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Volumn 74, Issue 1, 2017, Pages 93-115

Role of CFTR in epithelial physiology

Author keywords

Bicarbonate; CFTR; Chloride; Epithelial transport; Physiology

Indexed keywords

BICARBONATE; CHLORIDE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR;

EID: 84990988081     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-016-2391-y     Document Type: Review
Times cited : (292)

References (224)
  • 1
    • 84904253124 scopus 로고    scopus 로고
    • Mechanism and synergism in epithelial fluid and electrolyte secretion
    • COI: 1:CAS:528:DC%2BC3sXhslyls7%2FO, PID: 24240699
    • Hong JH, Park S, Shcheynikov N, Muallem S (2014) Mechanism and synergism in epithelial fluid and electrolyte secretion. Pflugers Arch 466:1487–1499
    • (2014) Pflugers Arch , vol.466 , pp. 1487-1499
    • Hong, J.H.1    Park, S.2    Shcheynikov, N.3    Muallem, S.4
  • 2
    • 33645843051 scopus 로고    scopus 로고
    • Claudin-8 modulates paracellular permeability to acidic and basic ions in MDCK II cells
    • COI: 1:CAS:528:DC%2BD28XislKnu7w%3D, PID: 16322055
    • Angelow S, Kim KJ, Yu AS (2006) Claudin-8 modulates paracellular permeability to acidic and basic ions in MDCK II cells. J Physiol 571:15–26
    • (2006) J Physiol , vol.571 , pp. 15-26
    • Angelow, S.1    Kim, K.J.2    Yu, A.S.3
  • 4
    • 84873658440 scopus 로고    scopus 로고
    • Claudins and the kidney
    • COI: 1:CAS:528:DC%2BC3sXjvFOnt74%3D, PID: 23140368
    • Hou J, Rajagopal M, Yu AS (2013) Claudins and the kidney. Annu Rev Physiol 75:479–501
    • (2013) Annu Rev Physiol , vol.75 , pp. 479-501
    • Hou, J.1    Rajagopal, M.2    Yu, A.S.3
  • 5
    • 84878506887 scopus 로고    scopus 로고
    • Claudins and the modulation of tight junction permeability
    • PID: 23589827
    • Gunzel D, Yu AS (2013) Claudins and the modulation of tight junction permeability. Physiol Rev 93:525–569
    • (2013) Physiol Rev , vol.93 , pp. 525-569
    • Gunzel, D.1    Yu, A.S.2
  • 6
    • 78149272646 scopus 로고    scopus 로고
    • Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization
    • COI: 1:CAS:528:DC%2BC3cXhtlCqsbfK, PID: 20921420
    • Hou J, Renigunta A, Yang J, Waldegger S (2010) Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization. Proc Natl Acad Sci USA 107:18010–18015
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 18010-18015
    • Hou, J.1    Renigunta, A.2    Yang, J.3    Waldegger, S.4
  • 7
    • 0035354574 scopus 로고    scopus 로고
    • Molecular structure of tight junctions and their role in epithelial transport
    • COI: 1:CAS:528:DC%2BD3MXkvFelsrs%3D, PID: 11443232
    • Anderson JM (2001) Molecular structure of tight junctions and their role in epithelial transport. News Physiol Sci 16:126–130
    • (2001) News Physiol Sci , vol.16 , pp. 126-130
    • Anderson, J.M.1
  • 8
    • 0015494421 scopus 로고
    • Route of passive ion permeation in epithelia
    • COI: 1:STN:280:DyaE387msVSgsQ%3D%3D, PID: 4502409
    • Fromter E, Diamond J (1972) Route of passive ion permeation in epithelia. Nat New Biol 235:9–13
    • (1972) Nat New Biol , vol.235 , pp. 9-13
    • Fromter, E.1    Diamond, J.2
  • 9
    • 78149479824 scopus 로고    scopus 로고
    • Fluid transport across leaky epithelia: central role of the tight junction and supporting role of aquaporins
    • COI: 1:CAS:528:DC%2BC3cXhsFSqtbvK, PID: 20959616
    • Fischbarg J (2010) Fluid transport across leaky epithelia: central role of the tight junction and supporting role of aquaporins. Physiol Rev 90:1271–1290
    • (2010) Physiol Rev , vol.90 , pp. 1271-1290
    • Fischbarg, J.1
  • 10
    • 0036211683 scopus 로고    scopus 로고
    • Paracellular fluid transport by epithelia
    • COI: 1:CAS:528:DC%2BD38XjsFCrt7k%3D, PID: 11952233
    • Shachar-Hill B, Hill AE (2002) Paracellular fluid transport by epithelia. Int Rev Cytol 215:319–350
    • (2002) Int Rev Cytol , vol.215 , pp. 319-350
    • Shachar-Hill, B.1    Hill, A.E.2
  • 11
    • 0034078270 scopus 로고    scopus 로고
    • Aquaporin water channels and lung physiology
    • COI: 1:CAS:528:DC%2BD3cXjvFagt7c%3D, PID: 10781416
    • Verkman AS, Matthay MA, Song Y (2000) Aquaporin water channels and lung physiology. Am J Physiol Lung Cell Mol Physiol 278:L867–L879
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.278 , pp. L867-L879
    • Verkman, A.S.1    Matthay, M.A.2    Song, Y.3
  • 12
    • 84868096271 scopus 로고    scopus 로고
    • Bicarbonate-dependent chloride transport drives fluid secretion by the human airway epithelial cell line Calu-3
    • COI: 1:CAS:528:DC%2BC38XhvVahtbfL, PID: 22777674
    • Shan J, Liao J, Huang J, Robert R, Palmer ML, Fahrenkrug SC, O’Grady SM, Hanrahan JW (2012) Bicarbonate-dependent chloride transport drives fluid secretion by the human airway epithelial cell line Calu-3. J Physiol 590:5273–5297
    • (2012) J Physiol , vol.590 , pp. 5273-5297
    • Shan, J.1    Liao, J.2    Huang, J.3    Robert, R.4    Palmer, M.L.5    Fahrenkrug, S.C.6    O’Grady, S.M.7    Hanrahan, J.W.8
  • 13
    • 79952441604 scopus 로고    scopus 로고
    • An overview of international literature from cystic fibrosis registries. Part 3. Disease incidence, genotype/phenotype correlation, microbiology, pregnancy, clinical complications, lung transplantation, and miscellanea
    • PID: 21257352
    • Salvatore D, Buzzetti R, Baldo E, Forneris MP, Lucidi V, Manunza D, Marinelli I, Messore B, Neri AS, Raia V, Furnari ML, Mastella G (2011) An overview of international literature from cystic fibrosis registries. Part 3. Disease incidence, genotype/phenotype correlation, microbiology, pregnancy, clinical complications, lung transplantation, and miscellanea. J Cyst Fibros 10:71–85
    • (2011) J Cyst Fibros , vol.10 , pp. 71-85
    • Salvatore, D.1    Buzzetti, R.2    Baldo, E.3    Forneris, M.P.4    Lucidi, V.5    Manunza, D.6    Marinelli, I.7    Messore, B.8    Neri, A.S.9    Raia, V.10    Furnari, M.L.11    Mastella, G.12
  • 14
    • 33845933518 scopus 로고    scopus 로고
    • A survey of newborn screening for cystic fibrosis in Europe
    • Southern KW, Munck A, Pollitt R, Travert G, Zanolla L, Dankert-Roelse J, Castellani C
    • Southern KW, Munck A, Pollitt R, Travert G, Zanolla L, Dankert-Roelse J, Castellani C, Group ECNSW (2007) A survey of newborn screening for cystic fibrosis in Europe. J Cyst Fibros 6:57–65
    • (2007) J Cyst Fibros , vol.6 , pp. 57-65
  • 15
    • 84902333547 scopus 로고    scopus 로고
    • The relative frequency of CFTR mutation classes in European patients with cystic fibrosis
    • PID: 24440181
    • De Boeck K, Zolin A, Cuppens H, Olesen HV, Viviani L (2014) The relative frequency of CFTR mutation classes in European patients with cystic fibrosis. J Cyst Fibros 13:403–409
    • (2014) J Cyst Fibros , vol.13 , pp. 403-409
    • De Boeck, K.1    Zolin, A.2    Cuppens, H.3    Olesen, H.V.4    Viviani, L.5
  • 17
  • 18
    • 0032913809 scopus 로고    scopus 로고
    • Physiological basis of cystic fibrosis: a historical perspective
    • COI: 1:CAS:528:DyaK1MXhs1Oku7k%3D, PID: 9922374
    • Quinton PM (1999) Physiological basis of cystic fibrosis: a historical perspective. Physiol Rev 79:S3–S22
    • (1999) Physiol Rev , vol.79 , pp. S3-S22
    • Quinton, P.M.1
  • 19
    • 84941049266 scopus 로고    scopus 로고
    • CFTR, bicarbonate, and the pathophysiology of cystic fibrosis
    • PID: 26335950
    • Borowitz D (2015) CFTR, bicarbonate, and the pathophysiology of cystic fibrosis. Pediatr Pulmonol 50(Suppl 40):S24–S30
    • (2015) Pediatr Pulmonol , vol.50 , pp. S24-S30
    • Borowitz, D.1
  • 20
    • 84893001120 scopus 로고    scopus 로고
    • SLC26 anion exchangers in uterine epithelial cells and spermatozoa: clues from the past and hints to the future
    • COI: 1:CAS:528:DC%2BC3sXhvFyrt73E, PID: 24115633
    • Chan HC, Sun X (2014) SLC26 anion exchangers in uterine epithelial cells and spermatozoa: clues from the past and hints to the future. Cell Biol Int 38:1–7
    • (2014) Cell Biol Int , vol.38 , pp. 1-7
    • Chan, H.C.1    Sun, X.2
  • 22
    • 84864020925 scopus 로고    scopus 로고
    • The physiology of bicarbonate transporters in mammalian reproduction
