-
1
-
-
84886808679
-
Chromatin proteins and modifications as drug targets
-
Helin K, & Dhanak D. Chromatin proteins and modifications as drug targets. Nature 502, 480-488 (2013).
-
(2013)
Nature
, vol.502
, pp. 480-488
-
-
Helin, K.1
Dhanak, D.2
-
2
-
-
84902185617
-
Chromatin repressive complexes in stem cells, development, and cancer
-
Laugesen A, & Helin K. Chromatin repressive complexes in stem cells, development, and cancer. Cell Stem Cell 14, 735-751 (2014).
-
(2014)
Cell Stem Cell
, vol.14
, pp. 735-751
-
-
Laugesen, A.1
Helin, K.2
-
3
-
-
84876871047
-
Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put
-
Simon J. A, & Kingston R. E. Occupying chromatin: polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Mol. Cell 49, 808-824 (2013).
-
(2013)
Mol. Cell
, vol.49
, pp. 808-824
-
-
Simon, J.A.1
Kingston, R.E.2
-
4
-
-
84903845704
-
Revolution in the polycomb hierarchy
-
Comet I, & Helin K. Revolution in the polycomb hierarchy. Nat. Struct. Mol. Biol. 21, 573-575 (2014).
-
(2014)
Nat. Struct. Mol. Biolq
, vol.21
, pp. 573-575
-
-
Comet, I.1
Helin, K.2
-
5
-
-
78751662908
-
The polycomb complex PRC2 and its mark in life
-
Margueron R, & Reinberg D. The polycomb complex PRC2 and its mark in life. Nature 469, 343-349 (2011).
-
(2011)
Nature
, vol.469
, pp. 343-349
-
-
Margueron, R.1
Reinberg, D.2
-
6
-
-
34848812584
-
Polycomb group proteins: An evolutionary perspective
-
Whitcomb S. J, Basu A, Allis C. D, & Bernstein E. Polycomb group proteins: an evolutionary perspective. Trends Genet. 23, 494-502 (2007).
-
(2007)
Trends Genet
, vol.23
, pp. 494-502
-
-
Whitcomb, S.J.1
Basu, A.2
Allis, C.D.3
Bernstein, E.4
-
7
-
-
18644382388
-
The polycomb group qnqnqprotein EZH2 is involved in progression of prostate cancer
-
Varambally S, et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419, 624-629 (2002).
-
(2002)
Nature
, vol.419
, pp. 624-629
-
-
Varambally, S.1
-
8
-
-
0141816752
-
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
-
Kleer C. G, et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc. Natl Acad. Sci. USA 100, 11606-11611 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 11606-11611
-
-
Kleer, C.G.1
-
9
-
-
0142105414
-
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
-
Bracken A. P, et al. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J. 22, 5323-5335 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 5323-5335
-
-
Bracken, A.P.1
-
10
-
-
75749124332
-
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B cell lymphomas of germinal-center origin
-
Morin R. D, et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B cell lymphomas of germinal-center origin. Nat. Genet. 42, 181-185 (2010).
-
(2010)
Nat. Genetqnq
, vol.42
, pp. 181-185
-
-
Morin, R.D.1
-
11
-
-
78650454078
-
Coordinated activities of wild-Type plus mutant EZH2 drive tumor-Associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B cell lymphomas
-
Sneeringer C. J, et al. Coordinated activities of wild-Type plus mutant EZH2 drive tumor-Associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B cell lymphomas. Proc. Natl Acad. Sci. USA 107, 20980-20985 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 20980-20985
-
-
Sneeringer, C.J.1
-
12
-
-
80052029516
-
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
-
Morin R. D, et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature 476, 298-303 (2011).
-
(2011)
Nature
, vol.476
, pp. 298-303
-
-
Morin, R.D.1
-
13
-
-
80052269038
-
Analysis of the coding genome of diffuse large B cell lymphoma
-
Pasqualucci L, et al. Analysis of the coding genome of diffuse large B cell lymphoma. Nat. Genet. 43, 830-837 (2011).
-
(2011)
Nat. Genet
, vol.43
, pp. 830-837
-
-
Pasqualucci, L.1
-
14
-
-
79952167230
-
Somatic mutationqs at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
-
Yap D. B, et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood 117, 2451-2459 (2011).
-
(2011)
Blood
, vol.117
, pp. 2451-2459
-
-
Yap, D.B.1
-
15
-
-
80053279825
-
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
-
Wigle T. J, et al. The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states. FEBS Lett. 585, 3011-3014 (2011).
