-
1
-
-
79952430906
-
Inactivating mutations of acetyltransferase genes in b-cell lymphoma
-
Pasqualucci L, Dominguez-Sola D, Chiarenza A, et al. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature. 2011; 471(7337):189-195.
-
(2011)
Nature
, vol.471
, Issue.7337
, pp. 189-195
-
-
Pasqualucci, L.1
Dominguez-Sola, D.2
Chiarenza, A.3
-
2
-
-
80052029516
-
Frequent mutation of histone-modifying genes in non-hodgkin lymphoma
-
Morin RD, Mendez-Lago M, Mungall AJ, et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011;476(7360): 298-303.
-
(2011)
Nature
, vol.476
, Issue.7360
, pp. 298-303
-
-
Morin, R.D.1
Mendez-Lago, M.2
Mungall, A.J.3
-
3
-
-
32844459336
-
The polycomb group protein ezh2 directly controls dna methylation
-
Viré E, Brenner C, Deplus R, et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature. 2006;439(7078):871-874.
-
(2006)
Nature
, vol.439
, Issue.7078
, pp. 871-874
-
-
Viré, E.1
Brenner, C.2
Deplus, R.3
-
4
-
-
79954435405
-
Ezh2 y641 mutations in follicular lymphoma
-
Bödör C, O’Riain C, Wrench D, et al. EZH2 Y641 mutations in follicular lymphoma. Leukemia. 2011; 25(4):726-729.
-
(2011)
Leukemia
, vol.25
, Issue.4
, pp. 726-729
-
-
Bödör, C.1
O’Riain, C.2
Wrench, D.3
-
5
-
-
75749124332
-
Somatic mutations altering ezh2 (tyr641) in follicular and diffuse large b-cell lymphomas of germinal-center origin
-
Morin RD, Johnson NA, Severson TM, et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet. 2010;42(2): 181-185.
-
(2010)
Nat Genet
, vol.42
, Issue.2
, pp. 181-185
-
-
Morin, R.D.1
Johnson, N.A.2
Severson, T.M.3
-
6
-
-
78650454078
-
Coordinated activities of wild-type plus mutant ezh2 drive tumor-associated hypertrimethylation of lysine 27 on histone h3 (h3k27) in human b-cell lymphomas
-
Sneeringer CJ, Scott MP, Kuntz KW, et al. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc Natl Acad Sci USA. 2010; 107(49):20980-20985.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.49
, pp. 20980-20985
-
-
Sneeringer, C.J.1
Scott, M.P.2
Kuntz, K.W.3
-
7
-
-
79952167230
-
Somatic mutations at ezh2 y641 act dominantly through a mechanism of selectively altered prc2 catalytic activity, to increase h3k27 trimethylation
-
Yap DB, Chu J, Berg T, et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood. 2011;117(8):2451-2459.
-
(2011)
Blood
, vol.117
, Issue.8
, pp. 2451-2459
-
-
Yap, D.B.1
Chu, J.2
Berg, T.3
-
8
-
-
83355173202
-
Ezh2 codon 641 mutations are common in bcl2-rearranged germinal center b cell lymphomas
-
Ryan RJ, Nitta M, Borger D, et al. EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas. PLoS ONE. 2011;6(12):e28585.
-
(2011)
Plos ONE
, vol.6
, Issue.12
-
-
Ryan, R.J.1
Nitta, M.2
Borger, D.3
-
9
-
-
84857942952
-
Discovery and prioritization of somatic mutations in diffuse large b-cell lymphoma (dlbcl) by whole-exome sequencing
-
Lohr JG, Stojanov P, Lawrence MS, et al. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci USA. 2012;109(10):3879-3884.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.10
, pp. 3879-3884
-
-
Lohr, J.G.1
Stojanov, P.2
Lawrence, M.S.3
-
10
-
-
84866597616
-
A687v ezh2 is a gain-of-function mutation found in lymphoma patients
-
Majer CR, Jin L, Scott MP, et al. A687V EZH2 is a gain-of-function mutation found in lymphoma patients. FEBS Lett. 2012;586(19):3448-3451.
-
(2012)
FEBS Lett.
, vol.586
, Issue.19
, pp. 3448-3451
-
-
Majer, C.R.1
Jin, L.2
Scott, M.P.3
-
11
-
-
84863165348
-
Mutation of a677 in histone methyltransferase ezh2 in human b-cell lymphoma promotes hypertrimethylation of histone h3 on lysine 27 (h3k27)
-
McCabe MT, Graves AP, Ganji G, et al. Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc Natl Acad Sci USA. 2012;109(8): 2989-2994.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.8
, pp. 2989-2994
-
-
McCabe, M.T.1
Graves, A.P.2
Ganji, G.3
-
12
-
-
84866336515
-
A novel selective ezh2 inhibitor exhibits anti-tumor activity in lymphoma with ezh2 activating mutations
-
March 31-April 4, 2012 Chicago, IL; Philadelphia, PA: AACR
-
Creasy CL. A novel selective EZH2 inhibitor exhibits anti-tumor activity in lymphoma with EZH2 activating mutations. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research, March 31-April 4, 2012 Chicago, IL; Philadelphia, PA: AACR; 2012:492.
