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Volumn 109, Issue 6, 2013, Pages 991-998

The physiological and Pathophysiological roles of platelet CLEC-2

Author keywords

CLEC 2; Lymphangiogenesis; Platelets; Podoplanin

Indexed keywords

ADAPTOR PROTEIN; ADENOSINE DIPHOSPHATE; BONE MORPHOGENETIC PROTEIN 9; C TYPE LECTIN LIKE RECEPTOR 2; COLLAGEN RECEPTOR; DECTIN 1; EZRIN; GLYCOSYLTRANSFERASE; IBUPROFEN; INDOMETACIN; INTEGRIN; LAT PROTEIN; LECTIN RECEPTOR; MOESIN; NEUROPILIN 2; PHOSPHATASE; PHOSPHOLIPASE C GAMMA2; PODOPLANIN; PROTEIN KINASE SYK; PROTEIN KINASE SYK INHIBITOR; PROTEIN TYROSINE KINASE; RAC PROTEIN; RADIXIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SNAKE VENOM; THROMBOXANE A2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 3;

EID: 84878642457     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH13-01-0060     Document Type: Review
Times cited : (73)

References (90)
  • 1
    • 0034728866 scopus 로고    scopus 로고
    • Platelets
    • George JN. Platelets. Lancet 2000; 355: 1531-1539.
    • (2000) Lancet , vol.355 , pp. 1531-1539
    • George, J.N.1
  • 2
    • 84882649720 scopus 로고    scopus 로고
    • The evolution of mammalian platelets
    • 2nd Edition: Academic Press
    • Levin J. The evolution of mammalian platelets. In: Platelets, 2nd Edition: Academic Press; 2007; pp. 3-22.
    • (2007) Platelets , pp. 3-22
    • Levin, J.1
  • 3
    • 37249068049 scopus 로고    scopus 로고
    • Platelet activation and atherothrombosis
    • Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007; 357: 2482-2494.
    • (2007) N Engl J Med , vol.357 , pp. 2482-2494
    • Davi, G.1    Patrono, C.2
  • 4
    • 52249099513 scopus 로고    scopus 로고
    • Platelets, petechiae, and preservation of the vascular wall
    • Nachman RL, Rafii S. Platelets, petechiae, and preservation of the vascular wall. N Engl J Med 2008; 359: 1261-1270.
    • (2008) N Engl J Med , vol.359 , pp. 1261-1270
    • Nachman, R.L.1    Rafii, S.2
  • 5
    • 1642475081 scopus 로고    scopus 로고
    • Autologous platelets as a source of proteins for healing and tissue regeneration
    • Anitua E, Andia I, Ardanza B, et al. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2004; 91: 4-15.
    • (2004) Thromb Haemost , vol.91 , pp. 4-15
    • Anitua, E.1    Andia, I.2    Ardanza, B.3
  • 6
    • 79961016308 scopus 로고    scopus 로고
    • Platelets, inflammation and tissue regeneration
    • Nurden AT. Platelets, inflammation and tissue regeneration. Thromb Haemost 2011; 105 (Suppl 1): S13-33.
    • (2011) Thromb Haemost , vol.105 , Issue.SUPPL. 1
    • Nurden, A.T.1
  • 7
    • 73849131692 scopus 로고    scopus 로고
    • Platelets contribute to postnatal occlusion of the ductus arteriosus
    • Echtler K, Stark K, Lorenz M, et al. Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med 2009; 16: 75-82.
    • (2009) Nat Med , vol.16 , pp. 75-82
    • Echtler, K.1    Stark, K.2    Lorenz, M.3
  • 8
    • 77952885004 scopus 로고    scopus 로고
    • Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling
    • Bertozzi CC, Schmaier AA, Mericko P, et al. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood 2010; 116: 661-670.
    • (2010) Blood , vol.116 , pp. 661-670
    • Bertozzi, C.C.1    Schmaier, A.A.2    Mericko, P.3
  • 9
    • 77951296956 scopus 로고    scopus 로고
    • Platelets Play an Essential Role in Separating the Blood and Lymphatic Vasculatures During Embryonic Angiogenesis
    • Carramolino L, Fuentes J, García-Andrés C, et al. Platelets Play an Essential Role in Separating the Blood and Lymphatic Vasculatures During Embryonic Angiogenesis. Circ Res 2010; 106: 1197-1201.
    • (2010) Circ Res , vol.106 , pp. 1197-1201
    • Carramolino, L.1    Fuentes, J.2    García-Andrés, C.3
  • 10
    • 84857565263 scopus 로고    scopus 로고
    • CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development
    • Finney BA, Schweighoffer E, Navarro-Nuñez L, et al. CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood 2012; 119: 1747-1756.
