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Volumn 14, Issue 12, 2013, Pages 853-864

A new world of Polycombs: Unexpected partnerships and emerging functions

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN; POLYCOMB GROUP PROTEIN; POLYCOMB REPRESSIVE COMPLEX 2; HISTONE;

EID: 84888001513     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg3603     Document Type: Review
Times cited : (235)

References (145)
  • 1
    • 0021880669 scopus 로고
    • A group of genes controlling the spatial expression of the bithorax complex in Drosophila
    • Jürgens, G. A group of genes controlling the spatial expression of the bithorax complex in Drosophila. Nature 316, 153-155 (1985).
    • (1985) Nature , vol.316 , pp. 153-155
    • Jürgens, G.1
  • 2
    • 34548420176 scopus 로고    scopus 로고
    • Genetic screen identifies novel Polycomb group genes in Drosophila
    • Gaytán de Ayala Alonso, A. et al. Genetic screen identifies novel Polycomb group genes in Drosophila. Genetics 176, 2099-2108 (2007).
    • (2007) Genetics , vol.176 , pp. 2099-2108
    • De Ayala Alonso Gaytán, A.1
  • 3
    • 0029790427 scopus 로고    scopus 로고
    • Hunchback-independent silencing of late Ubx enhancers by a Polycomb group response element
    • Poux, S., Kostic, C. & Pirrotta, V. Hunchback-independent silencing of late Ubx enhancers by a Polycomb group response element. EMBO J. 15, 4713-4722 (1996).
    • (1996) EMBO J. , vol.15 , pp. 4713-4722
    • Poux, S.1    Kostic, C.2    Pirrotta, V.3
  • 4
    • 76149142791 scopus 로고    scopus 로고
    • Polycomb complexes act redundantly to repress genomic repeats and genes
    • Leeb, M. et al. Polycomb complexes act redundantly to repress genomic repeats and genes. Genes Dev. 24, 265-276 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 265-276
    • Leeb, M.1
  • 5
    • 38149098408 scopus 로고    scopus 로고
    • Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation
    • Zhou, W. et al. Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Mol. Cell 29, 69-80 (2008).
    • (2008) Mol. Cell , vol.29 , pp. 69-80
    • Zhou, W.1
  • 6
    • 1842473890 scopus 로고    scopus 로고
    • Polycomb silencing blocks transcription initiation
    • Dellino, G. I. et al. Polycomb silencing blocks transcription initiation. Mol. Cell 13, 887-893 (2004).
    • (2004) Mol. Cell , vol.13 , pp. 887-893
    • Dellino, G.I.1
  • 7
    • 80054746191 scopus 로고    scopus 로고
    • Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge
    • Grau, D. J. et al. Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge. Genes Dev. 25, 2210-2221 (2011).
    • (2011) Genes Dev. , vol.25 , pp. 2210-2221
    • Grau, D.J.1
  • 8
    • 77951947926 scopus 로고    scopus 로고
    • Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination
    • Eskeland, R. et al. Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol. Cell 38, 452-464 (2010).
    • (2010) Mol. Cell , vol.38 , pp. 452-464
    • Eskeland, R.1
  • 9
    • 82855181068 scopus 로고    scopus 로고
    • The role of the histone H2A ubiquitinase Sce in Polycomb repression
    • Gutiérrez, L. et al. The role of the histone H2A ubiquitinase Sce in Polycomb repression. Development139, 117-127 (2012).
    • (2012) Development , vol.139 , pp. 117-127
    • Gutiérrez, L.1
  • 10
    • 33745225872 scopus 로고    scopus 로고
    • Genome-wide analysis of Polycomb targets in Drosophila melanogaster
    • Schwartz, Y. B. et al. Genome-wide analysis of Polycomb targets in Drosophila melanogaster. NatureGenet. 38, 700-705 (2006).
    • (2006) NatureGenet. , vol.38 , pp. 700-705
    • Schwartz, Y.B.1
  • 11
    • 54349083294 scopus 로고    scopus 로고
    • DKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing
    • Lagarou, A. et al. dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing. Genes Dev. 22, 2799-2810 (2008).
    • (2008) Genes Dev. , vol.22 , pp. 2799-2810
    • Lagarou, A.1
  • 12
    • 84878988149 scopus 로고    scopus 로고
    • KDM2B links the Polycomb repressive complex 1 (PRC1) to recognition of CpG islands
    • Farcas, A. M. et al. KDM2B links the Polycomb repressive complex 1 (PRC1) to recognition of CpG islands. eLife Sciences 1, e00205 (2012).
    • (2012) ELife Sciences , vol.1
    • Farcas, A.M.1
  • 13
    • 84875799835 scopus 로고    scopus 로고
    • Fbxl10/Kdm2b recruits Polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation
    • Wu, X., Johansen, J. V. & Helin, K. Fbxl10/Kdm2b recruits Polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. Mol. Cell. 49, 1134-1146 (2013).
    • (2013) Mol. Cell. , vol.49 , pp. 1134-1146
    • Wu, X.1    Johansen, J.V.2    Helin, K.3
  • 14
    • 84876497474 scopus 로고    scopus 로고
    • Kdm2b maintains murine embryonic stemcell status by recruiting PRC1 complex to CpG islands of developmental genes
    • He, J. et al. Kdm2b maintains murine embryonic stemcell status by recruiting PRC1 complex to CpG islands of developmental genes. Nature Cell Biol. 15, 373-384 (2013).
    • (2013) Nature Cell Biol. , vol.15 , pp. 373-384
    • He, J.1
  • 15
    • 84863011309 scopus 로고    scopus 로고
    • PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes
    • Gao, Z. et al. PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol. Cell 45, 344-356 (2012).
    • (2012) Mol. Cell , vol.45 , pp. 344-356
    • Gao, Z.1
  • 16
    • 84857367297 scopus 로고    scopus 로고
    • RYBP-PRC1 complexes mediate H2A ubiquitylation at Polycomb target sites independently of PRC2 and H3K27me3
    • Tavares, L. et al. RYBP-PRC1 complexes mediate H2A ubiquitylation at Polycomb target sites independently of PRC2 and H3K27me3. Cell 148, 664-678 (2012).
    • (2012) Cell , vol.148 , pp. 664-678
    • Tavares, L.1
  • 17
    • 41149116609 scopus 로고    scopus 로고
    • Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process
    • Pfau, R. et al. Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. Proc. Natl Acad. Sci. USA 105, 1907-1912 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 1907-1912
    • Pfau, R.1
  • 18
    • 62449276460 scopus 로고    scopus 로고
    • Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus
    • Tzatsos, A., Pfau, R., Kampranis, S. C. & Tsichlis, P. N. Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus. Proc. Natl Acad. Sci. USA 106, 2641-2646 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 2641-2646
    • Tzatsos, A.1    Pfau, R.2    Kampranis, S.C.3    Tsichlis, P.N.4
  • 19
    • 77955479981 scopus 로고    scopus 로고
    • Polycomb group targeting through different binding partners of RING1B C terminal domain
    • Wang, R. et al. Polycomb group targeting through different binding partners of RING1B C?terminal domain. Structure 18, 966-975 (2010).
