-
1
-
-
0036851876
-
Platelets in atherothrombosis
-
Ruggeri ZM. Platelets in atherothrombosis. Nat Med. 2002;8:1227-34.
-
(2002)
Nat Med
, vol.8
, pp. 1227-1234
-
-
Ruggeri, Z.M.1
-
2
-
-
39749109478
-
Triggers, targets and treatments for thrombosis
-
Mackman N. Triggers, targets and treatments for thrombosis. Nature. 2008;451:914-8.
-
(2008)
Nature
, vol.451
, pp. 914-918
-
-
Mackman, N.1
-
3
-
-
84989895722
-
Platelets, immune-mediated thrombocytopenias, and fetal hemorrhage
-
Xu XR, Gallant RC, Ni H. Platelets, immune-mediated thrombocytopenias, and fetal hemorrhage. Thromb Res. 2016;141 Suppl 2:S76-9.
-
(2016)
Thromb Res
, vol.141
, pp. S76-S79
-
-
Xu, X.R.1
Gallant, R.C.2
Ni, H.3
-
4
-
-
0037410214
-
Platelets in hemostasis and thrombosis: role of integrins and their ligands
-
Ni H, Freedman J. Platelets in hemostasis and thrombosis: role of integrins and their ligands. Transfus Apher Sci. 2003;28:257-64.
-
(2003)
Transfus Apher Sci
, vol.28
, pp. 257-264
-
-
Ni, H.1
Freedman, J.2
-
5
-
-
33748753772
-
Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo
-
Yang H, Reheman A, Chen P, Zhu G, Hynes RO, Freedman J, et al. Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo. J Thromb Haemost. 2006;4:2230-7.
-
(2006)
J Thromb Haemost
, vol.4
, pp. 2230-2237
-
-
Yang, H.1
Reheman, A.2
Chen, P.3
Zhu, G.4
Hynes, R.O.5
Freedman, J.6
-
6
-
-
84957928395
-
Extracellular matrix proteins in the regulation of thrombus formation
-
Wang Y, Gallant RC, Ni H. Extracellular matrix proteins in the regulation of thrombus formation. Curr Opin Hematol. 2016;23:280-7.
-
(2016)
Curr Opin Hematol
, vol.23
, pp. 280-287
-
-
Wang, Y.1
Gallant, R.C.2
Ni, H.3
-
7
-
-
0024426540
-
A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion
-
Moroi M, Jung SM, Okuma M, Shinmyozu K. A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion. J Clin Invest. 1989;84:1440-5.
-
(1989)
J Clin Invest
, vol.84
, pp. 1440-1445
-
-
Moroi, M.1
Jung, S.M.2
Okuma, M.3
Shinmyozu, K.4
-
8
-
-
84865282307
-
Cadherin 6 has a functional role in platelet aggregation and thrombus formation
-
Dunne E, Spring CM, Reheman A, Jin W, Berndt MC, Newman DK, et al. Cadherin 6 has a functional role in platelet aggregation and thrombus formation. Arterioscler Thromb Vasc Biol. 2012;32:1724-31.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 1724-1731
-
-
Dunne, E.1
Spring, C.M.2
Reheman, A.3
Jin, W.4
Berndt, M.C.5
Newman, D.K.6
-
9
-
-
0026495238
-
Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets
-
Palabrica T, Lobb R, Furie BC, Aronovitz M, Benjamin C, Hsu YM, et al. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature. 1992;359:848-51.
-
(1992)
Nature
, vol.359
, pp. 848-851
-
-
Palabrica, T.1
Lobb, R.2
Furie, B.C.3
Aronovitz, M.4
Benjamin, C.5
Hsu, Y.M.6
-
10
-
-
67651098995
-
Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression
-
Yang H, Lang S, Zhai Z, Li L, Kahr WH, Chen P, et al. Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression. Blood. 2009;114:425-36.
-
(2009)
Blood
, vol.114
, pp. 425-436
-
-
Yang, H.1
Lang, S.2
Zhai, Z.3
Li, L.4
Kahr, W.H.5
Chen, P.6
-
11
-
-
84905252442
-
Platelet membrane glycoproteins: a historical review
-
Nurden AT. Platelet membrane glycoproteins: a historical review. Semin Thromb Hemost. 2014;40:577-84.
-
(2014)
Semin Thromb Hemost
, vol.40
, pp. 577-584
-
-
Nurden, A.T.1
-
13
-
-
81255143017
-
Arterial thrombosis--insidious, unpredictable and deadly
-
Jackson SP. Arterial thrombosis--insidious, unpredictable and deadly. Nat Med. 2011;17:1423-36.
-
(2011)
Nat Med
, vol.17
, pp. 1423-1436
-
-
Jackson, S.P.1
-
14
-
-
84897517457
-
Targeting activated platelets and fibrinolysis: hitting two birds with one stone
-
Reheman A, Xu X, Reddy EC, Ni H. Targeting activated platelets and fibrinolysis: hitting two birds with one stone. Circ Res. 2014;114:1070-3.
-
(2014)
Circ Res
, vol.114
, pp. 1070-1073
-
-
Reheman, A.1
Xu, X.2
Reddy, E.C.3
Ni, H.4
-
15
-
-
84969376984
-
Heart disease and stroke statistics-2016 update: a report from the American Heart Association
-
Writing Group Members, Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, et al. Heart disease and stroke statistics-2016 update: a report from the American Heart Association. Circulation. 2016;133:e38-60.
-
(2016)
Circulation
, vol.133
, pp. e38-e60
-
-
Mozaffarian, D.1
Benjamin, E.J.2
Go, A.S.3
Arnett, D.K.4
Blaha, M.J.5
-
16
-
-
75949128633
-
Antiplatelet therapies for the treatment of cardiovascular disease
-
Michelson AD. Antiplatelet therapies for the treatment of cardiovascular disease. Nat Rev Drug Discov. 2010;9:154-69.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 154-169
-
-
Michelson, A.D.1
-
17
-
-
84921578013
-
Novel antiplatelet agents in acute coronary syndrome
-
Franchi F, Angiolillo DJ. Novel antiplatelet agents in acute coronary syndrome. Nat Rev Cardiol. 2015;12:30-47.
-
(2015)
Nat Rev Cardiol
, vol.12
, pp. 30-47
-
-
Franchi, F.1
Angiolillo, D.J.2
-
18
-
-
84931327443
-
Antiplatelet drugs: which targets for which treatments?
-
Gachet C. Antiplatelet drugs: which targets for which treatments? J Thromb Haemost. 2015;13 Suppl 1:S313-22.
-
(2015)
J Thromb Haemost
, vol.13
, pp. S313-S322
-
-
Gachet, C.1
-
19
-
-
84957440989
-
Platelets in hemostasis and thrombosis: novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis
-
Hou Y, Carrim N, Wang Y, Gallant RC, Marshall A, Ni H. Platelets in hemostasis and thrombosis: novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis. J Biomed Res. 2015;29:437-44.
-
(2015)
J Biomed Res
, vol.29
, pp. 437-444
-
-
Hou, Y.1
Carrim, N.2
Wang, Y.3
Gallant, R.C.4
Marshall, A.5
Ni, H.6
-
20
-
-
84901951856
-
Phosphatidylserine exposure, microparticle formation and mitochondrial depolarisation in Glanzmann thrombasthenia platelets
-
Wang H, Bang KW, Blanchette VS, Nurden AT, Rand ML. Phosphatidylserine exposure, microparticle formation and mitochondrial depolarisation in Glanzmann thrombasthenia platelets. Thromb Haemost. 2014;111:1184-6.
-
(2014)
Thromb Haemost
, vol.111
, pp. 1184-1186
-
-
Wang, H.1
Bang, K.W.2
Blanchette, V.S.3
Nurden, A.T.4
Rand, M.L.5
-
21
-
-
84907487892
-
Plasma fibronectin supports hemostasis and regulates thrombosis
-
Wang Y, Reheman A, Spring CM, Kalantari J, Marshall AH, Wolberg AS, et al. Plasma fibronectin supports hemostasis and regulates thrombosis. J Clin Invest. 2014;124:4281-93.
-
(2014)
J Clin Invest
, vol.124
, pp. 4281-4293
-
-
Wang, Y.1
Reheman, A.2
Spring, C.M.3
Kalantari, J.4
Marshall, A.H.5
Wolberg, A.S.6
-
22
-
-
84964335727
-
Fibronectin maintains the balance between hemostasis and thrombosis
-
Wang Y, Ni H. Fibronectin maintains the balance between hemostasis and thrombosis. Cell Mol Life Sci. 2016;73(17):3265-77. doi: 10.1007/s00018-016-2225-y.
