Trypsin reduces pancreatic ductal bicarbonate secretion by inhibiting CFTR Cl- channels and luminal anion exchangers

Gastroenterology

Volumn 141, Issue 6, 2011, Pages

  Pallagi, Petra ^a   Venglovecz, Viktória ^b   Rakonczay, Zoltán ^a   Borka, Katalin ^c   Korompay, Anna ^c   Zsvári, Béla ^a   Judák, Linda ^a   Sahintóth, Miklós ^d   Geisz, Andrea ^a,d   Schnr, Andrea ^a,d   Maléth, József ^a   Takács, Tamás ^a   Gray, Mike A ^e   Argent, Barry E ^e   Mayerle, Julia ^f   Lerch, Markus M ^f   Wittmann, Tibor ^a   Hegyi, Péter ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

^c SEMMELWEIS UNIVERSITY   (Hungary)

^d BOSTON UNIVERSITY   (United States)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

^f UNIVERSITY MEDICINE GREIFSWALD   (Germany)

Author keywords

Acinar Cells; Animal Model; Ductal Epithelium; Pancreatic Enzymes

Indexed keywords

BICARBONATE; CHLORIDE CHANNEL; INTRACELLULAR CALCIUM SENSING PROTEIN; PROTEINASE ACTIVATED RECEPTOR 2; TRANSMEMBRANE CONDUCTANCE REGULATOR; TRYPSIN; TRYPSINOGEN;

ADULT; ALKALOSIS; ANIMAL TISSUE; ANION EXCHANGE; ARTICLE; CELL PH; CHRONIC PANCREATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GUINEA PIG; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PANCREAS DUCT; PERFUSION; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

EID: 81855167481     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.08.039     Document Type: Article

References (57)