    • (2010) Structure , vol.18 , pp. 966-975
    • Wang, R.1
  • 20
    • 79953311668 scopus 로고    scopus 로고
    • Interaction proteomics analysis of Polycomb proteins defines distinct PRC1 complexes in mammalian cells
    • M110.002642
    • Vandamme, J., Völkel, P., Rosnoblet, C., Le Faou, P. & Angrand, P.O. Interaction proteomics analysis of Polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol. Cell. Proteomics 10, M110.002642 (2011).
    • (2011) Mol. Cell. Proteomics , vol.10
    • Vandamme, J.1    Völkel, P.2    Rosnoblet, C.3    Le Faou, P.4    Angrand, P.O.5
  • 21
    • 29144487990 scopus 로고    scopus 로고
    • Role of Bmi?1 and Ring1A in H2A ubiquitylation and Hox gene silencing
    • Cao, R., Tsukada, Y.?I. & Zhang, Y. Role of Bmi?1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol. Cell 20, 845-854 (2005).
    • (2005) Mol. Cell , vol.20 , pp. 845-854
    • Cao, R.1    Tsukada, Y.I.2    Zhang, Y.3
  • 22
    • 33747337000 scopus 로고    scopus 로고
    • Role of Bmi1 in H2A ubiquitylation and hox gene silencing
    • Wei, J., Zhai, L., Xu, J. & Wang, H. Role of Bmi1 in H2A ubiquitylation and hox gene silencing. J. Biol. Chem. 281, 22537-22544 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 22537-22544
    • Wei, J.1    Zhai, L.2    Xu, J.3    Wang, H.4
  • 23
    • 46349105014 scopus 로고    scopus 로고
    • Cooperation between EZH2, NSPc1 mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing
    • Wu, X. et al. Cooperation between EZH2, NSPc1?mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing. Nucleic Acids Res. 36, 3590-3599 (2008).
    • (2008) Nucleic Acids Res. , vol.36 , pp. 3590-3599
    • Wu, X.1
  • 24
    • 84855516244 scopus 로고    scopus 로고
    • Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells
    • Morey, L. et al. Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells. Cell Stem Cell. 10, 47-62 (2012).
    • (2012) Cell Stem Cell. , vol.10 , pp. 47-62
    • Morey, L.1
  • 25
    • 84862908896 scopus 로고    scopus 로고
    • MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation
    • O'Loghlen, A. et al. MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation. Cell Stem Cell. 10, 33-46 (2012).
    • (2012) Cell Stem Cell. , vol.10 , pp. 33-46
    • O'loghlen, A.1
  • 26
    • 84876485242 scopus 로고    scopus 로고
    • Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation
    • Klauke, K. et al. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nature Cell Biol. 15, 353-362 (2013).
    • (2013) Nature Cell Biol. , vol.15 , pp. 353-362
    • Klauke, K.1
  • 27
    • 10344258563 scopus 로고    scopus 로고
    • Enhanced self-renewal of hematopoietic stem cells mediated by the Polycomb gene product Bmi?1
    • Iwama, A. et al. Enhanced self-renewal of hematopoietic stem cells mediated by the Polycomb gene product Bmi?1. Immunity. 21, 843-851 (2004).
    • (2004) Immunity. , vol.21 , pp. 843-851
    • Iwama, A.1
  • 28
    • 0028201742 scopus 로고
    • Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi?1 proto-oncogene
    • van der Lugt, N. M. et al. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi?1 proto-oncogene. Genes Dev. 8, 757-769 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 757-769
    • Van Der Lugt, N.M.1
  • 29
    • 79955972412 scopus 로고    scopus 로고
    • L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure
    • Trojer, P. et al. L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol. Cell 42, 438-450 (2011).
    • (2011) Mol. Cell , vol.42 , pp. 438-450
    • Trojer, P.1
  • 30
    • 0037052539 scopus 로고    scopus 로고
    • A complex with chromatin modifiers that occupies E2F-and Myc-responsive genes in G0 cells
    • Ogawa, H., Ishiguro, K., Gaubatz, S., Livingston, D. M. & Nakatani, Y. A complex with chromatin modifiers that occupies E2F-and Myc-responsive genes in G0 cells. Science 296, 1132-1136 (2002).
    • (2002) Science , vol.296 , pp. 1132-1136
    • Ogawa, H.1    Ishiguro, K.2    Gaubatz, S.3    Livingston, D.M.4    Nakatani, Y.5
  • 31
    • 55949124844 scopus 로고    scopus 로고
    • EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency
    • Shen, X. et al. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol. Cell 32, 491-502 (2008).
    • (2008) Mol. Cell , vol.32 , pp. 491-502
    • Shen, X.1
  • 32
    • 0034977239 scopus 로고    scopus 로고
    • The Polycomb-group gene Ezh2 is required for early mouse development
    • O'Carroll, D. et al. The Polycomb-group gene Ezh2 is required for early mouse development. Mol. Cell. Biol. 21, 4330-4336 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4330-4336
    • O'carroll, D.1
  • 33
    • 79952220410 scopus 로고    scopus 로고
    • EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair
    • Ezhkova, E. et al. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes Dev. 25, 485-498 (2011).
    • (2011) Genes Dev. , vol.25 , pp. 485-498
    • Ezhkova, E.1
  • 34
    • 1942502862 scopus 로고    scopus 로고
    • Different Ezh2 containing complexes target methylation of histone H1 or nucleosomal histone H3
    • Kuzmichev, A., Jenuwein, T., Tempst, P. & Reinberg, D. Different Ezh2?containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol. Cell 14, 183-193 (2004).
    • (2004) Mol. Cell , vol.14 , pp. 183-193
    • Kuzmichev, A.1    Jenuwein, T.2    Tempst, P.3    Reinberg, D.4
  • 35
    • 9144268924 scopus 로고    scopus 로고
    • Partitioning and plasticity of repressive histone methylation states in mammalian chromatin
    • Peters, A. H. F. M. et al. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol. Cell12, 1577-1589(2003).
    • (2003) Mol. Cell , vol.12 , pp. 1577-1589
    • Peters, A.H.F.M.1
  • 36
    • 77951855269 scopus 로고    scopus 로고
    • Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12 deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at lys 27 and lys 36
    • Jung, H. R., Pasini, D., Helin, K. & Jensen, O. N. Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12?deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at lys?27 and lys?36. Mol. Cell. Proteomics9, 838-850(2010).