-
(2012)
Proceedings of The 103rd Annual Meeting of The American Association for Cancer Research
, pp. 492
-
-
Creasy, C.L.1
-
13
-
-
84870573126
-
Ezh2 inhibition as a therapeutic strategy for lymphoma with ezh2-activating mutations
-
McCabe MT, Ott HM, Ganji G, et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature. 2012; 492(7427):108-112.
-
(2012)
Nature
, vol.492
, Issue.7427
, pp. 108-112
-
-
McCabe, M.T.1
Ott, H.M.2
Ganji, G.3
-
14
-
-
84871841675
-
Selective inhibition of ezh2 by a small molecule inhibitor blocks tumor cells proliferation
-
Qi W, Chan H, Teng L, et al. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci USA. 2012; 109(52):21360-21365.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.52
, pp. 21360-21365
-
-
Qi, W.1
Chan, H.2
Teng, L.3
-
15
-
-
8644252736
-
Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells
-
Dave SS, Wright G, Tan B, et al. Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med. 2004;351(21):2159-2169.
-
(2004)
N Engl J Med.
, vol.351
, Issue.21
, pp. 2159-2169
-
-
Dave, S.S.1
Wright, G.2
Tan, B.3
-
16
-
-
79955810336
-
Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in .80% of patients with tet2 and ezh2 being of high prognostic relevance
-
Grossmann V, Kohlmann A, Eder C, et al. Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in .80% of patients with TET2 and EZH2 being of high prognostic relevance. Leukemia. 2011;25(5): 877-879.
-
(2011)
Leukemia
, vol.25
, Issue.5
, pp. 877-879
-
-
Grossmann, V.1
Kohlmann, A.2
Eder, C.3
-
17
-
-
83555166249
-
The interlaboratory robustness of next-generation sequencing (iron) study: A deep sequencing investigation of tet2, cbl and kras mutations by an international consortium involving 10 laboratories
-
Kohlmann A, Klein HU, Weissmann S, et al. The Interlaboratory RObustness of Next-generation sequencing (IRON) study: a deep sequencing investigation of TET2, CBL and KRAS mutations by an international consortium involving 10 laboratories. Leukemia. 2011;25(12):1840-1848.
-
(2011)
Leukemia
, vol.25
, Issue.12
, pp. 1840-1848
-
-
Kohlmann, A.1
Klein, H.U.2
Weissmann, S.3
-
18
-
-
26644463218
-
Mutation screen and association study of ezh2 as a susceptibility gene for aggressive prostate cancer
-
Bachmann N, Hoegel J, Haeusler J, et al. Mutation screen and association study of EZH2 as a susceptibility gene for aggressive prostate cancer. Prostate. 2005;65(3):252-259.
-
(2005)
Prostate
, vol.65
, Issue.3
, pp. 252-259
-
-
Bachmann, N.1
Hoegel, J.2
Haeusler, J.3
-
20
-
-
85022346413
-
Tnfrsf14 and ezh2 mutations, chr2p gain and copy number changes targeting genes whose proteins interact with the microenvironment
-
ASH meeting abstract
-
Wrench D SA, Tayyib H, Kang MK, et al. TNFRSF14 and EZH2 mutations, Chr2p gain and copy number changes targeting genes whose proteins interact with the microenvironment. In: Transformed follicular lymphoma. ASH meeting abstract. 2010.
-
(2010)
Transformed Follicular Lymphoma
-
-
Wrench, D.S.A.1
Tayyib, H.2
Kang, M.K.3
-
21
-
-
78549281806
-
Acquired tnfrsf14 mutations in follicular lymphoma are associated with worse prognosis
-
Cheung KJ, Johnson NA, Affleck JG, et al. Acquired TNFRSF14 mutations in follicular lymphoma are associated with worse prognosis. Cancer Res. 2010;70(22):9166-9174.
-
(2010)
Cancer Res.
, vol.70
, Issue.22
, pp. 9166-9174
-
-
Cheung, K.J.1
Johnson, N.A.2
Affleck, J.G.3
-
22
-
-
64049088845
-
Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation
-
O’Shea D, O’Riain C, Gupta M, et al. Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation. Blood. 2009;113(10):2298-2301.
-
(2009)
Blood
, vol.113
, Issue.10
, pp. 2298-2301
-
-
O’Shea, D.1
O’Riain, C.2
Gupta, M.3
-
23
-
-
70350103292
-
Array-based dna methylation profiling in follicular lymphoma
-
O’Riain C, O’Shea DM, Yang Y, et al. Array-based DNA methylation profiling in follicular lymphoma. Leukemia. 2009;23(10):1858-1866.
-
(2009)
Leukemia
, vol.23
, Issue.10
, pp. 1858-1866
-
-
O’Riain, C.1
O’Shea, D.M.2
Yang, Y.3
-
24
-
-
84876460347
-
Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma
-
Green MR, Gentles AJ, Nair RV, et al. Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma. Blood. 2013;121(9):1604-1611.
-
(2013)
Blood
, vol.121
, Issue.9
, pp. 1604-1611
-
-
Green, M.R.1
Gentles, A.J.2
Nair, R.V.3
|