Pancreatic dysfunction in cystic fibrosis occurs as a result of impairments in luminal pH, apical trafficking of zymogen granule membranes, and solubilization of secretory enzymes

Pancreas

Volumn 12, Issue 1, 1996, Pages 1-9

  Scheele, George A ^a,b,c   Fukuoka, Shin Ichi ^d   Kern, Horst F ^e   Freedman, Steven D ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c Institute of Genomic Medicine   (United States)

^d KYOTO UNIVERSITY   (Japan)

^e PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Apical membrane trafficking; Cystic fibrosis; GP1 anchored proteins; GP2; Luminal pH; Regulated endocytosis; Secretory enzymes; Zymogen granule membranes

Indexed keywords

CHOLECYSTOKININ; ENZYME PRECURSOR; ZYMOGEN GRANULE;

ACID BASE BALANCE; ARTICLE; AUTOSOMAL RECESSIVE INHERITANCE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; CYSTIC FIBROSIS; ENDOCYTOSIS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PANCREAS INSUFFICIENCY; PRIORITY JOURNAL;

EID: 0030067573     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-199601000-00001     Document Type: Article

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