    • (2012) Blood , vol.119 , pp. 1747-1756
    • Finney, B.A.1    Schweighoffer, E.2    Navarro-Nuñez, L.3
  • 11
    • 77955301210 scopus 로고    scopus 로고
    • Essential in Vivo Roles of the C-type Lectin Receptor CLEC-2
    • Suzuki-Inoue K, Inoue O, Ding G, et al. Essential in Vivo Roles of the C-type Lectin Receptor CLEC-2. J Biol Chem 2010; 285: 24494-24507.
    • (2010) J Biol Chem , vol.285 , pp. 24494-24507
    • Suzuki-Inoue, K.1    Inoue, O.2    Ding, G.3
  • 12
    • 81255188905 scopus 로고    scopus 로고
    • The lymphatic vasculature in disease
    • Alitalo K. The lymphatic vasculature in disease. Nat Med 2011; 17: 1371-1380.
    • (2011) Nat Med , vol.17 , pp. 1371-1380
    • Alitalo, K.1
  • 13
    • 0041312675 scopus 로고    scopus 로고
    • T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema
    • Schacht V, Ramirez MI, Hong YK, et al. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J 2003; 22: 3546-3556.
    • (2003) EMBO J , vol.22 , pp. 3546-3556
    • Schacht, V.1    Ramirez, M.I.2    Hong, Y.K.3
  • 14
    • 76749148097 scopus 로고    scopus 로고
    • Novel function for blood platelets and podo-planin in developmental separation of blood and lymphatic circulation
    • Uhrin P, Zaujec J, Breuss JM, et al. Novel function for blood platelets and podo-planin in developmental separation of blood and lymphatic circulation. Blood 2010; 115: 3997-4005.
    • (2010) Blood , vol.115 , pp. 3997-4005
    • Uhrin, P.1    Zaujec, J.2    Breuss, J.M.3
  • 15
    • 55849149808 scopus 로고    scopus 로고
    • Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice
    • Fu J, Gerhardt H, McDaniel JM, et al. Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest 2008; 118: 3725-3737.
    • (2008) J Clin Invest , vol.118 , pp. 3725-3737
    • Fu, J.1    Gerhardt, H.2    McDaniel, J.M.3
  • 16
    • 0037428102 scopus 로고    scopus 로고
    • Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk
    • Abtahian F, Guerriero A, Sebzda E, et al. Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 2003; 299: 247-251.
    • (2003) Science , vol.299 , pp. 247-251
    • Abtahian, F.1    Guerriero, A.2    Sebzda, E.3
  • 17
    • 77950585593 scopus 로고    scopus 로고
    • Regulation of developmental lymphan-giogenesis by Syk(+) leukocytes
    • Bohmer R, Neuhaus B, Buhren S, et al. Regulation of developmental lymphan-giogenesis by Syk(+) leukocytes. Dev Cell 2010; 18: 437-449.
    • (2010) Dev Cell , vol.18 , pp. 437-449
    • Bohmer, R.1    Neuhaus, B.2    Buhren, S.3
  • 18
    • 62349108155 scopus 로고    scopus 로고
    • Phospholipase C gamma2 is necessary for separation of blood and lymphatic vasculature in mice
    • Ichise H, Ichise T, Ohtani O, et al. Phospholipase C gamma2 is necessary for separation of blood and lymphatic vasculature in mice. Development 2009; 136: 191-195.
    • (2009) Development , vol.136 , pp. 191-195
    • Ichise, H.1    Ichise, T.2    Ohtani, O.3
  • 19
    • 30444452843 scopus 로고    scopus 로고
    • A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2
    • Suzuki-Inoue K, Fuller GL, García A, et al. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood 2006; 107: 542-549.
    • (2006) Blood , vol.107 , pp. 542-549
    • Suzuki-Inoue, K.1    Fuller, G.L.2    García, A.3
  • 20
    • 34548843614 scopus 로고    scopus 로고
    • Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells
    • Suzuki-Inoue K, Kato Y, Inoue O, et al. Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. J Biol Chem 2007; 282: 25993-26001.
    • (2007) J Biol Chem , vol.282 , pp. 25993-26001
    • Suzuki-Inoue, K.1    Kato, Y.2    Inoue, O.3
  • 21
    • 80053155199 scopus 로고    scopus 로고
    • CLEC-2 signaling via Syk in mye-loid cells can regulate inflammatory responses
    • Mourão-Sã D, Robinson MJ, Zelenay S, et al. CLEC-2 signaling via Syk in mye-loid cells can regulate inflammatory responses. Eur J Immunol 2011; 41: 3040-3053.
    • (2011) Eur J Immunol , vol.41 , pp. 3040-3053
    • Mourão-Sã, D.1    Robinson, M.J.2    Zelenay, S.3
  • 22
    • 57449083602 scopus 로고    scopus 로고
    • The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors
    • Huysamen C, Brown GD. The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors. FEMS Microbiol Lett 2009; 290: 121-128.
