Podoplanin-positive periarteriolar stromal cells promote megakaryocyte growth and proplatelet formation in mice by CLEC-2

Blood

Volumn 127, Issue 13, 2016, Pages 1701-1710

  Tamura, Shogo ^a,b   Suzuki Lnoue, Katsue ^a   Tsukiji, Nagaharu ^a   Shirai, Toshiaki ^a   Sasaki, Tomoyuki ^a   Osada, Makoto ^c   Satoh, Kaneo ^c   Ozaki, Vukio ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c YAMANASHI PREFECTURAL CENTRAL HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

C TYPE LECTIN LIKE RECEPTOR 2; CXCL2 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; PODOPLANIN; PROTEIN KINASE B; RANTES; THROMBOCYTE RECEPTOR; UNCLASSIFIED DRUG; CLEC-2 PROTEIN, MOUSE; GP38 PROTEIN, MOUSE; LECTIN; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BONE MARROW STROMA CELL; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL EXPANSION; CELL GROWTH; CELL LINEAGE; CELLULAR DISTRIBUTION; COCULTURE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; IN VITRO STUDY; MEGAKARYOBLAST; MEGAKARYOCYTE; MOUSE; NONHUMAN; PERICYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RETICULUM CELL; THROMBOCYTOPOIESIS; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CYTOLOGY; GENETICS; HEMATOPOIETIC STEM CELL; KNOCKOUT MOUSE; MAMMALIAN EMBRYO; METABOLISM; PHYSIOLOGY; STROMA CELL; THROMBOCYTE;

ANIMALS; ARTERIOLES; BLOOD PLATELETS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; EMBRYO, MAMMALIAN; HEMATOPOIETIC STEM CELLS; LECTINS, C-TYPE; MEGAKARYOCYTES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; STROMAL CELLS; THROMBOPOIESIS;

EID: 84963491567     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-08-663708     Document Type: Article

References (46)