-
(2016)
Cell Mol Life Sci
, vol.73
, Issue.17
, pp. 3265-3277
-
-
Wang, Y.1
Ni, H.2
-
23
-
-
84986563688
-
Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond
-
Published online
-
Xu XR, Zhang D, Oswald BE, Carrim N, Wang X, Hou Y, et al. Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond. Crit Rev Clin Lab Sci. 2016. Published online:1-69. doi: 10.1080/10408363.2016.1200008.
-
(2016)
Crit Rev Clin Lab Sci.
, pp. 1-69
-
-
Xu, X.R.1
Zhang, D.2
Oswald, B.E.3
Carrim, N.4
Wang, X.5
Hou, Y.6
-
26
-
-
0242300217
-
Antiplatelet therapy: in search of the 'magic bullet'
-
Jackson SP, Schoenwaelder SM. Antiplatelet therapy: in search of the 'magic bullet'. Nat Rev Drug Discov. 2003;2:775-89.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 775-789
-
-
Jackson, S.P.1
Schoenwaelder, S.M.2
-
27
-
-
84859555815
-
Vorapaxar in the secondary prevention of atherothrombotic events
-
Morrow DA, Braunwald E, Bonaca MP, Ameriso SF, Dalby AJ, Fish MP, et al. Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med. 2012;366:1404-13.
-
(2012)
N Engl J Med
, vol.366
, pp. 1404-1413
-
-
Morrow, D.A.1
Braunwald, E.2
Bonaca, M.P.3
Ameriso, S.F.4
Dalby, A.J.5
Fish, M.P.6
-
28
-
-
84990027129
-
Drug Trials Snapshot Zontivity (vorapaxar)
-
Accessed 15 June 2016
-
Adminstration USFaD. Drug Trials Snapshot Zontivity (vorapaxar). 2014. http://www.fda.gov/Drugs/InformationOnDrugs/ucm423935.htm. Accessed 15 June 2016.
-
(2014)
-
-
-
29
-
-
84990031337
-
-
Accessed 15 June 2016
-
ClinicalTrials.gov. 2011. https://clinicaltrials.gov/ct2/show/NCT00527943?term=Vorapaxar&rank=5. Accessed 15 June 2016.
-
(2011)
-
-
-
30
-
-
0037145037
-
Integrins: bidirectional, allosteric signaling machines
-
Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell. 2002;110:673-87.
-
(2002)
Cell
, vol.110
, pp. 673-687
-
-
Hynes, R.O.1
-
31
-
-
0032400917
-
The selective inhibition of beta 1 and beta 7 integrin-mediated lymphocyte adhesion by bacitracin
-
Mou Y, Ni H, Wilkins JA. The selective inhibition of beta 1 and beta 7 integrin-mediated lymphocyte adhesion by bacitracin. J Immunol. 1998;161:6323-9.
-
(1998)
J Immunol
, vol.161
, pp. 6323-6329
-
-
Mou, Y.1
Ni, H.2
Wilkins, J.A.3
-
34
-
-
84963491567
-
Podoplanin-positive periarteriolar stromal cells promote megakaryocyte growth and proplatelet formation in mice by CLEC-2
-
Tamura S, Suzuki-Inoue K, Tsukiji N, Shirai T, Sasaki T, Osada M, et al. Podoplanin-positive periarteriolar stromal cells promote megakaryocyte growth and proplatelet formation in mice by CLEC-2. Blood. 2016;127:1701-10.
-
(2016)
Blood
, vol.127
, pp. 1701-1710
-
-
Tamura, S.1
Suzuki-Inoue, K.2
Tsukiji, N.3
Shirai, T.4
Sasaki, T.5
Osada, M.6
-
35
-
-
84867391556
-
Crosstalk between platelets and the immune system: old systems with new discoveries
-
Li C, Li J, Li Y, Lang S, Yougbare I, Zhu G, et al. Crosstalk between platelets and the immune system: old systems with new discoveries. Adv Hematol. 2012;2012:384685.
-
(2012)
Adv Hematol
, vol.2012
, pp. 384685
-
-
Li, C.1
Li, J.2
Li, Y.3
Lang, S.4
Yougbare, I.5
Zhu, G.6
-
38
-
-
41149162116
-
Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis
-
Siegel-Axel D, Daub K, Seizer P, Lindemann S, Gawaz M. Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis. Cardiovasc Res. 2008;78:8-17.
-
(2008)
Cardiovasc Res
, vol.78
, pp. 8-17
-
-
Siegel-Axel, D.1
Daub, K.2
Seizer, P.3
Lindemann, S.4
Gawaz, M.5
-
39
-
-
34250790330
-
Platelets, inflammation and atherosclerosis
-
Lindemann S, Kramer B, Seizer P, Gawaz M. Platelets, inflammation and atherosclerosis. J Thromb Haemost. 2007;5 Suppl 1:203-11.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 203-211
-
-
Lindemann, S.1
Kramer, B.2
Seizer, P.3
Gawaz, M.4
-
40
-
-
84877356252
-
Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis
-
Murphy AJ, Bijl N, Yvan-Charvet L, Welch CB, Bhagwat N, Reheman A, et al. Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. Nat Med. 2013;19:586-94.
-
(2013)
Nat Med
, vol.19
, pp. 586-594
-
-
Murphy, A.J.1
Bijl, N.2
Yvan-Charvet, L.3
Welch, C.B.4
Bhagwat, N.5
Reheman, A.6
-
41
-
-
84892923313
-
Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life
-
Hess PR, Rawnsley DR, Jakus Z, Yang Y, Sweet DT, Fu J, et al. Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. J Clin Invest. 2014;124:273-84.
-
(2014)
J Clin Invest
, vol.124
, pp. 273-284
-
-
Hess, P.R.1
Rawnsley, D.R.2
Jakus, Z.3
Yang, Y.4
Sweet, D.T.5
Fu, J.6
-
43
-
-
84862702605
-
Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells
-
Osada M, Inoue O, Ding G, Shirai T, Ichise H, Hirayama K, et al. Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells. J Biol Chem. 2012;287:22241-52.
-
(2012)
J Biol Chem
, vol.287
, pp. 22241-22252
-
-
Osada, M.1
Inoue, O.2
Ding, G.3
Shirai, T.4
Ichise, H.5
Hirayama, K.6
-
44
-
-
84885624688
-
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2
-
Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, et al. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013;502:105-9.
-
(2013)
Nature
, vol.502
, pp. 105-109
-
-
Herzog, B.H.1
Fu, J.2
Wilson, S.J.3
Hess, P.R.4
Sen, A.5
McDaniel, J.M.6
-
45
-
-
38949178835
-
Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released
-
Italiano Jr JE, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, et al. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood. 2008;111:1227-33.
-
(2008)
Blood
, vol.111
, pp. 1227-1233
-
-
Italiano, J.E.1
Richardson, J.L.2
Patel-Hett, S.3
Battinelli, E.4
Zaslavsky, A.5
Short, S.6
-
46
-
-
79953826916
-
Distinct platelet packaging, release, and surface expression of proangiogenic and antiangiogenic factors on different platelet stimuli
-
Chatterjee M, Huang Z, Zhang W, Jiang L, Hultenby K, Zhu L, et al. Distinct platelet packaging, release, and surface expression of proangiogenic and antiangiogenic factors on different platelet stimuli. Blood. 2011;117:3907-11.
-
(2011)
Blood
, vol.117
, pp. 3907-3911
-
-
Chatterjee, M.1
Huang, Z.2
Zhang, W.3
Jiang, L.4
Hultenby, K.5
Zhu, L.6
-
47
-
-
84926312039
-
Maternal anti-platelet beta3 integrins impair angiogenesis and cause intracranial hemorrhage
-
Yougbare I, Lang S, Yang H, Chen P, Zhao X, Tai WS, et al. Maternal anti-platelet beta3 integrins impair angiogenesis and cause intracranial hemorrhage. J Clin Invest. 2015;125:1545-56.
-
(2015)
J Clin Invest
, vol.125
, pp. 1545-1556
-
-
Yougbare, I.1
Lang, S.2
Yang, H.3
Chen, P.4
Zhao, X.5
Tai, W.S.6
-
48
-
-
80555134759
-
The maternal immune response to fetal platelet GPIbalpha causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies
-
Li C, Piran S, Chen P, Lang S, Zarpellon A, Jin JW, et al. The maternal immune response to fetal platelet GPIbalpha causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies. J Clin Invest. 2011;121:4537-47.