    • (2009) FEMS Microbiol Lett , vol.290 , pp. 121-128
    • Huysamen, C.1    Brown, G.D.2
  • 23
    • 0033952396 scopus 로고    scopus 로고
    • Molecular characterisation of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells
    • Colonna M, Samaridis J, Angman L. Molecular characterisation of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. Eur J Immunol 2000; 30: 697-704.
    • (2000) Eur J Immunol , vol.30 , pp. 697-704
    • Colonna, M.1    Samaridis, J.2    Angman, L.3
  • 24
    • 34250309213 scopus 로고    scopus 로고
    • The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade
    • Fuller GL, Williams JA, Tomlinson MG, et al. The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade. J Biol Chem 2007; 282: 12397-12409.
    • (2007) J Biol Chem , vol.282 , pp. 12397-12409
    • Fuller, G.L.1    Williams, J.A.2    Tomlinson, M.G.3
  • 25
    • 77951062027 scopus 로고    scopus 로고
    • CLEC-2 activates Syk through dimerisation
    • Hughes CE, Pollitt AY, Mori J, et al. CLEC-2 activates Syk through dimerisation. Blood 2010; 115: 2947-2955.
    • (2010) Blood , vol.115 , pp. 2947-2955
    • Hughes, C.E.1    Pollitt, A.Y.2    Mori, J.3
  • 27
    • 84871476375 scopus 로고    scopus 로고
    • A detailed proteomic analysis of rhodocy-tin-activated platelets reveals novel clues on the CLEC-2 signalosome: Implications for CLEC-2 signaling regulation
    • Parguiña AF, Alonso J, Rosa I, et al. A detailed proteomic analysis of rhodocy-tin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation. Blood 2012; 120: e117-e126.
    • (2012) Blood , vol.120
    • Parguiña, A.F.1    Alonso, J.2    Rosa, I.3
  • 28
    • 77951082802 scopus 로고    scopus 로고
    • Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerisation, secondary mediators, and Rac
    • Pollitt AY, Grygielska B, Leblond B, et al. Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerisation, secondary mediators, and Rac. Blood 2010; 115: 2938-2946.
    • (2010) Blood , vol.115 , pp. 2938-2946
    • Pollitt, A.Y.1    Grygielska, B.2    Leblond, B.3
  • 29
    • 70350111448 scopus 로고    scopus 로고
    • CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis
    • May F, Hagedorn I, Pleines I, et al. CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis. Blood 2009; 114: 3464-3472.
    • (2009) Blood , vol.114 , pp. 3464-3472
    • May, F.1    Hagedorn, I.2    Pleines, I.3
  • 30
    • 84876289215 scopus 로고    scopus 로고
    • Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice
    • Epub ahead of print
    • Bender M, May F, Lorenz V, et al. Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice. Arterioscler Thromb Vasc Biol 2013; Epub ahead of print.
    • (2013) Arterioscler Thromb Vasc Biol
    • Bender, M.1    May, F.2    Lorenz, V.3
  • 31
    • 78649377122 scopus 로고    scopus 로고
    • CLEC-2 is not required for platelet aggregation at arteriolar shear
    • Hughes CE, Navarro-Nuñez L, Finney BA, et al. CLEC-2 is not required for platelet aggregation at arteriolar shear. J Thromb Haemost 2010; 8: 2328-2332.
    • (2010) J Thromb Haemost , vol.8 , pp. 2328-2332
    • Hughes, C.E.1    Navarro-Nuñez, L.2    Finney, B.A.3
  • 32
    • 0033561189 scopus 로고    scopus 로고
    • Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets
    • Law DA, Nannizzi-Alaimo L, Ministri K, et al. Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets. Blood 1999; 93: 2645-2652.
    • (1999) Blood , vol.93 , pp. 2645-2652
    • Law, D.A.1    Nannizzi-Alaimo, L.2    Ministri, K.3
  • 33
    • 0030917981 scopus 로고    scopus 로고
    • The Fc receptor gamma-chain and the ty-rosine kinase Syk are essential for activation of mouse platelets by collagen
    • Poole A, Gibbins JM, Turner M, et al. The Fc receptor gamma-chain and the ty-rosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J 1997; 16: 2333-2341.
    • (1997) EMBO J , vol.16 , pp. 2333-2341
    • Poole, A.1    Gibbins, J.M.2    Turner, M.3
  • 34
    • 80855144790 scopus 로고    scopus 로고
    • Critical role for Syk in responses to vascular injury
    • Andre P, Morooka T, Sim D, et al. Critical role for Syk in responses to vascular injury. Blood 2011; 118: 5000-5010.