1. O.H. Petersen Physiology of acinar cell secretion Hans Beger, Andrew Warshaw, Markus Bchler, The pancreas 2nd ed. 2008 Blackwell Publishing Malden, MA 71 77
2. M.M. Lerch, and F.S. Gorelick Early trypsinogen activation in acute pancreatitis Med Clin North Am 84 2000 549 563 (Pubitemid 30346151)
3. E.C. Thrower, F.S. Gorelick, and S.Z. Husain Molecular and cellular mechanisms of pancreatic injury Curr Opin Gastroenterol 84 2010 549 563
4. M.C. Geokas, and H. Rinderknecht Free proteolytic enzymes in pancreatic juice of patients with acute pancreatitis Am J Dig Dis 19 1974 591 598
5. I.G. Renner, H. Rinderknecht, and A.P. Douglas Profiles of pure pancreatic secretions in patients with acute pancreatitis: the possible role of proteolytic enzymes in pathogenesis Gastroenterology 75 1978 1090 1098 (Pubitemid 9039566)
6. D. Withcomb, and H. Beger Definitions of pancreatic diseases and their complications Hans Beger, Andrew Warshaw, Markus Bchler, The pancreas 2nd ed. 2008 Blackwell Publishing Malden, MA 1 6
7. V.P. Singh, L. Bhagat, and S. Navina Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion Gut 56 2007 958 964 (Pubitemid 46999080)
8. A. Kawabata, R. Kuroda, and M. Nishida Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland:Immunolocalization and involvement of nitric oxide in the evoked amylase secretion Life Sci 71 2002 2435 2446 (Pubitemid 35257909)
9. T.D. Nguyen, M.W. Moody, and M. Steinhoff Trypsin activates pancreatic duct epithelial cell ion channels through proteinase activated receptor-2 J Clin Invest 103 1999 261 269 (Pubitemid 29053144)
10. - transport in pancreatic duct cells J Biol Chem 278 2003 200 207 (Pubitemid 36043563)
11. C. Alvarez, J.P. Regan, and D. Merianos Protease-activated receptor-2 regulates bicarbonate secretion by pancreatic duct cells in vitro Surgery 136 2004 669 676 (Pubitemid 39186582)
12. M. Lee, and S. Muallem Physiology of duct cell secretion Hans Beger, Andrew Warshaw, Markus Bchler, The pancreas 2nd ed. 2008 Blackwell Publishing Malden, MA 78 90
13. B.E. Argent Cell physiology of pancreatic ducts L.R. Johnson, Physiology of the gastrointestinal tract. Volume 2 4th ed. 2006 Elsevier San Diego, CA 1376 1396
14. P. Hegyi, Z. Rakonczay Jr, and K. Farkas Controversies in the role of SLC26 anion exchangers in pancreatic ductal bicarbonate secretion Pancreas 37 2008 232 234
15. H. Ishiguro, M.C. Steward, and Y. Sohma Membrane potential and bicarbonate secretion in isolated interlobular ducts from guinea-pig pancreas J Gen Physiol 120 2002 617 628 (Pubitemid 35332583)
16. - transport in a mathematical model of the pancreatic ductal epithelium J Membr Biol 176 2000 77 100 (Pubitemid 30451991)
17. J.M. Laukkarinen, E.R. Weiss, and G.J. van Acker Protease-activated receptor-2 exerts contrasting model-specific effects on acute experimental pancreatitis J Biol Chem 283 2008 20703 20712
18. A. Kawabata, M. Matsunami, and M. Tsutsumi Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice Br J Pharmacol 148 2006 54 60 (Pubitemid 43675600)
19. A. Sharma, X. Tao, and A. Gopal Protection against acute pancreatitis by activation of protease-activated receptor-2 Am J Physiol Gastrointest Liver Physiol 288 2005 G388 G395
20. W. Namkung, W. Han, and X. Luo Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis Gastroenterology 126 2004 1844 1859 (Pubitemid 38736349)
21. B.E. Argent, S. Arkle, and M.J. Cullen Morphological, biochemical and secretory studies on rat pancreatic ducts maintained in tissue culture Q J Exp Physiol 71 1986 633 648 (Pubitemid 17208273)
22. - secretion from guinea pig pancreatic ducts Am J Physiol Cell Physiol 288 2005 C1030 C1041
23. N. Behrendorff, M. Floetenmeyer, and C. Schwiening Protons released during pancreatic acinar cell secretion acidify the lumen and contribute to pancreatitis in mice Gastroenterology 139 2010 1711 1720
24. H. Ishiguro, M.C. Steward, and R.W. Wilson Bicarbonate secretion in interlobular ducts from guinea-pig pancreas J Physiol 495 1996 179 191 (Pubitemid 26288463)
25. Z. Kukor, J. Mayerle, and B. Kruger Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis J Biol Chem 277 2002 21389 21396 (Pubitemid 34952279)
26. F. Tympner, and W. Rosch Viscosity and trypsin activity of pure pancreatic juice in chronic pancreatitis Acta Hepatogastroenterol (Stuttg) 25 1978 73 76 (Pubitemid 8294045)
27. S.S. Fedail, R.F. Harvey, and P.R. Salmon Trypsin and lactoferrin levels in pure pancreatic juice in patients with pancreatic disease Gut 20 1979 983 986 (Pubitemid 10167198)