-
(2011)
FEBS Lett
, vol.585
, pp. 3011-3014
-
-
Wigle, T.J.1
-
16
-
-
84863165348
-
Mutation of A677 in histone methyltransferase EZH2 in human B cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27
-
McCabe M. T, et al. Mutation of A677 in histone methyltransferase EZH2 in human B cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc. Natl Acad. Sci. USA 109, 2989-2994 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 2989-2994
-
-
McCabe, M.T.1
-
17
-
-
84866597616
-
A687V EZH2 is a gain of function mutation found in lymphoma patients
-
Majer C. R, et al. A687V EZH2 is a gain of function mutation found in lymphoma patients. FEBS Lett. 586, 3448-3451 (2012).
-
(2012)
FEBS Lett
, vol.586
, pp. 3448-3451
-
-
Majer, C.R.1
-
18
-
-
84857051756
-
Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies
-
Puda A, et al. Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies. Am. J. Hematol. 87, 245-250 (2012).
-
(2012)
Am. J. Hematol
, vol.87
, pp. 245-250
-
-
Puda, A.1
-
19
-
-
84856747744
-
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
-
Ntziachristos P, et al. Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nat. Med. 18, 298-301 (2012).
-
(2012)
Nat. Med
, vol.18
, pp. 298-301
-
-
Ntziachristos, P.1
-
20
-
-
84862907593
-
The genetic basiqs of early T cell precursor acute lymphoblastic leukaemia
-
Zhang J, et al. The genetic basis of early T cell precursor acute lymphoblastic leukaemia. Nature 481, 157-163 (2012).
-
(2012)
Nature
, vol.481
, pp. 157-163
-
-
Zhang, J.1
-
21
-
-
77955085750
-
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
-
Ernst T, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat. Genet. 42, 722-726 (2010).
-
(2010)
Nat. Genet
, vol.42
, pp. 722-726
-
-
Ernst, T.1
-
22
-
-
84878921669
-
Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies
-
Khan S. N, et al. Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies. Leukemia 27, 1301-1309 (2013).
-
(2013)
Leukemia
, vol.27
, pp. 1301-1309
-
-
Khan, S.N.1
-
23
-
-
77955087290
-
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
-
Nikoloski G, et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat. Genet. 42, 665-667 (2010).
-
(2010)
Nat. Genet
, vol.42
, pp. 665-667
-
-
Nikoloski, G.1
-
24
-
-
84856596417
-
Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
-
Score J, et al. Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms. Blood 119, 1208-1213 (2012).
-
(2012)
Blood
, vol.119
, pp. 1208-1213
-
-
Score, J.1
-
25
-
-
84871204903
-
EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms
-
Ueda T, et al. EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms. Leukemia 26, 2557-2560 (2012).
-
(2012)
Leukemia
, vol.26
, pp. 2557-2560
-
-
Ueda, T.1
-
26
-
-
84908321120
-
PRC2 loss amplifieqs Ras-driven transcription and confers sensitivity to BRD4 based therapies
-
De Raedt T, et al. PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4 based therapies. Nature 514, 247-251 (2014).
-
(2014)
Nature
, vol.514
, pp. 247-251
-
-
De Raedt, T.1
-
27
-
-
84908666344
-
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors
-
Lee W, et al. PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. Nat. Genet. 46, 1227-1232 (2014).
-
(2014)
Nat. Genet
, vol.46
, pp. 1227-1232
-
-
Lee, W.1
-
28
-
-
84862777348
-
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
-
Schwartzentruber J, et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 482, 226-231 (2012).
-
(2012)
Nature
, vol.482
, pp. 226-231
-
-
Schwartzentruber, J.1
-
29
-
-
84867606428
-
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
-
Sturm D, et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 22, 425-437 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 425-437
-
-
Sturm, D.1
-
30
-
-
84862777410
-
Somatic histonqnqe H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
-
Wu G, et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat. Genet. 44, 251-253 (2012).
-
(2012)
Nat. Genetqnqn
, vol.44
, pp. 251-253
-
-
Wu, G.1
-
31
-
-
84877324084
-
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
-
Knutson S. K, et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. Proc. Natl Acad. Sci. USA 110, 7922-7927 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 7922-7927
-
-
Knutson, S.K.1
-
32
-
-
84870573126
-
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2 activating mutations
-
McCabe M. T, et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2 activating mutations. Nature 492, 108-112 (2012).
-
(2012)
Nature
, vol.492
, pp. 108-112
-
-
McCabe, M.T.1
-
33
-
-
84871841675
-
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
-
Qi W, et al. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc. Natl Acad. Sci. USA 109, 21360-21365 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 21360-21365
-
-
Qi, W.1
-
34
-
-
84879750981
-
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
-
Konze K. D, et al. An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1. ACS Chem. Biol. 8, 1324-1334 (2013).
-
(2013)
ACS Chem. Biol
, vol.8
, pp. 1324-1334
-
-
Konze, K.D.1
-
35
-
-
84945459499
-
-
US National Library of Medicine
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01897571 (2013).
-
(2013)
ClinicalTrials.gov
-
-
-
36
-
-
84973302297
-
-
ClinicalTrials.gov
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02601937 (2015).
