invest. 74 1996 43 47
44. D.L. Morton, J.F. Thompson, A.J. Cochran, N. Mozzillo, O.E. Nieweg, D.F. Roses, H.J. Hoekstra, C.P. Karakousis, C.A. Puleo, B.J. Coventry MSLT Group Final trial report of sentinel-node biopsy versus nodal observation in melanoma N. Engl. J. Med. 370 2014 599 609
45. S.I. Nikolaev, D. Rimoldi, C. Iseli, A. Valsesia, D. Robyr, C. Gehrig, K. Harshman, M. Guipponi, O. Bukach, and V. Zoete Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma Nat. Genet. 44 2012 133 139
46. M.H. Nissan, C.A. Pratilas, A.M. Jones, R. Ramirez, H. Won, C. Liu, S. Tiwari, L. Kong, A.J. Hanrahan, and Z. Yao Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence Cancer Res. 74 2014 2340 2350
47. H. Noushmehr, D.J. Weisenberger, K. Diefes, H.S. Phillips, K. Pujara, B.P. Berman, F. Pan, C.E. Pelloski, E.P. Sulman, K.P. Bhat Cancer Genome Atlas Research Network Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma Cancer Cell 17 2010 510 522
48. P.M. Pollock, U.L. Harper, K.S. Hansen, L.M. Yudt, M. Stark, C.M. Robbins, T.Y. Moses, G. Hostetter, U. Wagner, and J. Kakareka High frequency of BRAF mutations in nevi Nat. Genet. 33 2003 19 20
49. Z. Rakosy, S. Ecsedi, R. Toth, L. Vizkeleti, H. Hernandez-Vargas, V. Lazar, G. Emri, I. Szatmari, Z. Herceg, R. Adany, and M. Balazs Integrative genomics identifies gene signature associated with melanoma ulceration PLoS ONE 8 2013 e54958
50. M. Ranzani, C. Alifrangis, D. Perna, K. Dutton-Regester, A. Pritchard, K. Wong, M. Rashid, C.D. Robles-Espinoza, N.K. Hayward, and U. McDermott BRAF/NRAS wild-type melanoma, NF1 status and sensitivity to trametinib Pigment Cell Melanoma Res. 28 2015 117 119
51. P.F. Robbins, Y.C. Lu, M. El-Gamil, Y.F. Li, C. Gross, J. Gartner, J.C. Lin, J.K. Teer, P. Cliften, and E. Tycksen Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells Nat. Med. 19 2013 747 752
52. C. Robert, A. Ribas, J.D. Wolchok, F.S. Hodi, O. Hamid, R. Kefford, J.S. Weber, A.M. Joshua, W.J. Hwu, and T.C. Gangadhar Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial Lancet 384 2014 1109 1117
53. D.J. Santa Cruz, P.D. Hamilton, D.J. Klos, and J.A. Fernandez-Pol Differential expression of metallopanstimulin/S27 ribosomal protein in melanocytic lesions of the skin J. Cutan. Pathol. 24 1997 533 542
54. J.M. Shields, N.E. Thomas, M. Cregger, A.J. Berger, M. Leslie, C. Torrice, H. Hao, S. Penland, J. Arbiser, and G. Scott Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma Cancer Res. 67 2007 1502 1512
55. A. Snyder, V. Makarov, T. Merghoub, J. Yuan, J.M. Zaretsky, A. Desrichard, L.A. Walsh, M.A. Postow, P. Wong, and T.S. Ho Genetic basis for clinical response to CTLA-4 blockade in melanoma N. Engl. J. Med. 371 2014 2189 2199
56. D. Sun, Z. Li, Y. Rew, M. Gribble, M.D. Bartberger, H.P. Beck, J. Canon, A. Chen, X. Chen, and D. Chow Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development J. Med. Chem. 57 2014 1454 1472
57. TCGA (Cancer Genome Atlas Research Network) Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature 455 2008 1061 1068
58. TCGA (Cancer Genome Atlas Research Network) Comprehensive genomic characterization of squamous cell lung cancers Nature 489 2012 519 525
59. TCGA (Cancer Genome Atlas Research Network) Comprehensive molecular characterization of urothelial bladder carcinoma Nature 507 2014 315 322
60. TCGA (Cancer Genome Atlas Research Network) Comprehensive molecular profiling of lung adenocarcinoma Nature 511 2014 543 550
61. P. Terheyden, R. Houben, P. Pajouh, C. Thorns, D. Zillikens, and J.C. Becker Response to imatinib mesylate depends on the presence of the V559A-mutated KIT oncogene J. Invest. Dermatol. 130 2010 314 316
62. S.L. Topalian, F.S. Hodi, J.R. Brahmer, S.N. Gettinger, D.C. Smith, D.F. McDermott, J.D. Powderly, R.D. Carvajal, J.A. Sosman, and M.B. Atkins Safety, activity, and immune correlates of anti-PD-1 antibody in cancer N. Engl. J. Med. 366 2012 2443 2454
63. H. Tsao, L. Chin, L.A. Garraway, and D.E. Fisher Melanoma: from mutations to medicine Genes Dev. 26 2012 1131 1155
64. P.C. Tumeh, C.L. Harview, J.H. Yearley, I.P. Shintaku, E.J. Taylor, L. Robert, B. Chmielowski, M. Spasic, G. Henry, and V. Ciobanu PD-1 blockade induces responses by inhibiting adaptive immune resistance Nature 515 2014 568 571
65. E.M. Van Allen, N. Wagle, A. Sucker, D.J. Treacy, C.M. Johannessen, E.M. Goetz, C.S. Place, A. Taylor-Weiner, S. Whittaker, G.V. Kryukov Dermatologic Cooperative Oncology Group of Germany (DeCOG) The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma Cancer Discov. 4 2014 94 109
66. I.R. Watson, L. Li, P.K. Cabeceiras, M. Mahdavi, T. Gutschner, G. Genovese, G. Wang, Z. Fang, J.M. Tepper, and K. Stemke-Hale The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF Cancer Res. 74 2014 4845 4852
67. S.R. Whittaker, J.P. Theurillat, E. Van Allen, N. Wagle, J. Hsiao, G.S. Cowley, D. Schadendorf, D.E. Root, and L.A. Garraway A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition Cancer Discov. 3 2013 350 362
68. V. Winnepenninckx, V. Lazar, S. Michiels, P. Dessen, M. Stas, S.R. Alonso, M.F. Avril, P.L. Ortiz Romero, T. Robert, O. Balacescu Melanoma Group of the European Organization for Research and Treatment of Cancer Gene expression profiling of primary cutaneous melanoma and clinical outcome J. Natl. Cancer Inst. 98 2006 472 482