    • (2010) Mol. Cell. Proteomics , vol.9 , pp. 838-850
    • Jung, H.R.1    Pasini, D.2    Helin, K.3    Jensen, O.N.4
  • 37
    • 84867009687 scopus 로고    scopus 로고
    • Asymmetrically modified nucleosomes
    • Voigt, P. et al. Asymmetrically modified nucleosomes. Cell151, 181-193(2012).
    • (2012) Cell , vol.151 , pp. 181-193
    • Voigt, P.1
  • 38
    • 0037404421 scopus 로고    scopus 로고
    • A 1 megadalton ESC/E(Z) complex from Drosophila that contains Polycomblike and RPD3
    • Tie, F., Prasad-Sinha, J., Birve, A., Rasmuson-Lestander, Å. & Harte, P. J. A 1?megadalton ESC/E(Z) complex from Drosophila that contains Polycomblike and RPD3. Mol. Cell. Biol. 23, 3352-3362 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 3352-3362
    • Tie, F.1    Prasad-Sinha, J.2    Birve, A.3    Rasmuson-Lestander, Å.4    Harte, P.J.5
  • 39
    • 34648834735 scopus 로고    scopus 로고
    • Pcl-PRC2 is needed to generate high levels of H3?K27 trimethylation at Polycomb target genes
    • Nekrasov, M. et al. Pcl-PRC2 is needed to generate high levels of H3?K27 trimethylation at Polycomb target genes. EMBO J. 26, 4078-4088 (2007).
    • (2007) EMBO J. , vol.26 , pp. 4078-4088
    • Nekrasov, M.1
  • 40
    • 42149149895 scopus 로고    scopus 로고
    • Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation invivo
    • Sarma, K., Margueron, R., Ivanov, A., Pirrotta, V. & Reinberg, D. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation invivo. Mol. Cell. Biol. 28, 2718-2731 (2008).
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 2718-2731
    • Sarma, K.1    Margueron, R.2    Ivanov, A.3    Pirrotta, V.4    Reinberg, D.5
  • 41
    • 40749126138 scopus 로고    scopus 로고
    • Role of hPHF1 in H3K27 methylation and Hox gene silencing
    • Cao, R. et al. Role of hPHF1 in H3K27 methylation and Hox gene silencing. Mol. Cell. Biol. 28, 1862-1872 (2008).
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 1862-1872
    • Cao, R.1
  • 42
    • 84870833161 scopus 로고    scopus 로고
    • Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity
    • Ballaré, C. et al. Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. NatureStruct. Mol. Biol. 19, 1257-1265 (2012).
    • (2012) NatureStruct. Mol. Biol. , vol.19 , pp. 1257-1265
    • Ballaré, C.1
  • 43
    • 84873417354 scopus 로고    scopus 로고
    • An H3K36 methylation-engaging Tudor motif of Polycomb-like proteins mediates PRC2 complex targeting
    • Cai, L. et al. An H3K36 methylation-engaging Tudor motif of Polycomb-like proteins mediates PRC2 complex targeting. Mol. Cell 49, 571-582 (2013).
    • (2013) Mol. Cell , vol.49 , pp. 571-582
    • Cai, L.1
  • 44
    • 42149149344 scopus 로고    scopus 로고
    • Recruitment of Drosophila Polycomb-group proteins by Polycomblike, a component of a novel protein complex in larvae
    • Savla, U., Benes, J., Zhang, J. & Jones, R. S. Recruitment of Drosophila Polycomb-group proteins by Polycomblike, a component of a novel protein complex in larvae. Development 135, 813-817 (2008).
    • (2008) Development , vol.135 , pp. 813-817
    • Savla, U.1    Benes, J.2    Zhang, J.3    Jones, R.S.4
  • 45
    • 0020378065 scopus 로고
    • Polycomblike: A gene that appears to be required for the normal expression of the Bithorax and Antennapedia gene complexes of Drosophila melanogaster
    • Duncan, I. M. Polycomblike: a gene that appears to be required for the normal expression of the Bithorax and Antennapedia gene complexes of Drosophila melanogaster. Genetics 102, 49-70 (1982).
    • (1982) Genetics , vol.102 , pp. 49-70
    • Duncan, I.M.1
  • 46
    • 33746600716 scopus 로고    scopus 로고
    • Histone trimethylation and the maintenance of transcriptional on and off states by trxG and PcG proteins
    • Papp, B. & Muller, J. Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins. Genes Dev. 20, 2041-2054 (2006).
    • (2006) Genes Dev. , vol.20 , pp. 2041-2054
    • Papp, B.1    Muller, J.2
  • 47
    • 75349104610 scopus 로고    scopus 로고
    • Polycomb-like 2 associates with PRC2 and regulates rranscriptional networks during mouse embryonic stem cell self-renewal and differentiation
    • Walker, E. et al. Polycomb-like 2 associates with PRC2 and regulates rranscriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell 6, 153-166 (2010).
    • (2010) Cell Stem Cell , vol.6 , pp. 153-166
    • Walker, E.1
  • 48
    • 84859258692 scopus 로고    scopus 로고
    • Polycomb-Like 3 promotes Polycomb repressive complex 2 binding to CpG Islands and embryonic stem cell self-renewal
    • Hunkapiller, J. et al. Polycomb-Like 3 promotes Polycomb repressive complex 2 binding to CpG Islands and embryonic stem cell self-renewal. PLoS Genet. 8, e1002576 (2012).
    • (2012) PLoS Genet. , vol.8
    • Hunkapiller, J.1
  • 49
    • 84870855250 scopus 로고    scopus 로고
    • Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1
    • Musselman, C. A. et al. Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nature Struct. Mol. Biol. 19, 1266-1272 (2012).
    • (2012) Nature Struct. Mol. Biol. , vol.19 , pp. 1266-1272
    • Musselman, C.A.1
  • 50
    • 77957298474 scopus 로고    scopus 로고
    • Structure of an atypical Tudor domain in the Drosophila Polycomblike protein
    • Friberg, A., Oddone, A., Klymenko, T., Müller, J. & Sattler, M. Structure of an atypical Tudor domain in the Drosophila Polycomblike protein. Protein Sci. 19, 1906-1916 (2010).
    • (2010) Protein Sci. , vol.19 , pp. 1906-1916
    • Friberg, A.1    Oddone, A.2    Klymenko, T.3    Müller, J.4    Sattler, M.5
  • 51
    • 72249104107 scopus 로고    scopus 로고
    • Jumonji modulates Polycomb activity and self-renewal versus differentiation of stem cells
    • Shen, X. et al. Jumonji modulates Polycomb activity and self-renewal versus differentiation of stem cells. Cell 139, 1303-1314 (2009).
    • (2009) Cell , vol.139 , pp. 1303-1314
    • Shen, X.1
  • 52
    • 72249119297 scopus 로고    scopus 로고
    • Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells
    • Peng, J. C. et al. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell 139, 1290-1302 (2009).