-
(2015)
US National Library of Medicine
-
-
-
37
-
-
84973302297
-
-
ClinicalTrials.gov
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02601950 (2015).
-
(2015)
US National Library of Medicine
-
-
-
38
-
-
84988017945
-
-
US National Library of Medicine
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02082977 (2014).
-
(2014)
ClinicalTrials.gov
-
-
-
39
-
-
84973302297
-
-
ClinicalTrials.gov
-
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02395601 (2015).
-
(2015)
US National Library of Medicine
-
-
-
40
-
-
77957154350
-
Throwing the cancer switch: Reciprocal roles of polycomb and trithorax proteins
-
Mills A. A. Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins. Nat. Rev. Cancer 10, 669-682 (2010).
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 669-682
-
-
Mills, A.A.1
-
41
-
-
84930603937
-
Context-dependent actions of Polycomb repressors in cancer
-
Koppens M, & van Lohuizen M. Context-dependent actions of Polycomb repressors in cancer. Oncogene 35, 1341-1352 (2016).
-
(2016)
Oncogene
, vol.35
, pp. 1341-1352
-
-
Koppens, M.1
Van Lohuizen, M.2
-
42
-
-
84945452552
-
Targeting Polycomb systems to regulate gene expression: Modifications to a complex story
-
Blackledge N. P, Rose N. R, & Klose R. J. Targeting Polycomb systems to regulate gene expression: modifications to a complex story. Nat. Rev. Mol. Cell. Biol. 16, 643-649 (2015).
-
(2015)
Nat. Rev. Mol. Cell. Biol
, vol.16
, pp. 643-649
-
-
Blackledge, N.P.1
Rose, N.R.2
Klose, R.J.3
-
43
-
-
84928535677
-
The controversial role of the Polycomb group proteins in transcription and cancer: How much do we not understand Polycomb proteins?
-
Scelfo A, Piunti A, & Pasini D. The controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins?. FEBS J. 282, 1703-1722 (2015).
-
(2015)
FEBS J.
, vol.282
, pp. 1703-1722
-
-
Scelfo, A.1
Piunti, A.2
Pasini, D.3
-
44
-
-
0018240421
-
A gene complex controlling segmentation in Drosophila
-
Lewis E. B. A gene complex controlling segmentation in Drosophila. Nature 276 565-570 (1978).
-
(1978)
Nature
, vol.276
, pp. 565-570
-
-
Lewis, E.B.1
-
45
-
-
0025149495
-
Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster
-
Jones R. S, & Gelbart W. M. Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster. Genetics 126, 185-199 (1990).
-
(1990)
Genetics
, vol.126
, pp. 185-199
-
-
Jones, R.S.1
Gelbart, W.M.2
-
46
-
-
0026503711
-
Ten different Polycomb group genes are required for spatial control of the AbdA and AbdB homeotic products
-
Simon J, Chiang A, & Bender W. Ten different Polycomb group genes are required for spatial control of the AbdA and AbdB homeotic products. Development 114, 493-505 (1992).
-
(1992)
Development
, vol.114
, pp. 493-505
-
-
Simon, J.1
Chiang, A.2
Bender, W.3
-
47
-
-
0022326910
-
Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila
-
Struhl G, & Akam M. Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila. EMBO J. 4, 3259-3264 (1985).
-
(1985)
EMBO J.
, vol.4
, pp. 3259-3264
-
-
Struhl, G.1
Akam, M.2
-
48
-
-
0023635756
-
The molecular basis for metameric pattern in the Drosophila embryo
-
Akam M. The molecular basis for metameric pattern in the Drosophila embryo. Development 101, 1-22 (1987).
-
(1987)
Development
, vol.101
, pp. 1-22
-
-
Akam, M.1
-
49
-
-
0035148407
-
Recruitment of components of Polycomb group chromatin complexes in Drosophila
-
Poux S, McCabe D, & Pirrotta V. Recruitment of components of Polycomb group chromatin complexes in Drosophila. Development 128, 75-85 (2001).
-
(2001)
Development
, vol.128
, pp. 75-85
-
-
Poux, S.1
McCabe, D.2
Pirrotta, V.3
-
50
-
-
33745604636
-
Suz12 binds to silenced regions of the genome in a cell-Type-specific manner
-
Squazzo S. L, et al. Suz12 binds to silenced regions of the genome in a cell-Type-specific manner. Genome Res. 16, 890-900 (2006).
-
(2006)
Genome Res
, vol.16
, pp. 890-900
-
-
Squazzo, S.L.1
-
51
-
-
51649129596
-
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
-
Mohn F, et al. Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol. Cell 30, 755-766 (2008).
-
(2008)
Mol. Cell
, vol.30
, pp. 755-766
-
-
Mohn, F.1
-
52
-
-
33646870495
-
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
-
Bracken A. P, Dietrich N, Pasini D, Hansen K. H, & Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev. 20, 1123-1136 (2006).