-
(2011)
J Clin Invest
, vol.121
, pp. 4537-4547
-
-
Li, C.1
Piran, S.2
Chen, P.3
Lang, S.4
Zarpellon, A.5
Jin, J.W.6
-
49
-
-
84990030694
-
Natural killer cells contribute to pathophysiology of placenta leading to miscarriage in fetal and neonatal alloimmune thrombocytopenia
-
Yougbare I, Wei-She T, Zdravic D, Chen P, Zhu G, Leong-Poi H, et al. Natural killer cells contribute to pathophysiology of placenta leading to miscarriage in fetal and neonatal alloimmune thrombocytopenia. Blood. 2015;126:2254.
-
(2015)
Blood
, vol.126
, pp. 2254
-
-
Yougbare, I.1
Wei-She, T.2
Zdravic, D.3
Chen, P.4
Zhu, G.5
Leong-Poi, H.6
-
50
-
-
84871485133
-
The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination
-
Labelle M, Hynes RO. The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov. 2012;2:1091-9.
-
(2012)
Cancer Discov
, vol.2
, pp. 1091-1099
-
-
Labelle, M.1
Hynes, R.O.2
-
51
-
-
84905014848
-
Platelets guide the formation of early metastatic niches
-
Labelle M, Begum S, Hynes RO. Platelets guide the formation of early metastatic niches. Proc Natl Acad Sci U S A. 2014;111:E3053-61.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. E3053-E3061
-
-
Labelle, M.1
Begum, S.2
Hynes, R.O.3
-
52
-
-
84940202183
-
Platelets at the interface of thrombosis, inflammation, and cancer
-
Franco AT, Corken A, Ware J. Platelets at the interface of thrombosis, inflammation, and cancer. Blood. 2015;126:582-8.
-
(2015)
Blood
, vol.126
, pp. 582-588
-
-
Franco, A.T.1
Corken, A.2
Ware, J.3
-
53
-
-
33846235429
-
Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet
-
Luo SZ, Mo X, Afshar-Kharghan V, Srinivasan S, Lopez JA, Li R. Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet. Blood. 2007;109:603-9.
-
(2007)
Blood
, vol.109
, pp. 603-609
-
-
Luo, S.Z.1
Mo, X.2
Afshar-Kharghan, V.3
Srinivasan, S.4
Lopez, J.A.5
Li, R.6
-
54
-
-
34250007429
-
The growing complexity of platelet aggregation
-
Jackson SP. The growing complexity of platelet aggregation. Blood. 2007;109:5087-95.
-
(2007)
Blood
, vol.109
, pp. 5087-5095
-
-
Jackson, S.P.1
-
55
-
-
34250818668
-
Adhesion mechanisms in platelet function
-
Ruggeri ZM, Mendolicchio GL. Adhesion mechanisms in platelet function. Circ Res. 2007;100:1673-85.
-
(2007)
Circ Res
, vol.100
, pp. 1673-1685
-
-
Ruggeri, Z.M.1
Mendolicchio, G.L.2
-
56
-
-
0037119003
-
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain
-
Huizinga EG, Tsuji S, Romijn RA, Schiphorst ME, de Groot PG, Sixma JJ, et al. Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science. 2002;297:1176-9.
-
(2002)
Science
, vol.297
, pp. 1176-1179
-
-
Huizinga, E.G.1
Tsuji, S.2
Romijn, R.A.3
Schiphorst, M.E.4
Groot, P.G.5
Sixma, J.J.6
-
57
-
-
84947997089
-
Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice
-
Verhenne S, Denorme F, Libbrecht S, Vandenbulcke A, Pareyn I, Deckmyn H, et al. Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice. Blood. 2015;126:1715-22.
-
(2015)
Blood
, vol.126
, pp. 1715-1722
-
-
Verhenne, S.1
Denorme, F.2
Libbrecht, S.3
Vandenbulcke, A.4
Pareyn, I.5
Deckmyn, H.6
-
58
-
-
0038157329
-
Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation
-
Dumas JJ, Kumar R, Seehra J, Somers WS, Mosyak L. Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation. Science. 2003;301:222-6.
-
(2003)
Science
, vol.301
, pp. 222-226
-
-
Dumas, J.J.1
Kumar, R.2
Seehra, J.3
Somers, W.S.4
Mosyak, L.5
-
59
-
-
0037815126
-
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha
-
Celikel R, McClintock RA, Roberts JR, Mendolicchio GL, Ware J, Varughese KI, et al. Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha. Science. 2003;301:218-21.
-
(2003)
Science
, vol.301
, pp. 218-221
-
-
Celikel, R.1
McClintock, R.A.2
Roberts, J.R.3
Mendolicchio, G.L.4
Ware, J.5
Varughese, K.I.6
-
60
-
-
84882690197
-
The GPIb-IX-V Complex
-
In: Michelson AD, editor. Platelets. 3rd ed.
-
Andrews RK, Berndt MC. The GPIb-IX-V Complex. In: Michelson AD, editor. Platelets. 3rd ed. Amsterdam: Academic Press/Elsevier; 2013. p. 195-213.
-
(2013)
Amsterdam: Academic Press/Elsevier
, pp. 195-213
-
-
Andrews, R.K.1
Berndt, M.C.2
-
61
-
-
0035895962
-
Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets
-
De Candia E, Hall SW, Rutella S, Landolfi R, Andrews RK, De Cristofaro R. Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets. J Biol Chem. 2001;276:4692-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 4692-4698
-
-
Candia, E.1
Hall, S.W.2
Rutella, S.3
Landolfi, R.4
Andrews, R.K.5
Cristofaro, R.6
-
62
-
-
0035852682
-
A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V
-
Ramakrishnan V, DeGuzman F, Bao M, Hall SW, Leung LL, Phillips DR. A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V. Proc Natl Acad Sci U S A. 2001;98:1823-8.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 1823-1828
-
-
Ramakrishnan, V.1
DeGuzman, F.2
Bao, M.3
Hall, S.W.4
Leung, L.L.5
Phillips, D.R.6
-
63
-
-
0035880252
-
Increased thrombogenesis and embolus formation in mice lacking glycoprotein V
-
Ni H, Ramakrishnan V, Ruggeri ZM, Papalia JM, Phillips DR, Wagner DD. Increased thrombogenesis and embolus formation in mice lacking glycoprotein V. Blood. 2001;98:368-73.
-
(2001)
Blood
, vol.98
, pp. 368-373
-
-
Ni, H.1
Ramakrishnan, V.2
Ruggeri, Z.M.3
Papalia, J.M.4
Phillips, D.R.5
Wagner, D.D.6
-
64
-
-
0041703023
-
Thrombospondin-1 mediates platelet adhesion at high shear via glycoprotein Ib (GPIb): an alternative/backup mechanism to von Willebrand factor
-
Jurk K, Clemetson KJ, de Groot PG, Brodde MF, Steiner M, Savion N, et al. Thrombospondin-1 mediates platelet adhesion at high shear via glycoprotein Ib (GPIb): an alternative/backup mechanism to von Willebrand factor. FASEB J. 2003;17:1490-2.
-
(2003)
FASEB J
, vol.17
, pp. 1490-1492
-
-
Jurk, K.1
Clemetson, K.J.2
Groot, P.G.3
Brodde, M.F.4
Steiner, M.5
Savion, N.6
-
65
-
-
0037127251
-
Factor XI binding to the platelet glycoprotein Ib-IX-V complex promotes factor XI activation by thrombin
-
Baglia FA, Badellino KO, Li CQ, Lopez JA, Walsh PN. Factor XI binding to the platelet glycoprotein Ib-IX-V complex promotes factor XI activation by thrombin. J Biol Chem. 2002;277:1662-8.
-
(2002)
J Biol Chem
, vol.277
, pp. 1662-1668
-
-
Baglia, F.A.1
Badellino, K.O.2
Li, C.Q.3
Lopez, J.A.4
Walsh, P.N.5
-
66
-
-
0034725612
-
Human factor XII binding to the glycoprotein Ib-IX-V complex inhibits thrombin-induced platelet aggregation
-
Bradford HN, Pixley RA, Colman RW. Human factor XII binding to the glycoprotein Ib-IX-V complex inhibits thrombin-induced platelet aggregation. J Biol Chem. 2000;275:22756-63.
