The mycinose-biosynthetic genes of Streptomyces fradiae, producer of tylosin

Journal of Industrial Microbiology and Biotechnology

Volumn 23, Issue 2, 1999, Pages 118-122

  Bate, N ^a   Cundliffe, E ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Antibiotic biosynthetic genes; Mycinose; Streptomyces fradiae; Tylosin production

Indexed keywords

ALLOSE; CARBOHYDRATE; EPIMERASE; FERREDOXIN; LACTONE; MACROLIDE; MYCINOSE; OXIDOREDUCTASE; TYLOSIN; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIAL GENE; GENE CLUSTER; HYDROXYLATION; METHYLATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; STREPTOMYCES FRADIAE;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); PROKARYOTA; STREPTOMYCES FRADIAE; UNCULTURED ACTINOMYCETE;

EID: 0032872074     PISSN: 13675435     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jim.2900707     Document Type: Article

References (31)

1. 1 Andrianopoulos K, L Wang and PR Reeves. 1998. Identification of the fucose synthetase gene in the colanic acid gene cluster of Escherichia coli K-12. J Bacteriol 180: 998-1001.
2. 2 Baltz RH and ET Seno. 1981. Properties of Streptomyces fradiae mutants blocked in biosynthesis of the macrolide antibiotic tylosin. Antimicrob Agents Chemother 20: 214-225.
3. 3 Baltz RH and ET Seno. 1988. Genetics of Streptomyces fradiae and tylosin biosynthesis. Annu Rev Microbiol 42: 547-574.
4. 4 Baltz RH, ET Seno, J Stonesifer and GM Wild. 1983. Biosynthesis of the macrolide antibiotic tylosin. A preferred pathway from tylactone to tylosin. J Antibiot 36: 131-141.
5. 5 Bate N, AR Butler, AR Gandecha and E Cundliffe. 1999. Multiple regulatory genes in the tylosin-biosynthetic cluster of Streptomyces fradiae. Chem Biol 6: 617-624.
6. 6 Bauer NJ, AJ Kreuzman, JE Dotzlaf and W-K Yeh. 1988. Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine: macrocin O-methyltransferase from Streptomyces fradiae. J Biol Chem 263: 15619-15625.
7. 7 Beckmann RJ, K Cox and ET Seno. 1989. A cluster of tylosin biosynthetic genes is interrupted by a structurally unstable segment containing four repeated sequences. In: Genetics and Molecular Biology of Industrial Microorganisms (Hershberger CL, Queener SW and Hegeman G, eds), pp 176-186, American Society for Microbiology, Washington, DC.
8. 8 Fishman SE, K Cox, JL Larson, PA Reynolds, ET Seno, W-K Yeh, R Van Frank and CL Hershberger. 1987. Cloning genes for the biosynthesis of a macrolide antibiotic. Proc Natl Acad Sci USA 84: 8248-8252.
9. 9 Fouces R, E Mellado, B Diez and JL Barredo. 1999. The tylosin biosynthetic cluster from Streptomyces fradiae: genetic organization of the left region. Microbiology 145: 855-868.
10. 10 Gaisser S, GA Böhm, J Cortés and PF Leadlay. 1997. Analysis of seven genes from the eryAl-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea. Mol Gen Genet 256: 239-251.
11. 11 Gandecha AR and E Cundliffe. 1996. Molecular analysis of tlrD, an MLS resistance determinant from the tylosin producer, Streptomyces fradiae. Gene 180: 173-176.
12. 12 Gandecha AR, SL Large and E Cundliffe. 1997. Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome. Gene 184: 197-203.
13. 13 Inouye M, H Suzuki, Y Takada, N Muto, S Horinouchi and T Beppu. 1994. A gene encoding mycinamicin III O-methyltransferase from Micromonospora griseorubida. Gene 141: 121-124.
14. 14 Janssen GR and MJ Bibb. 1993. Derivatives of pUC18 that have Bg/II sites flanking a modified multiple cloning site and that retain the ability to identify recombinant clones by visual screening of Escherichia coli colonies. Gene 124: 133-134.
15. 15 Kagan RM and S Clarke. 1994. Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes. Arch Biochem Biophys 310: 417-427.
16. 16 Kreuzman AJ, JR Turner and W-K Yeh. 1988 Two distinctive O-methyltransferases catalysing penultimate and terminal reactions of macrolide (tylosin) biosynthesis. J Biol Chem 263: 15626-15633.
17. 17 Merson-Davies LA and E Cundliffe. 1994. Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome. Mol Microbiol 13: 349-355.
18. 18 Munro AW and JG Lindsay. 1996. Bacterial cytochromes P-450. Mol Microbiol 20: 1115-1125.
19. 19 O'Keefe DP, KJ Gibson, MH Emptage, R Lenstra, JA Romesser, PJ Litle and CA Omer. 1991. Ferredoxins from two sulfonylurea herbicide monooxygenase systems in Streptomyces griseolus. Biochemistry 30: 447-455.
20. 20 Omer CA, R Lenstra, PJ Litle, C Dean, JM Tepperman, KJ Leto, JA Romesser and DP O'Keefe. 1990. Genes for two herbicide-inducible cytochromes P-450 from Streptomyces griseolus. J Bacteriol 172: 3335-3345.
21. 21 Pissowotzki K, K Mansouri and W Piepersberg. 1991. Genetics of streptomycin production in Streptomyces griseus: molecular structure and putative function of genes strELMB2N. Mol Gen Genet 231: 113-123.
22. 22 Poulos TL, BC Finzel and AJ Howard. 1987. High-resolution crystal structure of cytochrome P450cam. J Mol Biol 195: 687-700.
23. 23 Rosteck Jr PR, PA Reynolds and CL Hershberger. 1991. Homology between proteins controlling Streptomyces fradiae tylosin resistance and ATP-binding transport. Gene 102: 27-32.
24. 24 Seno ET and RH Baltz. 1981. Properties of S-adenosyl-L-methionine: macrocin O-methyltransferase in extracts of Streptomyces fradiae strains which produce normal or elevated levels of tylosin and in mutants blocked in specific O-methylations. Antimicrob Agents Chemother 20: 370-377.
25. 25 Seno ET and RH Baltz. 1982. S-adenosyl-L-methionine: macrocin O-methyltransferase activities in a series of Streptomyces fradiae mutants that produce different levels of the macrolide antibiotic tylosin. Antimicrob Agents Chemother 21: 758-763.
26. 26 Solenberg PJ, CA Cantwell, AJ Tietz, D McGilvray, SW Queener and RH Baltz. 1996. Transposon mutagenesis in Streptomyces fradiae: identification of a neutral site for the stable insertion of DNA by transposon exchange. Gene 168: 67-72.
27. 27 Stevenson G, K Andrianopoulos, M Hobbs and PR Reeves. 1996. Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid. J Bacteriol 178: 4885-4893.
28. 28 Summers RG, S Donadio, MJ Staver, E Wendt-Pienkowski, CR Hutchinson and L Katz. 1997. Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production. Microbiology 143: 3251-3262.
29. soy (SoyB) from Streptomyces griseus. Mol Microbiol 6: 2125-2134.
30. 30 Wilson VTW and E Cundliffe. 1998. Characterization and targeted disruption of a glycosyltransferase gene in the tylosin producer, Streptomyces fradiae. Gene 214: 95-100.
31. 31 Wilson VTW and E Cundliffe. 1999. Molecular analysis of tlrB, an antibiotic-resistance gene from tylosin-producing Streptomyces fradiae, and discovery of a novel resistance mechanism. J Antibiot 52: 288-296.