    • (2009) Cell , vol.139 , pp. 1290-1302
    • Peng, J.C.1
  • 53
    • 77949414371 scopus 로고    scopus 로고
    • JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in EScells
    • Pasini, D. et al. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in EScells. Nature 464, 306-310 (2010).
    • (2010) Nature , vol.464 , pp. 306-310
    • Pasini, D.1
  • 54
    • 76749083433 scopus 로고    scopus 로고
    • Jarid2 and PRC2, partners in regulating gene expression
    • Li, G. et al. Jarid2 and PRC2, partners in regulating gene expression. Genes Dev. 24, 368-380 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 368-380
    • Li, G.1
  • 55
    • 77953120646 scopus 로고    scopus 로고
    • Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators
    • Landeira, D. et al. Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nature Cell Biol. 12, 618-624 (2010).
    • (2010) Nature Cell Biol. , vol.12 , pp. 618-624
    • Landeira, D.1
  • 56
    • 84861365971 scopus 로고    scopus 로고
    • Polycomb repressive complex 2 dependent and-independent functions of Jarid2 in transcriptional regulation in Drosophila
    • Herz, H.?M. et al. Polycomb repressive complex 2?dependent and-independent functions of Jarid2 in transcriptional regulation in Drosophila. Mol. Cell. Biol. 32, 1683-1693 (2012).
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 1683-1693
    • Herz, H.M.1
  • 57
    • 0029004775 scopus 로고
    • Gene trap capture of a novel mouse gene, Jumonji, required for neural tube formation
    • Takeuchi, T. et al. Gene trap capture of a novel mouse gene, Jumonji, required for neural tube formation. Genes Dev. 9, 1211-1222 (1995).
    • (1995) Genes Dev. , vol.9 , pp. 1211-1222
    • Takeuchi, T.1
  • 58
    • 0034640295 scopus 로고    scopus 로고
    • Jumonji, a nuclear protein that is necessary for normal heart development
    • Lee, Y. et al. Jumonji, a nuclear protein that is necessary for normal heart development. Circ. Res. 86, 932-938 (2000).
    • (2000) Circ. Res. , vol.86 , pp. 932-938
    • Lee, Y.1
  • 59
    • 84855323192 scopus 로고    scopus 로고
    • PRC2 directly methylates GATA4 and represses its transcriptional activity
    • He, A. et al. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev. 26, 37-42 (2012).
    • (2012) Genes Dev. , vol.26 , pp. 37-42
    • He, A.1
  • 60
    • 21044451441 scopus 로고    scopus 로고
    • Polycomb group protein Ezh2 controls actin polymerization and cell signaling
    • Su, I.?h. et al. Polycomb group protein Ezh2 controls actin polymerization and cell signaling. Cell 121, 425-436 (2005).
    • (2005) Cell , vol.121 , pp. 425-436
    • Su, I.H.1
  • 61
    • 6944253702 scopus 로고    scopus 로고
    • SIR2 is required for Polycomb silencing and is associated with an E(z) histone methyltransferase complex
    • Furuyama, T., Banerjee, R., Breen, T. R. & Harte, P. J. SIR2 is required for Polycomb silencing and is associated with an E(z) histone methyltransferase complex. Curr. Biol. 14, 1812-1821 (2004).
    • (2004) Curr. Biol. , vol.14 , pp. 1812-1821
    • Furuyama, T.1    Banerjee, R.2    Breen, T.R.3    Harte, P.J.4
  • 62
    • 13844315463 scopus 로고    scopus 로고
    • Composition and histone substrates of Polycomb repressive group complexes change during cellular differentiation
    • Kuzmichev, A. et al. Composition and histone substrates of Polycomb repressive group complexes change during cellular differentiation. Proc. Natl Acad. Sci. USA 102, 1859-1864 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1859-1864
    • Kuzmichev, A.1
  • 63
    • 0028321783 scopus 로고
    • Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression
    • Chan, C.?S., Rastelli, L. & Pirrotta, V. A. Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression. EMBO J. 13, 2553-2564 (1994).
    • (1994) EMBO J. , vol.13 , pp. 2553-2564
    • Chan, C.S.1    Rastelli, L.2    Pirrotta, V.A.3
  • 64
    • 33748419671 scopus 로고    scopus 로고
    • Polycomb response elements and targeting of Polycomb group proteins in Drosophila
    • Müller, J. & Kassis, J. A. Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Curr. Opin. Genet. Dev. 16, 476-484 (2006).
    • (2006) Curr. Opin. Genet. Dev. , vol.16 , pp. 476-484
    • Müller, J.1    Kassis, J.A.2
  • 65
    • 0033996526 scopus 로고    scopus 로고
    • Structure of a Polycomb response element and invitro binding of Polycomb group complexes containing GAGA factor
    • Horard, B., Tatout, C., Poux, S. & Pirrotta, V. Structure of a Polycomb response element and invitro binding of Polycomb group complexes containing GAGA factor. Mol. Cell. Biol. 20, 3187-3197 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3187-3197
    • Horard, B.1    Tatout, C.2    Poux, S.3    Pirrotta, V.4
  • 66
    • 33749060536 scopus 로고    scopus 로고
    • Polycomb complexes and the propagation of the methylation mark at the Drosophila Ubx gene
    • Kahn, T. G., Schwartz, Y. B., Dellino, G. I. & Pirrotta, V. Polycomb complexes and the propagation of the methylation mark at the Drosophila Ubx gene. J. Biol. Chem. 281, 29064-29075 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 29064-29075
    • Kahn, T.G.1    Schwartz, Y.B.2    Dellino, G.I.3    Pirrotta, V.4
  • 67
    • 79953060951 scopus 로고    scopus 로고
    • Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
    • Kharchenko, P. V. et al. Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. Nature 471, 480-485 (2011).
    • (2011) Nature , vol.471 , pp. 480-485
    • Kharchenko, P.V.1
  • 68
    • 0034953140 scopus 로고    scopus 로고
    • Site-specific recognition of a 70 base-pair element containing d(GA)(n) repeats mediates bithoraxoid Polycomb group response element-dependent silencing
    • Hodgson, J. W., Argiropoulos, B. & Brock, H. W. Site-specific recognition of a 70?base-pair element containing d(GA)(n) repeats mediates bithoraxoid Polycomb group response element-dependent silencing. Mol. Cell. Biol. 21, 4528-4543 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4528-4543
    • Hodgson, J.W.1    Argiropoulos, B.2    Brock, H.W.3
  • 69
    • 15844430105 scopus 로고    scopus 로고
    • Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1
    • Dejardin, J. et al. Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1. Nature 434, 533-538 (2005).
