Amiloride-sensitive fluid resorption in NCI-H441 lung epithelia depends on an apical Cl- conductance

Physiological Reports

Volumn 2, Issue 1, 2014, Pages

  Korbmacher, Jonas P ^a   Michel, Christiane ^a   Neubauer, Daniel ^a   Thompson, Kristin ^a   Mizaikoff, Boris ^a   Frick, Manfred ^a   Dietl, Paul ^a   Wittekindt, Oliver H ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Cl channels; Epithelial transport; Fluid resorption; Lung

Indexed keywords

AMILORIDE; CHLORIDE CHANNEL; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DEUTERIUM OXIDE; EPITHELIAL SODIUM CHANNEL; FORSKOLIN; GLIBENCLAMIDE;

ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; FOURIER TRANSFORM INFRARED PHOTOACOUSTIC SPECTROSCOPY; HUMAN; HUMAN CELL; ION TRANSPORT; LUNG ALVEOLUS EPITHELIUM; LUNG FUNCTION; TRANSPORT AT THE CELLULAR LEVEL;

EID: 85008882683     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.1002/phy2.201     Document Type: Article

References (31)

1. - channels in human osteoblasts. Am. J. Physiol. Cell Physiol. 285: C22-C30.
2. Catalán, M. A., T. Nakamoto, M. Gonzalez-Begne, J. M. Camden, S. M. Wall, L. L. Clarke, et al. 2010. Cftr and ENaC ion channels mediate NaCl absorption in the mouse submandibular gland. J. Physiol. 588: 713-724.
3. Downs, C. A., L. H. Kriener, L. Yu, D. C. Eaton, L. Jain, and M. N. Helms. 2012. β-Adrenergic agonists differentially regulate highly selective and nonselective epithelial sodium channels to promote alveolar fluid clearance in vivo. Am. J. Physiol. Lung Cell. Mol. Physiol. 302: L1167-L1178.
4. Edinger, R. S., C. A. Bertrand, C. Rondandino, G. A. Apodaca, J. P. Johnson, and M. B. Butterworth. 2012. The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation. PLoS One 7: e46593.
5. Eisenhut, M. 2007. The role of cystic fibrosis transmembrane conductance regulator chloride channel in beta-receptor-mediated regulation of alveolar fluid clearance. J. Appl. Physiol. 103: 413.
6. Elias, N., B. Rafii, M. Rahman, G. Otulakowski, E. Cutz, and H. O’Brodovich. 2007. The role of alpha-, beta-, and gamma-ENaC subunits in distal lung epithelial fluid absorption induced by pulmonary edema fluid. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L537-L545.
7. Fang, X., N. Fukuda, P. Barbry, C. Sartori, A. S. Verkman, and M. A. Matthay. 2002. Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J. Gen. Physiol. 119: 199-207.
8. Fang, X., Y. Song, J. Hirsch, L. J. Galietta, N. Pedemonte, R. L. Zemans, et al. 2006. Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 290: L242-L249.
9. - cotransporter inhibitor. Eur. J. Pharmacol. 560: 123-126.
10. - ]-cotransport system. Mol. Pharmacol. 33: 696-701.
11. Hermanns, M. I., R. E. Unger, K. Kehe, K. Peters, and C. J. Kirkpatrick. 2004. Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: development of an alveolo-capillary barrier in vitro. Lab. Invest. J. Tech. Methods Pathol. 84: 736-752.
12. Hummler, E., P. Barker, J. Gatzy, F. Beermann, C. Verdumo, A. Schmidt, et al. 1996. Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat. Genet. 12: 325-328.
13. + transport is associated with regulated ENaC and sgk1 expression. Am. J. Physiol. Lung Cell. Mol. Physiol. 282: L631-L641.
14. Ito, Y., M. Aoyama, N. Yamada, Y. Mizuno, H. Kume, and K. Yamaki. 2001. [(Dihydroindenyl)oxy]alkonic acid inhibits the cystic fibrosis transmembrane conductance regulator. Eur. J. Pharmacol. 426: 175-178.
15. - channel activation and transport function in cultures with an apical air. J. Membr. Biol. 181: 195-204.
16. - channels. Am. J. Physiol. 275: C1610-C1620.
17. Kim, K. J., J. M. Cheek, and E. D. Crandall. 1991. Contribution of active Na+ and Cl- fluxes to net ion transport by alveolar epithelium. Respir. Physiol. 85: 245-256.
18. Kulaksiz, H., A. Schmid, M. Hönscheid, A. Ramaswamy, and Y. Cetin. 2002. Clara cell impact in air-side activation of CFTR in small pulmonary airways. Proc. Natl. Acad. Sci. USA 99: 6796-6801.
19. - transport is stimulated by terbutaline in adult rat alveolar epithelial cells. J. Membr. Biol. 191: 133-139.
20. Li, X., A. P. Comellas, P. H. Karp, S. E. Ernst, T. O. Moninger, N. D. Gansemer, et al. 2012. CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia. Am. J. Physiol. Lung Cell. Mol. Physiol. 303: L152-L160.
21. Lindert, J., C. E. Perlman, K. Parthasarathi, and J. Bhattacharya. 2007. Chloride-dependent secretion of alveolar wall liquid determined by optical-sectioning microscopy. Am. J. Respir. Cell Mol. Biol. 36: 688-696.
22. + transport is dependent on beta2-adrenergic receptor signaling. Circ. Res. 94: 1091-1100.
23. + transport. Circ. Res. 96: 999-1005.
24. Neubauer, D., J. Korbmacher, M. Frick, J. Kiss, M. Timmler, P. Dietl, et al. 2013. Deuterium oxide dilution: a novel method to study apical water layers and transepithelial water transport. Anal. Chem. 85: 4247-4250.
25. O’Brodovich, H. 2001. Fetal lung liquid secretion: insights using the tools of inhibitors and genetic knock-out experiments. Am. J. Respir. Cell Mol. Biol. 25: 8-10.
26. O’Grady, S. M., X. Jiang, and D. H. Ingbar. 2000. Cl-channel activation is necessary for stimulation of Na transport in adult alveolar epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 278: L239-L244.
27. O’Reilly, M. A., T. E. Weaver, T. J. Pilot-Matias, V. K. Sarin, A. F. Gazdar, and J. A. Whitsett. 1989. In vitro translation, post-translational processing and secretion of pulmonary surfactant protein B precursors. Biochim. Biophys. Acta 1011: 140-148.
28. Robins, G. G., K. A. Maclennan, R. P. Boot-Handford, and G. I. Sandle. 2013. Rapid stimulation of human renal ENaC by cAMP in Xenopus laevis oocytes. J. Physiol. Biochem. 69: 419-427.
29. Wang, X., C. Lytle, and P. M. Quinton. 2005. Predominant constitutive CFTR conductance in small airways. Respir. Res. 6: 7.
30. Wispé, J. R., J. C. Clark, B. B. Warner, D. Fajardo, W. E. Hull, R. B. Holtzman, et al. 1990. Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein. J. Clin. Investig. 86: 1954-1960.
31. Woollhead, A. M., and D. L. Baines. 2006. Forskolin-induced cell shrinkage and apical translocation of functional enhanced green fluorescent protein-human alphaENaC in H441 lung epithelial cell monolayers. J. Biol. Chem. 281: 5158-5168.