Platelet GPVI: A target for antithrombotic therapy?!

Trends in Pharmacological Sciences

Volumn 33, Issue 11, 2012, Pages 583-590

  Dütting, Sebastian ^a   Bender, Markus ^a   Nieswandt, Bernhard ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBOCYTIC AGENT; GLYCOPROTEIN VI; PROTEIN KINASE SYK INHIBITOR; PRT 318; UNCLASSIFIED DRUG;

ARTERY THROMBOSIS; BLOOD CLOTTING; BRAIN ISCHEMIA; DRUG TARGETING; HEMOSTASIS; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; IN VIVO STUDY; INFLAMMATORY DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; THROMBOCYTE FUNCTION; THROMBOEMBOLISM; THROMBOSIS;

ANIMALS; BLOOD PLATELETS; HUMANS; PLATELET ACTIVATION; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN STRUCTURE, TERTIARY; THROMBOSIS;

EID: 84867888747     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2012.07.004     Document Type: Review

References (76)

1. A.D. Michelson Antiplatelet therapies for the treatment of cardiovascular disease Nat. Rev. Drug Discov. 9 2010 154 169
2. S.P. Jackson Arterial thrombosis - insidious, unpredictable and deadly Nat. Med. 17 2011 1423 1436
3. B. Nieswandt Ischaemic stroke: a thrombo-inflammatory disease? J. Physiol. 589 2011 4115 4123
4. B. Nieswandt Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke J. Thromb. Haemost. 9 Suppl. 1 2011 92 104
5. F. Ye Molecular mechanism of inside-out integrin regulation J. Thromb. Haemost. 9 Suppl. 1 2011 20 25
6. Z. Li Signaling during platelet adhesion and activation Arterioscler. Thromb. Vasc. Biol. 30 2010 2341 2349
7. W.S. Nesbitt A shear gradient-dependent platelet aggregation mechanism drives thrombus formation Nat. Med. 15 2009 665 673
8. B. Nieswandt, and S.P. Watson Platelet-collagen interaction: is GPVI the central receptor? Blood 102 2003 449 461
9. S.P. Watson GPVI and CLEC-2 in hemostasis and vascular integrity J. Thromb. Haemost. 8 2010 1456 1467
10. D. Varga-Szabo STIM and Orai in platelet function Cell Calcium 50 2011 270 278
11. C. Schulz Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation Blood 115 2010 4102 4110
12. T. Renne The procoagulant and proinflammatory plasma contact system Semin. Immunopathol. 34 2012 31 41
13. D. Gailani, and T. Renne Intrinsic pathway of coagulation and arterial thrombosis Arterioscler. Thromb. Vasc. Biol. 27 2007 2507 2513
14. M. Moroi A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion J. Clin. Invest. 84 1989 1440 1445
15. J.M. Clemetson The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcαR and the natural killer receptors J. Biol. Chem. 274 1999 29019 29024
16. M. Jandrot-Perrus Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily Blood 96 2000 1798 1807
17. O. Berlanga Glycoprotein VI oligomerization in cell lines and platelets J. Thromb. Haemost. 5 2007 1026 1033
18. Y. Miura Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen J. Biol. Chem. 277 2002 46197 46204
19. K. Horii Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI Blood 108 2006 936 942
20. P.A. Smethurst Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet glycoprotein VI contains two glycine-proline-hydroxyproline triplets J. Biol. Chem. 282 2007 1296 1304
21. J.F. Arthur Ligand binding rapidly induces disulfide-dependent dimerization of glycoprotein VI on the platelet plasma membrane J. Biol. Chem. 282 2007 30434 30441
22. S. Loyau Platelet glycoprotein VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity Arterioscler. Thromb. Vasc. Biol. 32 2012 778 785
23. S. Dutting, and B. Nieswandt Better safe than sorry: glycoprotein VI dimerization as a novel checkpoint and early biomarker of platelet activation Arterioscler. Thromb. Vasc. Biol. 32 2012 552 553
24. P.A. Smethurst Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody Blood 103 2004 903 911
25. C. Lecut Identification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites J. Biol. Chem. 279 2004 52293 52299
26. E.E. Gardiner Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases J. Thromb. Haemost. 5 2007 1530 1537
27. J.F. Arthur Platelet glycoprotein VI-related clinical defects Br. J. Haematol. 139 2007 363 372
28. B. Dumont Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations Blood 114 2009 1900 1903
29. C. Hermans A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder J. Thromb. Haemost. 7 2009 1356 1363
30. K. Kato The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion Blood 102 2003 1701 1707
31. S. Lockyer GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism Thromb. Res. 118 2006 371 380
32. M. Bender Genetic and antibody-induced glycoprotein VI deficiency equally protects mice from mechanically and FeCl(3)-induced thrombosis J. Thromb. Haemost. 9 2011 1423 1426
33. B. Nieswandt Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRγ chain J. Biol. Chem. 275 2000 23998 24002
34. B. Nieswandt Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice J. Exp. Med. 193 2001 459 469