    • (2011) Blood , vol.118 , pp. 5000-5010
    • Andre, P.1    Morooka, T.2    Sim, D.3
  • 35
    • 77956912413 scopus 로고    scopus 로고
    • A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis
    • Hou TZ, Bystrom J, Sherlock J P, et al. A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis. FEBS Lett 2010; 584: 3955-3961.
    • (2010) FEBS Lett , vol.584 , pp. 3955-3961
    • Hou, T.Z.1    Bystrom, J.2    Sherlock, J.P.3
  • 36
    • 77955051297 scopus 로고    scopus 로고
    • New trends in the study of podoplanin as a cell morphological regulator
    • Sawa Y. New trends in the study of podoplanin as a cell morphological regulator. JDSR 2010; 46: 165-172.
    • (2010) JDSR , vol.46 , pp. 165-172
    • Sawa, Y.1
  • 37
    • 0036346708 scopus 로고    scopus 로고
    • ERM proteins and merlin: Integrators at the cell cortex
    • Bretscher A, Edwards K, Fehon RG. ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol 2002; 3: 586-599.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 586-599
    • Bretscher, A.1    Edwards, K.2    Fehon, R.G.3
  • 38
    • 32844474692 scopus 로고    scopus 로고
    • Role of ERM (ezrin-radixin-moesin) proteins in T lymphocyte polarisation, immune synapse formation and in T cell receptor-mediated signaling
    • Charrin S, Alcover A. Role of ERM (ezrin-radixin-moesin) proteins in T lymphocyte polarisation, immune synapse formation and in T cell receptor-mediated signaling. Front Biosci 2006; 11: 1987-1997.
    • (2006) Front Biosci , vol.11 , pp. 1987-1997
    • Charrin, S.1    Alcover, A.2
  • 39
    • 0033398793 scopus 로고    scopus 로고
    • Identification of PA2.26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes
    • Scholl FG, Gamallo C, Vilaro S, et al. Identification of PA2.26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes. J Cell Sci 1999; 112: 4601-4613.
    • (1999) J Cell Sci , vol.112 , pp. 4601-4613
    • Scholl, F.G.1    Gamallo, C.2    Vilaro, S.3
  • 40
    • 33645758275 scopus 로고    scopus 로고
    • Tumor invasion in the absence of epithelial-mesenchymal transition: Podoplanin-mediated remodeling of the actin cytos-keleton
    • Wicki A, Lehembre F, Wick N, et al. Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytos-keleton. Cancer Cell 2006; 9: 261-272.
    • (2006) Cancer Cell , vol.9 , pp. 261-272
    • Wicki, A.1    Lehembre, F.2    Wick, N.3
  • 41
    • 56149111087 scopus 로고    scopus 로고
    • T1alpha/podoplanin is essential for capillary morphogenesis in lymphatic endothelial cells
    • Navarro A, Perez RE, Rezaiekhaligh M, et al. T1alpha/podoplanin is essential for capillary morphogenesis in lymphatic endothelial cells. Am J Physiol Lung Cell Mol Physiol 2008; 295: L543-L551.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295
    • Navarro, A.1    Perez, R.E.2    Rezaiekhaligh, M.3
  • 42
    • 78650665215 scopus 로고    scopus 로고
    • Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42
    • Navarro A, Perez RE, Rezaiekhaligh MH, et al. Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42. Am J Physiol Lung Cell Mol Physiol 2011; 300: L32-L42.
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.300
    • Navarro, A.1    Perez, R.E.2    Rezaiekhaligh, M.H.3
  • 43
    • 33751539322 scopus 로고    scopus 로고
    • Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition
    • Martin-Villar E, Megias D, Castel S, et al. Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition. J Cell Sci 2006; 119: 4541-4553.
    • (2006) J Cell Sci , vol.119 , pp. 4541-4553
    • Martin-Villar, E.1    Megias, D.2    Castel, S.3
  • 44
    • 84860367807 scopus 로고    scopus 로고
    • What is bad in cancer is good in the embryo: Importance of EMT in neural crest development
    • Kerosuo L, Bronner-Fraser M. What is bad in cancer is good in the embryo: Importance of EMT in neural crest development. Semin Cell Dev Biol 2012; 23: 320-332.
    • (2012) Semin Cell Dev Biol , vol.23 , pp. 320-332
    • Kerosuo, L.1    Bronner-Fraser, M.2
  • 45
    • 58149269010 scopus 로고    scopus 로고
    • Podoplanin deficient mice show a RhoA-related hypoplasia of the sinus venosus myocardium including the sinoatrial node
    • Mahtab EA, Vicente-Steijn R, Hahurij ND, et al. Podoplanin deficient mice show a RhoA-related hypoplasia of the sinus venosus myocardium including the sinoatrial node. Dev Dyn 2009; 238: 183-193.
