Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice

Blood

Volumn 126, Issue 14, 2015, Pages 1715-1722

  Verhenne, Sebastien ^a   Denorme, Frederik ^a   Libbrecht, Sarah ^a   Vandenbulcke, Aline ^a   Pareyn, Inge ^a   Deckmyn, Hans ^a   Lambrecht, Antoon ^b   Nieswandt, Bernhard ^c   Kleinschnitz, Christoph ^d   Vanhoorelbeke, Karen ^a   De Meyer, Simon F ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b AZ GROENINGE   (Belgium)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN; VON WILLEBRAND FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CAROTID ARTERY THROMBOSIS; CHIMERA; CONTROLLED STUDY; ENDOTHELIUM CELL; FLOW CYTOMETRY; HEMOSTASIS; MEGAKARYOCYTE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CEREBROVASCULAR ACCIDENT; DISEASE MODEL; HISTOCOMPATIBILITY; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; THROMBOSIS;

ANIMALS; BLOOD PLATELETS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; HEMOSTASIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; STROKE; THROMBOSIS; TRANSPLANTATION CHIMERA; VON WILLEBRAND FACTOR;

EID: 84947997089     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-03-632901     Document Type: Article

References (35)

1. De Meyer SF, Deckmyn H, Vanhoorelbeke K. von Willebrand factor to the rescue. Blood. 2009; 113(21):5049-5057.
2. Rauch A, Wohner N, Christophe OD, Denis CV, Susen S, Lenting PJ. On the versatility of von Willebrand factor. Mediterr J Hematol Infect Dis. 2013;5(1):e2013046.
3. Kleinschnitz C, De Meyer SF, Schwarz T, et al. Deficiency of von Willebrand factor protects mice from ischemic stroke. Blood. 2009;113(15): 3600-3603.
4. Zhao B-Q, Chauhan AK, Canault M, et al. von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke. Blood. 2009;114(15): 3329-3334.
5. De Meyer SF, Schwarz T, Deckmyn H, et al. Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice- brief report. Arterioscler Thromb Vasc Biol. 2010; 30(10):1949-1951.
6. De Meyer SF, Stoll G, Wagner DD, Kleinschnitz C. von Willebrand factor: an emerging target in stroke therapy. Stroke. 2012;43(2):599-606.
7. Mannucci PM. Platelet/von Willebrand factor inhibitors to the rescue of ischemic stroke. Arterioscler Thromb Vasc Biol. 2010;30(10): 1882-1884.
8. McGrath RT, McRae E, Smith OP, O'Donnell JS. Platelet von Willebrand factor-structure, function and biological importance. Br J Haematol. 2010; 148(6):834-843.
9. Williams SB, McKeown LP, Krutzsch H, Hansmann K, Gralnick HR. Purification and characterization of human platelet von Willebrand factor. Br J Haematol. 1994;88(3):582-591.
10. McGrath RT, van den Biggelaar M, Byrne B, et al. Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis. Blood. 2013;122(25): 4107-4110.
11. De Meyer SF, Savchenko AS, Haas MS, et al. Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice. Blood. 2012;120(26):5217-5223.
12. Khan MM, Motto DG, Lentz SR, Chauhan AK. ADAMTS13 reduces VWF-mediated acute inflammation following focal cerebral ischemia in mice. J Thromb Haemost. 2012;10(8):1665-1671.
13. Fressinaud E, Baruch D, Rothschild C, Baumgartner HR, Meyer D. Platelet von Willebrand factor: evidence for its involvement in platelet adhesion to collagen. Blood. 1987;70(4): 1214-1217.
14. Fressinaud E, Federici AB, Castaman G, et al. The role of platelet von Willebrand factor in platelet adhesion and thrombus formation: a study of 34 patients with various subtypes of type I von Willebrand disease. Br J Haematol. 1994;86(2): 327-332.
15. Kanaji S, Fahs SA, Shi Q, Haberichter SL, Montgomery RR. Contribution of platelet vs. endothelial VWF to platelet adhesion and hemostasis. J Thromb Haemost. 2012;10(8): 1646-1652.