    • PID: 22262691
    • Liu Y, Wang DK, Chen LM (2012) The physiology of bicarbonate transporters in mammalian reproduction. Biol Reprod 86:99
    • (2012) Biol Reprod , vol.86 , pp. 99
    • Liu, Y.1    Wang, D.K.2    Chen, L.M.3
  • 23
    • 84888203558 scopus 로고    scopus 로고
    • Gastrointestinal HCO3- transport and epithelial protection in the gut: new techniques, transport pathways and regulatory pathways
    • COI: 1:CAS:528:DC%2BC3sXhs1yqs77P, PID: 24280619
    • Seidler UE (2013) Gastrointestinal HCO3- transport and epithelial protection in the gut: new techniques, transport pathways and regulatory pathways. Curr Opin Pharmacol 13:900–908
    • (2013) Curr Opin Pharmacol , vol.13 , pp. 900-908
    • Seidler, U.E.1
  • 24
    • 59349091561 scopus 로고    scopus 로고
    • Chloride channels as drug targets
    • COI: 1:CAS:528:DC%2BD1MXntFKjsA%3D%3D, PID: 19153558
    • Verkman AS, Galietta LJ (2009) Chloride channels as drug targets. Nat Rev Drug Discov 8:153–171
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 153-171
    • Verkman, A.S.1    Galietta, L.J.2
  • 25
    • 0014840076 scopus 로고
    • Ultrastructure of cells in the human bronchial submucosal glands
    • COI: 1:STN:280:DyaE3M%2FlslyltA%3D%3D, PID: 5487122
    • Meyrick B, Reid L (1970) Ultrastructure of cells in the human bronchial submucosal glands. J Anat 107:281–299
    • (1970) J Anat , vol.107 , pp. 281-299
    • Meyrick, B.1    Reid, L.2
  • 26
    • 0032731843 scopus 로고    scopus 로고
    • CFTR involvement in chloride, bicarbonate, and liquid secretion by airway submucosal glands
    • COI: 1:CAS:528:DyaK1MXntFCju74%3D, PID: 10516209
    • Ballard ST, Trout L, Bebok Z, Sorscher EJ, Crews A (1999) CFTR involvement in chloride, bicarbonate, and liquid secretion by airway submucosal glands. Am J Physiol 277:L694–L699
    • (1999) Am J Physiol , vol.277 , pp. L694-L699
    • Ballard, S.T.1    Trout, L.2    Bebok, Z.3    Sorscher, E.J.4    Crews, A.5
  • 27
    • 84940884841 scopus 로고    scopus 로고
    • Airway gland structure and function
    • COI: 1:CAS:528:DC%2BC28XnvVKqsb8%3D, PID: 26336032
    • Widdicombe JH, Wine JJ (2015) Airway gland structure and function. Physiol Rev 95:1241–1319
    • (2015) Physiol Rev , vol.95 , pp. 1241-1319
    • Widdicombe, J.H.1    Wine, J.J.2
  • 28
    • 0036194724 scopus 로고    scopus 로고
    • Mucus clearance as a primary innate defense mechanism for mammalian airways
    • COI: 1:CAS:528:DC%2BD38XitVeqt78%3D, PID: 11877463
    • Knowles MR, Boucher RC (2002) Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest 109:571–577
    • (2002) J Clin Invest , vol.109 , pp. 571-577
    • Knowles, M.R.1    Boucher, R.C.2
  • 30
    • 0037184993 scopus 로고    scopus 로고
    • Absent secretion to vasoactive intestinal peptide in cystic fibrosis airway glands
    • COI: 1:CAS:528:DC%2BD38Xps12nt7Y%3D, PID: 12368280
    • Joo NS, Irokawa T, Wu JV, Robbins RC, Whyte RI, Wine JJ (2002) Absent secretion to vasoactive intestinal peptide in cystic fibrosis airway glands. J Biol Chem 277:50710–50715
    • (2002) J Biol Chem , vol.277 , pp. 50710-50715
    • Joo, N.S.1    Irokawa, T.2    Wu, J.V.3    Robbins, R.C.4    Whyte, R.I.5    Wine, J.J.6
  • 32
    • 0031836088 scopus 로고    scopus 로고
    • Effect of anion secretion inhibitors on mucin content of airway submucosal gland ducts
    • COI: 1:CAS:528:DyaK1cXjsFSiuro%3D, PID: 9612291
    • Inglis SK, Corboz MR, Ballard ST (1998) Effect of anion secretion inhibitors on mucin content of airway submucosal gland ducts. Am J Physiol 274:L762–L766
    • (1998) Am J Physiol , vol.274 , pp. L762-L766
    • Inglis, S.K.1    Corboz, M.R.2    Ballard, S.T.3
  • 37
    • 84868108269 scopus 로고    scopus 로고
    • Basolateral chloride loading by the anion exchanger type 2: role in fluid secretion by the human airway epithelial cell line Calu-3
    • COI: 1:CAS:528:DC%2BC38XhvVahtbfE, PID: 22802585
    • Huang J, Shan J, Kim D, Liao J, Evagelidis A, Alper SL, Hanrahan JW (2012) Basolateral chloride loading by the anion exchanger type 2: role in fluid secretion by the human airway epithelial cell line Calu-3. J Physiol 590:5299–5316
    • (2012) J Physiol , vol.590 , pp. 5299-5316
    • Huang, J.1    Shan, J.2    Kim, D.3    Liao, J.4    Evagelidis, A.5    Alper, S.L.6    Hanrahan, J.W.7
  • 38
    • 0022638101 scopus 로고
    • Increased nasal potential difference and amiloride sensitivity in neonates with cystic fibrosis
    • COI: 1:STN:280:DyaL287ntV2mtg%3D%3D, PID: 3958823
    • Gowen CW, Lawson EE, Gingras-Leatherman J, Gatzy JT, Boucher RC, Knowles MR (1986) Increased nasal potential difference and amiloride sensitivity in neonates with cystic fibrosis. J Pediatr 108:517–521
    • (1986) J Pediatr , vol.108 , pp. 517-521
    • Gowen, C.W.1    Lawson, E.E.2    Gingras-Leatherman, J.3    Gatzy, J.T.4    Boucher, R.C.5    Knowles, M.R.6
  • 39
    • 34548286919 scopus 로고    scopus 로고
    • Detection of cystic fibrosis transmembrane conductance regulator activity in early-phase clinical trials
    • COI: 1:CAS:528:DC%2BD2sXpslejurw%3D, PID: 17652506
    • Rowe SM, Accurso F, Clancy JP (2007) Detection of cystic fibrosis transmembrane conductance regulator activity in early-phase clinical trials. Proc Am Thorac Soc 4:387–398
    • (2007) Proc Am Thorac Soc , vol.4 , pp. 387-398
    • Rowe, S.M.1    Accurso, F.2    Clancy, J.P.3
  • 41
    • 84861879494 scopus 로고    scopus 로고
    • The CFTR and ENaC debate: how important is ENaC in CF lung disease?
    • COI: 1:CAS:528:DC%2BC38XhtVGlsrjO, PID: 22492740
    • Collawn JF, Lazrak A, Bebok Z, Matalon S (2012) The CFTR and ENaC debate: how important is ENaC in CF lung disease? Am J Physiol Lung Cell Mol Physiol 302:L1141–L1146
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.302 , pp. L1141-L1146
    • Collawn, J.F.1    Lazrak, A.2    Bebok, Z.3    Matalon, S.4
  • 43
    • 80053376536 scopus 로고    scopus 로고
    • Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung
    • COI: 1:CAS:528:DC%2BC3MXhtlersbbN, PID: 21743028
    • Lazrak A, Jurkuvenaite A, Chen L, Keeling KM, Collawn JF, Bedwell DM, Matalon S (2011) Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung. Am J Physiol Lung Cell Mol Physiol 301:L557–L567
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.301 , pp. L557-L567
    • Lazrak, A.1    Jurkuvenaite, A.2    Chen, L.3    Keeling, K.M.4    Collawn, J.F.5    Bedwell, D.M.6    Matalon, S.7
  • 45
    • 84878978974 scopus 로고    scopus 로고
    • New pulmonary therapies directed at targets other than CFTR
    • PID: 23732851
    • Donaldson SH, Galietta L (2013) New pulmonary therapies directed at targets other than CFTR. Cold Spring Harb Perspect Med 3:a009787
    • (2013) Cold Spring Harb Perspect Med , vol.3 , pp. a009787
    • Donaldson, S.H.1    Galietta, L.2
  • 46
    • 84875206850 scopus 로고    scopus 로고
    • The SLC26 gene family of anion transporters and channels
    • COI: 1:CAS:528:DC%2BC3sXksVyrsL0%3D, PID: 23506885
    • Alper SL, Sharma AK (2013) The SLC26 gene family of anion transporters and channels. Mol Aspects Med 34:494–515
    • (2013) Mol Aspects Med , vol.34 , pp. 494-515
    • Alper, S.L.1    Sharma, A.K.2
  • 47
    • 0029963073 scopus 로고    scopus 로고
    • Pendred syndrome maps to chromosome 7q21-34 and is caused by an intrinsic defect in thyroid iodine organification
    • COI: 1:CAS:528:DyaK28XjtFaisrs%3D, PID: 8630498
    • Sheffield VC, Kraiem Z, Beck JC, Nishimura D, Stone EM, Salameh M, Sadeh O, Glaser B (1996) Pendred syndrome maps to chromosome 7q21-34 and is caused by an intrinsic defect in thyroid iodine organification. Nat Genet 12:424–426
    • (1996) Nat Genet , vol.12 , pp. 424-426
    • Sheffield, V.C.1    Kraiem, Z.2    Beck, J.C.3    Nishimura, D.4    Stone, E.M.5    Salameh, M.6    Sadeh, O.7    Glaser, B.8
  • 50
    • 0037134440 scopus 로고    scopus 로고
    • Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9
    • COI: 1:CAS:528:DC%2BD38XjsFWntbY%3D, PID: 11834742
    • Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (2002) Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. J Biol Chem 277:14246–14254
