Functional analysis and crystallographic structure of clotrimazole bound OleP, a cytochrome P450 epoxidase from Streptomyces antibioticus involved in oleandomycin biosynthesis

Biochimica et Biophysica Acta - General Subjects

Volumn 1860, Issue 3, 2016, Pages 465-475

  Montemiglio, Linda Celeste ^a   Parisi, Giacomo ^a   Scaglione, Antonella ^a   Sciara, Giuliano ^a   Savino, Carmelinda ^b,c   Vallone, Beatrice ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CNR   (Italy)

^c AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

Clotrimazole and Ketoconazole; Crystal structure; Cyp107d1; Epoxigenases; Oleandomycin; P450

Indexed keywords

CLOTRIMAZOLE; CYTOCHROME P450; HEME; KETOCONAZOLE; MYCG PROTEIN; OLEANDOMYCIN; OLEP PROTEIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; EPOXIDASE; OXIDOREDUCTASE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BINDING AFFINITY; BINDING KINETICS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; STREPTOMYCES ANTIBIOTICUS; STRUCTURE ACTIVITY RELATION; BIOSYNTHESIS; CHEMISTRY; CRYSTALLOGRAPHY; ENZYMOLOGY; PHYSIOLOGY;

ANTI-BACTERIAL AGENTS; CATALYTIC DOMAIN; CLOTRIMAZOLE; CRYSTALLOGRAPHY; CYTOCHROME P-450 ENZYME SYSTEM; OLEANDOMYCIN; OXIDOREDUCTASES; PROTEIN STRUCTURE, SECONDARY; STREPTOMYCES ANTIBIOTICUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84951100326     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2015.10.009     Document Type: Article

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