-
(2006)
Genes Dev
, vol.20
, pp. 1123-1136
-
-
Bracken, A.P.1
Dietrich, N.2
Pasini, D.3
Hansen, K.H.4
Helin, K.5
-
53
-
-
33646882068
-
Polycomb complexes repress developmental regulators in murine embryonic stem cells
-
Boyer L. A, et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441, 349-353 (2006).
-
(2006)
Nature
, vol.441
, pp. 349-353
-
-
Boyer, L.A.1
-
54
-
-
33646865180
-
Control of developmental regulators by Polycomb in human embryonic stem cells
-
Lee T. I, et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125, 301-313 (2006).
-
(2006)
Cell
, vol.125
, pp. 301-313
-
-
Lee, T.I.1
-
55
-
-
33646856965
-
Chromosomal distribution of PcG proteins during Drosophila development
-
Nègre N, et al. Chromosomal distribution of PcG proteins during Drosophila development. PLoS Biol. 4, e170 (2006).
-
(2006)
PLoS Biol
, vol.4
, pp. e170
-
-
Nègre, N.1
-
56
-
-
33745225872
-
Genome-wide analysis of Polycomb targets in Drosophila melanogaster
-
Schwartz Y. B, et al. Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Nat. Genet. 38, 700-705 (2006).
-
(2006)
Nat. Genet
, vol.38
, pp. 700-705
-
-
Schwartz, Y.B.1
-
57
-
-
33745258986
-
Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster
-
Tolhuis B, et al. Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster. Nat. Genet. 38, 694-699 (2006).
-
(2006)
Nat. Genet
, vol.38
, pp. 694-699
-
-
Tolhuis, B.1
-
58
-
-
84870899395
-
H3K36me3 key to Polycomb-mediated gene silencing in lineage specification
-
Abed J. A, & Jones R. S. H3K36me3 key to Polycomb-mediated gene silencing in lineage specification. Nat. Struct. Mol. Biol. 19, 1214-1215 (2012).
-
(2012)
Nat Struct. Mol. Biol
, vol.19
, pp. 1214-1215
-
-
Abed, J.A.1
Jones, R.S.2
-
59
-
-
78751590899
-
Silencing chromatin: Comparing modes and mechanisms
-
Beisel C, & Paro R. Silencing chromatin: comparing modes and mechanisms. Nat. Rev. Genet. 12, 123-135 (2011).
-
(2011)
Nat. Rev. Genet
, vol.12
, pp. 123-135
-
-
Beisel, C.1
Paro, R.2
-
60
-
-
84888001513
-
A new world of Polycombs: Unexpected partnerships and emerging functions
-
Schwartz Y. B, & Pirrotta V. A new world of Polycombs: unexpected partnerships and emerging functions. Nat. Rev. Genet. 14, 853-864 (2013).
-
(2013)
Nat Rev. Genet
, vol.14
, pp. 853-864
-
-
Schwartz, Y.B.1
Pirrotta, V.2
-
61
-
-
84879260661
-
A double take on bivalent promoters
-
Voigt P, Tee W. W, & Reinberg D. A double take on bivalent promoters. Genes Dev. 27, 1318-1338 (2013).
-
(2013)
Genes Dev
, vol.27
, pp. 1318-1338
-
-
Voigt, P.1
Tee, W.W.2
Reinberg, D.3
-
62
-
-
84905572005
-
Gene silencing triggers Polycomb repressive complex 2 recruitment to CpG islands genome wide
-
Riising E. M, et al. Gene silencing triggers Polycomb repressive complex 2 recruitment to CpG islands genome wide. Mol. Cell 55, 347-360 (2014).
-
(2014)
Mol. Cell
, vol.55
, pp. 347-360
-
-
Riising, E.M.1
-
63
-
-
84865292901
-
Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation
-
Yuan W, et al. Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science 337, 971-975 (2012).
-
(2012)
Science
, vol.337
, pp. 971-975
-
-
Yuan, W.1
-
64
-
-
84884616025
-
Ras-induced changes in H3K27me3 occur after those in transcriptional activity
-
Hosogane M, Funayama R, Nishida Y, Nagashima T, & Nakayama K. Ras-induced changes in H3K27me3 occur after those in transcriptional activity. PLoS Genet. 9, e1003698 (2013).
-
(2013)
PLoS Genet
, vol.9
, pp. e1003698
-
-
Hosogane, M.1
Funayama, R.2
Nishida, Y.3
Nagashima, T.4
Nakayama, K.5
-
65
-
-
84906302982
-
Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation
-
Jermann P, Hoerner L, Burger L, & Schubeler D. Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation. Proc. Natl Acad. Sci. USA 111, E3415-E3421 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. E3415-E3421
-
-
Jermann, P.1
Hoerner, L.2
Burger, L.3
Schubeler, D.4
-
66
-
-
78650684739
-
GC rich sequence elements recruit PRC2 in mammalian ES cells
-
Mendenhall E. M, et al. GC rich sequence elements recruit PRC2 in mammalian ES cells. PLoS Genet. 6, e1001244 (2010).