    • (2005) Nature , vol.434 , pp. 533-538
    • Dejardin, J.1
  • 70
    • 42349103792 scopus 로고    scopus 로고
    • Changes in the distributions and dynamics of Polycomb repressive complexes during embryonic stem cell differentiation
    • Ren, X., Vincenz, C. & Kerppola, T. K. Changes in the distributions and dynamics of Polycomb repressive complexes during embryonic stem cell differentiation. Mol. Cell. Biol. 28, 2884-2895 (2008).
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 2884-2895
    • Ren, X.1    Vincenz, C.2    Kerppola, T.K.3
  • 71
    • 69449086947 scopus 로고    scopus 로고
    • A vertebrate Polycomb response element governs segmentation of the posterior hindbrain
    • Sing, A. et al. A vertebrate Polycomb response element governs segmentation of the posterior hindbrain. Cell 138, 885-897 (2009).
    • (2009) Cell , vol.138 , pp. 885-897
    • Sing, A.1
  • 72
    • 73149111929 scopus 로고    scopus 로고
    • A region of the human HOXD cluster that confers Polycomb-group responsiveness
    • Woo, C. J., Kharchenko, P. V., Daheron, L., Park, P. J. & Kingston, R. E. A region of the human HOXD cluster that confers Polycomb-group responsiveness. Cell140, 99-110 (2010).
    • (2010) Cell , vol.140 , pp. 99-110
    • Woo, C.J.1    Kharchenko, P.V.2    Daheron, L.3    Park, P.J.4    Kingston, R.E.5
  • 73
    • 55449105221 scopus 로고    scopus 로고
    • Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
    • Ku, M. et al. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genetics 4, e1000242 (2008).
    • (2008) PLoS Genetics , vol.4
    • Ku, M.1
  • 74
    • 78650684739 scopus 로고    scopus 로고
    • GCrich sequence elements recruit PRC2 in mammalian ES cells
    • Mendenhall, E. M. et al. GC?rich sequence elements recruit PRC2 in mammalian ES cells. PLoS Genet. 6, e1001244 (2010).
    • (2010) PLoS Genet. , vol.6
    • Mendenhall, E.M.1
  • 75
    • 84857190178 scopus 로고    scopus 로고
    • An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment
    • Lynch, M. D. et al. An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment. EMBO J. 31, 317-329 (2012).
    • (2012) EMBO J. , vol.31 , pp. 317-329
    • Lynch, M.D.1
  • 76
    • 77951116072 scopus 로고    scopus 로고
    • CpG islands influence chromatin structure via the CpG-binding protein Cfp1
    • Thomson, J. P. et al. CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature 464, 1082-1086 (2010).
    • (2010) Nature , vol.464 , pp. 1082-1086
    • Thomson, J.P.1
  • 77
    • 77950882645 scopus 로고    scopus 로고
    • CpG islands recruit a histone H3 lysine 36 demethylase
    • Blackledge, N. P. et al. CpG islands recruit a histone H3 lysine 36 demethylase. Mol. Cell 38, 179-190 (2010).
    • (2010) Mol. Cell , vol.38 , pp. 179-190
    • Blackledge, N.P.1
  • 78
    • 84859260959 scopus 로고    scopus 로고
    • REST-mediated recruitment of Polycomb repressor complexes in mammalian cells
    • Dietrich, N. et al. REST-mediated recruitment of Polycomb repressor complexes in mammalian cells. PLoS Genet. 8, e1002494 (2012).
    • (2012) PLoS Genet. , vol.8
    • Dietrich, N.1
  • 79
    • 84871984418 scopus 로고    scopus 로고
    • Modeling of epigenome dynamics identifies transcription factors that mediate Polycomb targeting
    • Arnold, P. et al. Modeling of epigenome dynamics identifies transcription factors that mediate Polycomb targeting. Genome Res. 23, 60-73 (2013).
    • (2013) Genome Res. , vol.23 , pp. 60-73
    • Arnold, P.1
  • 80
    • 34250729138 scopus 로고    scopus 로고
    • Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
    • Rinn, J. L. et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129, 1311-1323 (2007).
    • (2007) Cell , vol.129 , pp. 1311-1323
    • Rinn, J.L.1
  • 81
    • 77954572735 scopus 로고    scopus 로고
    • Long noncoding RNA as modular scaffold of histone modification complexes
    • Tsai, M.?C. et al. Long noncoding RNA as modular scaffold of histone modification complexes. Science 329, 689-693 (2010).
    • (2010) Science , vol.329 , pp. 689-693
    • Tsai, M.C.1
  • 82
    • 77951118936 scopus 로고    scopus 로고
    • Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
    • Gupta, R. A. et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464, 1071-1076 (2010).
    • (2010) Nature , vol.464 , pp. 1071-1076
    • Gupta, R.A.1
  • 83
    • 79957983437 scopus 로고    scopus 로고
    • Structural and functional differences in the long non-coding RNA Hotair in mouse and human
    • Schorderet, P. & Duboule, D. Structural and functional differences in the long non-coding RNA Hotair in mouse and human. PLoS Genet. 7, e1002071 (2011).
    • (2011) PLoS Genet. , vol.7
    • Schorderet, P.1    Duboule, D.2
  • 84
    • 55349109963 scopus 로고    scopus 로고
    • Polycomb proteins targeted by a short repeat RNA to the mouse Xchromosome
    • Zhao, J., Sun, B. K., Erwin, J. A., Song, J.?J. & Lee, J. T. Polycomb proteins targeted by a short repeat RNA to the mouse Xchromosome. Science 322, 750-756 (2008).
    • (2008) Science , vol.322 , pp. 750-756
    • Zhao, J.1    Sun, B.K.2    Erwin, J.A.3    Song, J.J.4    Lee, J.T.5
  • 85
    • 77953096072 scopus 로고    scopus 로고
    • Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by Polycomb CBX7 in transcriptional silencing of INK4a
    • Yap, K. L. et al. Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by Polycomb CBX7 in transcriptional silencing of INK4a. Mol. Cell 38, 662-667 (2010).
    • (2010) Mol. Cell , vol.38 , pp. 662-667
    • Yap, K.L.1
  • 86
    • 84871069553 scopus 로고    scopus 로고
    • Epigenetic regulation by long noncoding RNAs
    • Lee, J. T. Epigenetic regulation by long noncoding RNAs. Science 338, 1435-1439 (2012).
    • (2012) Science , vol.338 , pp. 1435-1439
    • Lee, J.T.1
  • 87
    • 67650921949 scopus 로고    scopus 로고
    • Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
    • Khalil, A. M. et al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc. Natl Acad. Sci. USA 106, 11667-11672 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 11667-11672
    • Khalil, A.M.1
  • 88
    • 78650253763 scopus 로고    scopus 로고
    • Genome-wide identification of Polycomb-associated RNAs by RIP-seq
    • Zhao, J. et al. Genome-wide identification of Polycomb-associated RNAs by RIP-seq. Mol. Cell 40, 939-953 (2010).