35. S. Massberg A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo J. Exp. Med. 197 2003 41 49
36. A. Eckly Mechanisms underlying FeCl3-induced arterial thrombosis J. Thromb. Haemost. 9 2011 779 789
37. P.L. Gross, and J.I. Weitz New antithrombotic drugs Clin. Pharmacol. Ther. 86 2009 139 146
38. P. Mangin Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRγ deficiency Blood 107 2006 4346 4353
39. S. Penz Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI FASEB J. 19 2005 898 909
40. J.M. Cosemans Contribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions Atherosclerosis 181 2005 19 27
41. A.J. Reininger A 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques J. Am. Coll. Cardiol. 55 2010 1147 1158
42. M.J. Kuijpers Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model J. Thromb. Haemost. 7 2009 152 161
43. B. Hechler, and C. Gachet Comparison of two murine models of thrombosis induced by atherosclerotic plaque injury Thromb. Haemost. 105 Suppl. 1 2011 S3 S12
44. B. Bigalke Expression of platelet glycoprotein VI is associated with transient ischemic attack and stroke Eur. J. Neurol. 17 2010 111 117
45. M. Al-Tamimi Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke Stroke 42 2011 498 500
46. C. Kleinschnitz Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding Circulation 115 2007 2323 2330
47. G. Stoll Combating innate inflammation: a new paradigm for acute treatment of stroke? Ann. N. Y. Acad. Sci. 1207 2010 149 154
48. B. Petri von Willebrand factor promotes leukocyte extravasation Blood 116 2010 4712 4719
49. P. Thornton Platelet interleukin-1α drives cerebrovascular inflammation Blood 115 2010 3632 3639
50. F. Muller Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo Cell 139 2009 1143 1156
51. E. Boilard Platelets amplify inflammation in arthritis via collagen-dependent microparticle production Science 327 2010 580 583
52. L. Totani, and V. Evangelista Platelet-leukocyte interactions in cardiovascular disease and beyond Arterioscler. Thromb. Vasc. Biol. 30 2010 2357 2361
53. S. Devi Platelet recruitment to the inflamed glomerulus occurs via an αIIbβ3/GPVI-dependent pathway Am. J. Pathol. 177 2010 1131 1142
54. -/- mice Cardiovasc. Res. 80 2008 131 137
55. A. Bultmann Impact of glycoprotein VI and platelet adhesion on atherosclerosis - a possible role of fibronectin J. Mol. Cell. Cardiol. 49 2010 532 542
56. S. Jain Platelets: linking hemostasis and cancer Arterioscler. Thromb. Vasc. Biol. 30 2010 2362 2367
57. S. Jain Platelet glycoprotein VI facilitates experimental lung metastasis in syngenic mouse models J. Thromb. Haemost. 7 2009 1713 1717
58. H. Li The Fab fragment of a novel anti-GPVI monoclonal antibody, OM4, reduces in vivo thrombosis without bleeding risk in rats Arterioscler. Thromb. Vasc. Biol. 27 2007 1199 1205
59. Y. Matsumoto Ex vivo evaluation of anti-GPVI antibody in cynomolgus monkeys: dissociation between anti-platelet aggregatory effect and bleeding time Thromb. Haemost. 96 2006 167 175
60. P. Ohlmann Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression J. Thromb. Haemost. 6 2008 1003 1011
61. B. Boylan Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agents Blood 108 2006 908 914
62. T. Rabie Diverging signaling events control the pathway of GPVI down-regulation in vivo Blood 110 2007 529 535
63. M. Bender Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases Blood 116 2010 3347 3355
64. M. Al-Tamimi Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa Blood 117 2011 3912 3920
65. M. Al-Tamimi Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels Blood 119 2012 4311 4320
66. M.P. Reilly PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model Blood 117 2011 2241 2246
67. T.E. Witzig, and M. Gupta Signal transduction inhibitor therapy for lymphoma Hematol. Am. Soc. Hematol. Educ. Program 2010 2010 265 270
68. S. Massberg Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo FASEB J. 18 2004 397 399
69. M. Ungerer Novel antiplatelet drug revacept (dimeric glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans Circulation 123 2011 1891 1899
70. S. Gruner Relative antithrombotic effect of soluble GPVI dimer compared with anti-GPVI antibodies in mice Blood 105 2005 1492 1499
71. S. Grüner Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced α2β1 levels or concomitant aspirin therapy Circulation 110 2004 2946 2951
72. K. Suzuki-Inoue A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2 Blood 107 2006 542 549
73. -/- mice Blood 111 2008 1266 1273
74. P.H. Mangin A humanized glycoprotein VI (GPVI) mouse model to assess the antithrombotic efficacies of anti-GPVI agents J. Pharmacol. Exp. Ther. 341 2012 156 163
75. C. Dubois Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo Blood 107 2006 3902 3906
76. T. Sugiyama A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia Blood 69 1987 1712 1720