The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae

Journal of Biological Chemistry

Volumn 281, Issue 36, 2006, Pages 26289-26297

  Sherman, David H ^a   Li, Shengying ^a   Yermalitskaya, Liudmila V ^b   Kim, Youngchang ^c   Smith, Jarrod A ^b   Waterman, Michael R ^b   Podust, Larissa M ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME-SUBSTRATE INTERACTION; MACROLIDES; POLYKETIDE BIOSYNTHESIS; STREPTOMYCES VENEZUELAE;

ANTIBIOTICS; BIOSYNTHESIS; CRYSTAL STRUCTURE; HYDROXYLATION; SUBSTRATES; X RAY ANALYSIS;

BIOCHEMISTRY;

CYTOCHROME P450; PIKROMYCIN;

ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; STREPTOMYCES VENEZUELAE; X RAY ANALYSIS; X RAY DIFFRACTION;

AMINO SUGARS; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; LIGANDS; MACROLIDES; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; STREPTOMYCES;

STREPTOMYCES VENEZUELAE;

EID: 33748750539     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M605478200     Document Type: Article

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