Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway

ACS Chemical Biology

Volumn 11, Issue 9, 2016, Pages 2642-2654

  Demars, Matthew D ^a   Sheng, Fang ^b   Park, Sung Ryeol ^a   Lowell, Andrew N ^a   Podust, Larissa M ^b   Sherman, David H ^a,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGLYCONE; CYTOCHROME P450; CYTOCHROME P450 MYCCI; ERYTHROMYCIN; FERREDOXIN; MACROCYCLIC COMPOUND; MACROLIDE; MYCINAMICIN; MYCINAMICIN DERIVATIVE; MYCINAMICIN VIII; NARBOMYCIN; PIKROMYCIN; TYLOSIN; UNCLASSIFIED DRUG; MYCINAMICINS;

ANTIBIOTIC BIOSYNTHESIS; APPARENT DISSOCIATION CONSTANT; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOCATALYST; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVITY; GENE CLUSTER; GLYCOSYLATION; MICROMONOSPORA; MICROMONOSPORA GRISEORUBIDA; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; STEADY STATE; STREPTOMYCES; STREPTOMYCES BIKINIENSIS; STREPTOMYCES FRADIAE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; HYDROXYLATION; METABOLISM;

BIOCATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; MACROLIDES; MOLECULAR STRUCTURE; SUBSTRATE SPECIFICITY;

EID: 84987791152     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.6b00479     Document Type: Article

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