    • (2002) J Biol Chem , vol.277 , pp. 14246-14254
    • Lohi, H.1    Kujala, M.2    Makela, S.3    Lehtonen, E.4    Kestila, M.5    Saarialho-Kere, U.6    Markovich, D.7    Kere, J.8
  • 53
    • 64549085967 scopus 로고    scopus 로고
    • SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia
    • COI: 1:CAS:528:DC%2BD1MXltVOlt78%3D, PID: 19289574
    • Bertrand CA, Zhang R, Pilewski JM, Frizzell RA (2009) SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia. J Gen Physiol 133:421–438
    • (2009) J Gen Physiol , vol.133 , pp. 421-438
    • Bertrand, C.A.1    Zhang, R.2    Pilewski, J.M.3    Frizzell, R.A.4
  • 55
    • 0027052928 scopus 로고
    • − secretion in human nasal epithelium: responses of apical and basolateral membranes
    • COI: 1:CAS:528:DyaK3sXhtFOgsr4%3D, PID: 1335687
    • − secretion in human nasal epithelium: responses of apical and basolateral membranes. Am J Physiol 263:C1190–C1199
    • (1992) Am J Physiol , vol.263 , pp. C1190-C1199
    • Clarke, L.L.1    Paradiso, A.M.2    Boucher, R.C.3
  • 57
    • 0028333866 scopus 로고
    • − secretion in nasal epithelia of CF mice
    • COI: 1:CAS:528:DyaK2cXktlamsr8%3D, PID: 7515571
    • − secretion in nasal epithelia of CF mice. Am J Physiol 266:C1478–C1483
    • (1994) Am J Physiol , vol.266 , pp. C1478-C1483
    • Grubb, B.R.1    Vick, R.N.2    Boucher, R.C.3
  • 59
    • 51549120559 scopus 로고    scopus 로고
    • Expression cloning of TMEM16A as a calcium-activated chloride channel subunit
    • COI: 1:CAS:528:DC%2BD1cXht1Sns7rP, PID: 18805094
    • Schroeder BC, Cheng T, Jan YN, Jan LY (2008) Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell 134:1019–1029
    • (2008) Cell , vol.134 , pp. 1019-1029
    • Schroeder, B.C.1    Cheng, T.2    Jan, Y.N.3    Jan, L.Y.4
  • 62
    • 0033597331 scopus 로고    scopus 로고
    • The cystic fibrosis transmembrane conductance regulator activates aquaporin 3 in airway epithelial cells
    • COI: 1:CAS:528:DyaK1MXislGls7Y%3D, PID: 10206998
    • Schreiber R, Nitschke R, Greger R, Kunzelmann K (1999) The cystic fibrosis transmembrane conductance regulator activates aquaporin 3 in airway epithelial cells. J Biol Chem 274:11811–11816
    • (1999) J Biol Chem , vol.274 , pp. 11811-11816
    • Schreiber, R.1    Nitschke, R.2    Greger, R.3    Kunzelmann, K.4
  • 63
    • 74749090086 scopus 로고    scopus 로고
    • CFTR and tight junctions in cultured bronchial epithelial cells
    • COI: 1:CAS:528:DC%2BC3cXhtlCls7o%3D, PID: 19818767
    • Nilsson HE, Dragomir A, Lazorova L, Johannesson M, Roomans GM (2010) CFTR and tight junctions in cultured bronchial epithelial cells. Exp Mol Pathol 88:118–127
    • (2010) Exp Mol Pathol , vol.88 , pp. 118-127
    • Nilsson, H.E.1    Dragomir, A.2    Lazorova, L.3    Johannesson, M.4    Roomans, G.M.5
  • 65
    • 48149090717 scopus 로고    scopus 로고
    • Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis
    • COI: 1:CAS:528:DC%2BD1cXpt1Gqtb4%3D, PID: 18675692
    • Quinton PM (2008) Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis. Lancet 372:415–417
    • (2008) Lancet , vol.372 , pp. 415-417
    • Quinton, P.M.1
  • 67
    • 0023162229 scopus 로고
    • Fluid absorption by rat lung in situ: pathways for sodium entry in the luminal membrane of alveolar epithelium
    • COI: 1:CAS:528:DyaL2sXot1ajsg%3D%3D, PID: 3116209
    • Basset G, Crone C, Saumon G (1987) Fluid absorption by rat lung in situ: pathways for sodium entry in the luminal membrane of alveolar epithelium. J Physiol 384:325–345
    • (1987) J Physiol , vol.384 , pp. 325-345
    • Basset, G.1    Crone, C.2    Saumon, G.3
  • 68
    • 0023162228 scopus 로고
    • Significance of active ion transport in transalveolar water absorption: a study on isolated rat lung
    • COI: 1:STN:280:DyaL1c%2FhtVKqug%3D%3D, PID: 3656149
    • Basset G, Crone C, Saumon G (1987) Significance of active ion transport in transalveolar water absorption: a study on isolated rat lung. J Physiol 384:311–324
    • (1987) J Physiol , vol.384 , pp. 311-324
    • Basset, G.1    Crone, C.2    Saumon, G.3
  • 69
    • 0023141533 scopus 로고
    • Beta-adrenergic agonists increase lung liquid clearance in anesthetized sheep
    • COI: 1:CAS:528:DyaL2sXhtFentbY%3D, PID: 2879851
    • Berthiaume Y, Staub NC, Matthay MA (1987) Beta-adrenergic agonists increase lung liquid clearance in anesthetized sheep. J Clin Invest 79:335–343
    • (1987) J Clin Invest , vol.79 , pp. 335-343
    • Berthiaume, Y.1    Staub, N.C.2    Matthay, M.A.3
  • 71
    • 0036097028 scopus 로고    scopus 로고
    • Novel role for CFTR in fluid absorption from the distal airspaces of the lung
    • COI: 1:CAS:528:DC%2BD38XhsVGqsLo%3D, PID: 11815669
    • Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA (2002) Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J Gen Physiol 119:199–207
    • (2002) J Gen Physiol , vol.119 , pp. 199-207
    • Fang, X.1    Fukuda, N.2    Barbry, P.3    Sartori, C.4    Verkman, A.S.5    Matthay, M.A.6
  • 74
    • 0034745438 scopus 로고    scopus 로고
    • The neglected ion: HCO3
    • COI: 1:CAS:528:DC%2BD3MXhvVOksr8%3D, PID: 11231624
    • Quinton PM (2001) The neglected ion: HCO3. Nat Med 7:292–293
    • (2001) Nat Med , vol.7 , pp. 292-293
    • Quinton, P.M.1
  • 78
    • 84860506911 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane conductance regulator gene abnormalities in patients with asthma and recurrent neutrophilic bronchitis
    • PID: 22332135
    • Goodwin J, Spitale N, Yaghi A, Dolovich M, Nair P (2012) Cystic fibrosis transmembrane conductance regulator gene abnormalities in patients with asthma and recurrent neutrophilic bronchitis. Can Respir J 19:46–48
    • (2012) Can Respir J , vol.19 , pp. 46-48
    • Goodwin, J.1    Spitale, N.2    Yaghi, A.3    Dolovich, M.4    Nair, P.5
  • 79
    • 84861922716 scopus 로고    scopus 로고
    • Association of CFTR gene mutation with bronchial asthma
    • COI: 1:CAS:528:DC%2BC38XhsF2ku7zO, PID: 22664493
    • Maurya N, Awasthi S, Dixit P (2012) Association of CFTR gene mutation with bronchial asthma. Indian J Med Res 135:469–478
    • (2012) Indian J Med Res , vol.135 , pp. 469-478
    • Maurya, N.1    Awasthi, S.2    Dixit, P.3
  • 80
    • 84860536505 scopus 로고    scopus 로고
    • The role of CFTR mutations in asthma
    • PID: 22332134
    • Sandford A (2012) The role of CFTR mutations in asthma. Can Respir J 19:44–45
    • (2012) Can Respir J , vol.19 , pp. 44-45
    • Sandford, A.1
  • 81
    • 0029016718 scopus 로고
    • Protection against bronchial asthma by CFTR delta F508 mutation: a heterozygote advantage in cystic fibrosis
    • COI: 1:CAS:528:DyaK2MXms1Kgtro%3D, PID: 7585155
    • Schroeder SA, Gaughan DM, Swift M (1995) Protection against bronchial asthma by CFTR delta F508 mutation: a heterozygote advantage in cystic fibrosis. Nat Med 1:703–705
    • (1995) Nat Med , vol.1 , pp. 703-705
    • Schroeder, S.A.1    Gaughan, D.M.2    Swift, M.3
  • 82
    • 0020529166 scopus 로고
    • Cigarette smoke inhibition of ion transport in canine tracheal epithelium
    • COI: 1:CAS:528:DyaL3sXks1Gks7o%3D, PID: 6863537
    • Welsh MJ (1983) Cigarette smoke inhibition of ion transport in canine tracheal epithelium. J Clin Invest 71:1614–1623
    • (1983) J Clin Invest , vol.71 , pp. 1614-1623
    • Welsh, M.J.1
  • 86
    • 33645451580 scopus 로고    scopus 로고
    • Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis
    • COI: 1:CAS:528:DC%2BD28Xjt1Sltbs%3D, PID: 16207791
    • Song Y, Salinas D, Nielson DW, Verkman AS (2006) Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis. Am J Physiol Cell Physiol 290:C741–C749
    • (2006) Am J Physiol Cell Physiol , vol.290 , pp. C741-C749
    • Song, Y.1    Salinas, D.2    Nielson, D.W.3    Verkman, A.S.4
  • 88
    • 84864313785 scopus 로고    scopus 로고
    • Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype
    • COI: 1:CAS:528:DC%2BC38XhtVegtrfE, PID: 22711878
    • Gustafsson JK, Ermund A, Ambort D, Johansson ME, Nilsson HE, Thorell K, Hebert H, Sjovall H, Hansson GC (2012) Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype. J Exp Med 209:1263–1272
    • (2012) J Exp Med , vol.209 , pp. 1263-1272
