Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 3, 2009, Pages 719-724

  Miller, Meredith W ^a   Basra, Sandeep ^a   Kulp, Daniel W ^a   Billings, Paul C ^a   Choi, Sungwook ^a   Beavers, Mary Pat ^a   McCarty, Owen J T ^b   Zou, Zhiying ^a   Kahn, Mark L ^a   Bennett, Joel S ^a   DeGrado, William F ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Oregon Health and Science University Department of Biomedical Engineering   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alpha(2) beta(1); I domain; Integrin; Platelet; Thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; MUTANT PROTEIN; OXAZOLIDINE DERIVATIVE; PROPIONIC ACID DERIVATIVE; PROPYL 2,3 DIAMINOPROPIONIC ACID DERIVATIVE; PROTEIN INHIBITOR; THIAZOLIDINE DERIVATIVE; THROMBOCYTE RECEPTOR; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG TARGETING; IC 50; IN VIVO STUDY; LIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; THROMBOGENESIS; THROMBUS;

ALLOSTERIC REGULATION; ANIMALS; BETA-ALANINE; FIBRINOLYTIC AGENTS; HUMANS; INTEGRIN ALPHA2BETA1; MICE; MICE, INBRED C57BL; PROLINE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES; THROMBOSIS;

ANIMALIA;

EID: 58849165421     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0811622106     Document Type: Article

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