Azole drugs trap cytochrome P450 EryK in alternative conformational states

Biochemistry

Volumn 49, Issue 43, 2010, Pages 9199-9206

  Montemiglio, Linda Celeste ^a   Gianni, Stefano ^a   Vallone, Beatrice ^a   Savino, Carmelinda ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING POCKETS; BIOSYNTHETIC PATHWAY; CONFORMATIONAL STATE; CYTOCHROME P450; ERYTHROMYCIN A; HEME IRON; IMIDAZOLE MOIETY; LIGAND-FREE; OPEN CONFORMATION;

CONFORMATIONS; PORPHYRINS;

LIGANDS;

CLOTRIMAZOLE; CYTOCHROME P450; CYTOCHROME P450 ERYK; KETOCONAZOLE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; MOLECULAR INTERACTION; PRIORITY JOURNAL;

AZOLES; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CLOTRIMAZOLE; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; KETOCONAZOLE; PROTEIN CONFORMATION; SACCHAROPOLYSPORA;

BACTERIA (MICROORGANISMS); SACCHAROPOLYSPORA ERYTHRAEA;

EID: 78049311396     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101062v     Document Type: Article

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