Novel role for CFTR in fluid absorption from the distal airspaces of the lung

Journal of General Physiology

Volumn 119, Issue 2, 2002, Pages 199-207

  Fang, X ^a   Fukuda, N ^a   Barbry, P ^a   Sartori, C ^a   Verkman, A S ^a   Matthay, M A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cAMP; Cystic fibrosis; Lung epithelium; Lung fluid balance; Pulmonary edema

Indexed keywords

CHLORIDE CHANNEL; CHLORIDE ION; CYCLIC AMP; GLIBENCLAMIDE; ISOPRENALINE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ABSORPTION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHLORIDE TRANSPORT; CONTROLLED STUDY; CYSTIC FIBROSIS; FLUID BALANCE; HUMAN; HUMAN TISSUE; LUNG ALVEOLUS; LUNG ALVEOLUS EPITHELIUM; LUNG CLEARANCE; LUNG EDEMA; LUNG FLUID; MOUSE; NONHUMAN; SODIUM TRANSPORT;

ABSORPTION; ANIMALS; BRONCHODILATOR AGENTS; CHLORIDE CHANNELS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMANS; ISOTONIC SOLUTIONS; LUNG; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; PULMONARY EDEMA; SODIUM CHLORIDE;

EID: 0036097028     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.119.2.199     Document Type: Article

References (45)

1. Regulation of Na and Cl transport in sheep distal airways
2. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice
3. Regional bioelectric properties of porcine airway epithelium
4. β-adrenergic agonists increase lung liquid clearance in anesthetized sheep
5. Sodium transport proteins are expressed by rat alveolar epithlelial type I cells
6. Cystic fibrosis
7. Clearance of lung edema into the pleural space of volume-loaded anesthetized sheep
8. Alveolar epithelial fluid clearance persists in the presence of moderate left atrial hypertension in sheep
9. Autoradiographic visualization of beta-adrenoreceptor subtypes in human lung
10. Tight monolayers of rat alveolar epithelial cells: Bioelectric properties and active sodium transport
11. Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis
12. Generation and characterization of a ΔF508 cystic fibrosis mouse model
13. Cloning and widespread distribution of the rat rodetype cyclic nucleotide-gated cation channel
14. Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspaces and vasculature in rat lung
15. New evidence for active sodium transport from fluid-filled rat lungs
16. Expression of the cystic fibrosis gene in adult human lung
17. Transepithelial water permeability in microperfused distal airways: Evidence for channel-mediated water transport
18. β-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats
19. Relationship of interstitial fluid volume to alveolar fluid clearance in mice: Ventilated vs. in situ studies
20. Early death due to defective neonatal lung liquid clearance in α-ENaC-deficient mice
21. Expression of highly selective sodium channels in alveolar type II cells is determined by culture conditions
22. - channels
23. - channel activation and transport functions in cultures with apical air interface
24. Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis
25. Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema
26. Phenotypic abnormalities in long-term surviving cystic fibrosis mice
27. Mechanisms of increased sodium transport in alveolar type II cells by cAMP: We agree or disagree to do more experiments
28. 2 adrenergic receptors are expressed in rat alveolar epithelial type I cells
29. Lung fluid transport in aquaporin-5 knock out mice
30. Sodium channels in alveolar epithelial cells: Molecular characterization, biophysical properties, and physiological significance
31. Salt and water transport across alveolar and distal airway epithelia in the adult lung
32. Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anesthetized rats
33. Alveolar liquid clearance is increased by endogenous catecholamines in hemorrhagic shock in rats
34. Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-α-dependent mechanism
35. Distribution of ion transport mRNAs throughout murine nose and lung
36. Alveolar fluid clearance in the resected human lung
37. Alveolar epithelial fluid transport mechanisms are preserved in the rewarmed human lung following severe hypothermia
38. Effects of ATP-sensitive potassium channel opener on potassium transport and alveolar fluid clearance in the resected human lung
39. Pharmacology of CFTR channel activity
40. Effect of temperature on alveolar liquid and protein clearance in an in situ perfused goat lung
41. Role of aquaporin water channels in ainvay fluid transport, humidification, and surface liquid hydration
42. Alveolar epithelial fluid transport and the resolution of clinically sex,ere hydrostatic pulmonary edema
43. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome
44. Lung morphometry and models in respiratory physiology
45. + absorption across alveolar epithelium?