    • (2010) Mol. Cell , vol.40 , pp. 939-953
    • Zhao, J.1
  • 89
    • 77953107585 scopus 로고    scopus 로고
    • Short RNAs are transcribed from repressed Polycomb target genes and Interact with Polycomb repressive complex?2
    • Kanhere, A. et al. Short RNAs are transcribed from repressed Polycomb target genes and Interact with Polycomb repressive complex?2. Mol. Cell 38, 675-688 (2010).
    • (2010) Mol. Cell , vol.38 , pp. 675-688
    • Kanhere, A.1
  • 90
    • 10044244766 scopus 로고    scopus 로고
    • Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila
    • Ebert, A. et al. Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Genes Dev. 18, 2973-2983 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 2973-2983
    • Ebert, A.1
  • 91
    • 23344450547 scopus 로고    scopus 로고
    • Subunit contributions to histone methyltransferase activities of fly and worm Polycomb group complexes
    • Ketel, C. S. et al. Subunit contributions to histone methyltransferase activities of fly and worm Polycomb group complexes. Mol. Cell. Biol. 25, 6857-6868 (2005).
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 6857-6868
    • Ketel, C.S.1
  • 92
    • 79955494277 scopus 로고    scopus 로고
    • Histone methylation by PRC2 is inhibited by active chromatin marks
    • Schmitges, F. W. et al. Histone methylation by PRC2 is inhibited by active chromatin marks. Mol. Cell 42, 330-341 (2011).
    • (2011) Mol. Cell , vol.42 , pp. 330-341
    • Schmitges, F.W.1
  • 93
    • 79953143753 scopus 로고    scopus 로고
    • H3K36 methylation antagonizes PRC2 mediated H3K27 methylation
    • Yuan, W. et al. H3K36 methylation antagonizes PRC2?mediated H3K27 methylation. J. Biol. Chem. 286, 7983-7989 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 7983-7989
    • Yuan, W.1
  • 94
    • 84865292901 scopus 로고    scopus 로고
    • Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation
    • Yuan, W. et al. Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science 337, 971-975 (2012).
    • (2012) Science , vol.337 , pp. 971-975
    • Yuan, W.1
  • 95
    • 70349952171 scopus 로고    scopus 로고
    • Role of the Polycomb protein EED in the propagation of repressive histone marks
    • Margueron, R. et al. Role of the Polycomb protein EED in the propagation of repressive histone marks. Nature 461, 762-767 (2009).
    • (2009) Nature , vol.461 , pp. 762-767
    • Margueron, R.1
  • 96
    • 0037418829 scopus 로고    scopus 로고
    • ThePolycomb protein Pc2 is a SUMO E3
    • Kagey, M. H., Melhuish, T. A. & Wotton, D. ThePolycomb protein Pc2 is a SUMO E3. Cell 113, 127-137 (2003).
    • (2003) Cell , vol.113 , pp. 127-137
    • Kagey, M.H.1    Melhuish, T.A.2    Wotton, D.3
  • 97
    • 13244271351 scopus 로고    scopus 로고
    • Multiple activities contribute to Pc2 E3 function
    • Kagey, M. H., Melhuish, T. A., Powers, S. E. & Wotton, D. Multiple activities contribute to Pc2 E3 function. EMBO J. 24, 108-119 (2005).
    • (2005) EMBO J. , vol.24 , pp. 108-119
    • Kagey, M.H.1    Melhuish, T.A.2    Powers, S.E.3    Wotton, D.4
  • 98
    • 2442439113 scopus 로고    scopus 로고
    • SUMO modification is required for invivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP?2
    • Zhang, H. et al. SUMO modification is required for invivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP?2. NatureGenet. 36, 507-511 (2004).
    • (2004) NatureGenet. , vol.36 , pp. 507-511
    • Zhang, H.1
  • 99
    • 77950907937 scopus 로고    scopus 로고
    • SUMO-specific protease 2 is essential for suppression of Polycomb group protein-mediated gene silencing during embryonic development
    • Kang, X. et al. SUMO-specific protease 2 is essential for suppression of Polycomb group protein-mediated gene silencing during embryonic development. Mol. Cell 38, 191-201 (2010).
    • (2010) Mol. Cell , vol.38 , pp. 191-201
    • Kang, X.1
  • 100
    • 84863198650 scopus 로고    scopus 로고
    • CBX4 mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage
    • Ismail, I. H. et al. CBX4?mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage. Nucleic Acids Res. 40, 5497-5510 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. 5497-5510
    • Ismail, I.H.1
  • 101
    • 14044263532 scopus 로고    scopus 로고
    • MAPKAP Kinase 3pK phosphorylates and regulates chromatin association of the Polycomb group protein Bmi1
    • Voncken, J. W. et al. MAPKAP Kinase 3pK phosphorylates and regulates chromatin association of the Polycomb group protein Bmi1. J. Biol. Chem. 280, 5178-5187 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 5178-5187
    • Voncken, J.W.1
  • 102
    • 35148894474 scopus 로고    scopus 로고
    • A phosphorylated form of Mel?18 targets the Ring1B histone H2A ubiquitin ligase to chromatin
    • Elderkin, S. et al. A phosphorylated form of Mel?18 targets the Ring1B histone H2A ubiquitin ligase to chromatin. Mol. Cell 28, 107-120 (2007).
    • (2007) Mol. Cell , vol.28 , pp. 107-120
    • Elderkin, S.1
  • 103
    • 0029841672 scopus 로고    scopus 로고
    • Positional cloning of a global regulator of anterior-posterior patterning in mice
    • Schumacher, A., Faust, C. & Magnuson, T. Positional cloning of a global regulator of anterior-posterior patterning in mice. Nature 383, 250-253 (1996).
    • (1996) Nature , vol.383 , pp. 250-253
    • Schumacher, A.1    Faust, C.2    Magnuson, T.3
  • 104
    • 0345269795 scopus 로고    scopus 로고
    • Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition
    • Voncken, J. W. et al. Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc. Natl Acad. Sci. USA 100, 2468-2473 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 2468-2473
    • Voncken, J.W.1
  • 105
    • 0025863346 scopus 로고
    • Identification of cooperating oncogenes in E?-myc transgenic mice by provirus tagging
    • van Lohuizen, M. et al. Identification of cooperating oncogenes in E?-myc transgenic mice by provirus tagging. Cell. 65, 737-752 (1991).
    • (1991) Cell. , vol.65 , pp. 737-752
    • Van Lohuizen, M.1
  • 106
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • Sparmann, A. & van Lohuizen, M. Polycomb silencers control cell fate, development and cancer. Nature Rev. Cancer 6, 846-856 (2006).
