PKA mediates constitutive activation of CFTR in human sweat duct

Journal of Membrane Biology

Volumn 231, Issue 2-3, 2009, Pages 65-78

  Reddy, M M ^a   Quinton, P M ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

F508 CFTR; toxin; CFTR; G proteins; Glutamate; Okadaic acid; PKA; PKG; R117H CFTR

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN TISSUE; MALE; PROTEIN DEPHOSPHORYLATION; SWEAT GLAND; SWEAT GLAND DUCT;

ADULT; BACTERIAL TOXINS; CHLORIDES; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ENZYME ACTIVATION; HUMANS; MALE; OKADAIC ACID; PHOSPHORYLATION; SWEAT GLANDS;

EID: 71449106534     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-009-9205-1     Document Type: Article

References (43)

1. - channel by specific protein kinases and protein phosphatases J Biol Chem 268 2037 2047 1:CAS:528: DyaK3sXhsVGisLk%3D 7678414
2. SH Cheng DP Rich J Marshall RJ Gregory MJ Welsh AE Smith 1991 Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel Cell 66 1027 1036 10.1016/0092-8674(91)90446-6 1:CAS:528:DyaK3MXmtVGitLs%3D 1716180
3. AM Dulhanty JR Riordan 1994 Phosphorylation by cAMP-dependent protein kinase causes a conformational change in the R domain of the cystic fibrosis transmembrane conductance regulator Biochemistry 33 4072 4079 10.1021/bi00179a036 1:CAS:528:DyaK2cXitFCnu7s%3D 7511414
4. H Fischer B Illek TE Machen 1998 Regulation of CFTR by protein phosphatase 2B and protein kinase C Pfluegers Arch 436 175 181 10.1007/s004240050620 1:CAS:528:DyaK1cXjtVelt7o%3D (Pubitemid 28253130)
5. PJ French J Bijman M Edixhoven AB Vaandrager BJ Scholte SM Lohmann AC Nairn HR De Jonge 1995 Isotype-specific activation of cystic fibrosis transmembrane conductance regulator-chloride channels by cGMP-dependent protein kinase II J Biol Chem 270 26626 26631 10.1074/jbc.270.44.26626 1:CAS:528:DyaK2MXpt1eit7o%3D 7592887
6. DC Gadsby AC Nairn 1999 Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis Physiol Rev 79 S77 S107 1:CAS:528:DyaK1MXhs1Orsr4%3D 9922377
7. R Greger 1981 Cation selectivity of the isolated perfused cortical thick ascending limb of Henle's loop of rabbit kidney Pfluegers Arch 390 30 37 10.1007/BF00582707 1:STN:280:DyaL3M3it1Omtg%3D%3D (Pubitemid 11105541)
8. SR Gudi CB Clark JA Frangos 1996 Fluid flow rapidly activates G proteins in human endothelial cells. Involvement of G proteins in mechanochemical signal transduction Circ Res 79 834 839 1:CAS:528:DyaK28XmtVCmsbo%3D 8831508
9. SI Helman JJ Grantham MB Burg 1971 Effect of vasopressin on electrical resistance of renal cortical collecting tubules Am J Physiol 220 1825 1832 1:CAS:528:DyaE3MXktlSksro%3D 5087832
10. Y Jia CJ Mathews JW Hanrahan 1997 Phosphorylation by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A J Biol Chem 272 4978 4984 10.1074/jbc.272.8.4978 1:CAS:528:DyaK2sXhsValtb8%3D 9030559 (Pubitemid 27090049)
11. J Luo MD Pato JR Riordan JW Hanrahan 1998 Differential regulation of single CFTR channels by PP2C, PP2A, and other phosphatases Am J Physiol 274 C1397 C1410 1:CAS:528:DyaK1cXjsFSisL8%3D 9612228
12. - secretion in Calu-3 human airway cells requires CFTR Am J Physiol 273 L1208 L1219 1:CAS:528:DyaK1cXjvFWnsQ%3D%3D 9435576
13. MR Picciotto JA Cohn G Bertuzzi P Greengard AC Nairn 1992 Phosphorylation of the cystic fibrosis transmembrane conductance regulator J Biol Chem 267 12742 12752 1:CAS:528:DyaK38XltVKltL0%3D 1377674
14. PM Quinton 1986 Missing Cl conductance in cystic fibrosis Am J Physiol 251 C649 C652 1:CAS:528:DyaL28XmtVOitLk%3D 2429558
15. PM Quinton 1999 Physiological basis of cystic fibrosis: a historical perspective Physiol Rev 79 S3 S22 1:CAS:528:DyaK1MXhs1Oku7k%3D 9922374
16. PM Quinton MM Reddy 1991 Regulation of absorption in the human sweat duct Adv Exp Med Biol 290 159 170 1:CAS:528:DyaK38Xls1antw%3D%3D 1719756
17. PM Quinton MM Reddy 1992 Control of CFTR chloride conductance by ATP levels through non-hydrolytic binding Nature 360 79 81 10.1038/360079a0 1:CAS:528:DyaK3sXksVen 1279436
18. PM Quinton MM Reddy 1994 Regulation of absorption by phosphorylation of CFTR Jpn J Physiol 44 suppl 2 S207 S213 1:CAS:528:DyaK2MXjvFSit78%3D 7538608
19. MM Reddy PM Quinton 1991 Intracellular potassium activity and the role of potassium in transepithelial salt transport in the human reabsorptive sweat duct J Membr Biol 119 199 210 10.1007/BF01868725 1:STN:280:DyaK3M3nvVSksQ%3D%3D 2056520