-
(2000)
J Biol Chem.
, vol.275
, pp. 22756-22763
-
-
Bradford, H.N.1
Pixley, R.A.2
Colman, R.W.3
-
67
-
-
54049130877
-
The glycoprotein Ib-IX-V complex contributes to tissue factor-independent thrombin generation by recombinant factor VIIa on the activated platelet surface
-
Weeterings C, de Groot PG, Adelmeijer J, Lisman T. The glycoprotein Ib-IX-V complex contributes to tissue factor-independent thrombin generation by recombinant factor VIIa on the activated platelet surface. Blood. 2008;112:3227-33.
-
(2008)
Blood
, vol.112
, pp. 3227-3233
-
-
Weeterings, C.1
Groot, P.G.2
Adelmeijer, J.3
Lisman, T.4
-
68
-
-
0242580951
-
High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib
-
Chavakis T, Santoso S, Clemetson KJ, Sachs UJ, Isordia-Salas I, Pixley RA, et al. High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib. J Biol Chem. 2003;278:45375-81.
-
(2003)
J Biol Chem
, vol.278
, pp. 45375-45381
-
-
Chavakis, T.1
Santoso, S.2
Clemetson, K.J.3
Sachs, U.J.4
Isordia-Salas, I.5
Pixley, R.A.6
-
69
-
-
0033588901
-
The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin
-
Romo GM, Dong JF, Schade AJ, Gardiner EE, Kansas GS, Li CQ, et al. The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin. J Exp Med. 1999;190:803-14.
-
(1999)
J Exp Med
, vol.190
, pp. 803-814
-
-
Romo, G.M.1
Dong, J.F.2
Schade, A.J.3
Gardiner, E.E.4
Kansas, G.S.5
Li, C.Q.6
-
70
-
-
84937850992
-
Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4
-
Kaplan ZS, Zarpellon A, Alwis I, Yuan Y, McFadyen J, Ghasemzadeh M, et al. Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4. Nat Commun. 2015;6:7835.
-
(2015)
Nat Commun
, vol.6
, pp. 7835
-
-
Kaplan, Z.S.1
Zarpellon, A.2
Alwis, I.3
Yuan, Y.4
McFadyen, J.5
Ghasemzadeh, M.6
-
71
-
-
0034679329
-
Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)
-
Simon DI, Chen Z, Xu H, Li CQ, Dong J, McIntire LV, et al. Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med. 2000;192:193-204.
-
(2000)
J Exp Med
, vol.192
, pp. 193-204
-
-
Simon, D.I.1
Chen, Z.2
Xu, H.3
Li, C.Q.4
Dong, J.5
McIntire, L.V.6
-
72
-
-
84920411218
-
Critical role of platelet glycoprotein ibalpha in arterial remodeling
-
Chandraratne S, von Bruehl ML, Pagel JI, Stark K, Kleinert E, Konrad I, et al. Critical role of platelet glycoprotein ibalpha in arterial remodeling. Arterioscler Thromb Vasc Biol. 2015;35:589-97.
-
(2015)
Arterioscler Thromb Vasc Biol
, vol.35
, pp. 589-597
-
-
Chandraratne, S.1
Bruehl, M.L.2
Pagel, J.I.3
Stark, K.4
Kleinert, E.5
Konrad, I.6
-
73
-
-
84937605469
-
Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia
-
Li J, van der Wal DE, Zhu G, Xu M, Yougbare I, Ma L, et al. Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia. Nat Commun. 2015;6:7737.
-
(2015)
Nat Commun
, vol.6
, pp. 7737
-
-
Li, J.1
Wal, D.E.2
Zhu, G.3
Xu, M.4
Yougbare, I.5
Ma, L.6
-
74
-
-
84897390496
-
Severe platelet desialylation in a patient with glycoprotein Ib/IX antibody-mediated immune thrombocytopenia and fatal pulmonary hemorrhage
-
Li J, Callum JL, Lin Y, Zhou Y, Zhu G, Ni H. Severe platelet desialylation in a patient with glycoprotein Ib/IX antibody-mediated immune thrombocytopenia and fatal pulmonary hemorrhage. Haematologica. 2014;99:e61-3.
-
(2014)
Haematologica
, vol.99
, pp. e61-e63
-
-
Li, J.1
Callum, J.L.2
Lin, Y.3
Zhou, Y.4
Zhu, G.5
Ni, H.6
-
75
-
-
84867144010
-
Inhibitors of the interaction between von Willebrand factor and platelet GPIb/IX/V
-
Gresele P, Momi S. Inhibitors of the interaction between von Willebrand factor and platelet GPIb/IX/V. Handb Exp Pharmacol. 2012;(210):287-309.
-
(2012)
Handb Exp Pharmacol
, Issue.210
, pp. 287-309
-
-
Gresele, P.1
Momi, S.2
-
76
-
-
79960058122
-
Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs
-
Ulrichts H, Silence K, Schoolmeester A, de Jaegere P, Rossenu S, Roodt J, et al. Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs. Blood. 2011;118:757-65.
-
(2011)
Blood
, vol.118
, pp. 757-765
-
-
Ulrichts, H.1
Silence, K.2
Schoolmeester, A.3
Jaegere, P.4
Rossenu, S.5
Roodt, J.6
-
77
-
-
84877750064
-
Novel antiplatelet agents: ALX-0081, a Nanobody directed towards von Willebrand factor
-
Bartunek J, Barbato E, Heyndrickx G, Vanderheyden M, Wijns W, Holz JB. Novel antiplatelet agents: ALX-0081, a Nanobody directed towards von Willebrand factor. J Cardiovasc Transl Res. 2013;6:355-63.
-
(2013)
J Cardiovasc Transl Res
, vol.6
, pp. 355-363
-
-
Bartunek, J.1
Barbato, E.2
Heyndrickx, G.3
Vanderheyden, M.4
Wijns, W.5
Holz, J.B.6
-
78
-
-
84877784741
-
von Willebrand factor inhibition improves endothelial function in patients with stable angina
-
Muller O, Bartunek J, Hamilos M, Berza CT, Mangiacapra F, Ntalianis A, et al. von Willebrand factor inhibition improves endothelial function in patients with stable angina. J Cardiovasc Transl Res. 2013;6:364-70.
-
(2013)
J Cardiovasc Transl Res
, vol.6
, pp. 364-370
-
-
Muller, O.1
Bartunek, J.2
Hamilos, M.3
Berza, C.T.4
Mangiacapra, F.5
Ntalianis, A.6
-
79
-
-
84975520856
-
Caplacizumab for acquired thrombotic thrombocytopenic purpura
-
Peyvandi F, Scully M, Kremer Hovinga JA, Cataland S, Knobl P, Wu H, et al. Caplacizumab for acquired thrombotic thrombocytopenic purpura. N Engl J Med. 2016;374:511-22.
-
(2016)
N Engl J Med
, vol.374
, pp. 511-522
-
-
Peyvandi, F.1
Scully, M.2
Kremer Hovinga, J.A.3
Cataland, S.4
Knobl, P.5
Wu, H.6
-
80
-
-
84962074417
-
Thrombotic microangiopathy: caplacizumab accelerates resolution of acute acquired TTP
-
Lammle B. Thrombotic microangiopathy: caplacizumab accelerates resolution of acute acquired TTP. Nat Rev Nephrol. 2016;12:259-60.
-
(2016)
Nat Rev Nephrol
, vol.12
, pp. 259-260
-
-
Lammle, B.1
-
81
-
-
84959308771
-
Willebrand factor--a new target for TTP treatment?
-
Von VA. Willebrand factor--a new target for TTP treatment? N Engl J Med. 2016;374:583-5.
-
(2016)
N Engl J Med
, vol.374
, pp. 583-585
-
-
Von, V.A.1
-
82
-
-
84906806362
-
Management of thrombotic thrombocytopenic purpura: current perspectives
-
Blombery P, Scully M. Management of thrombotic thrombocytopenic purpura: current perspectives. J Blood Med. 2014;5:15-23.
-
(2014)
J Blood Med
, vol.5
, pp. 15-23
-
-
Blombery, P.1
Scully, M.2
-
83
-
-
84893185728
-
Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis
-
Lei X, Reheman A, Hou Y, Zhou H, Wang Y, Marshall AH, et al. Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis. Thromb Haemost. 2014;111:279-89.