16. Denis C, Methia N, Frenette PS, et al. A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc Natl Acad Sci USA. 1998;95(16):9524-9529.
17. De Meyer SF, Vandeputte N, Pareyn I, et al. Restoration of plasma von Willebrand factor deficiency is sufficient to correct thrombus formation after gene therapy for severe von Willebrand disease. Arterioscler Thromb Vasc Biol. 2008;28(9):1621-1626.
18. Massberg S, Gawaz M, Grüner S, et al. A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med. 2003; 197(1):41-49.
19. Roussi J, Drouet L, Sigman J, et al. Absence of incorporation of plasma von Willebrand factor into porcine platelet alpha-granules. Br J Haematol. 1995;90(3):661-668.
20. Fujioka M, Hayakawa K, Mishima K, et al. ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion. Blood. 2010;115(8):1650-1653.
21. Morganti JM, Jopson TD, Liu S, Gupta N, Rosi S. Cranial irradiation alters the brain's microenvironment and permits CCR21 macrophage infiltration. PLoS One. 2014;9(4): e93650.
22. Moravan MJ, Olschowka JA, Williams JP, O'Banion MK. Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain. Radiat Res. 2011;176(4):459-473.
23. Kleinschnitz C, Pozgajova M, Pham M, Bendszus M, Nieswandt B, Stoll G. Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding. Circulation. 2007;115(17):2323-2330.
24. Sultan Y, Jeanneau C, Lamaziere J, Maisonneuve P, Caen JP. Platelet factor VIII-related antigen: studies in vivo after transfusion in patients with von Willebrand disease. Blood. 1978;51(4): 751-761.
25. Castillo R, Escolar G, Monteagudo J, et al. Role for platelet von Willebrand factor in supporting platelet-vessel wall interactions in von Willebrand disease. Am J Hematol. 1989;31(3):153-158.
26. Castillo R, Monteagudo J, Escolar G, Ordinas A, Magallón M, Martín Villar J. Hemostatic effect of normal platelet transfusion in severe von Willebrand disease patients. Blood. 1991;77(9): 1901-1905.
27. Ware RE, Parker RI, McKeown LP, Graham ML. A human chimera for von Willebrand disease following bone marrow transplantation. Am J Pediatr Hematol Oncol. 1993;15(3):338-342.
28. Castillo R, Escolar G, Monteagudo J, Aznar-Salatti J, Reverter JC, Ordinas A. Hemostasis in patients with severe von Willebrand disease improves after normal platelet transfusion and normalizes with further correction of the plasma defect. Transfusion. 1997;37(8):785-790.
29. Nichols TC, Samama CM, Bellinger DA, et al. Function of von Willebrand factor after crossed bone marrow transplantation between normal and von Willebrand disease pigs: effect on arterial thrombosis in chimeras. Proc Natl Acad Sci USA. 1995;92(7):2455-2459.
30. André P, Brouland JP, Roussi J, et al. Role of plasma and platelet von Willebrand factor in arterial thrombogenesis and hemostasis in the pig. Exp Hematol. 1998;26(7):620-626.
31. Denis CV, Marx I, Badirou I, Pendu R, Christophe O. Mouse models to study von Willebrand factor structure-function relationships in vivo. Hamostaseologie. 2009;29(1):17-8, 20.
32. Lenting PJ, Denis CV. Platelet von Willebrand factor: sweet resistance. Blood. 2013;122(25): 4006-4007.
33. Tersteeg C, Seinen C, Heijnen HF. Platelet granule release patterns under flow. J Thromb Haemost. 2013;11(supplement s2).
34. De Meyer SF, Schwarz T, Schatzberg D, Wagner DD. Platelet glycoprotein Iba is an important mediator of ischemic stroke in mice. Exp Transl Stroke Med. 2011;3(1):9.
35. Morowski M, Vögtle T, Kraft P, Kleinschnitz C, Stoll G, Nieswandt B. Only severe thrombocytopenia results in bleeding and defective thrombus formation in mice. Blood. 2013;121(24):4938-4947.