1. Pang L, Weiss MJ, Poncz M. Megakaryocyte biology and related disorders. J Clin Invest. 2005; 115(12):3332-3338.
2. Avanzi MP, Mitchell W8 Ex vivo production ol platelets from stem cells. Br J Haematol. 2014; 165(2):237-247.
3. Chang V, Bluteau D, Debili N, Vainchenker W From hematopoietic stem cells to platelets. J Thromb Haemost. 2007;5(suppl 1) 318-327.
4. Deutsch VR, Tomer A. Advances in megakaryocytopoiesis and thrombopoiesis: from bench to bedside. Br J Haematol. 2013, 161(6): 778-793.
5. Machlus KR, Thon JN, Italiano JE Jr. Interpreting the developmental dance of the megakaryocyte: A review of the cellular and molecular processes mediating platelet formation. Br J Haematol. 2014; 165(2)227-236.
6. Avecilla ST, Hatlori K, Heissig B, et al. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med. 2004; 10(1):64-71.
7. Malara A, Abbonante V, Di Buduo CA, Tozzi L, Currao M, Balduini A The secret life of a megakaryocyte; emerging roles in bone marrow homeostasis control. Cell Mot Lite Scl. 2015:72(8): 1517-1536.
8. Suzuki-Inoue K. Puller GL, Garcia A, et al A novel Syk-dopendent mechanism ol platelet activation by the C- Type lectin receptor CLEC-2. Blood. 2006;107(2):542-549.
9. Suzuki-Inoue K, Kato Y, Inoue O, et al. Involvement of the snake toxin receptor CLEC-2, In podoplanin-medlated platelet activation, by cancer cells. J Biol Chem. 2007:282(36): 25993-26001.
10. Suzuki-Inoue K, Inoue O, Ozaki Y. Novel platelet activation receptor CLEC-2: from disoovery to prospects. J Thromb Haemost. 2011;9(suppl 1 ):44-55.
11. Link A., Vogt TK, Favre S, et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol. 2007; 8(11): 1255-1265.
12. Herzog BH, Fu J, Wilson SJ, et al. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013; 502(74891):105-109 .
13. Astarita JL, Cremasco V, Fu J, et al. The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture. Nat Immunol. 2015, 16(1):75-84.
14. Acton SE, Farrugla AJ, Astarita JL, et al Dendritic cells control fibroblastic reticular network tension and lymph node expansion. Nature. 2014; 514(7523):498-502.
15. Acton SE, Astarita JL, Malhotra D, et al. Podoplanin-rich etromal networks Induce dendritic cell motility via activation of the C- Type lectin receptor CLEC-2. Immunity. 2012;37(2):276-289.
16. Hess PR, Rawnsley DR, Jakus Z, et al. Platelets mediate lymphovenous hemostasia to maintain blood-lymphatic separation throughout life. J Clin Invest. 2014; 124(11):273-284.
17. Uhrin P. Zaujec J, Breuss JM, et al. Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood. 2010;115(19):3997-4005.
18. Suzuki-Inoue K, Inoue O, Ding G, et al. Essential in vivo roles of the C- Type lectin receptor CLEC-2: Embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. J Biol Chem. 2010;285(32):24494-24507.
19. Osada M, Inoue O, Ding G, et al. Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells. J Biol Chem. 2012; 287(26):22241 -22252.
20. Schacht V, Ramirez Ml, Hong YK, et al. Tlalpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBOJ. 2003;22(14):3546-3556.
21. Bertozzi CC, Schmaier AA, Mericko P, at al. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 2010:116(41):661-670.
22. Tang T, Li L, Tang J, et al. A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol 2010;28(7):749-755.
23. Bender M, May F, Lorenz V, et al. Combined in vivo depletion of glycoprotein VI and C- Type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice. Arterioscler Thromb Vase Biol. 2013;33(5):926-934.
24. Matsumura-Takeda K, Sogo S, Isakarl Y, et al. CD41 +/CD45+ cells without acetylcholinesterase activity are immature and a major megakaryocyte population in murine bone marrow. Stem Cells. 2007;25(4):862-870.
25. Kim JH, Thimmulappa RK, Kumar V, et al. NRF2- mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation. J Clin Invest. 2014; 124(2):730-741.
26. Kawamoto T. Use of a new adhesive film for the preparation of multi-purpose fresh-frozen sections from hard tissues, whole- Animals, insects and plants. Arch Histot Cytol. 2003:66(2) 123-143.
27. Kunlshima S, Kashiwagl H, Otsu M, et al. Heterozygous ITGA2B R995W mutation inducing constitutive activation of the llb(J3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia. Blood. 2011; 117(20):5479-5484.
28. Yumimoto K, Akiyoshl S, Ueo H, et al. F-box protein FBXW7 inhibits cancer metastasis in a non-cell- Autonomous manner .J Clin Invest. 2015; 125(2)621-635.
29. Hooper AT, Butler JM, Nolan DJ, et al. Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell. 2009;4(3):263-274.
30. Zhang J, Niu C, Ye L, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003;425(6960):836-841.
31. Sugiyama T, Kohara H, Noda M, Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity. 2006;25(6):977-988.
32. Omatsu Y, Sugiyama T, Kohara H, et al. The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity. 2010;33(3):387-399.
33. Kazama F, Nakamura J, Osada M, et al. Measurement of soluble C- Type lectin-like receptor 2 in human plasma. Platelets. 2015;26(8):711-719.
34. Moroi AJ, Watson SP. Akt and mitogen- Activated protein kinase enhance C- Type lectin-like receptor 2-mediated platelet activation by Inhibition of glycogen synthase kinase 3u/(l. J Thromb Haemost. 2015:13(6): 1139-1150.
35. Manne BK, Badolia R, Dangelmaier C, et al. Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemlTAM receptors in platelets. J Biol Chem. 2015;290(18):11557-11568.
36. Kauskot A, Vandenbriele C, Louwette S, et al. PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway. Blood. 2013; 121 (26):5208-5217.
37. Perez LE, Desponts C, Parquet N, Kerr WG. SH2- inositol phosphatase 1 negatively influences early megakaryocyte progenitors. PLoS One 2008; 3(10):e3565.
38. Mazharian A, Watson SP, Sdverin S. Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation. Exp Hematol. 2009; 37(10):1238-1249.
39. Miyazaki R, Ogata H, Kobayashi Y. Requirement of thrombopoietin-induced activation of ERK for megakaryocyte differentiation and ol p38 for erythroid differentiation. Ann Hematol. 2001;80(5):284-291.
40. Majka M, Ratajczak J, Baj-Krzyworzek M, et al. Biological significance of chemokine receptor expression by normal human megakaryoblasts. Folia Histochem Cytobiol. 2001;39(3):235-244.
41. Mondal D, Williams CA, Ali M, Eilers M, Agrawal KC. The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression In megakaryocyte K562 cells. Exp Biol Med (Maywood). 2005;230(9):631-644.
42. Wu Y, Yoder A. Chemokine coreceptor signaling in HIV-1 infection and pathogenesis. Plos pathog. 2009;5(12):e1000520.
43. Pollitt AY, Poulter NS, Gitz E, et al. Syk and Src family kinases regulate C- Type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells. J Biol Chem. 2014;289(52):35695-35710.
44. Hamada T, Mflhle R, Hesselgesser J, et al. Transendothelial migration of megakaryocytes In response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation. J Exp Med. 1998; 188(31):539-548.
45. Wang JF, Liu ZY, Groopman JE. The alpha- chemokine receptor CXCR4 Is expressed on the megakaryocyte lineage from progenitor to platelets and modulates migration and adhesion. Blood 1998;92(3):756-764.
46. Kunisaki Y, Bruns I, Scheiermann C, et al. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature. 2013;502(7473): 637-643.