    • (2009) Dev Dyn , vol.238 , pp. 183-193
    • Mahtab, E.A.1    Vicente-Steijn, R.2    Hahurij, N.D.3
  • 47
    • 84862893491 scopus 로고    scopus 로고
    • Inherited platelet disorders
    • Nurden AT, Freson K, Seligsohn U. Inherited platelet disorders. Haemophilia 2012; 18 (Suppl 4): 154-160.
    • (2012) Haemophilia , vol.18 , Issue.SUPPL. 4 , pp. 154-160
    • Nurden, A.T.1    Freson, K.2    Seligsohn, U.3
  • 48
    • 0038445927 scopus 로고    scopus 로고
    • The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis
    • Emambokus NR, Frampton J. The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis. Immunity 2003; 19: 33-45.
    • (2003) Immunity , vol.19 , pp. 33-45
    • Emambokus, N.R.1    Frampton, J.2
  • 49
    • 0032590042 scopus 로고    scopus 로고
    • Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
    • Hodivala-Dilke KM, McHugh KP, Tsakiris DA, et al. Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest 1999; 103: 229-238.
    • (1999) J Clin Invest , vol.103 , pp. 229-238
    • Hodivala-Dilke, K.M.1    McHugh, K.P.2    Tsakiris, D.A.3
  • 50
    • 78650803540 scopus 로고    scopus 로고
    • Endothelial cell talin1 is essential for embryonic angiogenesis
    • Monkley SJ, Kostourou V, Spence L, et al. Endothelial cell talin1 is essential for embryonic angiogenesis. Dev Biol 2011, 349: 494-502.
    • (2011) Dev Biol , vol.349 , pp. 494-502
    • Monkley, S.J.1    Kostourou, V.2    Spence, L.3
  • 51
    • 77953317401 scopus 로고    scopus 로고
    • The Integrin Co-activator Kindlin-3 Is Expressed and Functional in a Non-hematopoietic Cell, the Endothelial Cell
    • Bialkowska K, Ma Y-Q, Bledzka K, et al. The Integrin Co-activator Kindlin-3 Is Expressed and Functional in a Non-hematopoietic Cell, the Endothelial Cell. J Biol Chem 2010; 285: 18640-18649.
    • (2010) J Biol Chem , vol.285 , pp. 18640-18649
    • Bialkowska, K.1    Ma, Y.-Q.2    Bledzka, K.3
  • 52
    • 61949240364 scopus 로고    scopus 로고
    • A point mutation in kindlin3 ablates activation of three integrin subfamilies in humans
    • Malinin NL, Zhang L, Choi J, et al. A point mutation in kindlin3 ablates activation of three integrin subfamilies in humans. Nat Med 2009; 15: 313-318.
    • (2009) Nat Med , vol.15 , pp. 313-318
    • Malinin, N.L.1    Zhang, L.2    Choi, J.3
  • 53
    • 68349105030 scopus 로고    scopus 로고
    • Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis
    • Bazigou E, Xie S, Chen C, et al. Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell 2009; 17: 175-186.
    • (2009) Dev Cell , vol.17 , pp. 175-186
    • Bazigou, E.1    Xie, S.2    Chen, C.3
  • 54
    • 0033948027 scopus 로고    scopus 로고
    • Fatal Bilateral Chylothorax in Mice Lacking the Integrin α9β1
    • Huang XZ, Wu JF, Ferrando R, et al. Fatal Bilateral Chylothorax in Mice Lacking the Integrin α9β1. Mol Cell Biol 2000; 20: 5208-5215.
    • (2000) Mol Cell Biol , vol.20 , pp. 5208-5215
    • Huang, X.Z.1    Wu, J.F.2    Ferrando, R.3
  • 55
    • 77951054237 scopus 로고    scopus 로고
    • Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis
    • Garmy-Susini B, Avraamides CJ, Schmid MC, et al. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res 2010; 70: 3042-3051.
    • (2010) Cancer Res , vol.70 , pp. 3042-3051
    • Garmy-Susini, B.1    Avraamides, C.J.2    Schmid, M.C.3
  • 56
    • 78650452381 scopus 로고    scopus 로고
    • Podoplanin associates with CD44 to promote directional cell migration
    • Martin-Villar E, Fernandez-Munoz B, Parsons M, et al. Podoplanin associates with CD44 to promote directional cell migration. Mol Biol Cell 2010; 21: 4387-4399.
    • (2010) Mol Biol Cell , vol.21 , pp. 4387-4399
    • Martin-Villar, E.1    Fernandez-Munoz, B.2    Parsons, M.3
  • 57
    • 80052462264 scopus 로고    scopus 로고
    • Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma
    • Kunita A, Kashima TG, Ohazama A, et al. Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma. Am J Pathol 2011; 179: 1041-1049.