    • Gustafsson, J.K.1    Ermund, A.2    Ambort, D.3    Johansson, M.E.4    Nilsson, H.E.5    Thorell, K.6    Hebert, H.7    Sjovall, H.8    Hansson, G.C.9
  • 90
    • 20444478657 scopus 로고    scopus 로고
    • pH-dependent intraluminal organization of mucin granules in live human mucous/goblet cells
    • COI: 1:CAS:528:DC%2BD2MXjsFOgsbw%3D, PID: 15718243
    • Perez-Vilar J, Olsen JC, Chua M, Boucher RC (2005) pH-dependent intraluminal organization of mucin granules in live human mucous/goblet cells. J Biol Chem 280:16868–16881
    • (2005) J Biol Chem , vol.280 , pp. 16868-16881
    • Perez-Vilar, J.1    Olsen, J.C.2    Chua, M.3    Boucher, R.C.4
  • 91
    • 0023283053 scopus 로고
    • Molecular mechanism of mucin secretion: I. The role of intragranular charge shielding
    • COI: 1:CAS:528:DyaL2sXhvFemu7c%3D, PID: 3476567
    • Verdugo P, Deyrup-Olsen I, Aitken M, Villalon M, Johnson D (1987) Molecular mechanism of mucin secretion: I. The role of intragranular charge shielding. J Dent Res 66:506–508
    • (1987) J Dent Res , vol.66 , pp. 506-508
    • Verdugo, P.1    Deyrup-Olsen, I.2    Aitken, M.3    Villalon, M.4    Johnson, D.5
  • 92
    • 84871512983 scopus 로고    scopus 로고
    • Expression of pendrin and periostin in allergic rhinitis and chronic rhinosinusitis
    • COI: 1:CAS:528:DC%2BC3sXmslGrtg%3D%3D, PID: 22918213
    • Ishida A, Ohta N, Suzuki Y, Kakehata S, Okubo K, Ikeda H, Shiraishi H, Izuhara K (2012) Expression of pendrin and periostin in allergic rhinitis and chronic rhinosinusitis. Allergol Int 61:589–595
    • (2012) Allergol Int , vol.61 , pp. 589-595
    • Ishida, A.1    Ohta, N.2    Suzuki, Y.3    Kakehata, S.4    Okubo, K.5    Ikeda, H.6    Shiraishi, H.7    Izuhara, K.8
  • 95
    • 84907100425 scopus 로고    scopus 로고
    • Epithelial anion transporter pendrin contributes to inflammatory lung pathology in mouse models of Bordetella pertussis infection
    • PID: 25069981
    • Scanlon KM, Gau Y, Zhu J, Skerry C, Wall SM, Soleimani M, Carbonetti NH (2014) Epithelial anion transporter pendrin contributes to inflammatory lung pathology in mouse models of Bordetella pertussis infection. Infect Immun 82:4212–4221
    • (2014) Infect Immun , vol.82 , pp. 4212-4221
    • Scanlon, K.M.1    Gau, Y.2    Zhu, J.3    Skerry, C.4    Wall, S.M.5    Soleimani, M.6    Carbonetti, N.H.7
  • 96
    • 81755189072 scopus 로고    scopus 로고
    • Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cells
    • COI: 1:CAS:528:DC%2BC3MXhsVOqu7fL, PID: 21914796
    • Garnett JP, Hickman E, Burrows R, Hegyi P, Tiszlavicz L, Cuthbert AW, Fong P, Gray MA (2011) Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cells. J Biol Chem 286:41069–41082
    • (2011) J Biol Chem , vol.286 , pp. 41069-41082
    • Garnett, J.P.1    Hickman, E.2    Burrows, R.3    Hegyi, P.4    Tiszlavicz, L.5    Cuthbert, A.W.6    Fong, P.7    Gray, M.A.8
  • 101
    • 0036076704 scopus 로고    scopus 로고
    • Primary inflammation in human cystic fibrosis small airways
    • COI: 1:CAS:528:DC%2BD38XmslSgurY%3D, PID: 12114207
    • Tirouvanziam R, Khazaal I, Peault B (2002) Primary inflammation in human cystic fibrosis small airways. Am J Physiol Lung Cell Mol Physiol 283:L445–L451
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.283 , pp. L445-L451
    • Tirouvanziam, R.1    Khazaal, I.2    Peault, B.3
  • 102
    • 77953010658 scopus 로고    scopus 로고
    • The development of lung disease in cystic fibrosis pigs
    • Wine JJ (2010) The development of lung disease in cystic fibrosis pigs. Sci Transl Med 2:29ps20
    • (2010) Sci Transl Med 2:29ps20
    • Wine, J.J.1
  • 104
    • 0031851457 scopus 로고    scopus 로고
    • Glutathione permeability of CFTR
    • COI: 1:CAS:528:DyaK1cXkvVOnt74%3D, PID: 9688865
    • Linsdell P, Hanrahan JW (1998) Glutathione permeability of CFTR. Am J Physiol 275:C323–C326
    • (1998) Am J Physiol , vol.275 , pp. C323-C326
    • Linsdell, P.1    Hanrahan, J.W.2
  • 108
    • 73949105483 scopus 로고    scopus 로고
    • The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases
    • COI: 1:CAS:528:DC%2BC3cXislGnug%3D%3D, PID: 19918082
    • Xu Y, Szep S, Lu Z (2009) The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases. Proc Natl Acad Sci USA 106:20515–20519
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20515-20519
    • Xu, Y.1    Szep, S.2    Lu, Z.3
  • 109
    • 11044233754 scopus 로고    scopus 로고
    • Reconstitution of human airway tissue in the humanized xenograft model
    • COI: 1:CAS:528:DC%2BD2cXnsVyrsbo%3D, PID: 15463929
    • Escotte S, Catusse C, Coraux C, Puchelle E (2004) Reconstitution of human airway tissue in the humanized xenograft model. J Cyst Fibros 3(Suppl 2):63–65
    • (2004) J Cyst Fibros , vol.3 , pp. 63-65
    • Escotte, S.1    Catusse, C.2    Coraux, C.3    Puchelle, E.4
  • 111
    • 33846570486 scopus 로고    scopus 로고
    • Human airway surface epithelial regeneration is delayed and abnormal in cystic fibrosis
    • COI: 1:CAS:528:DC%2BD2sXisFyksLk%3D, PID: 17186573
    • Hajj R, Lesimple P, Nawrocki-Raby B, Birembaut P, Puchelle E, Coraux C (2007) Human airway surface epithelial regeneration is delayed and abnormal in cystic fibrosis. J Pathol 211:340–350
    • (2007) J Pathol , vol.211 , pp. 340-350
    • Hajj, R.1    Lesimple, P.2    Nawrocki-Raby, B.3    Birembaut, P.4    Puchelle, E.5    Coraux, C.6
  • 115
    • 0025834174 scopus 로고
    • Localization of the cystic fibrosis transmembrane conductance regulator in pancreas
    • COI: 1:STN:280:DyaK3MzisVGisg%3D%3D, PID: 1713921
    • Marino CR, Matovcik LM, Gorelick FS, Cohn JA (1991) Localization of the cystic fibrosis transmembrane conductance regulator in pancreas. J Clin Invest 88:712–716
    • (1991) J Clin Invest , vol.88 , pp. 712-716
    • Marino, C.R.1    Matovcik, L.M.2    Gorelick, F.S.3    Cohn, J.A.4
  • 116
    • 0024824522 scopus 로고
    • The pathophysiology of the pancreatic defect in cystic fibrosis
    • COI: 1:STN:280:DyaK3czosF2guw%3D%3D, PID: 2701923
    • Durie PR (1989) The pathophysiology of the pancreatic defect in cystic fibrosis. Acta Paediatr Scand Suppl 363:41–44
    • (1989) Acta Paediatr Scand Suppl , vol.363 , pp. 41-44
    • Durie, P.R.1
  • 117
    • 0021917723 scopus 로고
    • Pancreatic fluid secretion and protein hyperconcentration in cystic fibrosis
    • COI: 1:STN:280:DyaL2M7htFSjtA%3D%3D, PID: 3969086
    • Kopelman H, Durie P, Gaskin K, Weizman Z, Forstner G (1985) Pancreatic fluid secretion and protein hyperconcentration in cystic fibrosis. N Engl J Med 312:329–334
    • (1985) N Engl J Med , vol.312 , pp. 329-334
    • Kopelman, H.1    Durie, P.2    Gaskin, K.3    Weizman, Z.4    Forstner, G.5
  • 118
    • 84891714062 scopus 로고    scopus 로고
    • Acid-base transport in pancreas-new challenges
    • PID: 24391597
    • Novak I, Haanes KA, Wang J (2013) Acid-base transport in pancreas-new challenges. Front Physiol 4:380
    • (2013) Front Physiol , vol.4 , pp. 380
    • Novak, I.1    Haanes, K.A.2    Wang, J.3
  • 120
    • 78049452453 scopus 로고    scopus 로고
    • Protons released during pancreatic acinar cell secretion acidify the lumen and contribute to pancreatitis in mice
    • COI: 1:CAS:528:DC%2BC3cXhtlKhurvI, PID: 20691184
    • Behrendorff N, Floetenmeyer M, Schwiening C, Thorn P (2010) Protons released during pancreatic acinar cell secretion acidify the lumen and contribute to pancreatitis in mice. Gastroenterology 139:1711–1720
    • (2010) Gastroenterology , vol.139 , pp. 1711-1720
    • Behrendorff, N.1    Floetenmeyer, M.2    Schwiening, C.3    Thorn, P.4
  • 121
    • 14644421996 scopus 로고    scopus 로고
    • Mechanisms of bicarbonate secretion in the pancreatic duct
    • COI: 1:CAS:528:DC%2BD2MXjsFeksr0%3D, PID: 15709963
    • Steward MC, Ishiguro H, Case RM (2005) Mechanisms of bicarbonate secretion in the pancreatic duct. Annu Rev Physiol 67:377–409
    • (2005) Annu Rev Physiol , vol.67 , pp. 377-409
    • Steward, M.C.1    Ishiguro, H.2    Case, R.M.3
  • 122
    • 0034787415 scopus 로고    scopus 로고
    • Pancreatic acinar cell dysfunction in CFTR(−/−) mice is associated with impairments in luminal pH and endocytosis
    • COI: 1:CAS:528:DC%2BD3MXnvVynu7o%3D, PID: 11606508