    • (2006) Nature Rev. Cancer , vol.6 , pp. 846-856
    • Sparmann, A.1    Van Lohuizen, M.2
  • 107
    • 84875217558 scopus 로고    scopus 로고
    • Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms
    • Radulovic, V., de Haan, G. & Klauke, K. Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms. Leukemia 27, 523-533 (2013).
    • (2013) Leukemia , vol.27 , pp. 523-533
    • Radulovic, V.1    De Haan, G.2    Klauke, K.3
  • 108
    • 1642633053 scopus 로고    scopus 로고
    • Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas
    • Leung, C. et al. Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature 428, 337-341 (2004).
    • (2004) Nature , vol.428 , pp. 337-341
    • Leung, C.1
  • 109
    • 0035906853 scopus 로고    scopus 로고
    • The bmi?1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression
    • Vonlanthen, S. et al. The bmi?1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression. Br. J. Cancer 84, 1372-1376 (2001).
    • (2001) Br. J. Cancer , vol.84 , pp. 1372-1376
    • Vonlanthen, S.1
  • 110
    • 35148840173 scopus 로고    scopus 로고
    • Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma
    • Bruggeman, S. W. et al. Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma. Cancer Cell 12, 328-341 (2007).
    • (2007) Cancer Cell , vol.12 , pp. 328-341
    • Bruggeman, S.W.1
  • 111
    • 84877836210 scopus 로고    scopus 로고
    • Invivo RNAi screen for bmi1 targets identifies TGF/BMP-ER stress pathways as key regulators of neural-and malignant glioma-stem cell homeostasis
    • Gargiulo, G. et al. Invivo RNAi screen for bmi1 targets identifies TGF/BMP-ER stress pathways as key regulators of neural-and malignant glioma-stem cell homeostasis. Cancer Cell 23, 660-676 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 660-676
    • Gargiulo, G.1
  • 112
    • 55949136562 scopus 로고    scopus 로고
    • Roles of the Ezh2 histone methyltransferase in cancer epigenetics
    • Simon, J. A. & Lange, C. A. Roles of the Ezh2 histone methyltransferase in cancer epigenetics. Mut. Res. 647, 21-29 (2008).
    • (2008) Mut. Res. , vol.647 , pp. 21-29
    • Simon, J.A.1    Lange, C.A.2
  • 113
    • 78650454078 scopus 로고    scopus 로고
    • Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B cell lymphomas
    • Sneeringer, C. J. et al. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B?cell lymphomas. Proc. Natl Acad. Sci. USA 107, 20980-20985 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 20980-20985
    • Sneeringer, C.J.1
  • 114
    • 84863165348 scopus 로고    scopus 로고
    • Mutation of A677 in histone methyltransferase EZH2 in human B cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
    • McCabe, M. T. et al. Mutation of A677 in histone methyltransferase EZH2 in human B?cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc. Natl Acad. Sci. USA 109, 2989-2994 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 2989-2994
    • McCabe, M.T.1
  • 115
    • 84870573126 scopus 로고    scopus 로고
    • EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2 activating mutations
    • McCabe, M. T. et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2?activating mutations. Nature 492, 108-112 (2012).
    • (2012) Nature , vol.492 , pp. 108-112
    • McCabe, M.T.1
  • 116
    • 84867632489 scopus 로고    scopus 로고
    • A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
    • Knutson, S. K. et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nature Chem. Biol. 8, 890-896 (2012).
    • (2012) Nature Chem. Biol. , vol.8 , pp. 890-896
    • Knutson, S.K.1
  • 117
    • 84859295400 scopus 로고    scopus 로고
    • A key role for EZH2 and associated genes in mouse and human adult T cell acute leukemia
    • Simon, C. et al. A key role for EZH2 and associated genes in mouse and human adult T?cell acute leukemia. Genes Dev. 26, 651-656 (2012).
    • (2012) Genes Dev. , vol.26 , pp. 651-656
    • Simon, C.1
  • 118
    • 84877299145 scopus 로고    scopus 로고
    • The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
    • Chan, K. M. et al. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev. 27, 985-990 (2013).
    • (2013) Genes Dev. , vol.27 , pp. 985-990
    • Chan, K.M.1
  • 119
    • 84877785024 scopus 로고    scopus 로고
    • Inhibition of PRC2 activity by a gain of function H3 mutation found in pediatric glioblastoma
    • Lewis, P. W. et al. Inhibition of PRC2 activity by a gain?of?function H3 mutation found in pediatric glioblastoma. Science 340, 857-861 (2013).
    • (2013) Science , vol.340 , pp. 857-861
    • Lewis, P.W.1
  • 120
    • 84871052080 scopus 로고    scopus 로고
    • EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent
    • Xu, K. et al. EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science 338, 1465-1469 (2012).
    • (2012) Science , vol.338 , pp. 1465-1469
    • Xu, K.1
  • 121
    • 84870308969 scopus 로고    scopus 로고
    • EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex
    • Lee, J. M. et al. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3?ubiquitin ligase complex. Mol. Cell 48, 572-586 (2012).
    • (2012) Mol. Cell , vol.48 , pp. 572-586
    • Lee, J.M.1
  • 122
    • 0033538578 scopus 로고    scopus 로고
    • Stabilization of chromatin structure by PRC1, a Polycomb complex
    • Shao, Z. et al. Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell 98, 37-46 (1999).
    • (1999) Cell , vol.98 , pp. 37-46
    • Shao, Z.1
  • 123
    • 0034785891 scopus 로고    scopus 로고
    • Reconstitution of a functional core Polycomb repressive complex
    • Francis, N. J., Saurin, A. J., Shao, Z. & Kingston, R. E. Reconstitution of a functional core Polycomb repressive complex. Mol. Cell 8, 545-556 (2001).
    • (2001) Mol. Cell , vol.8 , pp. 545-556
    • Francis, N.J.1    Saurin, A.J.2    Shao, Z.3    Kingston, R.E.4
  • 124
    • 0035833718 scopus 로고    scopus 로고
    • Drosophila Polycomb group complex includes Zeste and dTAFII proteins
    • Saurin, A. J., Shao, Z., Erdjument-Bromage, H., Tempst, P. & Kingston, R. E. A. Drosophila Polycomb group complex includes Zeste and dTAFII proteins. Nature 412, 655-660 (2001).
    • (2001) Nature , vol.412 , pp. 655-660
    • Saurin, A.J.1    Shao, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Kingston, R.E.A.5
  • 125
    • 33745753378 scopus 로고    scopus 로고
    • Structure and E3 ligase activity of the Ring-Ring complex of Polycomb proteins Bmi1 and Ring1b
    • Buchwald, G. et al. Structure and E3?ligase activity of the Ring-Ring complex of Polycomb proteins Bmi1 and Ring1b. EMBO J. 25, 2465-2474 (2006).