-
(2014)
Thromb Haemost
, vol.111
, pp. 279-289
-
-
Lei, X.1
Reheman, A.2
Hou, Y.3
Zhou, H.4
Wang, Y.5
Marshall, A.H.6
-
84
-
-
84933050866
-
The first in vitro and in vivo assessment of anfibatide, a novel glycoprotein ib antagonist, in mice and in a phase i human clinical trial
-
Hou Y, Li BX, Dai X, Yang Z, Qian F, Zhang G, et al. The first in vitro and in vivo assessment of anfibatide, a novel glycoprotein ib antagonist, in mice and in a phase i human clinical trial. Blood. 2013;122:577.
-
(2013)
Blood
, vol.122
, pp. 577
-
-
Hou, Y.1
Li, B.X.2
Dai, X.3
Yang, Z.4
Qian, F.5
Zhang, G.6
-
85
-
-
84986628832
-
First ex vivo and in vivo assessment of anfibatide, a novel glycoprotein Ib-IV-V complex antagonist, in healthy human volunteers in phase I clinical trial
-
Li B, Dai X, Yang Z, Qian F, Zhang G, Xu Z, et al. First ex vivo and in vivo assessment of anfibatide, a novel glycoprotein Ib-IV-V complex antagonist, in healthy human volunteers in phase I clinical trial. J Thromb Haemost. 2013;11 Suppl 2:23.
-
(2013)
J Thromb Haemost
, vol.11
, pp. 23
-
-
Li, B.1
Dai, X.2
Yang, Z.3
Qian, F.4
Zhang, G.5
Xu, Z.6
-
86
-
-
80052210855
-
Ischaemic stroke: a thrombo-inflammatory disease?
-
Nieswandt B, Kleinschnitz C, Stoll G. Ischaemic stroke: a thrombo-inflammatory disease? J Physiol. 2011;589:4115-23.
-
(2011)
J Physiol
, vol.589
, pp. 4115-4123
-
-
Nieswandt, B.1
Kleinschnitz, C.2
Stoll, G.3
-
87
-
-
55749101354
-
Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment
-
Stoll G, Kleinschnitz C, Nieswandt B. Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment. Blood. 2008;112:3555-62.
-
(2008)
Blood
, vol.112
, pp. 3555-3562
-
-
Stoll, G.1
Kleinschnitz, C.2
Nieswandt, B.3
-
88
-
-
34247643257
-
Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding
-
Kleinschnitz C, Pozgajova M, Pham M, Bendszus M, Nieswandt B, Stoll G. Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding. Circulation. 2007;115:2323-30.
-
(2007)
Circulation
, vol.115
, pp. 2323-2330
-
-
Kleinschnitz, C.1
Pozgajova, M.2
Pham, M.3
Bendszus, M.4
Nieswandt, B.5
Stoll, G.6
-
89
-
-
84990054768
-
A novel snake venomderived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury
-
Li TT, Fan ML, Hou SX, Li XY, Barry DM, Jin H, Luo SY, Kong F, Lau LF, Dai XR, Zhang GH, Zhou LL. A novel snake venomderived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury. Br J Pharmacol.
-
Br J Pharmacol
-
-
Li, T.T.1
Fan, M.L.2
Hou, S.X.3
Li, X.Y.4
Barry, D.M.5
Jin, H.6
Luo, S.Y.7
Kong, F.8
Lau, L.F.9
Dai, X.R.10
Zhang, G.H.11
Zhou, L.L.12
-
90
-
-
54949095069
-
The humanized anti-glycoprotein Ib monoclonal antibody h6B4-Fab is a potent and safe antithrombotic in a high shear arterial thrombosis model in baboons
-
Fontayne A, Meiring M, Lamprecht S, Roodt J, Demarsin E, Barbeaux P, et al. The humanized anti-glycoprotein Ib monoclonal antibody h6B4-Fab is a potent and safe antithrombotic in a high shear arterial thrombosis model in baboons. Thromb Haemost. 2008;100:670-7.
-
(2008)
Thromb Haemost
, vol.100
, pp. 670-677
-
-
Fontayne, A.1
Meiring, M.2
Lamprecht, S.3
Roodt, J.4
Demarsin, E.5
Barbeaux, P.6
-
91
-
-
33645540605
-
Pharmacologic inhibition of platelet vWF-GPIb alpha interaction prevents coronary artery thrombosis
-
Hennan JK, Swillo RE, Morgan GA, Leik CE, Brooks JM, Shaw GD, et al. Pharmacologic inhibition of platelet vWF-GPIb alpha interaction prevents coronary artery thrombosis. Thromb Haemost. 2006;95:469-75.
-
(2006)
Thromb Haemost
, vol.95
, pp. 469-475
-
-
Hennan, J.K.1
Swillo, R.E.2
Morgan, G.A.3
Leik, C.E.4
Brooks, J.M.5
Shaw, G.D.6
-
92
-
-
84990054744
-
Novel monoclonal antibodies against platelet GPIb-alpha: potential anti-thrombotic drugs and research reagents for study of thrombosis and hemostasis
-
US8323652
-
Ni H, Zhu G. Novel monoclonal antibodies against platelet GPIb-alpha: potential anti-thrombotic drugs and research reagents for study of thrombosis and hemostasis. 2012. US8323652.
-
(2012)
-
-
Ni, H.1
Zhu, G.2
-
93
-
-
84925505672
-
Impact of the PI3-kinase/Akt pathway on ITAM and hemITAM receptors: haemostasis, platelet activation and antithrombotic therapy
-
Moroi AJ, Watson SP. Impact of the PI3-kinase/Akt pathway on ITAM and hemITAM receptors: haemostasis, platelet activation and antithrombotic therapy. Biochem Pharmacol. 2015;94:186-94.
-
(2015)
Biochem Pharmacol
, vol.94
, pp. 186-194
-
-
Moroi, A.J.1
Watson, S.P.2
-
94
-
-
84942279085
-
Fibrin activates GPVI in human and mouse platelets
-
Alshehri OM, Hughes CE, Montague S, Watson SK, Frampton J, Bender M, et al. Fibrin activates GPVI in human and mouse platelets. Blood. 2015;126:1601-8.
-
(2015)
Blood
, vol.126
, pp. 1601-1608
-
-
Alshehri, O.M.1
Hughes, C.E.2
Montague, S.3
Watson, S.K.4
Frampton, J.5
Bender, M.6
-
95
-
-
84940023454
-
Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation
-
Mammadova-Bach E, Ollivier V, Loyau S, Schaff M, Dumont B, Favier R, et al. Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation. Blood. 2015;126:683-91.
-
(2015)
Blood
, vol.126
, pp. 683-691
-
-
Mammadova-Bach, E.1
Ollivier, V.2
Loyau, S.3
Schaff, M.4
Dumont, B.5
Favier, R.6
-
96
-
-
73449086712
-
Expression of platelet glycoprotein VI is associated with transient ischemic attack and stroke
-
Bigalke B, Stellos K, Geisler T, Kremmer E, Seizer P, May AE, et al. Expression of platelet glycoprotein VI is associated with transient ischemic attack and stroke. Eur J Neurol. 2010;17:111-7.
-
(2010)
Eur J Neurol
, vol.17
, pp. 111-117
-
-
Bigalke, B.1
Stellos, K.2
Geisler, T.3
Kremmer, E.4
Seizer, P.5
May, A.E.6
-
97
-
-
84979911429
-
Beyond antiplatelets: the role of glycoprotein VI in ischemic stroke
-
Induruwa I, Jung SM, Warburton EA. Beyond antiplatelets: the role of glycoprotein VI in ischemic stroke. Int J Stroke. 2016. doi: 10.1177/1747493016654532.
-
(2016)
Int J Stroke
-
-
Induruwa, I.1
Jung, S.M.2
Warburton, E.A.3
-
98
-
-
79251631764
-
Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke
-
Al-Tamimi M, Gardiner EE, Thom JY, Shen Y, Cooper MN, Hankey GJ, et al. Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke. Stroke. 2011;42:498-500.
-
(2011)
Stroke
, vol.42
, pp. 498-500
-
-
Al-Tamimi, M.1
Gardiner, E.E.2
Thom, J.Y.3
Shen, Y.4
Cooper, M.N.5
Hankey, G.J.6
-
99
-
-
78149237097
-
Combating innate inflammation: a new paradigm for acute treatment of stroke?
-
Stoll G, Kleinschnitz C, Nieswandt B. Combating innate inflammation: a new paradigm for acute treatment of stroke? Ann N Y Acad Sci. 2010;1207:149-54.