    • Freedman SD, Kern HF, Scheele GA (2001) Pancreatic acinar cell dysfunction in CFTR(−/−) mice is associated with impairments in luminal pH and endocytosis. Gastroenterology 121:950–957
    • (2001) Gastroenterology , vol.121 , pp. 950-957
    • Freedman, S.D.1    Kern, H.F.2    Scheele, G.A.3
  • 126
    • 0023782863 scopus 로고
    • Secretin-regulated chloride channel on the apical plasma membrane of pancreatic duct cells
    • COI: 1:STN:280:DyaL1M7htV2mtg%3D%3D, PID: 2464063
    • Gray MA, Greenwell JR, Argent BE (1988) Secretin-regulated chloride channel on the apical plasma membrane of pancreatic duct cells. J Membr Biol 105:131–142
    • (1988) J Membr Biol , vol.105 , pp. 131-142
    • Gray, M.A.1    Greenwell, J.R.2    Argent, B.E.3
  • 127
    • 0024426797 scopus 로고
    • Two types of chloride channel on duct cells cultured from human fetal pancreas
    • COI: 1:STN:280:DyaL1MzkvFegtA%3D%3D, PID: 2475028
    • Gray MA, Harris A, Coleman L, Greenwell JR, Argent BE (1989) Two types of chloride channel on duct cells cultured from human fetal pancreas. Am J Physiol 257:C240–C251
    • (1989) Am J Physiol , vol.257 , pp. C240-C251
    • Gray, M.A.1    Harris, A.2    Coleman, L.3    Greenwell, J.R.4    Argent, B.E.5
  • 128
    • 0027526366 scopus 로고
    • cAMP-regulated whole cell chloride currents in pancreatic duct cells
    • COI: 1:CAS:528:DyaK3sXkt1Ggu78%3D, PID: 7681623
    • Gray MA, Plant S, Argent BE (1993) cAMP-regulated whole cell chloride currents in pancreatic duct cells. Am J Physiol 264:C591–C602
    • (1993) Am J Physiol , vol.264 , pp. C591-C602
    • Gray, M.A.1    Plant, S.2    Argent, B.E.3
  • 129
    • 0025092468 scopus 로고
    • Anion selectivity and block of the small-conductance chloride channel on pancreatic duct cells
    • COI: 1:CAS:528:DyaK3MXlvFCjuw%3D%3D, PID: 1700622
    • Gray MA, Pollard CE, Harris A, Coleman L, Greenwell JR, Argent BE (1990) Anion selectivity and block of the small-conductance chloride channel on pancreatic duct cells. Am J Physiol 259:C752–C761
    • (1990) Am J Physiol , vol.259 , pp. C752-C761
    • Gray, M.A.1    Pollard, C.E.2    Harris, A.3    Coleman, L.4    Greenwell, J.R.5    Argent, B.E.6
  • 130
    • 0023920052 scopus 로고
    • Properties of the luminal membrane of isolated perfused rat pancreatic ducts. Effect of cyclic AMP and blockers of chloride transport
    • COI: 1:CAS:528:DyaL1cXitVahtr4%3D, PID: 2455270
    • Novak I, Greger R (1988) Properties of the luminal membrane of isolated perfused rat pancreatic ducts. Effect of cyclic AMP and blockers of chloride transport. Pflugers Arch 411:546–553
    • (1988) Pflugers Arch , vol.411 , pp. 546-553
    • Novak, I.1    Greger, R.2
  • 131
    • 0023864243 scopus 로고
    • Electrophysiological study of transport systems in isolated perfused pancreatic ducts: properties of the basolateral membrane
    • COI: 1:STN:280:DyaL1c7ns1ertQ%3D%3D, PID: 3353213
    • Novak I, Greger R (1988) Electrophysiological study of transport systems in isolated perfused pancreatic ducts: properties of the basolateral membrane. Pflugers Arch 411:58–68
    • (1988) Pflugers Arch , vol.411 , pp. 58-68
    • Novak, I.1    Greger, R.2
  • 132
    • 0023877672 scopus 로고
    • pH regulatory mechanisms in rat pancreatic ductal cells
    • COI: 1:STN:280:DyaL1c3jvVyiug%3D%3D, PID: 2837099
    • Stuenkel EL, Machen TE, Williams JA (1988) pH regulatory mechanisms in rat pancreatic ductal cells. Am J Physiol 254:G925–G930
    • (1988) Am J Physiol , vol.254 , pp. G925-G930
    • Stuenkel, E.L.1    Machen, T.E.2    Williams, J.A.3
  • 133
    • 0028946139 scopus 로고
    • Secretin causes H+/HCO3− secretion from pig pancreatic ductules by vacuolar-type H(+)-adenosine triphosphatase
    • COI: 1:CAS:528:DyaK2MXltleiu7c%3D, PID: 7875488
    • Villanger O, Veel T, Raeder MG (1995) Secretin causes H+/HCO3− secretion from pig pancreatic ductules by vacuolar-type H(+)-adenosine triphosphatase. Gastroenterology 108:850–859
    • (1995) Gastroenterology , vol.108 , pp. 850-859
    • Villanger, O.1    Veel, T.2    Raeder, M.G.3
  • 134
    • 0029851860 scopus 로고    scopus 로고
    • A mathematical model of the pancreatic ductal epithelium
    • COI: 1:CAS:528:DyaK28XntVGjs7w%3D, PID: 8881027
    • Sohma Y, Gray MA, Imai Y, Argent BE (1996) A mathematical model of the pancreatic ductal epithelium. J Membr Biol 154:53–67
    • (1996) J Membr Biol , vol.154 , pp. 53-67
    • Sohma, Y.1    Gray, M.A.2    Imai, Y.3    Argent, B.E.4
  • 135
    • 0034218365 scopus 로고    scopus 로고
    • − transport in a mathematical model of the pancreatic ductal epithelium
    • COI: 1:CAS:528:DC%2BD3cXkvFCktb4%3D, PID: 10882430
    • − transport in a mathematical model of the pancreatic ductal epithelium. J Membr Biol 176:77–100
    • (2000) J Membr Biol , vol.176 , pp. 77-100
    • Sohma, Y.1    Gray, M.A.2    Imai, Y.3    Argent, B.E.4
  • 141
    • 2342656361 scopus 로고    scopus 로고
    • Bicarbonate secretion: it takes two to tango
    • COI: 1:CAS:528:DC%2BD2cXis1GltL8%3D, PID: 15057243
    • Gray MA (2004) Bicarbonate secretion: it takes two to tango. Nat Cell Biol 6:292–294
    • (2004) Nat Cell Biol , vol.6 , pp. 292-294
    • Gray, M.A.1
  • 145
    • 0037369278 scopus 로고    scopus 로고
    • Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains
    • COI: 1:CAS:528:DC%2BD3sXisFegtL8%3D, PID: 12444019
    • Lohi H, Lamprecht G, Markovich D, Heil A, Kujala M, Seidler U, Kere J (2003) Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains. Am J Physiol Cell Physiol 284:C769–C779
    • (2003) Am J Physiol Cell Physiol , vol.284 , pp. C769-C779
    • Lohi, H.1    Lamprecht, G.2    Markovich, D.3    Heil, A.4    Kujala, M.5    Seidler, U.6    Kere, J.7
  • 146
  • 147
    • 0037085533 scopus 로고    scopus 로고
    • Chloride transport in microperfused interlobular ducts isolated from guinea-pig pancreas
    • COI: 1:CAS:528:DC%2BD38XislGnt7k%3D, PID: 11850511
    • Ishiguro H, Naruse S, Kitagawa M, Mabuchi T, Kondo T, Hayakawa T, Case RM, Steward MC (2002) Chloride transport in microperfused interlobular ducts isolated from guinea-pig pancreas. J Physiol 539:175–189
    • (2002) J Physiol , vol.539 , pp. 175-189
    • Ishiguro, H.1    Naruse, S.2    Kitagawa, M.3    Mabuchi, T.4    Kondo, T.5    Hayakawa, T.6    Case, R.M.7    Steward, M.C.8
  • 149
    • 2542463894 scopus 로고    scopus 로고
    • Dynamic control of cystic fibrosis transmembrane conductance regulator Cl(−)/HCO3(−) selectivity by external Cl(−)
    • COI: 1:CAS:528:DC%2BD2cXjvF2kurk%3D, PID: 15010471
    • Shcheynikov N, Kim KH, Kim KM, Dorwart MR, Ko SB, Goto H, Naruse S, Thomas PJ, Muallem S (2004) Dynamic control of cystic fibrosis transmembrane conductance regulator Cl(−)/HCO3(−) selectivity by external Cl(−). J Biol Chem 279:21857–21865
    • (2004) J Biol Chem , vol.279 , pp. 21857-21865
    • Shcheynikov, N.1    Kim, K.H.2    Kim, K.M.3    Dorwart, M.R.4    Ko, S.B.5    Goto, H.6    Naruse, S.7    Thomas, P.J.8    Muallem, S.9
  • 151
    • 0032167722 scopus 로고    scopus 로고
    • Fluid secretion in interlobular ducts isolated from guinea-pig pancreas
    • COI: 1:CAS:528:DyaK1cXmsFOnsb4%3D, PID: 9706019
    • Ishiguro H, Naruse S, Steward MC, Kitagawa M, Ko SB, Hayakawa T, Case RM (1998) Fluid secretion in interlobular ducts isolated from guinea-pig pancreas. J Physiol 511(Pt 2):407–422
    • (1998) J Physiol , vol.511 , pp. 407-422
    • Ishiguro, H.1    Naruse, S.2    Steward, M.C.3    Kitagawa, M.4    Ko, S.B.5    Hayakawa, T.6    Case, R.M.7
  • 153
    • 0029821496 scopus 로고    scopus 로고
    • − cotransport in interlobular ducts from guinea-pig pancreas
    • COI: 1:CAS:528:DyaK28XlsVChu7g%3D, PID: 8866360
    • − cotransport in interlobular ducts from guinea-pig pancreas. J Physiol 495(Pt 1):169–178
    • (1996) J Physiol , vol.495 , pp. 169-178
    • Ishiguro, H.1    Steward, M.C.2    Lindsay, A.R.3    Case, R.M.4
  • 154
    • 0029802579 scopus 로고    scopus 로고
    • Bicarbonate secretion in interlobular ducts from guinea-pig pancreas
    • COI: 1:CAS:528:DyaK28XlsVChu7c%3D, PID: 8866361
