Enzymatic hydroxylation of an unactivated methylene C-H bond guided by molecular dynamics simulations

Nature Chemistry

Volumn 7, Issue 8, 2015, Pages 653-660

  Narayan, Alison R H ^a   Jiménez Osés, Gonzalo ^b   Liu, Peng ^b   Negretti, Solymar ^a   Zhao, Wanxiang ^a   Gilbert, Michael M ^a   Ramabhadran, Raghunath O ^b   Yang, Yun Fang ^b   Furan, Lawrence R ^b   Li, Zhe ^b   Podust, Larissa M ^c   Montgomery, John ^a   Houk, K N ^b   Sherman, David H ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; MENTHOL;

ANALOGS AND DERIVATIVES; CATALYSIS; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; HYDROXYLATION; METABOLISM; MOLECULAR DYNAMICS; OXIDATION REDUCTION REACTION; QUANTUM THEORY; STEREOISOMERISM; STREPTOMYCES;

CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; MENTHOL; MOLECULAR DYNAMICS SIMULATION; OXIDATION-REDUCTION; QUANTUM THEORY; STEREOISOMERISM; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 84937899531     PISSN: 17554330     EISSN: 17554349     Source Type: Journal    
DOI: 10.1038/nchem.2285     Document Type: Article

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