    • (2006) EMBO J. , vol.25 , pp. 2465-2474
    • Buchwald, G.1
  • 126
    • 7744228427 scopus 로고    scopus 로고
    • Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation
    • de Napoles, M. et al. Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev. Cell 7, 663-676 (2004).
    • (2004) Dev. Cell , vol.7 , pp. 663-676
    • De Napoles, M.1
  • 127
    • 7244234099 scopus 로고    scopus 로고
    • Role of histone H2A ubiquitination in Polycomb silencing
    • Wang, H. et al. Role of histone H2A ubiquitination in Polycomb silencing. Nature 431, 873-878 (2004).
    • (2004) Nature , vol.431 , pp. 873-878
    • Wang, H.1
  • 128
    • 0029896251 scopus 로고    scopus 로고
    • The Drosophila Polycomb group gene Sex comb on midleg (Scm) encodes a zinc finger protein with similarity to polyhomeotic protein
    • Bornemann, D., Miller, E. & Simon, J. The Drosophila Polycomb group gene Sex comb on midleg (Scm) encodes a zinc finger protein with similarity to polyhomeotic protein. Development 122, 1621-1630 (1996).
    • (1996) Development , vol.122 , pp. 1621-1630
    • Bornemann, D.1    Miller, E.2    Simon, J.3
  • 129
    • 0030832045 scopus 로고    scopus 로고
    • A domain shared by the Polycomb group proteins Scm and Ph mediates heterotypic and homotypic interactions
    • Peterson, A. J. et al. A domain shared by the Polycomb group proteins Scm and Ph mediates heterotypic and homotypic interactions. Mol. Cell. Biol. 17, 6683-6692 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6683-6692
    • Peterson, A.J.1
  • 130
    • 0036830642 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in Polycomb-group silencing
    • Cao, R. et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298, 1039-1043 (2002).
    • (2002) Science , vol.298 , pp. 1039-1043
    • Cao, R.1
  • 131
    • 0037131523 scopus 로고    scopus 로고
    • Drosophila Enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites
    • Czermin, B. et al. Drosophila Enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell111, 185-196 (2002).
    • (2002) Cell , vol.111 , pp. 185-196
    • Czermin, B.1
  • 132
    • 18644383738 scopus 로고    scopus 로고
    • Histone methyltransferase activity of a Drosophila Polycomb group repressor complex
    • Müller, J. et al. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell111, 197-208 (2002).
    • (2002) Cell , vol.111 , pp. 197-208
    • Müller, J.1
  • 133
    • 0037111831 scopus 로고    scopus 로고
    • Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of zeste protein
    • Kuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P. & Reinberg, D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of zeste protein. Genes Dev. 22, 2893-2905 (2002).
    • (2002) Genes Dev. , vol.22 , pp. 2893-2905
    • Kuzmichev, A.1    Nishioka, K.2    Erdjument-Bromage, H.3    Tempst, P.4    Reinberg, D.5
  • 134
    • 84873513937 scopus 로고    scopus 로고
    • A histone mutant reproduces the phenotype caused by loss of histone-modifying factor Polycomb
    • Pengelly, A. R., Copur, Ö., Jäckle, H., Herzig, A. & Müller, J. A histone mutant reproduces the phenotype caused by loss of histone-modifying factor Polycomb. Science 339, 698-699 (2013).
    • (2013) Science , vol.339 , pp. 698-699
    • Pengelly, A.R.1    Copur, Ö.2    Jäckle, H.3    Herzig, A.4    Müller, J.5
  • 135
    • 3042801308 scopus 로고    scopus 로고
    • SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex
    • Cao, R. & Zhang, Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell 15, 57-67 (2004).
    • (2004) Mol. Cell , vol.15 , pp. 57-67
    • Cao, R.1    Zhang, Y.2
  • 136
    • 66249121737 scopus 로고    scopus 로고
    • AEBP2 as a potential targeting protein for Polycomb repression complex PRC2
    • Kim, H., Kang, K. & Kim, J. AEBP2 as a potential targeting protein for Polycomb repression complex PRC2. Nucl. Acids Res. 37, 2940-2950 (2009).
    • (2009) Nucl. Acids Res. , vol.37 , pp. 2940-2950
    • Kim, H.1    Kang, K.2    Kim, J.3
  • 137
    • 84881497258 scopus 로고    scopus 로고
    • Molecular architecture of human Polycomb repre ssive complex
    • Ciferri, C. et al. Molecular architecture of human Polycomb repre ssive complex. eLife 1, e00005 (2012).
    • (2012) ELife , vol.1
    • Ciferri, C.1
  • 138
    • 33745151459 scopus 로고    scopus 로고
    • A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities
    • Klymenko, T. et al. A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. Genes Dev. 20, 1110-1122 (2006).
    • (2006) Genes Dev. , vol.20 , pp. 1110-1122
    • Klymenko, T.1
  • 139
    • 57049141484 scopus 로고    scopus 로고
    • Dynamic regulation by Polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila
    • Oktaba, K. et al. Dynamic regulation by Polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila. Develop. Cell 15, 877-889 (2008).
    • (2008) Develop. Cell , vol.15 , pp. 877-889
    • Oktaba, K.1
  • 140
    • 78650684739 scopus 로고    scopus 로고
    • GCrich sequence elements recruit PRC2 in mammalian ES cells
    • Mendenhall, E. M. et al. GC?rich sequence elements recruit PRC2 in mammalian ES cells. PLoS Genet. 6, e1001244 (2010).
    • (2010) PLoS Genet. , vol.6
    • Mendenhall, E.M.1
  • 141
    • 84860370054 scopus 로고    scopus 로고
    • Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells
    • Vella, P., Barozzi, I., Cuomo, A., Bonaldi, T. & Pasini, D. Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells. Nucleic Acids Res. 40, 3403-3418 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. 3403-3418
    • Vella, P.1    Barozzi, I.2    Cuomo, A.3    Bonaldi, T.4    Pasini, D.5
  • 142
    • 77952429798 scopus 로고    scopus 로고
    • Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
    • Scheuermann, J. C. et al. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature 465, 243-247 (2010).
    • (2010) Nature , vol.465 , pp. 243-247
    • Scheuermann, J.C.1
  • 143
    • 81055140863 scopus 로고    scopus 로고
    • NcRNA-and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs
    • Yang, L. et al. ncRNA-and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell 147, 773-788 (2011).
    • (2011) Cell , vol.147 , pp. 773-788
    • Yang, L.1
  • 145
    • 33845799903 scopus 로고    scopus 로고
    • Polycomb silencing mechanisms and the management of genomic programmes
    • Schwartz, Y. B. and Pirrotta, V. Polycomb silencing mechanisms and the management of genomic programmes. Nature Rev. Genet. 8, 9-22 (2007).
    • (2007) Nature Rev. Genet. , vol.8 , pp. 9-22
    • Schwartz, Y.B.1    Pirrotta, V.2


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