-
(2010)
PLoS Genet
, vol.6
, pp. e1001244
-
-
Mendenhall, E.M.1
-
67
-
-
84884626274
-
Chromatin sampling-An emerging perspective on targeting polycomb repressor proteins
-
Klose R. J, Cooper S, Farcas A. M, Blackledge N. P, & Brockdorff N. Chromatin sampling-An emerging perspective on targeting polycomb repressor proteins. PLoS Genet. 9, e1003717 (2013).
-
(2013)
PLoS Genet
, vol.9
, pp. e1003717
-
-
Klose, R.J.1
Cooper, S.2
Farcas, A.M.3
Blackledge, N.P.4
Brockdorff, N.5
-
68
-
-
84876888289
-
Epigenetics: Core misconcept
-
Ptashne M. Epigenetics: core misconcept. Proc. Natl Acad. Sci. USA 110 7101-7103 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 7101-7103
-
-
Ptashne, M.1
-
69
-
-
84891603187
-
EZH2 mutations are frequent and represent an early event in follicular lymphoma
-
Bödör C, et al. EZH2 mutations are frequent and represent an early event in follicular lymphoma. Blood 122, 3165-3168 (2013).
-
(2013)
Blood
, vol.122
, pp. 3165-3168
-
-
Bödör, C.1
-
70
-
-
78651454089
-
EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1- β catenin signaling
-
Chang C. J, et al. EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1- β catenin signaling. Cancer Cell 19, 86-100 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 86-100
-
-
Chang, C.J.1
-
71
-
-
60749126576
-
Deregulated expression of miR 26a and Ezh2 in rhabdomyosarcoma
-
Ciarapica R, et al. Deregulated expression of miR 26a and Ezh2 in rhabdomyosarcoma. Cell Cycle 8, 172-175 (2009).
-
(2009)
Cell Cycle
, vol.8
, pp. 172-175
-
-
Ciarapica, R.1
-
72
-
-
33644765912
-
Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer
-
Collett K, et al. Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Clin. Cancer Res. 12, 1168-1174 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 1168-1174
-
-
Collett, K.1
-
73
-
-
84896894869
-
EZH2 expands breast stem cells through activation of NOTCH1 signaling
-
Gonzalez M. E, et al. EZH2 expands breast stem cells through activation of NOTCH1 signaling. Proc. Natl Acad. Sci. USA 111, 3098-3103 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 3098-3103
-
-
Gonzalez, M.E.1
-
74
-
-
84857942952
-
Discovery and prioritization of somatic mutations in diffuse large B cell lymphoma (DLBCL) by whole-exome sequencing
-
Lohr J. G, et al. Discovery and prioritization of somatic mutations in diffuse large B cell lymphoma (DLBCL) by whole-exome sequencing. Proc. Natl Acad. Sci. USA 109, 3879-3884 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 3879-3884
-
-
Lohr, J.G.1
-
75
-
-
77955541508
-
Regulation of tumor angiogenesis by EZH2
-
Lu C, et al. Regulation of tumor angiogenesis by EZH2. Cancer Cell 18, 185-197 (2010).
-
(2010)
Cancer Cell
, vol.18
, pp. 185-197
-
-
Lu, C.1
-
76
-
-
84895815322
-
Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
-
Okosun J, et al. Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. Nat. Genet. 46, 176-181 (2014).
-
(2014)
Nat. Genet
, vol.46
, pp. 176-181
-
-
Okosun, J.1
-
77
-
-
75749088216
-
BRCA1 deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb repressive complex 2 inhibitor 3 deazaneplanocin A
-
Puppe J, et al. BRCA1 deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb repressive complex 2 inhibitor 3 deazaneplanocin A. Breast Cancer Res. 11, R63 (2009).
-
(2009)
Breast Cancer Res
, vol.11
, pp. R63
-
-
Puppe, J.1
-
78
-
-
83355173202
-
EZH2 codon 641 mutations are common in BCL2 rearranged germinal center B cell lymphomas
-
Ryan R. J. H, et al. EZH2 codon 641 mutations are common in BCL2 rearranged germinal center B cell lymphomas. PLoS ONE 6, e28585 (2011).
-
(2011)
PLoS ONE
, vol.6
, pp. e28585
-
-
Ryan, R.J.H.1
-
79
-
-
79959267832
-
Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker
-
Takawa M, et al. Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker. Cancer Sci. 102, 1298-1305 (2011).
-
(2011)
Cancer Sci
, vol.102
, pp. 1298-1305
-
-
Takawa, M.1
-
80
-
-
58149239686
-
Genomic loss of microRNA 101 leads to overexpression of histone methyltransferase EZH2 in cancer
-
Varambally S, et al. Genomic loss of microRNA 101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 322, 1695-1699 (2008).