    • Ishiguro H, Steward MC, Wilson RW, Case RM (1996) Bicarbonate secretion in interlobular ducts from guinea-pig pancreas. J Physiol 495(Pt 1):179–191
    • (1996) J Physiol , vol.495 , pp. 179-191
    • Ishiguro, H.1    Steward, M.C.2    Wilson, R.W.3    Case, R.M.4
  • 155
    • 84930786219 scopus 로고    scopus 로고
    • Potassium channels in pancreatic duct epithelial cells: their role, function and pathophysiological relevance
    • COI: 1:CAS:528:DC%2BC2cXht1GnurnF, PID: 25074489
    • Venglovecz V, Rakonczay Z Jr, Gray MA, Hegyi P (2015) Potassium channels in pancreatic duct epithelial cells: their role, function and pathophysiological relevance. Pflugers Arch 467:625–640
    • (2015) Pflugers Arch , vol.467 , pp. 625-640
    • Venglovecz, V.1    Rakonczay, Z.2    Gray, M.A.3    Hegyi, P.4
  • 156
    • 61749090806 scopus 로고    scopus 로고
    • IRBIT coordinates epithelial fluid and HCO3− secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct
    • COI: 1:CAS:528:DC%2BD1MXmtFCgsQ%3D%3D, PID: 19033647
    • Yang D, Shcheynikov N, Zeng W, Ohana E, So I, Ando H, Mizutani A, Mikoshiba K, Muallem S (2009) IRBIT coordinates epithelial fluid and HCO3− secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest 119:193–202
    • (2009) J Clin Invest , vol.119 , pp. 193-202
    • Yang, D.1    Shcheynikov, N.2    Zeng, W.3    Ohana, E.4    So, I.5    Ando, H.6    Mizutani, A.7    Mikoshiba, K.8    Muallem, S.9
  • 159
    • 0042242920 scopus 로고    scopus 로고
    • Substance P inhibits bicarbonate secretion from guinea pig pancreatic ducts by modulating an anion exchanger
    • COI: 1:CAS:528:DC%2BD3sXmsVaiu7o%3D, PID: 12672654
    • Hegyi P, Gray MA, Argent BE (2003) Substance P inhibits bicarbonate secretion from guinea pig pancreatic ducts by modulating an anion exchanger. Am J Physiol Cell Physiol 285:C268–C276
    • (2003) Am J Physiol Cell Physiol , vol.285 , pp. C268-C276
    • Hegyi, P.1    Gray, M.A.2    Argent, B.E.3
  • 161
    • 79959837344 scopus 로고    scopus 로고
    • Substance P inhibits pancreatic ductal bicarbonate secretion via neurokinin receptors 2 and 3 in the guinea pig exocrine pancreas
    • PID: 21673544
    • Kemeny LV, Hegyi P, Rakonczay Z Jr, Borka K, Korompay A, Gray MA, Argent BE, Venglovecz V (2011) Substance P inhibits pancreatic ductal bicarbonate secretion via neurokinin receptors 2 and 3 in the guinea pig exocrine pancreas. Pancreas 40:793–795
    • (2011) Pancreas , vol.40 , pp. 793-795
    • Kemeny, L.V.1    Hegyi, P.2    Rakonczay, Z.3    Borka, K.4    Korompay, A.5    Gray, M.A.6    Argent, B.E.7    Venglovecz, V.8
  • 162
    • 0032480363 scopus 로고    scopus 로고
    • Pancreatitis and mutations of the cystic fibrosis gene
    • COI: 1:STN:280:DyaK1czotlygsQ%3D%3D, PID: 9725928
    • Durie PR (1998) Pancreatitis and mutations of the cystic fibrosis gene. N Engl J Med 339:687–688
    • (1998) N Engl J Med , vol.339 , pp. 687-688
    • Durie, P.R.1
  • 163
    • 0030067573 scopus 로고    scopus 로고
    • Pancreatic dysfunction in cystic fibrosis occurs as a result of impairments in luminal pH, apical trafficking of zymogen granule membranes, and solubilization of secretory enzymes
    • COI: 1:STN:280:DyaK28vgt1yquw%3D%3D, PID: 8927611
    • Scheele GA, Fukuoka SI, Kern HF, Freedman SD (1996) Pancreatic dysfunction in cystic fibrosis occurs as a result of impairments in luminal pH, apical trafficking of zymogen granule membranes, and solubilization of secretory enzymes. Pancreas 12:1–9
    • (1996) Pancreas , vol.12 , pp. 1-9
    • Scheele, G.A.1    Fukuoka, S.I.2    Kern, H.F.3    Freedman, S.D.4
  • 164
    • 23344450542 scopus 로고    scopus 로고
    • Pancreatitis among patients with cystic fibrosis: correlation with pancreatic status and genotype
    • PID: 15772171
    • De Boeck K, Weren M, Proesmans M, Kerem E (2005) Pancreatitis among patients with cystic fibrosis: correlation with pancreatic status and genotype. Pediatrics 115:e463–e469
    • (2005) Pediatrics , vol.115 , pp. e463-e469
    • De Boeck, K.1    Weren, M.2    Proesmans, M.3    Kerem, E.4
  • 165
    • 0036892322 scopus 로고    scopus 로고
    • Genotype and phenotype correlations in patients with cystic fibrosis and pancreatitis
    • PID: 12454843
    • Durno C, Corey M, Zielenski J, Tullis E, Tsui LC, Durie P (2002) Genotype and phenotype correlations in patients with cystic fibrosis and pancreatitis. Gastroenterology 123:1857–1864
    • (2002) Gastroenterology , vol.123 , pp. 1857-1864
    • Durno, C.1    Corey, M.2    Zielenski, J.3    Tullis, E.4    Tsui, L.C.5    Durie, P.6
  • 166
    • 0034109607 scopus 로고    scopus 로고
    • Genotype and phenotype in cystic fibrosis
    • COI: 1:STN:280:DC%2BD3c3jsl2itw%3D%3D, PID: 10773783
    • Zielenski J (2000) Genotype and phenotype in cystic fibrosis. Respiration 67:117–133
    • (2000) Respiration , vol.67 , pp. 117-133
    • Zielenski, J.1
  • 167
    • 0033524506 scopus 로고    scopus 로고
    • − exchange by cystic fibrosis transmembrane conductance regulator expressed in NIH 3T3 and HEK 293 cells
    • COI: 1:CAS:528:DyaK1MXhtVems7o%3D, PID: 9920885
    • − exchange by cystic fibrosis transmembrane conductance regulator expressed in NIH 3T3 and HEK 293 cells. J Biol Chem 274:3414–3421
    • (1999) J Biol Chem , vol.274 , pp. 3414-3421
    • Lee, M.G.1    Wigley, W.C.2    Zeng, W.3    Noel, L.E.4    Marino, C.R.5    Thomas, P.J.6    Muallem, S.7
  • 171
    • 79851510346 scopus 로고    scopus 로고
    • Pathophysiological relevance of apical large-conductance Ca(2)+-activated potassium channels in pancreatic duct epithelial cells
    • COI: 1:CAS:528:DC%2BC3MXjslGisL8%3D, PID: 20940280
    • Venglovecz V, Hegyi P, Rakonczay Z Jr, Tiszlavicz L, Nardi A, Grunnet M, Gray MA (2011) Pathophysiological relevance of apical large-conductance Ca(2)+-activated potassium channels in pancreatic duct epithelial cells. Gut 60:361–369
    • (2011) Gut , vol.60 , pp. 361-369
    • Venglovecz, V.1    Hegyi, P.2    Rakonczay, Z.3    Tiszlavicz, L.4    Nardi, A.5    Grunnet, M.6    Gray, M.A.7
  • 173
    • 84896738968 scopus 로고    scopus 로고
    • Ethanol and its non-oxidative metabolites profoundly inhibit CFTR function in pancreatic epithelial cells which is prevented by ATP supplementation
    • COI: 1:CAS:528:DC%2BC3sXht1yhs7nO, PID: 23948742
    • Judak L, Hegyi P, Rakonczay Z Jr, Maleth J, Gray MA, Venglovecz V (2014) Ethanol and its non-oxidative metabolites profoundly inhibit CFTR function in pancreatic epithelial cells which is prevented by ATP supplementation. Pflugers Arch 466:549–562
    • (2014) Pflugers Arch , vol.466 , pp. 549-562
    • Judak, L.1    Hegyi, P.2    Rakonczay, Z.3    Maleth, J.4    Gray, M.A.5    Venglovecz, V.6
  • 174
    • 78651245402 scopus 로고    scopus 로고
    • Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells
    • COI: 1:STN:280:DC%2BC3M%2FivFWlsw%3D%3D, PID: 20732916
    • Maleth J, Venglovecz V, Razga Z, Tiszlavicz L, Rakonczay Z Jr, Hegyi P (2011) Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells. Gut 60:136–138
    • (2011) Gut , vol.60 , pp. 136-138
    • Maleth, J.1    Venglovecz, V.2    Razga, Z.3    Tiszlavicz, L.4    Rakonczay, Z.5    Hegyi, P.6
  • 178
    • 84881353736 scopus 로고    scopus 로고
    • A conservative assessment of the major genetic causes of idiopathic chronic pancreatitis: data from a comprehensive analysis of PRSS1, SPINK1, CTRC and CFTR genes in 253 young French patients
    • COI: 1:CAS:528:DC%2BC3sXhtlamsrjF, PID: 23951356
    • Masson E, Chen JM, Audrezet MP, Cooper DN, Ferec C (2013) A conservative assessment of the major genetic causes of idiopathic chronic pancreatitis: data from a comprehensive analysis of PRSS1, SPINK1, CTRC and CFTR genes in 253 young French patients. PLoS One 8:e73522
    • (2013) PLoS One , vol.8
    • Masson, E.1    Chen, J.M.2    Audrezet, M.P.3    Cooper, D.N.4    Ferec, C.5
  • 179
    • 84866142563 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in pancreatitis
    • COI: 1:CAS:528:DC%2BC38XhtlOjurrO, PID: 22658665
    • Ooi CY, Durie PR (2012) Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in pancreatitis. J Cyst Fibros 11:355–362
    • (2012) J Cyst Fibros , vol.11 , pp. 355-362
    • Ooi, C.Y.1    Durie, P.R.2