-
(2010)
Ann N Y Acad Sci
, vol.1207
, pp. 149-154
-
-
Stoll, G.1
Kleinschnitz, C.2
Nieswandt, B.3
-
100
-
-
77951735539
-
Platelet interleukin-1alpha drives cerebrovascular inflammation
-
Thornton P, McColl BW, Greenhalgh A, Denes A, Allan SM, Rothwell NJ. Platelet interleukin-1alpha drives cerebrovascular inflammation. Blood. 2010;115:3632-9.
-
(2010)
Blood
, vol.115
, pp. 3632-3639
-
-
Thornton, P.1
McColl, B.W.2
Greenhalgh, A.3
Denes, A.4
Allan, S.M.5
Rothwell, N.J.6
-
101
-
-
84904675274
-
Targeting glycoprotein VI and the immunoreceptor tyrosine-based activation motif signaling pathway
-
Stegner D, Haining EJ, Nieswandt B. Targeting glycoprotein VI and the immunoreceptor tyrosine-based activation motif signaling pathway. Arterioscler Thromb Vasc Biol. 2014;34:1615-20.
-
(2014)
Arterioscler Thromb Vasc Biol
, vol.34
, pp. 1615-1620
-
-
Stegner, D.1
Haining, E.J.2
Nieswandt, B.3
-
103
-
-
84959194685
-
Inhibition of platelet GPVI protects against myocardial ischemia-reperfusion injury
-
Pachel C, Mathes D, Arias-Loza AP, Heitzmann W, Nordbeck P, Deppermann C, et al. Inhibition of platelet GPVI protects against myocardial ischemia-reperfusion injury. Arterioscler Thromb Vasc Biol. 2016;36:629-35.
-
(2016)
Arterioscler Thromb Vasc Biol
, vol.36
, pp. 629-635
-
-
Pachel, C.1
Mathes, D.2
Arias-Loza, A.P.3
Heitzmann, W.4
Nordbeck, P.5
Deppermann, C.6
-
104
-
-
84880753729
-
The GPVI-Fc fusion protein Revacept improves cerebral infarct volume and functional outcome in stroke
-
Goebel S, Li Z, Vogelmann J, Holthoff HP, Degen H, Hermann DM, et al. The GPVI-Fc fusion protein Revacept improves cerebral infarct volume and functional outcome in stroke. PLoS One. 2013;8:e66960.
-
(2013)
PLoS One
, vol.8
-
-
Goebel, S.1
Li, Z.2
Vogelmann, J.3
Holthoff, H.P.4
Degen, H.5
Hermann, D.M.6
-
105
-
-
85027958733
-
Novel antiplatelet drug revacept (Dimeric Glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans
-
Ungerer M, Rosport K, Bultmann A, Piechatzek R, Uhland K, Schlieper P, et al. Novel antiplatelet drug revacept (Dimeric Glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans. Circulation. 2011;123:1891-9.
-
(2011)
Circulation
, vol.123
, pp. 1891-1899
-
-
Ungerer, M.1
Rosport, K.2
Bultmann, A.3
Piechatzek, R.4
Uhland, K.5
Schlieper, P.6
-
106
-
-
84990048770
-
-
Accessed 15 June 2016
-
ClinicalTrials.gov. 2015. https://clinicaltrials.gov/ct2/show/NCT01645306?term=Revacept&rank=1. Accessed 15 June 2016.
-
(2015)
-
-
-
107
-
-
77949363102
-
Structural basis for platelet antiaggregation by angiotensin II type 1 receptor antagonist losartan (DuP-753) via glycoprotein VI
-
Ono K, Ueda H, Yoshizawa Y, Akazawa D, Tanimura R, Shimada I, et al. Structural basis for platelet antiaggregation by angiotensin II type 1 receptor antagonist losartan (DuP-753) via glycoprotein VI. J Med Chem. 2010;53:2087-93.
-
(2010)
J Med Chem
, vol.53
, pp. 2087-2093
-
-
Ono, K.1
Ueda, H.2
Yoshizawa, Y.3
Akazawa, D.4
Tanimura, R.5
Shimada, I.6
-
108
-
-
68149163242
-
Design and humanization of a murine scFv that blocks human platelet glycoprotein VI in vitro
-
Muzard J, Bouabdelli M, Zahid M, Ollivier V, Lacapere JJ, Jandrot-Perrus M, et al. Design and humanization of a murine scFv that blocks human platelet glycoprotein VI in vitro. FEBS J. 2009;276:4207-22.
-
(2009)
FEBS J
, vol.276
, pp. 4207-4222
-
-
Muzard, J.1
Bouabdelli, M.2
Zahid, M.3
Ollivier, V.4
Lacapere, J.J.5
Jandrot-Perrus, M.6
-
109
-
-
0037031906
-
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling
-
Takagi J, Petre BM, Walz T, Springer TA. Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Cell. 2002;110:599-611.
-
(2002)
Cell
, vol.110
, pp. 599-611
-
-
Takagi, J.1
Petre, B.M.2
Walz, T.3
Springer, T.A.4
-
110
-
-
0038644597
-
Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations
-
Li R, Mitra N, Gratkowski H, Vilaire G, Litvinov R, Nagasami C, et al. Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science. 2003;300:795-8.
-
(2003)
Science
, vol.300
, pp. 795-798
-
-
Li, R.1
Mitra, N.2
Gratkowski, H.3
Vilaire, G.4
Litvinov, R.5
Nagasami, C.6
-
111
-
-
1642529548
-
Membrane-mediated structural transitions at the cytoplasmic face during integrin activation
-
Vinogradova O, Vaynberg J, Kong X, Haas TA, Plow EF, Qin J. Membrane-mediated structural transitions at the cytoplasmic face during integrin activation. Proc Natl Acad Sci U S A. 2004;101:4094-9.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 4094-4099
-
-
Vinogradova, O.1
Vaynberg, J.2
Kong, X.3
Haas, T.A.4
Plow, E.F.5
Qin, J.6
-
112
-
-
0037031551
-
A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face
-
Vinogradova O, Velyvis A, Velyviene A, Hu B, Haas T, Plow E, et al. A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face. Cell. 2002;110:587-97.
-
(2002)
Cell
, vol.110
, pp. 587-597
-
-
Vinogradova, O.1
Velyvis, A.2
Velyviene, A.3
Hu, B.4
Haas, T.5
Plow, E.6
-
113
-
-
0033838314
-
Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen
-
Ni H, Denis CV, Subbarao S, Degen JL, Sato TN, Hynes RO, et al. Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J Clin Invest. 2000;106:385-92.
-
(2000)
J Clin Invest
, vol.106
, pp. 385-392
-
-
Ni, H.1
Denis, C.V.2
Subbarao, S.3
Degen, J.L.4
Sato, T.N.5
Hynes, R.O.6
-
114
-
-
0033592610
-
Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function
-
Law DA, DeGuzman FR, Heiser P, Ministri-Madrid K, Killeen N, Phillips DR. Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function. Nature. 1999;401:808-11.
-
(1999)
Nature
, vol.401
, pp. 808-811
-
-
Law, D.A.1
DeGuzman, F.R.2
Heiser, P.3
Ministri-Madrid, K.4
Killeen, N.5
Phillips, D.R.6
-
115
-
-
0032590042
-
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
-
Hodivala-Dilke KM, McHugh KP, Tsakiris DA, Rayburn H, Crowley D, Ullman-Cullere M, et al. Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest. 1999;103:229-38.
-
(1999)
J Clin Invest
, vol.103
, pp. 229-238
-
-
Hodivala-Dilke, K.M.1
McHugh, K.P.2
Tsakiris, D.A.3
Rayburn, H.4
Crowley, D.5
Ullman-Cullere, M.6
-
116
-
-
61849083539
-
Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor
-
Reheman A, Yang H, Zhu G, Jin W, He F, Spring CM, et al. Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor. Blood. 2009;113:1809-17.
-
(2009)
Blood
, vol.113
, pp. 1809-1817
-
-
Reheman, A.1
Yang, H.2
Zhu, G.3
Jin, W.4
He, F.5
Spring, C.M.6
-
117
-
-
23844514494
-
Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation
-
Reheman A, Gross P, Yang H, Chen P, Allen D, Leytin V, et al. Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation. J Thromb Haemost. 2005;3:875-83.
-
(2005)
J Thromb Haemost
, vol.3
, pp. 875-883
-
-
Reheman, A.1
Gross, P.2
Yang, H.3
Chen, P.4
Allen, D.5
Leytin, V.6
-
119
-
-
0030863733
-
Clinical pharmacology of eptifibatide
-
Phillips DR, Scarborough RM. Clinical pharmacology of eptifibatide. Am J Cardiol. 1997;80:11B-20B.