    • (2011) Am J Pathol , vol.179 , pp. 1041-1049
    • Kunita, A.1    Kashima, T.G.2    Ohazama, A.3
  • 58
    • 78549282833 scopus 로고    scopus 로고
    • Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin
    • Cueni LN, Chen L, Zhang H, et al. Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin. Blood 2010; 116: 4376-4384.
    • (2010) Blood , vol.116 , pp. 4376-4384
    • Cueni, L.N.1    Chen, L.2    Zhang, H.3
  • 59
    • 84862702605 scopus 로고    scopus 로고
    • Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells
    • Osada M, Inoue O, Ding G, et al. Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells. J Biol Chem 2012; 287: 22241-22252.
    • (2012) J Biol Chem , vol.287 , pp. 22241-22252
    • Osada, M.1    Inoue, O.2    Ding, G.3
  • 60
    • 34249727787 scopus 로고    scopus 로고
    • Moderation of the platelet releasate response by aspirin
    • Coppinger JA, O'Connor R, Wynne K, et al. Moderation of the platelet releasate response by aspirin. Blood 2007; 109: 4786-4792.
    • (2007) Blood , vol.109 , pp. 4786-4792
    • Coppinger, J.A.1    O'Connor, R.2    Wynne, K.3
  • 61
    • 77954491295 scopus 로고    scopus 로고
    • A mouse knockout library for secreted and transmem-brane proteins
    • 201
    • Tang T, Li L, Tang J, et al. A mouse knockout library for secreted and transmem-brane proteins. Nat Biotechnol. 201; 28: 749-755.
    • Nat Biotechnol , vol.28 , pp. 749-755
    • Tang, T.1    Li, L.2    Tang, J.3
  • 62
    • 33645915751 scopus 로고    scopus 로고
    • The choroid plexus-cerebrospinal fluid system: From development to aging
    • Redzic ZB, Preston JE, Duncan JA, et al. The choroid plexus-cerebrospinal fluid system: from development to aging. Curr Top Dev Biol 2005; 71: 1-52.
    • (2005) Curr Top Dev Biol , vol.71 , pp. 1-52
    • Redzic, Z.B.1    Preston, J.E.2    Duncan, J.A.3
  • 63
    • 65249175159 scopus 로고    scopus 로고
    • C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
    • Reboldi A, Coisne C, Baumjohann D, et al. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol 2009; 10: 514-523.
    • (2009) Nat Immunol , vol.10 , pp. 514-523
    • Reboldi, A.1    Coisne, C.2    Baumjohann, D.3
  • 64
    • 33745058119 scopus 로고    scopus 로고
    • The podocyte's response to injury: Role in proteinuria and glome-rulosclerosis
    • Shankland SJ. The podocyte's response to injury: Role in proteinuria and glome-rulosclerosis. Kidney Int 2006; 69: 2131-2147.
    • (2006) Kidney Int , vol.69 , pp. 2131-2147
    • Shankland, S.J.1
  • 65
    • 48749105664 scopus 로고    scopus 로고
    • Selective loss of podoplanin protein expression accompanies proteinuria and precedes alterations in podocyte morphology in a spontaneous proteinuric rat model
    • Koop K, Eikmans M, Wehland M, et al. Selective loss of podoplanin protein expression accompanies proteinuria and precedes alterations in podocyte morphology in a spontaneous proteinuric rat model. Am J Pathol 2008; 173: 315-326.
    • (2008) Am J Pathol , vol.173 , pp. 315-326
    • Koop, K.1    Eikmans, M.2    Wehland, M.3
  • 66
    • 0032919513 scopus 로고    scopus 로고
    • Podoplanin, a novel 43-kDa membrane protein, controls the shape of podocytes
    • Matsui K, Breitender-Geleff S, Soleiman A, et al. Podoplanin, a novel 43-kDa membrane protein, controls the shape of podocytes. Nephrol Dial Transplant 1999; 14 (Suppl 1): 9-11.
    • (1999) Nephrol Dial Transplant , vol.14 , Issue.SUPPL. 1 , pp. 9-11
    • Matsui, K.1    Breitender-Geleff, S.2    Soleiman, A.3
  • 67
    • 4344716629 scopus 로고    scopus 로고
    • Podocalyxin activates RhoA and induces actin reorganisation through NHERF1 and Ezrin in MDCK cells
    • Schmieder S, Nagai M, Orlando RA, et al. Podocalyxin activates RhoA and induces actin reorganisation through NHERF1 and Ezrin in MDCK cells. J Am Soc Nephrol 2004; 15: 2289-2298.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2289-2298
    • Schmieder, S.1    Nagai, M.2    Orlando, R.A.3
  • 68
    • 33748479435 scopus 로고    scopus 로고
    • Alterations in gene expression in T1 alpha null lung: A model of deficient alveolar sac development
    • Millien G, Spira A, Hinds A, et al. Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development. BMC Dev Biol 2006; 6: 35.