  • 183
    • 84896730466 scopus 로고    scopus 로고
    • The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology
    • COI: 1:CAS:528:DC%2BC2MXltVaqsL4%3D, PID: 23881310
    • Hegyi P, Petersen OH (2013) The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology. Rev Physiol Biochem Pharmacol 165:1–30
    • (2013) Rev Physiol Biochem Pharmacol , vol.165 , pp. 1-30
    • Hegyi, P.1    Petersen, O.H.2
  • 185
    • 85008397538 scopus 로고    scopus 로고
    • The human eccrine sweat gland: structure, function and disorders
    • Bovell D (2015) The human eccrine sweat gland: structure, function and disorders. J Local Global Health Sci 5
    • (2015) J Local Global Health Sci , pp. 5
    • Bovell, D.1
  • 186
    • 84939123246 scopus 로고    scopus 로고
    • Eccrine sweat gland development and sweat secretion
    • COI: 1:CAS:528:DC%2BC2MXhtlCrs7fP, PID: 26014472
    • Cui CY, Schlessinger D (2015) Eccrine sweat gland development and sweat secretion. Exp Dermatol 24:644–650
    • (2015) Exp Dermatol , vol.24 , pp. 644-650
    • Cui, C.Y.1    Schlessinger, D.2
  • 187
    • 0036450262 scopus 로고    scopus 로고
    • Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin
    • COI: 1:CAS:528:DC%2BD38XpslCrt7k%3D, PID: 12445197
    • Murakami M, Ohtake T, Dorschner RA, Schittek B, Garbe C, Gallo RL (2002) Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin. J Invest Dermatol 119:1090–1095
    • (2002) J Invest Dermatol , vol.119 , pp. 1090-1095
    • Murakami, M.1    Ohtake, T.2    Dorschner, R.A.3    Schittek, B.4    Garbe, C.5    Gallo, R.L.6
  • 188
    • 79952722634 scopus 로고    scopus 로고
    • An antimicrobial protein, lactoferrin exists in the sweat: proteomic analysis of sweat
    • COI: 1:CAS:528:DC%2BC3MXmtVKnsL4%3D, PID: 21366701
    • Park JH, Park GT, Cho IH, Sim SM, Yang JM, Lee DY (2011) An antimicrobial protein, lactoferrin exists in the sweat: proteomic analysis of sweat. Exp Dermatol 20:369–371
    • (2011) Exp Dermatol , vol.20 , pp. 369-371
    • Park, J.H.1    Park, G.T.2    Cho, I.H.3    Sim, S.M.4    Yang, J.M.5    Lee, D.Y.6
  • 189
    • 4944263392 scopus 로고    scopus 로고
    • Dermcidin is constitutively produced by eccrine sweat glands and is not induced in epidermal cells under inflammatory skin conditions
    • COI: 1:CAS:528:DC%2BD2cXpvFOjsbc%3D, PID: 15377337
    • Rieg S, Garbe C, Sauer B, Kalbacher H, Schittek B (2004) Dermcidin is constitutively produced by eccrine sweat glands and is not induced in epidermal cells under inflammatory skin conditions. Br J Dermatol 151:534–539
    • (2004) Br J Dermatol , vol.151 , pp. 534-539
    • Rieg, S.1    Garbe, C.2    Sauer, B.3    Kalbacher, H.4    Schittek, B.5
  • 190
    • 84897113701 scopus 로고    scopus 로고
    • Systematic review focusing on the excretion and protection roles of sweat in the skin
    • COI: 1:CAS:528:DC%2BC2cXltFGlurs%3D, PID: 24577280
    • Peng Y, Cui X, Liu Y, Li Y, Liu J, Cheng B (2014) Systematic review focusing on the excretion and protection roles of sweat in the skin. Dermatology 228:115–120
    • (2014) Dermatology , vol.228 , pp. 115-120
    • Peng, Y.1    Cui, X.2    Liu, Y.3    Li, Y.4    Liu, J.5    Cheng, B.6
  • 191
    • 84871261443 scopus 로고    scopus 로고
    • Eccrine sweat glands are major contributors to reepithelialization of human wounds
    • COI: 1:CAS:528:DC%2BC3sXhslCntro%3D, PID: 23159944
    • Rittie L, Sachs DL, Orringer JS, Voorhees JJ, Fisher GJ (2013) Eccrine sweat glands are major contributors to reepithelialization of human wounds. Am J Pathol 182:163–171
    • (2013) Am J Pathol , vol.182 , pp. 163-171
    • Rittie, L.1    Sachs, D.L.2    Orringer, J.S.3    Voorhees, J.J.4    Fisher, G.J.5
  • 192
    • 84920211040 scopus 로고
    • Abnormal electrolyte composition of sweat in cystic fibrosis of the pancreas; clinical significance and relationship to the disease
    • Di Sant’Agnese PA, Darling RC, Perera GA, Shea E (1953) Abnormal electrolyte composition of sweat in cystic fibrosis of the pancreas; clinical significance and relationship to the disease. Pediatrics 12:549–563
    • (1953) Pediatrics , vol.12 , pp. 549-563
    • Di Sant’Agnese, P.A.1    Darling, R.C.2    Perera, G.A.3    Shea, E.4
  • 193
    • 34447523813 scopus 로고    scopus 로고
    • Cystic fibrosis: lessons from the sweat gland
    • COI: 1:CAS:528:DC%2BD2sXnvFOhs70%3D
    • Quinton PM (2007) Cystic fibrosis: lessons from the sweat gland. Physiology (Bethesda) 22:212–225
    • (2007) Physiology (Bethesda) , vol.22 , pp. 212-225
    • Quinton, P.M.1
  • 195
    • 85028012047 scopus 로고    scopus 로고
    • Pharmacological blockers of STIM1 inhibit increases in intracellular calcium in horse sweat gland cells
    • Robertson J, Bovell D (2014) Pharmacological blockers of STIM1 inhibit increases in intracellular calcium in horse sweat gland cells. FASEB J 28:650.2
    • (2014) FASEB J , vol.28 , pp. 652.2
    • Robertson, J.1    Bovell, D.2
  • 196
    • 81455141244 scopus 로고    scopus 로고
    • The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis
    • COI: 1:CAS:528:DC%2BC38Xos1arug%3D%3D, PID: 21995840
    • Bovell DL, MacDonald A, Meyer BA, Corbett AD, MacLaren WM, Holmes SL, Harker M (2011) The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis. Exp Dermatol 20:1017–1020
    • (2011) Exp Dermatol , vol.20 , pp. 1017-1020
    • Bovell, D.L.1    MacDonald, A.2    Meyer, B.A.3    Corbett, A.D.4    MacLaren, W.M.5    Holmes, S.L.6    Harker, M.7
  • 197
    • 4644254296 scopus 로고    scopus 로고
    • US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey
    • PID: 15280843
    • Strutton DR, Kowalski JW, Glaser DA, Stang PE (2004) US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey. J Am Acad Dermatol 51:241–248
    • (2004) J Am Acad Dermatol , vol.51 , pp. 241-248
    • Strutton, D.R.1    Kowalski, J.W.2    Glaser, D.A.3    Stang, P.E.4
  • 198
    • 20444384801 scopus 로고    scopus 로고
    • Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo
    • COI: 1:CAS:528:DC%2BD2MXkvVOlsrc%3D, PID: 15944307
    • Rieg S, Steffen H, Seeber S, Humeny A, Kalbacher H, Dietz K, Garbe C, Schittek B (2005) Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo. J Immunol 174:8003–8010
    • (2005) J Immunol , vol.174 , pp. 8003-8010
    • Rieg, S.1    Steffen, H.2    Seeber, S.3    Humeny, A.4    Kalbacher, H.5    Dietz, K.6    Garbe, C.7    Schittek, B.8
  • 199
    • 84893234899 scopus 로고    scopus 로고
    • Sweat gland progenitors in development, homeostasis, and wound repair
    • PID: 24492848
    • Lu C, Fuchs E (2014) Sweat gland progenitors in development, homeostasis, and wound repair. Cold Spring Harb Perspect Med 4:a015222
    • (2014) Cold Spring Harb Perspect Med , vol.4 , pp. a015222
    • Lu, C.1    Fuchs, E.2
  • 200
    • 84863622334 scopus 로고    scopus 로고
    • Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair
    • COI: 1:CAS:528:DC%2BC38XpvFGhtrg%3D, PID: 22770217
    • Lu CP, Polak L, Rocha AS, Pasolli HA, Chen SC, Sharma N, Blanpain C, Fuchs E (2012) Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair. Cell 150:136–150
    • (2012) Cell , vol.150 , pp. 136-150
    • Lu, C.P.1    Polak, L.2    Rocha, A.S.3    Pasolli, H.A.4    Chen, S.C.5    Sharma, N.6    Blanpain, C.7    Fuchs, E.8
  • 202
    • 0008283534 scopus 로고
    • The fine structure of human eccrine sweat glands
    • COI: 1:STN:280:DyaG1M%2Fms1GqsQ%3D%3D, PID: 13636989
    • Hibbs RG (1958) The fine structure of human eccrine sweat glands. Am J Anat 103:201–217
    • (1958) Am J Anat , vol.103 , pp. 201-217
    • Hibbs, R.G.1
  • 203
    • 0026572720 scopus 로고
    • Evidence of two distinct epithelial cell types in primary cultures from human sweat gland secretory coil
    • COI: 1:CAS:528:DyaK38Xkt1eks7g%3D, PID: 1314491
    • Reddy MM, Bell CL, Quinton PM (1992) Evidence of two distinct epithelial cell types in primary cultures from human sweat gland secretory coil. Am J Physiol 262:C891–C898
    • (1992) Am J Physiol , vol.262 , pp. C891-C898
    • Reddy, M.M.1    Bell, C.L.2    Quinton, P.M.3
  • 204
    • 0034015881 scopus 로고    scopus 로고
