Severe platelet desialylation in a patient with glycoprotein Ib/IX antibody-mediated immune thrombocytopenia and fatal pulmonary hemorrhage

Haematologica

Volumn 99, Issue 4, 2014, Pages

  Li, June ^a,b   Callum, Jeannie L ^a,c   Lin, Yulia ^a,c   Zhou, Yan ^b   Zhu, Guangheng ^b   Ni, Heyu ^a,b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^d CANADIAN BLOOD SERVICES   (Canada)

Author keywords

Antibody specificity; Immune thrombocytopenia; Platelet desialylation; Pulmonary hemorrhage

Indexed keywords

CORTICOSTEROID; DEXAMETHASONE; GLYCOPROTEIN IB; IMMUNOGLOBULIN; PADGEM PROTEIN; SIALIDASE; THROMBIN RECEPTOR; THROMBOCYTE ANTIGEN; TRANEXAMIC ACID; AUTOANTIBODY;

ADULT; AUTOIMMUNE THROMBOCYTOPENIA; CASE REPORT; FLOW CYTOMETRY; HUMAN; LABORATORY TEST; LETTER; LUNG HEMORRHAGE; MALE; MIDDLE AGED; PLATELET DESIALYLATION; QUANTITATIVE ANALYSIS; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE DYSFUNCTION; COMPLICATION; FATALITY; HEMOPTYSIS; HEMORRHAGE; IMMUNOLOGY; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; THROMBOCYTE;

AUTOANTIBODIES; BLOOD PLATELETS; FATAL OUTCOME; HEMOPTYSIS; HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC;

EID: 84897390496     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2013.102897     Document Type: Letter

References (14)

1. Nieswandt B, Bergmeier W, Rackebrandt K, Gessner JE, Zirngibl H. Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. Blood. 2000;96(7):2520-7.
2. Webster ML, Sayeh E, Crow M, Chen P, Nieswandt B, Freedman J, et al. Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by antiplatelet GPIIbIIIa versus GPIbalpha antibodies. Blood. 2006;108(3):943-6.
3. Zeng Q, Zhu L, Tao L, Bao J, Yang M, Simpson EK, et al. Relative efficacy of steroid therapy in immune thrombocytopenia mediated by anti-platelet GPIIbIIIa versus GPIbalpha antibodies. Am J Hematol. 2012;87(2):206-8.
4. Go RS, Johnston KL, Bruden KC. The association between platelet autoantibody specificity and response to intravenous immunoglobulin G in the treatment of patients with immune thrombocytopenia. Haematologica. 2007;92(2):283-4.
5. Peng J, Ma S-H, Liu J, Hou Y, Liu X-M, Niu T, et al. Association of autoantibody specificity and response to intravenous immunoglobulin G therapy in immune thrombocytopenia: a multicentre cohort study. J Throm Haem. 2014;[epub ahead of print] doi: 10.1111/jth.12524.
6. Li J, van der Wal DE, Zhu L, Vadasz B, Simpson EK, Li C, et al. Fcindependent phagocytosis: implications for IVIG and other therapies in immune-mediated thrombocytopenia. Cardiovasc Hematol Disord Drug Targets. 2013;13(1):50-8.
7. Li C, Li J, Li Y, Lang S, Yougbare I, Zhu G, et al. Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries. Adv Hematol. 2012;2012:384685.
8. thASH Annual Meeting and Exposition, 2012:Abstract 265.
9. Yang H, Lang S, Zhai Z, Li L, Kahr WH, Chen P, et al. Fibrinogen is required for maintenance of platelet intracellular and cell-surface Pselectin expression. Blood. 2009;114(2):425-36.
10. Yang Y, Shi Z, Reheman A, Jin JW, Li C, Wang Y, et al. Plant food delphinidin-3-glucoside significantly inhibits platelet activation and thrombosis: novel protective roles against cardiovascular diseases. PloS One. 2012;7(5):e37323.
11. Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, et al. Desialylation accelerates platelet clearance after refrigeration and initiates GPIbalpha metalloproteinase-mediated cleavage in mice. Blood. 2012;119(5):1263-73.
12. Urbanus RT, van der Wal DE, Koekman CA, Huisman A, van den Heuvel DJ, Gerritsen HC, et al. Patient autoantibodies induce platelet destruction signals via raft-associated glycoprotein Ibalpha and Fc RIIa in immune thrombocytopenia. Haematologica. 2013;98(7):e70-2.
13. Li C, Piran S, Chen P, Lang S, Zarpellon A, Jin JW, et al. The maternal immune response to fetal platelet GPIbalpha causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies. J Clin Invest. 2011;121(11):4537-47.
14. Alioglu B, Tasar A, Ozen C, Selver B, Dallar Y. An experience of oseltamivir phosphate (tamiflu) in a pediatric patient with chronic idiopathic thrombocytopenic purpura: a case report. Pathophysiol Haemost Thromb. 2010;37(2-4):55-8.