-
(1997)
Am J Cardiol
, vol.80
, pp. 11B-20B
-
-
Phillips, D.R.1
Scarborough, R.M.2
-
120
-
-
0027968662
-
Non-peptide fibrinogen receptor antagonists. 2. Optimization of a tyrosine template as a mimic for Arg-Gly-Asp
-
Egbertson MS, Chang CT, Duggan ME, Gould RJ, Halczenko W, Hartman GD, et al. Non-peptide fibrinogen receptor antagonists. 2. Optimization of a tyrosine template as a mimic for Arg-Gly-Asp. J Med Chem. 1994;37:2537-51.
-
(1994)
J Med Chem
, vol.37
, pp. 2537-2551
-
-
Egbertson, M.S.1
Chang, C.T.2
Duggan, M.E.3
Gould, R.J.4
Halczenko, W.5
Hartman, G.D.6
-
121
-
-
80052626426
-
Anti-platelet therapy: glycoprotein IIb-IIIa antagonists
-
Schneider DJ. Anti-platelet therapy: glycoprotein IIb-IIIa antagonists. Br J Clin Pharmacol. 2011;72:672-82.
-
(2011)
Br J Clin Pharmacol
, vol.72
, pp. 672-682
-
-
Schneider, D.J.1
-
122
-
-
84931294411
-
alphaIIbbeta3: structure and function
-
Coller BS. alphaIIbbeta3: structure and function. J Thromb Haemost. 2015;13 Suppl 1:S17-25.
-
(2015)
J Thromb Haemost
, vol.13
, pp. S17-25
-
-
Coller, B.S.1
-
123
-
-
42749098715
-
Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke
-
Ciccone A, Motto C, Abraha I, Cozzolino F, Santilli I. Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke. Cochrane Database Syst Rev. 2014;3:CD005208.
-
(2014)
Cochrane Database Syst Rev
, vol.3
-
-
Ciccone, A.1
Motto, C.2
Abraha, I.3
Cozzolino, F.4
Santilli, I.5
-
124
-
-
84913554789
-
RUC-4: a novel alphaIIbbeta3 antagonist for prehospital therapy of myocardial infarction
-
Li J, Vootukuri S, Shang Y, Negri A, Jiang JK, Nedelman M, et al. RUC-4: a novel alphaIIbbeta3 antagonist for prehospital therapy of myocardial infarction. Arterioscler Thromb Vasc Biol. 2014;34:2321-9.
-
(2014)
Arterioscler Thromb Vasc Biol
, vol.34
, pp. 2321-2329
-
-
Li, J.1
Vootukuri, S.2
Shang, Y.3
Negri, A.4
Jiang, J.K.5
Nedelman, M.6
-
125
-
-
4644272216
-
A novel adaptation of the integrin PSI domain revealed from its crystal structure
-
Xiong JP, Stehle T, Goodman SL, Arnaout MA. A novel adaptation of the integrin PSI domain revealed from its crystal structure. J Biol Chem. 2004;279:40252-4.
-
(2004)
J Biol Chem
, vol.279
, pp. 40252-40254
-
-
Xiong, J.P.1
Stehle, T.2
Goodman, S.L.3
Arnaout, M.A.4
-
126
-
-
0035831488
-
Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2)
-
Zang Q, Springer TA. Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2). J Biol Chem. 2001;276:6922-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 6922-6929
-
-
Zang, Q.1
Springer, T.A.2
-
127
-
-
0032478739
-
Integrin activation by dithiothreitol or Mn2+ induces a ligand-occupied conformation and exposure of a novel NH2-terminal regulatory site on the beta1 integrin chain
-
Ni H, Li A, Simonsen N, Wilkins JA. Integrin activation by dithiothreitol or Mn2+ induces a ligand-occupied conformation and exposure of a novel NH2-terminal regulatory site on the beta1 integrin chain. J Biol Chem. 1998;273:7981-7.
-
(1998)
J Biol Chem
, vol.273
, pp. 7981-7987
-
-
Ni, H.1
Li, A.2
Simonsen, N.3
Wilkins, J.A.4
-
128
-
-
0034704162
-
A redox site involved in integrin activation
-
Yan B, Smith JW. A redox site involved in integrin activation. J Biol Chem. 2000;275:39964-72.
-
(2000)
J Biol Chem
, vol.275
, pp. 39964-39972
-
-
Yan, B.1
Smith, J.W.2
-
129
-
-
0037435609
-
Redox control of platelet aggregation
-
Essex DW, Li M. Redox control of platelet aggregation. Biochemistry. 2003;42:129-36.
-
(2003)
Biochemistry
, vol.42
, pp. 129-136
-
-
Essex, D.W.1
Li, M.2
-
130
-
-
79958068817
-
Vicinal thiols are required for activation of the alphaIIbbeta3 platelet integrin
-
Manickam N, Ahmad SS, Essex DW. Vicinal thiols are required for activation of the alphaIIbbeta3 platelet integrin. J Thromb Haemost. 2011;9:1207-15.
-
(2011)
J Thromb Haemost
, vol.9
, pp. 1207-1215
-
-
Manickam, N.1
Ahmad, S.S.2
Essex, D.W.3
-
131
-
-
84888229791
-
Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the alphaIIbbeta3 integrin
-
Wang L, Wu Y, Zhou J, Ahmad SS, Mutus B, Garbi N, et al. Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the alphaIIbbeta3 integrin. Blood. 2013;122:3642-50.
-
(2013)
Blood
, vol.122
, pp. 3642-3650
-
-
Wang, L.1
Wu, Y.2
Zhou, J.3
Ahmad, S.S.4
Mutus, B.5
Garbi, N.6
-
132
-
-
84986548114
-
Integrin PSI domain has endogenous thiol isomerase function and is a novel target for anti-thrombotic therapy
-
Carrim N, Zhu G, Reddy E, Xu M, Xu X, Wang Y, et al. Integrin PSI domain has endogenous thiol isomerase function and is a novel target for anti-thrombotic therapy. J Thromb Haemost. 2015;13(Supplement S2):60.
-
(2015)
J Thromb Haemost
, vol.13
, pp. 60
-
-
Carrim, N.1
Zhu, G.2
Reddy, E.3
Xu, M.4
Xu, X.5
Wang, Y.6
-
133
-
-
84897567751
-
Towards effective and safe thrombolysis and thromboprophylaxis: preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated platelets
-
Wang X, Palasubramaniam J, Gkanatsas Y, Hohmann JD, Westein E, Kanojia R, et al. Towards effective and safe thrombolysis and thromboprophylaxis: preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated platelets. Circ Res. 2014;114:1083-93.
-
(2014)
Circ Res
, vol.114
, pp. 1083-1093
-
-
Wang, X.1
Palasubramaniam, J.2
Gkanatsas, Y.3
Hohmann, J.D.4
Westein, E.5
Kanojia, R.6
-
134
-
-
84956924316
-
A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation
-
Fuentes RE, Zaitsev S, Ahn HS, Hayes V, Kowalska M, Lambert MP, et al. A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation. J Clin Invest. 2016;126:483-94.
-
(2016)
J Clin Invest
, vol.126
, pp. 483-494
-
-
Fuentes, R.E.1
Zaitsev, S.2
Ahn, H.S.3
Hayes, V.4
Kowalska, M.5
Lambert, M.P.6
-
135
-
-
84881093501
-
Integrin alpha6beta1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis
-
Schaff M, Tang C, Maurer E, Bourdon C, Receveur N, Eckly A, et al. Integrin alpha6beta1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis. Circulation. 2013;128:541-52.
-
(2013)
Circulation
, vol.128
, pp. 541-552
-
-
Schaff, M.1
Tang, C.2
Maurer, E.3
Bourdon, C.4
Receveur, N.5
Eckly, A.6
-
136
-
-
58849165421
-
Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism
-
Miller MW, Basra S, Kulp DW, Billings PC, Choi S, Beavers MP, et al. Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism. Proc Natl Acad Sci U S A. 2009;106:719-24.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 719-724
-
-
Miller, M.W.1
Basra, S.2
Kulp, D.W.3
Billings, P.C.4
Choi, S.5
Beavers, M.P.6
-
137
-
-
0034663794
-
Isolation and characterization of EMS16, a C-lectin type protein from Echis multisquamatus venom, a potent and selective inhibitor of the alpha2beta1 integrin
-
Marcinkiewicz C, Lobb RR, Marcinkiewicz MM, Daniel JL, Smith JB, Dangelmaier C, et al. Isolation and characterization of EMS16, a C-lectin type protein from Echis multisquamatus venom, a potent and selective inhibitor of the alpha2beta1 integrin. Biochemistry. 2000;39:9859-67.