-
(2008)
Science
, vol.322
, pp. 1695-1699
-
-
Varambally, S.1
-
81
-
-
77957282672
-
Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma
-
Wagener N, et al. Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma. BMC Cancer 10, 524 (2010).
-
(2010)
BMC Cancer
, vol.10
, pp. 524
-
-
Wagener, N.1
-
82
-
-
77957955244
-
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation
-
Wilson B. G, et al. Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell 18, 316-328 (2010).
-
(2010)
Cancer Cell
, vol.18
, pp. 316-328
-
-
Wilson, B.G.1
-
83
-
-
84880803070
-
EZH2 overexpression in natural killer/.T cell lymphoma confers growth advantage independently of histone methyltransferase activity
-
Yan J, et al. EZH2 overexpression in natural killer/.T cell lymphoma confers growth advantage independently of histone methyltransferase activity. Blood 121, 4512-4520 (2013).
-
(2013)
Blood
, vol.121
, pp. 4512-4520
-
-
Yan, J.1
-
84
-
-
84865152223
-
ASXL1 mutations promote myeloid transformation through loss of PRC2 mediated gene repression
-
Abdel-Wahab O, et al. ASXL1 mutations promote myeloid transformation through loss of PRC2 mediated gene repression. Cancer Cell 22, 180-193 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 180-193
-
-
Abdel-Wahab, O.1
-
85
-
-
84879773777
-
Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition
-
Amatangelo M. D, et al. Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition. Cell Cycle 12, 2113-2119 (2013).
-
(2013)
Cell Cycle
, vol.12
, pp. 2113-2119
-
-
Amatangelo, M.D.1
-
86
-
-
84877815031
-
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
-
Béguelin W, et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell 23, 677-692 (2013).
-
(2013)
Cancer Cell
, vol.23
, pp. 677-692
-
-
Béguelin, W.1
-
87
-
-
84902665681
-
A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis
-
Berg T, et al. A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis. Blood 123 3914-3924 (2014).
-
(2014)
Blood
, vol.123
, pp. 3914-3924
-
-
Berg, T.1
-
88
-
-
57649124289
-
Repression of e cadherin by the polycomb group protein EZH2 in cancer
-
Cao Q, et al. Repression of E cadherin by the polycomb group protein EZH2 in cancer. Oncogene 27, 7274-7284 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 7274-7284
-
-
Cao, Q.1
-
89
-
-
84856746717
-
Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease
-
Herrera-Merchan A, et al. Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease. Nat. Commun. 3, 623 (2012).
-
(2012)
Nat. Commun
, vol.3
, pp. 623
-
-
Herrera-Merchan, A.1
-
90
-
-
77956547097
-
Loss of miR 200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells
-
Iliopoulos D, et al. Loss of miR 200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol. Cell 39, 761-772 (2010).
-
(2010)
Mol. Cell
, vol.39
, pp. 761-772
-
-
Iliopoulos, D.1
-
91
-
-
84884532954
-
Targeted disruption of the EZH2 EED complex inhibits EZH2 dependent cancer
-
Kim W, et al. Targeted disruption of the EZH2 EED complex inhibits EZH2 dependent cancer. Nat. Chem. Biol. 9, 643-650 (2013).
-
(2013)
Nat. Chem. Biol
, vol.9
, pp. 643-650
-
-
Kim, W.1
-
92
-
-
84867632489
-
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
-
Knutson S. K, et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat. Chem. Biol. 8, 890-896 (2012).
-
(2012)
Nat Chem. Biol
, vol.8
, pp. 890-896
-
-
Knutson, S.K.1
-
93
-
-
84921318899
-
Selective inhibition of EZH2 by EPZ 6438 leads to potent antitumor activity in EZH2 mutant non-Hodgkin lymphoma
-
Knutson S. K, et al. Selective inhibition of EZH2 by EPZ 6438 leads to potent antitumor activity in EZH2 mutant non-Hodgkin lymphoma. Mol. Cancer Ther. 13, 842-854 (2014).
-
(2014)
Mol. Cancer Ther
, vol.13
, pp. 842-854
-
-
Knutson, S.K.1
-
94
-
-
84901651797
-
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation
-
Lane A. a et al. Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. Nat. Genet. 46, 618-623 (2014).
-
(2014)
Nat. Genet
, vol.46
, pp. 618-623
-
-
Lane, A.A.1
-
95
-
-
84891524411
-
Polycomb repressive complex 2 (PRC2) suppresses Eμ myc lymphoma
-
Lee S. C. W, et al. Polycomb repressive complex 2 (PRC2) suppresses Eμ myc lymphoma. Blood 122, 2654-2663 (2013).