28. F. Tympner Selectively aspirated pure pancreatic secretion Viscosity, trypsin activity, protein concentration and lactoferrin content of pancreatic juice in chronic pancreatitis Hepatogastroenterology 28 1981 169 172 (Pubitemid 11078717)
29. M. Sahin-Tóth, and M. Tóth Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogen Biochem Biophys Res Commun 278 2000 286 289
30. G.M. Cavestro, R.A. Zuppardo, and S. Bertolini Connections between genetics and clinical data:Role of MCP-1, CFTR, and SPINK-1 in the setting of acute, acute recurrent, and chronic pancreatitis Am J Gastroenterol 105 2010 199 206
31. P. Hegyi, and Z. Rakonczay Insufficiency of electrolyte and fluid secretion by pancreatic ductal cells lead to increase patients risk to pancreatitis Am J Gastroenterol 105 2010 2119 2120
32. G. Kloppel, J. Luttges, and B. Sipos Autoimmune pancreatitis: pathological findings Jop 6 2005 97 101 (Pubitemid 41573842)
33. N. Ectors, B. Maillet, and R. Aerts Non-alcoholic duct destructive chronic pancreatitis Gut 41 1997 263 268
34. P. Hegyi, S. Pandol, and V. Venglovecz The acinar-ductal tango in the pathogenesis of acute pancreatitis Gut 60 2011 544 552
35. S. Nousia-Arvanitakis Cystic fibrosis and the pancreas: recent scientific advances J Clin Gastroenterol 29 1999 138 142 (Pubitemid 29404459)
36. F.U. Weiss, P. Simon, and N. Bogdanova Functional characterisation of the CFTR mutations M348V and A1087P from patients with pancreatitis suggests functional interaction between CFTR monomers Gut 58 2009 733 734
37. J. Maleth, V. Venglovecz, and Z. Rázga The non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells Gut 60 2011 136 138
38. A. Yamamoto, H. Ishiguro, and S.B. Ko Ethanol induces fluid hypersecretion from guinea-pig pancreatic duct cells J Physiol 551 2003 917 926 (Pubitemid 37221083)
39. V. Venglovecz, Z. Rakonczay Jr, and B. Ozsvari Effects of bile acids on pancreatic ductal bicarbonate secretion in guinea pig Gut 57 2008 1102 1112
40. M.G. Lee, and S. Muallem Pancreatitis: the neglected duct Gut 57 2008 1037 1039
41. P.J. Padfield, A. Garner, and R.M. Case Patterns of pancreatic secretion in the anaesthetised guinea pig following stimulation with secretin, cholecystokinin octapeptide, or bombesin Pancreas 4 1989 204 209 (Pubitemid 19147823)
42. M.C. Steward, H. Ishiguro, and R.M. Case Mechanisms of bicarbonate secretion in the pancreatic duct Annu Rev Physiol 67 2005 377 409 (Pubitemid 40404495)
43. N. Vergnolle Review article: proteinase-activated receptors-novel signals for gastrointestinal pathophysiology Aliment Pharmacol Ther 14 2000 257 266 (Pubitemid 30145312)
44. S.K. Bohm, L.M. Khitin, and E.F. Grady Mechanisms of desensitization and resensitization of proteinase-activated receptor-2 J Biol Chem 271 1996 22003 22016 (Pubitemid 26303826)
45. J.A. Hoxie, M. Ahuja, and E. Belmonte Internalization and recycling of activated thrombin receptors J Biol Chem 268 1993 13756 13763 (Pubitemid 23307811)
46. - secretion by guinea pig interlobular pancreatic duct Am J Physiol Gastrointest Liver Physiol 296 2009 G1307 G1317
47. - transport in cystic fibrosis EMBO J 21 2002 5662 5672 (Pubitemid 35315266)
48. M.N. Chernova, L. Jiang, and B.E. Shmukler Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes J Physiol 549 2003 3 19 (Pubitemid 36626394)
49. H. Ishiguro, S. Naruse, and M.C. Steward Fluid secretion in interlobular ducts isolated from guinea-pig pancreas J Physiol 511 1998 407 422 (Pubitemid 28444611)
50. - secretion in guinea-pig pancreatic duct J Physiol 519 1999 551 558 (Pubitemid 29430016)
51. F. Schmidlin, S. Amadesi, and K. Dabbagh Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway J Immunol 169 2002 5315 5321 (Pubitemid 35217205)
52. V.P. Singh, L. Bhagat, and S. Navina Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion Gut 56 2007 958 964 (Pubitemid 46999080)
53. B.E. Argent, S. Arkle, and M.J. Cullen Morphological, biochemical and secretory studies on rat pancreatic ducts maintained in tissue culture Q J Exp Physiol 71 1986 633 648 (Pubitemid 17208273)
54. P. Hegyi, Z. Rakonczay Jr, and M.A. Gray Measurement of intracellular pH in pancreatic duct cells: a new method for calibrating the fluorescence data Pancreas 28 2004 427 434 (Pubitemid 38509748)
55. J.A. Thomas, R.N. Buchsbaum, and A. Zimniak Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ Biochemistry 18 1979 2210 2218 (Pubitemid 9191034)
56. M. Sahin-Tóth, and M. Tóth Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogen Biochem Biophys Res Commun 278 2000 286 289
57. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254