    • (2006) BMC Dev Biol , vol.6 , pp. 35
    • Millien, G.1    Spira, A.2    Hinds, A.3
  • 69
    • 0037376154 scopus 로고    scopus 로고
    • T1α, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolus formation at birth
    • Ramirez MI, Millien G, Hinds A, et al. T1α, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolus formation at birth. Dev Biol 2003; 256: 61-72.
    • (2003) Dev Biol , vol.256 , pp. 61-72
    • Ramirez, M.I.1    Millien, G.2    Hinds, A.3
  • 70
    • 64249085562 scopus 로고    scopus 로고
    • CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils
    • Kerrigan AM, Dennehy KM, Mourão-Sã D, et al. CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. J Immunol 2009; 182: 4150-4157.
    • (2009) J Immunol , vol.182 , pp. 4150-4157
    • Kerrigan, A.M.1    Dennehy, K.M.2    Mourão-Sã, D.3
  • 71
    • 84863412801 scopus 로고    scopus 로고
    • Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2
    • Kerrigan AM, Navarro-Nuñez L, Pyz E, et al. Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2. J Thromb Haemost 2012; 10: 484-486.
    • (2012) J Thromb Haemost , vol.10 , pp. 484-486
    • Kerrigan, A.M.1    Navarro-Nuñez, L.2    Pyz, E.3
  • 72
    • 80555153996 scopus 로고    scopus 로고
    • DC mobilisation from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling
    • Tal O, Lim HY, Gurevich I, et al. DC mobilisation from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling. J Exp Med 2011; 208: 2141-2153.
    • (2011) J Exp Med , vol.208 , pp. 2141-2153
    • Tal, O.1    Lim, H.Y.2    Gurevich, I.3
  • 73
    • 84865401654 scopus 로고    scopus 로고
    • Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2
    • Acton SE, Astarita JL, Malhotra D, et al. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity 2012; 37: 276-289.
    • (2012) Immunity , vol.37 , pp. 276-289
    • Acton, S.E.1    Astarita, J.L.2    Malhotra, D.3
  • 74
    • 77956175900 scopus 로고    scopus 로고
    • New insights into the development of lymphoid tissues
    • van de Pavert SA, Mebius RE. New insights into the development of lymphoid tissues. Nat Rev Immunol 2010; 10: 664-674.
    • (2010) Nat Rev Immunol , vol.10 , pp. 664-674
    • van de Pavert, S.A.1    Mebius, R.E.2
  • 75
    • 84355166761 scopus 로고    scopus 로고
    • Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation
    • Peters A, Pitcher LA, Sullivan JM, et al. Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity 2011; 35: 986-996.
    • (2011) Immunity , vol.35 , pp. 986-996
    • Peters, A.1    Pitcher, L.A.2    Sullivan, J.M.3
  • 76
    • 84871819532 scopus 로고    scopus 로고
    • Podoplanin is an inflammatory protein up-regulated in Th17 cells in SKG arthritic joints
    • Miyamoto Y, Uga H, Tanaka S, et al. Podoplanin is an inflammatory protein up-regulated in Th17 cells in SKG arthritic joints. Mol Immunol 2012; 54: 199-207.
    • (2012) Mol Immunol , vol.54 , pp. 199-207
    • Miyamoto, Y.1    Uga, H.2    Tanaka, S.3
  • 77
    • 79952344615 scopus 로고    scopus 로고
    • The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic syn-ovial lining layer in rheumatoid arthritis
    • Ekwall AK, Eisler T, Anderberg C, et al. The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic syn-ovial lining layer in rheumatoid arthritis. Arthritis Res Ther 2011; 13: R40.
    • (2011) Arthritis Res Ther , vol.13
    • Ekwall, A.K.1    Eisler, T.2    Anderberg, C.3
  • 78
    • 84873377815 scopus 로고    scopus 로고
    • Platelet ITAM signaling is critical for vascular integrity in inflammation
    • Epub ahead of print
    • Boulaftali Y, Hess PR, Getz TM, et al. Platelet ITAM signaling is critical for vascular integrity in inflammation. J Clin Invest 2013; Epub ahead of print.
    • (2013) J Clin Invest
    • Boulaftali, Y.1    Hess, P.R.2    Getz, T.M.3
  • 79
    • 0042442163 scopus 로고    scopus 로고
    • The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion
    • Kato K, Kanaji T, Russell S, et al. The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Blood 2003; 102: 1701-1707.