-
(2013)
Blood
, vol.122
, pp. 2654-2663
-
-
Lee, S.C.W.1
-
96
-
-
0033569427
-
Functional antagonism of the Polycomb-group genes eed and Bmi1 in hemopoietic cell proliferation
-
Lessard J, et al. Functional antagonism of the Polycomb-group genes eed and Bmi1 in hemopoietic cell proliferation. Genes Dev. 13, 2691-2703 (1999).
-
(1999)
Genes Dev
, vol.13
, pp. 2691-2703
-
-
Lessard, J.1
-
97
-
-
77749297990
-
An oncogene-Tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-?B
-
Min J, et al. An oncogene-Tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-?B. Nat. Med. 16, 286-294 (2010).
-
(2010)
Nat. Med
, vol.16
, pp. 286-294
-
-
Min, J.1
-
98
-
-
84859475727
-
Polycomb repressive complex 2 is required for MLL AF9 leukemia
-
Neff T, et al. Polycomb repressive complex 2 is required for MLL AF9 leukemia. Proc. Natl Acad. Sci. USA 109, 5028-5033 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 5028-5033
-
-
Neff, T.1
-
99
-
-
0037050254
-
The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T cell lymphomas
-
Richie E. R, et al. The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T cell lymphomas. Oncogene 21, 299-306 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 299-306
-
-
Richie, E.R.1
-
100
-
-
84903178102
-
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation
-
Sashida G, et al. Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation. Nat. Commun. 5, 4177 (2014).
-
(2014)
Nat. Commun
, vol.5
, pp. 4177
-
-
Sashida, G.1
-
101
-
-
84874106911
-
The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL AF9;Nras(G12D) acute myeloid leukemia
-
Shi J, et al. The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL AF9;Nras(G12D) acute myeloid leukemia. Oncogene 32, 930-938 (2013).
-
(2013)
Oncogene
, vol.32
, pp. 930-938
-
-
Shi, J.1
-
102
-
-
84859295400
-
A key role for EZH2 and associated genes in mouse and human adult T cell acute leukemia
-
Simon C, et al. A key role for EZH2 and associated genes in mouse and human adult T cell acute leukemia. Genes Dev. 26, 651-656 (2012).
-
(2012)
Genes Dev
, vol.26
, pp. 651-656
-
-
Simon, C.1
-
103
-
-
84864567410
-
Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia
-
Tanaka S, et al. Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. Blood 120, 1107-1117 (2012).
-
(2012)
Blood
, vol.120
, pp. 1107-1117
-
-
Tanaka, S.1
-
104
-
-
84878983107
-
Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming
-
Tiwari N, et al. Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming. Cancer Cell 23, 768-783 (2013).
-
(2013)
Cancer Cell
, vol.23
, pp. 768-783
-
-
Tiwari, N.1
-
105
-
-
84949943449
-
Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis
-
Wassef M, et al. Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis. Genes Dev. 29, 2547-2562 (2015).
-
(2015)
Genes Dev
, vol.29
, pp. 2547-2562
-
-
Wassef, M.1
-
106
-
-
84873568880
-
The ASXL-BAP1 axis: New factors in myelopoiesis, cancer and epigenetics
-
Abdel-Wahab O, & Dey A. The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics. Leukemia 27, 10-15 (2013).
-
(2013)
Leukemia
, vol.27
, pp. 10-15
-
-
Abdel-Wahab, O.1
Dey, A.2
-
107
-
-
84965020703
-
An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation
-
Souroullas G. P, et al. An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation. Nat. Med. 22, 632-640 (2016).
-
(2016)
Nat. Med
, vol.22
, pp. 632-640
-
-
Souroullas, G.P.1
-
108
-
-
84949551829
-
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
-
Kim K. H, et al. SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nat. Med. 21, 1491-1496 (2015).
-
(2015)
Nat. Med
, vol.21
, pp. 1491-1496
-
-
Kim, K.H.1
-
109
-
-
84927547043
-
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors
-
Fillmore C. M, et al. EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors. Nature 520, 239-242 (2015).
-
(2015)
Nature
, vol.520
, pp. 239-242
-
-
Fillmore, C.M.1
-
110
-
-
84958787612
-
Polycomb repressive complex 2 is a barrier to KRAS-driven inflammation and epithelial- mesenchymal transition in non-small-cell lung cancer
-
Serresi M, et al. Polycomb repressive complex 2 is a barrier to KRAS-driven inflammation and epithelial- mesenchymal transition in non-small-cell lung cancer. Cancer Cell 29, 17-31 (2016).
-
(2016)
Cancer Cell
, vol.29
, pp. 17-31
-
-
Serresi, M.1
-
111
-
-
78650062951
-
EZH2 mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
-
Velichutina I, et al. EZH2 mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis. Blood 116, 5247-5255 (2010).
-
(2010)
Blood
, vol.116
, pp. 5247-5255
-
-
Velichutina, I.1
-
112
-
-
33846569960
-
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
-
Ohm J. E, et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat. Genet. 39, 237-242 (2007).
