Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 4, 2012, Pages 1199-1203

  Cui, Chang Yi ^a   Childress, Victoria ^a   Piao, Yulan ^a   Michel, Marc ^a   Johnson, Adiv A ^b   Kunisada, Makoto ^c   Ko, Minoru S H ^a   Kaestner, Klaus H ^d   Marmorstein, Alan D ^b   Schlessinger, David ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cystic fibrosis; Ectodysplasin; Idiopathic acquired generalized anhidrosis

Indexed keywords

ANION CHANNEL; BICARBONATE; CALCIUM ION; GLYCOPROTEIN; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; SODIUM POTASSIUM CHLORIDE COTRANSPORTER;

ABLATION THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HYPERTHERMIA; ION TRANSPORT; MORPHOGENESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SWEAT GLAND; SWEATING; THERMOREGULATION; TRANSCRIPTION REGULATION;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; BODY TEMPERATURE REGULATION; CHLORIDE CHANNELS; CROSSES, GENETIC; DNA PRIMERS; EYE PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE; GALACTOSIDES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOTYPE; HEPATOCYTE NUCLEAR FACTOR 3-ALPHA; INDOLES; MICE; MODELS, BIOLOGICAL; REAL-TIME POLYMERASE CHAIN REACTION; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; SWEATING;

MAMMALIA; MUS;

EID: 84856395568     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1117213109     Document Type: Article

References (30)

1. Saga K (2002) Structure and function of human sweat glands studied with histochemistry and cytochemistry. Prog Histochem Cytochem 37:323-386.
2. Sato K, Kang WH, Saga K, Sato KT (1989) Biology of sweat glands and their disorders. I. Normal sweat gland function. J Am Acad Dermatol 20:537-563. (Pubitemid 19091250)
3. Cui CY, Schlessinger D (2006) EDA signaling and skin appendage development. Cell Cycle 5:2477-2483.
4. Kere J, et al. (1996) X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat Genet 13:409-416. (Pubitemid 26256613)
5. Kunisada M, Cui CY, Piao Y, Ko MS, Schlessinger D (2009) Requirement for Shh and Fox family genes at different stages in sweat gland development. Hum Mol Genet 18:1769-1778.
6. Friedman JR, Kaestner KH (2006) The Foxa family of transcription factors in development and metabolism. Cell Mol Life Sci 63:2317-2328. (Pubitemid 44653042)
7. Lee CS, Friedman JR, Fulmer JT, Kaestner KH (2005) The initiation of liver development is dependent on Foxa transcription factors. Nature 435:944-947. (Pubitemid 40896319)
8. Besnard V, Wert SE, Kaestner KH, Whitsett JA (2005) Stage-specific regulation of respiratory epithelial cell differentiation by Foxa1. Am J Physiol Lung Cell Mol Physiol 289:L750-L759. (Pubitemid 41504406)
9. Ye DZ, Kaestner KH (2009) Foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-cells in mice. Gastroenterology 137:2052-2062.
10. Gao N, et al. (2010) Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell. Mol Endocrinol 24:1594-1604.
11. Behr R, et al. (2004) Mild nephrogenic diabetes insipidus caused by Foxa1 deficiency. J Biol Chem 279:41936-41941. (Pubitemid 39313643)
12. Gao N, et al. (2008) Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev 22:3435-3448.
13. Yanagawa S, Yokozeki H, Sato K (1986) Origin of periodic acid-Schiff-reactive glycoprotein in human eccrine sweat. J Appl Physiol 60:1615-1622. (Pubitemid 16088051)
14. Heller DS, Haefner HK, Hameed M, Lieberman RW (2002) Vulvar hidradenitis suppurativa. Immunohistochemical evaluation of apocrine and eccrine involvement. J Reprod Med 47:695-700.
15. Zancanaro C, Merigo F, Crescimanno C, Orlandini S, Osculati A (1999) Immunohistochemical evidence suggests intrinsic regulatory activity of human eccrine sweat glands. J Anat 194:433-444. (Pubitemid 29241494)
16. Qu Z, Hartzell HC (2008) Bestrophin Cl- channels are highly permeable to HCO3-. Am J Physiol Cell Physiol 294:C1371-C1377.
17. Romanenko VG, et al. (2010) Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells. J Biol Chem 285:12990-13001.
18. Bakall B, et al. (2008) Bestrophin-2 is involved in the generation of intraocular pressure. Invest Ophthalmol Vis Sci 49:1563-1570.
19. Nejsum LN, Praetorius J, Nielsen S (2005) NKCC1 and NHE1 are abundantly expressed in the basolateral plasma membrane of secretory coil cells in rat, mouse, and human sweat glands. Am J Physiol Cell Physiol 289:C333-C340. (Pubitemid 41008880)
20. Lobitz WC, Jr., Dobson L (1965) Miliaria. Arch Environ Health 11:460-464.
21. Yu K, Lujan R, Marmorstein A, Gabriel S, Hartzell HC (2010) Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon. J Clin Invest 120:1722-1735.
22. Zhang Y, Patil RV, Marmorstein AD (2010) Bestrophin 2 is expressed in human nonpigmented ciliary epithelium but not retinal pigment epithelium. Mol Vis 16:200-206.
23. - transport in mucin secretion: Lessons from cystic fibrosis. Am J Physiol Cell Physiol 299:C1222-C1233.
24. Feldshtein M, et al. (2010) Hyperchlorhidrosis caused by homozygous mutation in CA12, encoding carbonic anhydrase XII. Am J Hum Genet 87:713-720.
25. Sun H, Tsunenari T, Yau KW, Nathans J (2002) The vitelliform macular dystrophy protein defines a new family of chloride channels. Proc Natl Acad Sci USA 99:4008-4013. (Pubitemid 34252220)
26. Hartzell HC, Qu Z, Yu K, Xiao Q, Chien LT (2008) Molecular physiology of bestrophins: Multifunctional membrane proteins linked to best disease and other retinopathies. Physiol Rev 88:639-672. (Pubitemid 351522747)
27. Sato K, Sato F (1982) Spontaneous sweat secretion in calcium-free strontium medium. Am J Physiol 242:C353-C359. (Pubitemid 12097185)
28. Ogino J, et al. (2004) Idiopathic acquired generalized anhidrosis due to occlusion of proximal coiled ducts. Br J Dermatol 150:589-593. (Pubitemid 38446320)
29. Srivastava AK, et al. (2001) Ectodysplasin-A1 is sufficient to rescue both hair growth and sweat glands in Tabby mice. Hum Mol Genet 10:2973-2981. (Pubitemid 34083483)
30. Cui CY, et al. (2010) Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair. PLoS ONE 5:e10009.