-
(2000)
Biochemistry
, vol.39
, pp. 9859-9867
-
-
Marcinkiewicz, C.1
Lobb, R.R.2
Marcinkiewicz, M.M.3
Daniel, J.L.4
Smith, J.B.5
Dangelmaier, C.6
-
138
-
-
84873607002
-
Identification of alpha2beta1 integrin inhibitor VP-i with anti-platelet properties in the venom of Vipera palaestinae
-
Arlinghaus FT, Momic T, Ammar NA, Shai E, Spectre G, Varon D, et al. Identification of alpha2beta1 integrin inhibitor VP-i with anti-platelet properties in the venom of Vipera palaestinae. Toxicon. 2013;64:96-105.
-
(2013)
Toxicon
, vol.64
, pp. 96-105
-
-
Arlinghaus, F.T.1
Momic, T.2
Ammar, N.A.3
Shai, E.4
Spectre, G.5
Varon, D.6
-
139
-
-
0023889506
-
Glycoprotein Ic-IIa functions as an activation-independent fibronectin receptor on human platelets
-
Piotrowicz RS, Orchekowski RP, Nugent DJ, Yamada KY, Kunicki TJ. Glycoprotein Ic-IIa functions as an activation-independent fibronectin receptor on human platelets. J Cell Biol. 1988;106:1359-64.
-
(1988)
J Cell Biol
, vol.106
, pp. 1359-1364
-
-
Piotrowicz, R.S.1
Orchekowski, R.P.2
Nugent, D.J.3
Yamada, K.Y.4
Kunicki, T.J.5
-
140
-
-
74749106019
-
Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis
-
Przyklenk K, Frelinger 3rd AL, Linden MD, Whittaker P, Li Y, Barnard MR, et al. Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis. J Thromb Haemost. 2010;8:331-40.
-
(2010)
J Thromb Haemost
, vol.8
, pp. 331-340
-
-
Przyklenk, K.1
Frelinger, A.L.2
Linden, M.D.3
Whittaker, P.4
Li, Y.5
Barnard, M.R.6
-
141
-
-
84862741838
-
The platelet "sugar high" in diabetes
-
Ni H. The platelet "sugar high" in diabetes. Blood. 2012;119:5949-51.
-
(2012)
Blood
, vol.119
, pp. 5949-5951
-
-
Ni, H.1
-
142
-
-
84969776766
-
Glucagon-like peptide 1 receptor activation attenuates platelet aggregation and thrombosis
-
Cameron-Vendrig A, Reheman A, Siraj MA, Xu XR, Wang Y, Lei X, et al. Glucagon-like peptide 1 receptor activation attenuates platelet aggregation and thrombosis. Diabetes. 2016;65:1714-23.
-
(2016)
Diabetes
, vol.65
, pp. 1714-1723
-
-
Cameron-Vendrig, A.1
Reheman, A.2
Siraj, M.A.3
Xu, X.R.4
Wang, Y.5
Lei, X.6
-
143
-
-
84890572455
-
Effects of glucagon-like peptide-1 receptor agonists on cardiovascular risk: a meta-analysis of randomized clinical trials
-
Monami M, Dicembrini I, Nardini C, Fiordelli I, Mannucci E. Effects of glucagon-like peptide-1 receptor agonists on cardiovascular risk: a meta-analysis of randomized clinical trials. Diabetes Obes Metab. 2014;16:38-47.
-
(2014)
Diabetes Obes Metab
, vol.16
, pp. 38-47
-
-
Monami, M.1
Dicembrini, I.2
Nardini, C.3
Fiordelli, I.4
Mannucci, E.5
-
144
-
-
84902104685
-
Thrombosis: tangled up in NETs
-
Martinod K, Wagner DD. Thrombosis: tangled up in NETs. Blood. 2014;123:2768-76.
-
(2014)
Blood
, vol.123
, pp. 2768-2776
-
-
Martinod, K.1
Wagner, D.D.2
-
145
-
-
0033574172
-
Recombinant soluble form of PSGL-1 accelerates thrombolysis and prevents reocclusion in a porcine model
-
Kumar A, Villani MP, Patel UK, Keith Jr JC, Schaub RG. Recombinant soluble form of PSGL-1 accelerates thrombolysis and prevents reocclusion in a porcine model. Circulation. 1999;99:1363-9.
-
(1999)
Circulation
, vol.99
, pp. 1363-1369
-
-
Kumar, A.1
Villani, M.P.2
Patel, U.K.3
Keith, J.C.4
Schaub, R.G.5
-
146
-
-
38749140235
-
Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis
-
Bedard PW, Clerin V, Sushkova N, Tchernychev B, Antrilli T, Resmini C, et al. Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis. J Pharmacol Exp Ther. 2008;324:497-506.
-
(2008)
J Pharmacol Exp Ther
, vol.324
, pp. 497-506
-
-
Bedard, P.W.1
Clerin, V.2
Sushkova, N.3
Tchernychev, B.4
Antrilli, T.5
Resmini, C.6
-
147
-
-
38949147126
-
Prophylactic P-selectin inhibition with PSI-421 promotes resolution of venous thrombosis without anticoagulation
-
Meier TR, Myers Jr DD, Wrobleski SK, Zajkowski PJ, Hawley AE, Bedard PW, et al. Prophylactic P-selectin inhibition with PSI-421 promotes resolution of venous thrombosis without anticoagulation. Thromb Haemost. 2008;99:343-51.
-
(2008)
Thromb Haemost
, vol.99
, pp. 343-351
-
-
Meier, T.R.1
Myers, D.D.2
Wrobleski, S.K.3
Zajkowski, P.J.4
Hawley, A.E.5
Bedard, P.W.6
-
148
-
-
84882613761
-
Novel antiplatelet therapies
-
In: Michelson AD, editor. Platelets. 3rd ed.
-
Kolandaivelu K, Bhatt DL. Novel antiplatelet therapies. In: Michelson AD, editor. Platelets. 3rd ed. Amsterdam: Academic Press/Elsevier; 2013. p. 1185-213.
-
(2013)
Amsterdam: Academic Press/Elsevier
, pp. 1185-1213
-
-
Kolandaivelu, K.1
Bhatt, D.L.2
-
149
-
-
0347535965
-
Soluble CD40 ligand in acute coronary syndromes
-
Conde ID, Kleiman NS. Soluble CD40 ligand in acute coronary syndromes. N Engl J Med. 2003;348:2575-7.
-
(2003)
N Engl J Med
, vol.348
, pp. 2575-2577
-
-
Conde, I.D.1
Kleiman, N.S.2
-
150
-
-
0035824895
-
CD40 signaling and plaque instability
-
Schonbeck U, Libby P. CD40 signaling and plaque instability. Circ Res. 2001;89:1092-103.
-
(2001)
Circ Res
, vol.89
, pp. 1092-1103
-
-
Schonbeck, U.1
Libby, P.2
-
151
-
-
84960091403
-
Essential roles of toll-like receptors in atherosclerosis
-
Lin J, Kakkar V, Lu X. Essential roles of toll-like receptors in atherosclerosis. Curr Med Chem. 2016;23:431-54.
-
(2016)
Curr Med Chem
, vol.23
, pp. 431-454
-
-
Lin, J.1
Kakkar, V.2
Lu, X.3
-
152
-
-
84931268779
-
The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis
-
Hovland A, Jonasson L, Garred P, Yndestad A, Aukrust P, Lappegard KT, et al. The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis. Atherosclerosis. 2015;241:480-94.
-
(2015)
Atherosclerosis
, vol.241
, pp. 480-494
-
-
Hovland, A.1
Jonasson, L.2
Garred, P.3
Yndestad, A.4
Aukrust, P.5
Lappegard, K.T.6
-
154
-
-
84990055362
-
Methods for inhibiting platelet aggregation using glp-1 receptor agonists
-
WO2014066992
-
Husain M, Aameron-Vendrig A, Ni H. Methods for inhibiting platelet aggregation using glp-1 receptor agonists. Google Patents; 2014. WO2014066992.
-
(2014)
Google Patents
-
-
Husain, M.1
Aameron-Vendrig, A.2
Ni, H.3
|