-
(2007)
Nat Genet
, vol.39
, pp. 237-242
-
-
Ohm, J.E.1
-
113
-
-
33846649587
-
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
-
Schlesinger Y, et al. Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat. Genet. 39, 232-236 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 232-236
-
-
Schlesinger, Y.1
-
114
-
-
33846576622
-
Epigenetic stem cell signature in cancer
-
Widschwendter M, et al. Epigenetic stem cell signature in cancer. Nat. Genet. 39, 157-158 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 157-158
-
-
Widschwendter, M.1
-
115
-
-
84860577189
-
A DNA hypermethylation module for the stem/progenitor cell signature of cancer
-
Easwaran H, et al. A DNA hypermethylation module for the stem/progenitor cell signature of cancer. Genome Res. 22, 837-849 (2012).
-
(2012)
Genome Res
, vol.22
, pp. 837-849
-
-
Easwaran, H.1
-
116
-
-
84859166725
-
The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer
-
Zhuang J, et al. The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer. PLoS Genet. 8, e1002517 (2012).
-
(2012)
PLoS Genet
, vol.8
, pp. e1002517
-
-
Zhuang, J.1
-
117
-
-
43249130490
-
SWI/SNF mediates Polycomb eviction and epigenetic reprogramming of the INK4b ARF INK4a locus
-
Kia S. K, Gorski M. M, Giannakopoulos S, & Verrijzer C. P. SWI/SNF mediates Polycomb eviction and epigenetic reprogramming of the INK4b ARF INK4a locus. Mol. Cell. Biol. 28, 3457-3464 (2008).
-
(2008)
Mol. Cell. Biol
, vol.28
, pp. 3457-3464
-
-
Kia, S.K.1
Gorski, M.M.2
Giannakopoulos, S.3
Verrijzer, C.P.4
-
118
-
-
33947134834
-
The Polycomb group proteins bind throughout the INK4A ARF locus and are disassociated in senescent cells
-
Bracken A. P, et al. The Polycomb group proteins bind throughout the INK4A ARF locus and are disassociated in senescent cells. Genes Dev. 21, 525-530 (2007).
-
(2007)
Genes Dev
, vol.21
, pp. 525-530
-
-
Bracken, A.P.1
-
119
-
-
84946215806
-
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell-And patient-derived tumor organoids
-
Huang L, et al. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell-And patient-derived tumor organoids. Nat. Med. 21, 1-10 (2015).
-
(2015)
Nat. Med
, vol.21
, pp. 1-10
-
-
Huang, L.1
-
120
-
-
55949132133
-
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
-
Margueron R, et al. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol. Cell 32, 503-518 (2008).
-
(2008)
Mol. Cell
, vol.32
, pp. 503-518
-
-
Margueron, R.1
-
121
-
-
8144230178
-
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
-
Pasini D, Bracken A. P, Jensen M. R, Lazzerini Denchi E, & Helin K. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 23, 4061-4071 (2004).
-
(2004)
EMBO J.
, vol.23
, pp. 4061-4071
-
-
Pasini, D.1
Bracken, A.P.2
Jensen, M.R.3
Lazzerini Denchi, E.4
Helin, K.5
-
122
-
-
20144363347
-
The murine polycomb group protein Eed is required for global histone H3 lysine 27 methylation
-
Montgomery N. D, et al. The murine polycomb group protein Eed is required for global histone H3 lysine 27 methylation. Curr. Biol. 15, 942-947 (2005).
-
(2005)
Curr. Biol
, vol.15
, pp. 942-947
-
-
Montgomery, N.D.1
-
123
-
-
84918547001
-
A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation
-
Ott H. M, et al. A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation. Mol. Cancer Ther. 13, 3062-3073 (2014).
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 3062-3073
-
-
Ott, H.M.1
-
124
-
-
84893203812
-
Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations
-
Wu H, et al. Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. PLoS ONE 8, e83737 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e83737
-
-
Wu, H.1
-
125
-
-
84877785024
-
Inhibition of PRC2 activity by a gain of function H3 mutation found in pediatric glioblastoma
-
Lewis P. W, et al. Inhibition of PRC2 activity by a gain of function H3 mutation found in pediatric glioblastoma. Science 340, 857-861 (2013).
-
(2013)
Science
, vol.340
, pp. 857-861
-
-
Lewis, P.W.1
-
126
-
-
84887617868
-
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
-
Bender S, et al. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell 24, 660-672 (2013).
-
(2013)
Cancer Cell
, vol.24
, pp. 660-672
-
-
Bender, S.1
-
127
-
-
84877299145
-
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
-
Chan K. M, et al. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev. 27, 985-990 (2013).
-
(2013)
Genes Dev
, vol.27
, pp. 985-990
-
-
Chan, K.M.1
|