Acidic pH increases airway surface liquid viscosity in cystic fibrosis

Journal of Clinical Investigation

Volumn 126, Issue 3, 2016, Pages 879-891

  Tang, Xiao Xiao ^a,b   Ostedgaard, Lynda S ^a   Hoegger, Mark J ^a   Moninger, Thomas O ^c   Karp, Philip H ^a   McMenimen, James D ^a   Choudhury, Biswa ^d   Varki, Ajit ^d,e   Stoltz, David A ^a,f   Welsh, Michael J ^a,b  

^a Department of Internal Medicine ^*  (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d University of California San Diego   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f University of Iowa   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HEPARIN; MUCIN; SODIUM CHLORIDE; BICARBONATE; MESSENGER RNA; METHACHOLINE CHLORIDE; MUCIN 5AC; MUCIN 5B; POLYSACCHARIDE;

ACIDITY; AIRWAY; AIRWAY SURFACE LIQUID; ALKALINIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DISULFIDE BOND; FEMALE; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GLYCOSYLATION; MALE; NEWBORN; NONHUMAN; PIGLET; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; STATIC ELECTRICITY; VISCOSITY; ANIMAL; CARBOHYDRATE ANALYSIS; CELL CULTURE; CHEMICALLY INDUCED; GENETICS; HUMAN; LUNG ALVEOLUS EPITHELIUM CELL; METABOLISM; MUCUS; PH; PIG; RESPIRATORY MUCOSA; SECRETION (PROCESS);

ALVEOLAR EPITHELIAL CELLS; ANIMALS; BICARBONATES; CARBOHYDRATE SEQUENCE; CELLS, CULTURED; CYSTIC FIBROSIS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; METHACHOLINE CHLORIDE; MUCIN 5AC; MUCIN-5B; MUCUS; POLYSACCHARIDES; RESPIRATORY MUCOSA; RNA, MESSENGER; SUS SCROFA; VISCOSITY;

EID: 84959908589     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI83922     Document Type: Article

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