    • cAMP-dependent Cl(−) channel protein (CFTR) and its mRNA are expressed in the secretory portion of human eccrine sweat gland
    • COI: 1:CAS:528:DC%2BD3cXhslSmur0%3D, PID: 10681388
    • Sato F, Sato K (2000) cAMP-dependent Cl(−) channel protein (CFTR) and its mRNA are expressed in the secretory portion of human eccrine sweat gland. J Histochem Cytochem 48:345–354
    • (2000) J Histochem Cytochem , vol.48 , pp. 345-354
    • Sato, F.1    Sato, K.2
  • 205
    • 84923375293 scopus 로고    scopus 로고
    • A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium-activated chloride secretion in human sweat gland epithelial cells
    • COI: 1:CAS:528:DC%2BC2cXhvVGlsL3J, PID: 25220078
    • Ertongur-Fauth T, Hochheimer A, Buescher JM, Rapprich S, Krohn M (2014) A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Exp Dermatol 23:825–831
    • (2014) Exp Dermatol , vol.23 , pp. 825-831
    • Ertongur-Fauth, T.1    Hochheimer, A.2    Buescher, J.M.3    Rapprich, S.4    Krohn, M.5
  • 206
    • 0018521767 scopus 로고
    • Mechanical properties and functions of the myoepithelium in the eccrine sweat gland
    • COI: 1:CAS:528:DyaE1MXltlyhurk%3D, PID: 38671
    • Sato K, Nishiyama A, Kobayashi M (1979) Mechanical properties and functions of the myoepithelium in the eccrine sweat gland. Am J Physiol 237:C177–C184
    • (1979) Am J Physiol , vol.237 , pp. C177-C184
    • Sato, K.1    Nishiyama, A.2    Kobayashi, M.3
  • 207
    • 84957434436 scopus 로고    scopus 로고
    • Identification of potassium and chloride channels in eccrine sweat glands
    • COI: 1:CAS:528:DC%2BC2MXhvFWlur7O, PID: 26627722
    • Cui CY, Sima J, Yin M, Michel M, Kunisada M, Schlessinger D (2016) Identification of potassium and chloride channels in eccrine sweat glands. J Dermatol Sci 81:129–131
    • (2016) J Dermatol Sci , vol.81 , pp. 129-131
    • Cui, C.Y.1    Sima, J.2    Yin, M.3    Michel, M.4    Kunisada, M.5    Schlessinger, D.6
  • 208
    • 0024436699 scopus 로고
    • − impermeability in cystic fibrosis sweat duct epithelium
    • COI: 1:STN:280:DyaK3c%2Fitlygsg%3D%3D, PID: 2478027
    • − impermeability in cystic fibrosis sweat duct epithelium. Am J Physiol 257:C727–C735
    • (1989) Am J Physiol , vol.257 , pp. C727-C735
    • Reddy, M.M.1    Quinton, P.M.2
  • 209
    • 71449106534 scopus 로고    scopus 로고
    • PKA mediates constitutive activation of CFTR in human sweat duct
    • COI: 1:CAS:528:DC%2BD1MXhsVSktr7J, PID: 19865788
    • Reddy MM, Quinton PM (2009) PKA mediates constitutive activation of CFTR in human sweat duct. J Membr Biol 231:65–78
    • (2009) J Membr Biol , vol.231 , pp. 65-78
    • Reddy, M.M.1    Quinton, P.M.2
  • 211
    • 0037277853 scopus 로고    scopus 로고
    • Functional interaction of CFTR and ENaC in sweat glands
    • COI: 1:CAS:528:DC%2BD3sXis1Gnsbs%3D, PID: 12548396
    • Reddy MM, Quinton PM (2003) Functional interaction of CFTR and ENaC in sweat glands. Pflugers Arch 445:499–503
    • (2003) Pflugers Arch , vol.445 , pp. 499-503
    • Reddy, M.M.1    Quinton, P.M.2
  • 212
    • 53949125760 scopus 로고    scopus 로고
    • Effect of cytosolic pH on epithelial Na+ channel in normal and cystic fibrosis sweat ducts
    • COI: 1:CAS:528:DC%2BD1cXhsVagsbbJ, PID: 18937003
    • Reddy MM, Wang XF, Quinton PM (2008) Effect of cytosolic pH on epithelial Na+ channel in normal and cystic fibrosis sweat ducts. J Membr Biol 225:1–11
    • (2008) J Membr Biol , vol.225 , pp. 1-11
    • Reddy, M.M.1    Wang, X.F.2    Quinton, P.M.3
  • 213
    • 0023213846 scopus 로고
    • Permeability properties of cell membranes and tight junctions of normal and cystic fibrosis sweat ducts
    • COI: 1:CAS:528:DyaL2sXktVGgsL0%3D, PID: 3601637
    • Bijman J, Quinton P (1987) Permeability properties of cell membranes and tight junctions of normal and cystic fibrosis sweat ducts. Pflugers Arch 408:505–510
    • (1987) Pflugers Arch , vol.408 , pp. 505-510
    • Bijman, J.1    Quinton, P.2
  • 214
    • 0028052138 scopus 로고
    • Intracellular Cl activity: evidence of dual mechanisms of cl absorption in sweat duct
    • COI: 1:CAS:528:DyaK2cXmvFOlur8%3D, PID: 7943277
    • Reddy MM, Quinton PM (1994) Intracellular Cl activity: evidence of dual mechanisms of cl absorption in sweat duct. Am J Physiol 267:C1136–C1144
    • (1994) Am J Physiol , vol.267 , pp. C1136-C1144
    • Reddy, M.M.1    Quinton, P.M.2
  • 215
    • 0024952837 scopus 로고
    • − conductance and acid secretion in the human sweat duct
    • COI: 1:STN:280:DyaK3c3jtlKltw%3D%3D, PID: 2561329
    • − conductance and acid secretion in the human sweat duct. Ann N Y Acad Sci 574:438–446
    • (1989) Ann N Y Acad Sci , vol.574 , pp. 438-446
    • Quinton, P.M.1    Reddy, M.M.2
  • 216
    • 0033847873 scopus 로고    scopus 로고
    • Vacuolar-type H+-ATPase distribution in unstimulated and acetylcholine-activated isolated human eccrine sweat glands
    • COI: 1:CAS:528:DC%2BD3cXnt1OhtrY%3D, PID: 10987504
    • Bovell DL, Clunes MT, Roussa E, Burry J, Elder HY (2000) Vacuolar-type H+-ATPase distribution in unstimulated and acetylcholine-activated isolated human eccrine sweat glands. Histochem J 32:409–413
    • (2000) Histochem J , vol.32 , pp. 409-413
    • Bovell, D.L.1    Clunes, M.T.2    Roussa, E.3    Burry, J.4    Elder, H.Y.5
  • 217
    • 16644403475 scopus 로고    scopus 로고
    • Localisation of the vacuolar proton pump (V-H+-ATPase) and carbonic anhydrase II in the human eccrine sweat gland
    • COI: 1:CAS:528:DC%2BD2cXntFCntLc%3D, PID: 15503807
    • Clunes MT, Lindsay SL, Roussa E, Quinton PM, Bovell DL (2004) Localisation of the vacuolar proton pump (V-H+-ATPase) and carbonic anhydrase II in the human eccrine sweat gland. J Mol Histol 35:339–345
    • (2004) J Mol Histol , vol.35 , pp. 339-345
    • Clunes, M.T.1    Lindsay, S.L.2    Roussa, E.3    Quinton, P.M.4    Bovell, D.L.5
  • 218
    • 0021271891 scopus 로고
    • Defective beta adrenergic response of cystic fibrosis sweat glands in vivo and in vitro
    • COI: 1:CAS:528:DyaL2cXksFartr4%3D, PID: 6327771
    • Sato K, Sato F (1984) Defective beta adrenergic response of cystic fibrosis sweat glands in vivo and in vitro. J Clin Invest 73:1763–1771
    • (1984) J Clin Invest , vol.73 , pp. 1763-1771
    • Sato, K.1    Sato, F.2
  • 219
    • 0006354668 scopus 로고
    • Heat prostration in fibrocystic disease of the pancreas and other conditions
    • COI: 1:STN:280:DyaG38%2FitFCgsw%3D%3D, PID: 14891321
    • Kessler WR, Andersen DH (1951) Heat prostration in fibrocystic disease of the pancreas and other conditions. Pediatrics 8:648–656
    • (1951) Pediatrics , vol.8 , pp. 648-656
    • Kessler, W.R.1    Andersen, D.H.2
  • 220
    • 9244225677 scopus 로고
    • A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis
    • COI: 1:CAS:528:DyaG1MXnvVWmuw%3D%3D, PID: 13633369
    • Gibson LE, Cooke RE (1959) A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis. Pediatrics 23:545–549
    • (1959) Pediatrics , vol.23 , pp. 545-549
    • Gibson, L.E.1    Cooke, R.E.2
  • 221
    • 84902649121 scopus 로고    scopus 로고
    • A synopsis of methods of sweat tests in pathology
    • PID: 24858243
    • Quinton PM (2014) A synopsis of methods of sweat tests in pathology. Clin Biochem 47:757–758
    • (2014) Clin Biochem , vol.47 , pp. 757-758
    • Quinton, P.M.1
  • 222
    • 0020533435 scopus 로고
    • Higher bioelectric potentials due to decreased chloride absorption in the sweat glands of patients with cystic fibrosis
    • COI: 1:STN:280:DyaL3s7pt1ejsQ%3D%3D, PID: 6843595
    • Quinton PM, Bijman J (1983) Higher bioelectric potentials due to decreased chloride absorption in the sweat glands of patients with cystic fibrosis. N Engl J Med 308:1185–1189
    • (1983) N Engl J Med , vol.308 , pp. 1185-1189
    • Quinton, P.M.1    Bijman, J.2
  • 224
    • 84942312604 scopus 로고    scopus 로고
    • Targeted therapies to improve CFTR function in cystic fibrosis
    • PID: 26403534
    • Brodlie M, Haq IJ, Roberts K, Elborn JS (2015) Targeted therapies to improve CFTR function in cystic fibrosis. Genome Med 7:101
    • (2015) Genome Med , vol.7 , pp. 101
    • Brodlie, M.1    Haq, I.J.2    Roberts, K.3    Elborn, J.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.