20. - conductance in both cell membranes of an absorptive epithelium J Membr Biol 130 49 62 1:CAS:528:DyaK3sXltVOm 1281885
21. MM Reddy PM Quinton 1994 Rapid regulation of electrolyte absorption in sweat duct J Membr Biol 140 57 67 1:CAS:528:DyaK2cXktlWksLg%3D 7519679
22. MM Reddy PM Quinton 1996 Deactivation of CFTR-Cl conductance by endogenous phosphatases in the native sweat duct Am J Physiol 270 C474 C480 1:CAS:528:DyaK28XhsFykt7Y%3D 8779909
23. MM Reddy PM Quinton 2001 cAMP-independent phosphorylation activation of CFTR by G proteins in native human sweat duct Am J Physiol 280 C604 C613 1:CAS:528:DC%2BD3MXjtVWrurg%3D
24. MM Reddy PM Quinton 2002 Effect of anion transport blockers on CFTR in the human sweat duct J Membr Biol 189 15 25 10.1007/s00232-001-0192-0 1:CAS:528:DC%2BD38XntFajsrc%3D 12202948 (Pubitemid 34985029)
25. MM Reddy PM Quinton 2003 Control of dynamic CFTR selectivity by glutamate and ATP in epithelial cells Nature 423 756 760 10.1038/nature01694 1:CAS:528:DC%2BD3sXksV2it7k%3D 12802335 (Pubitemid 36735698)
26. MM Reddy PM Quinton 2004 Distinctly different phosphatases deactivate PKA and G protein-activated CFTR in sweat duct Pediatr Pulmonol Suppl 26 196
27. - conductance by cGMP in sweat duct. FASEB J 19, abstract 672.48
28. MM Reddy PM Quinton 2005 Potassium sensitive phosphatases deactivate phosphorylation but not glutamate activated CFTR Pediatr Pulmonol Suppl 28 207
29. MM Reddy PM Quinton 2006 Cytosolic potassium controls CFTR deactivation in human sweat duct Am J Physiol 291 C122 C129 10.1152/ajpcell.00134.2005 1:CAS:528:DC%2BD28XntFGisL4%3D
30. Reddy MM, Quinton PM (2008) Synergistic regulation of CFTR-bicarbonate conductance by protein kinases and glutamate in the human sweat duct. IUPS abstracts. FASEB J 22, abstract 934.5
31. MM Reddy RR Kopito PM Quinton 2008 Cytosolic pH regulates GCl through control of phosphorylation states of CFTR Am J Physiol 275 Cell Physiol 44 C1040 C1047
32. - channel function Nature 402 301 304 10.1038/46297 1:CAS:528:DyaK1MXnvFShsL4%3D 10580502
33. MM Reddy D Sun PM Quinton 2001 Apical heterotrimeric G proteins activate CFTR in the native sweat duct J Membr Biol 179 51 61 10.1007/s002320010036 1:CAS:528:DC%2BD3MXitlWjsbg%3D 11155209 (Pubitemid 32125831)
34. K Sato M Ohtsuyama F Sato 1993 Whole cell K and Cl currents in dissociated eccrine secretory coil cells during stimulation J Membr Biol 134 93 106 1:CAS:528:DyaK3sXltlKiur8%3D 8411119
35. BD Schultz AK Singh DC Devor RJ Bridges 1999 Pharmacology of CFTR chloride channel activity Physiol Rev 79 S109 S144 1:CAS:528:DyaK1MXhs1Orsr8%3D 9922378
36. EM Schwiebert N Kizer DC Gruenert BA Stanton 1992 GTP-binding proteins inhibit cAMP activation of chloride channels in cystic fibrosis airway epithelial cells Proc Natl Acad Sci USA 89 10623 10627 10.1073/pnas.89.22.10623 1:CAS:528:DyaK3sXpvFOisQ%3D%3D 1279687
37. EM Schwiebert DJ Benos ME Egan MJ Stutts WB Guggino 1999 CFTR is a conductance regulator as well as a chloride channel Physiol Rev 79 S145 S166 1:CAS:528:DyaK1MXhs1Orsrw%3D 9922379
38. - secretion Am J Physiol 266 L493 L501 1:CAS:528:DyaK2cXktlWqt7g%3D 7515578
39. Y Suzuki M Ohtsuyama G Samman F Sata K Sato 1991 Ionic basis of methacholine-induced shrinkage of dissociated eccrine clear cells J Membr Biol 123 33 41 10.1007/BF01993960 1:CAS:528:DyaK3MXlslGkur8%3D 1723102
40. T Takemura F Sato K Saga Y Suzuki K Sato 1991 Intracellular ion concentrations and cell volume during cholinergic stimulation of eccrine secretory coil cells J Membr Biol 119 211 219 10.1007/BF01868726 1:CAS:528:DyaK3MXhsFOmsbc%3D 2056521
41. AB Vaandrager EM Ehlert T Jarchau SM Lohmann HR de Jonge 1996 N-terminal myristoylation is required for membrane localization of cGMP-dependent protein kinase type II J Biol Chem 271 7025 7029 10.1074/jbc.271.12.7025 1:CAS:528:DyaK28XhvVyit7c%3D 8636133 (Pubitemid 26104136)
42. - channel activation Proc Natl Acad Sci USA 95 1466 1471 10.1073/pnas.95.4.1466 1:CAS:528:DyaK1cXht1Wqtr4%3D 9465038 (Pubitemid 28103415)
43. X Wang C Lytle PM Quinton 2005 Predominant constitutive CFTR conductance in small airways Respir Res 6 7 10.1186/1465-9921-6-7 1:CAS:528: DC%2BD28XhtFWntbjM 15655076 (Pubitemid 41358061)