    • (2003) Blood , vol.102 , pp. 1701-1707
    • Kato, K.1    Kanaji, T.2    Russell, S.3
  • 80
    • 33746028224 scopus 로고    scopus 로고
    • GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary throm-boembolism
    • Lockyer S, Okuyama K, Begum S, et al. GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary throm-boembolism. Thromb Res 2006; 118: 371-380.
    • (2006) Thromb Res , vol.118 , pp. 371-380
    • Lockyer, S.1    Okuyama, K.2    Begum, S.3
  • 81
    • 77955517029 scopus 로고    scopus 로고
    • Gastrointestinal lymphatics in health and disease
    • Alexander JS, Ganta VC, Jordan PA, et al. Gastrointestinal lymphatics in health and disease. Pathophysiology 2010; 17: 315-335.
    • (2010) Pathophysiology , vol.17 , pp. 315-335
    • Alexander, J.S.1    Ganta, V.C.2    Jordan, P.A.3
  • 82
    • 84862140232 scopus 로고    scopus 로고
    • Platelet CLEC-2 and podoplanin in cancer metastasis
    • Lowe KL, Navarro-Nuñez L, Watson SP. Platelet CLEC-2 and podoplanin in cancer metastasis. Throm Res 2012; 129 (Suppl 1): S30-S37.
    • (2012) Throm Res , vol.129 , Issue.SUPPL. 1
    • Lowe, K.L.1    Navarro-Nuñez, L.2    Watson, S.P.3
  • 83
    • 77951708287 scopus 로고    scopus 로고
    • Deadly allies: The fatal interplay between platelets and metastasising cancer cells
    • Erpenbeck L, Schon M P. Deadly allies: the fatal interplay between platelets and metastasising cancer cells. Blood 2010; 115: 3427-3436.
    • (2010) Blood , vol.115 , pp. 3427-3436
    • Erpenbeck, L.1    Schon, M.P.2
  • 84
    • 77957284078 scopus 로고    scopus 로고
    • Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin
    • Cueni LN, Hegyi I, Shin J W, et al. Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin. Am J Pathol 2010; 177: 1004-1016.
    • (2010) Am J Pathol , vol.177 , pp. 1004-1016
    • Cueni, L.N.1    Hegyi, I.2    Shin, J.W.3
  • 85
    • 11844289678 scopus 로고    scopus 로고
    • Characterisation of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas
    • Martin-Villar E, Scholl FG, Gamallo C, et al. Characterisation of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas. Int J Cancer 2005; 113: 899-910.
    • (2005) Int J Cancer , vol.113 , pp. 899-910
    • Martin-Villar, E.1    Scholl, F.G.2    Gamallo, C.3
  • 86
    • 14644406264 scopus 로고    scopus 로고
    • Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors
    • Schacht V, Dadras SS, Johnson LA, et al. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol 2005; 166: 913-921.
    • (2005) Am J Pathol , vol.166 , pp. 913-921
    • Schacht, V.1    Dadras, S.S.2    Johnson, L.A.3
  • 87
    • 34247857541 scopus 로고    scopus 로고
    • The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis
    • Kunita A, Kashima TG, Morishita Y, et al. The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis. Am J Pathol 2007; 170: 1337-1347.
    • (2007) Am J Pathol , vol.170 , pp. 1337-1347
    • Kunita, A.1    Kashima, T.G.2    Morishita, Y.3
  • 88
    • 36949020661 scopus 로고    scopus 로고
    • Molecular analysis of the pathophysiologi-cal binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2
    • Kato Y, Kaneko MK, Kunita A, et al. Molecular analysis of the pathophysiologi-cal binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2. Cancer Sci 2008; 99: 54-61.
    • (2008) Cancer Sci , vol.99 , pp. 54-61
    • Kato, Y.1    Kaneko, M.K.2    Kunita, A.3
  • 89
    • 80054968142 scopus 로고    scopus 로고
    • Prevention of hematogenous metastasis by neutralising mice and its chimeric anti-Aggrus/podoplanin antibodies
    • Nakazawa Y, Takagi S, Sato S, et al. Prevention of hematogenous metastasis by neutralising mice and its chimeric anti-Aggrus/podoplanin antibodies. Cancer Sci 2011; 102: 2051-2057.
    • (2011) Cancer Sci , vol.102 , pp. 2051-2057
    • Nakazawa, Y.1    Takagi, S.2    Sato, S.3
  • 90
    • 84863396918 scopus 로고    scopus 로고
    • Podoplanin expression in advanced atherosclerotic lesions of human aortas
    • Hatakeyama K, Kaneko MK, Kato Y, et al. Podoplanin expression in advanced atherosclerotic lesions of human aortas. Thromb Res 2012; 129: e70-e76.
    • (2012) Thromb Res , vol.129
    • Hatakeyama, K.1    Kaneko, M.K.2    Kato, Y.3


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