Directing group-controlled regioselectivity in an enzymatic C-H bond oxygenation

Journal of the American Chemical Society

Volumn 136, Issue 13, 2014, Pages 4901-4904

  Negretti, Solymar ^a   Narayan, Alison R H ^a   Chiou, Karoline C ^a   Kells, Petrea M ^b   Stachowski, Jessica L ^a   Hansen, Douglas A ^a   Podust, Larissa M ^c   Montgomery, John ^a   Sherman, David H ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO SUGARS; CARBOXYLATION; HYDROXYLATION; SUBSTRATES;

ANCHORING GROUPS; ANCHORING MECHANISM; C-H BOND FUNCTIONALIZATION; C-H FUNCTIONALIZATION; NATURAL PRODUCTS; NATURAL SUBSTRATES; PROTEIN ENGINEERING; SUBSTRATE ENGINEERING;

REGIOSELECTIVITY;

AMINE; CARBON; CYTOCHROME P450 ISOENZYME; HYDROGEN; PROTEIN PIKC; SUGAR; UNCLASSIFIED DRUG; AMINOSUGAR; CYTOCHROME P450; DESOSAMINE; MACROLIDE; PIKC CYTOCHROME P450 HYDROXYLASE; YC-17 MACROLIDE;

ARTICLE; BIOCATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; HYDROGEN BOND; HYDROXYLATION; OXYGENATION; PROTEIN ENGINEERING; PROTEIN METABOLISM; RIGIDITY; STEREOCHEMISTRY; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; STEREOISOMERISM;

AMINO SUGARS; BIOCATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; MACROLIDES; MODELS, MOLECULAR; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 84897520202     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja5016052     Document Type: Article

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