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Volumn 291, Issue 37, 2016, Pages 19474-19486

An organic anion transporter 1 (oat1)-centered metabolic network

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; FATTY ACIDS; METABOLITES; NUCLEOTIDES; REMOTE SENSING;

EID: 84987615793     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.745216     Document Type: Article
Times cited : (44)

References (76)
  • 2
    • 84925285641 scopus 로고    scopus 로고
    • What do drug transporters really do? Nat
    • Nigam, S. K. (2015) What do drug transporters really do? Nat. Rev. Drug Discov. 14, 29-44
    • (2015) Rev. Drug Discov , vol.14 , pp. 29-44
    • Nigam, S.K.1
  • 3
    • 84884698943 scopus 로고    scopus 로고
    • Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways
    • Wu, W., Jamshidi, N., Eraly, S. A., Liu, H. C., Bush, K. T., Palsson, B. O., and Nigam, S. K. (2013) Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways. Drug Metab. Dispos. 41, 1825-1834
    • (2013) Drug Metab. Dispos , vol.41 , pp. 1825-1834
    • Wu, W.1    Jamshidi, N.2    Eraly, S.A.3    Liu, H.C.4    Bush, K.T.5    Palsson, B.O.6    Nigam, S.K.7
  • 4
    • 79954998791 scopus 로고    scopus 로고
    • Remote communication through solute carriers and ATP binding cassette drug transporter pathways: An update on the remote sensing and signaling hypothesis
    • Wu, W., Dnyanmote, A. V., and Nigam, S. K. (2011) Remote communication through solute carriers and ATP binding cassette drug transporter pathways: an update on the remote sensing and signaling hypothesis. Mol. Pharmacol. 79, 795-805
    • (2011) Mol. Pharmacol , vol.79 , pp. 795-805
    • Wu, W.1    Dnyanmote, A.V.2    Nigam, S.K.3
  • 5
    • 84946739389 scopus 로고    scopus 로고
    • Shared ligands between organic anion transporters (OAT1 and OAT6) and odorant receptors
    • Wu, W., Bush, K. T., Liu, H. C., Zhu, C., Abagyan, R., and Nigam, S. K. (2015) Shared ligands between organic anion transporters (OAT1 and OAT6) and odorant receptors. Drug Metab. Dispos. 43, 1855-1863
    • (2015) Drug Metab. Dispos , vol.43 , pp. 1855-1863
    • Wu, W.1    Bush, K.T.2    Liu, H.C.3    Zhu, C.4    Abagyan, R.5    Nigam, S.K.6
  • 6
    • 43749115381 scopus 로고    scopus 로고
    • Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination
    • Truong, D. M., Kaler, G., Khandelwal, A., Swaan, P. W., and Nigam, S. K. (2008) Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination. J. Biol. Chem. 283, 8654-8663
    • (2008) J. Biol. Chem. , vol.283 , pp. 8654-8663
    • Truong, D.M.1    Kaler, G.2    Khandelwal, A.3    Swaan, P.W.4    Nigam, S.K.5
  • 8
    • 33750821441 scopus 로고    scopus 로고
    • Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions
    • Kaler, G., Truong, D. M., Sweeney, D. E., Logan, D. W., Nagle, M., Wu, W., Eraly, S. A., and Nigam, S. K. (2006) Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions. Biochem. Biophys. Res. Commun. 351, 872- 876
    • (2006) Biochem. Biophys. Res. Commun , vol.351 , pp. 872-876
    • Kaler, G.1    Truong, D.M.2    Sweeney, D.E.3    Logan, D.W.4    Nagle, M.5    Wu, W.6    Eraly, S.A.7    Nigam, S.K.8
  • 9
    • 34547196949 scopus 로고    scopus 로고
    • Structural variation governs substrate spec-ificity for organic anion transporter (OAT) homologs: Potential remote sensing by OAT family members
    • Kaler, G., Truong, D. M., Khandelwal, A., Nagle, M., Eraly, S. A., Swaan, P. W., and Nigam, S. K. (2007) Structural variation governs substrate spec-ificity for organic anion transporter (OAT) homologs: potential remote sensing by OAT family members. J. Biol. Chem. 282, 23841-23853
    • (2007) J. Biol. Chem. , vol.282 , pp. 23841-23853
    • Kaler, G.1    Truong, D.M.2    Khandelwal, A.3    Nagle, M.4    Eraly, S.A.5    Swaan, P.W.6    Nigam, S.K.7
  • 10
    • 69549103730 scopus 로고    scopus 로고
    • Toward a systems level understanding of organic anion and other multispecific drug transporters: A remote sensing and signaling hypothesis
    • Ahn, S. Y., and Nigam, S. K. (2009) Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis. Mol. Pharmacol. 76, 481-490
    • (2009) Mol. Pharmacol , vol.76 , pp. 481-490
    • Ahn, S.Y.1    Nigam, S.K.2
  • 12
    • 84856694815 scopus 로고    scopus 로고
    • HIV medications: An update and review of metabolic complications
    • Hester, E. K. (2012) HIV medications: an update and review of metabolic complications. Nutr. Clin. Pract. 27, 51-64
    • (2012) Nutr. Clin. Pract , vol.27 , pp. 51-64
    • Hester, E.K.1
  • 16
    • 1342338182 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel transport protein with very high expression in the kidney
    • Lopez-Nieto, C. E., You, G., Barros, E. J. G., Beier, D. R., and Nigam, S. K. (1996) Molecular cloning and characterization of a novel transport protein with very high expression in the kidney. J. Am. Soc. Nephrol. 7, 1301
    • (1996) J. Am. Soc. Nephrol. , vol.7 , pp. 1301
    • Lopez-Nieto, C.E.1    You, G.2    Barros, E.J.G.3    Beier, D.R.4    Nigam, S.K.5
  • 17
    • 0030940999 scopus 로고    scopus 로고
    • Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney
    • Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J., Beier, D. R., and Nigam, S. K. (1997) Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J. Biol. Chem. 272, 6471- 6478
    • (1997) J. Biol. Chem. , vol.272 , pp. 6471-6478
    • Lopez-Nieto, C.E.1    You, G.2    Bush, K.T.3    Barros, E.J.4    Beier, D.R.5    Nigam, S.K.6
  • 18
    • 71449118407 scopus 로고    scopus 로고
    • Interaction of organic cations with organic anion transporters
    • Ahn, S. Y., Eraly, S. A., Tsigelny, I., and Nigam, S. K. (2009) Interaction of organic cations with organic anion transporters. J. Biol. Chem. 284, 31422-31430
    • (2009) J. Biol. Chem. , vol.284 , pp. 31422-31430
    • Ahn, S.Y.1    Eraly, S.A.2    Tsigelny, I.3    Nigam, S.K.4
  • 19
    • 78649665012 scopus 로고    scopus 로고
    • Vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy
    • Burckhardt, G., and Burckhardt, B. C. (2011) In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy. Handb. Exp. Pharmacol. 201, 29-104
    • (2011) Handb. Exp. Pharmacol. , vol.201 , pp. 29-104
    • Burckhardt, G.1    Burckhardt, B.C.2
  • 20
    • 84930483089 scopus 로고    scopus 로고
    • Organic anion transporters and their implications in pharmacotherapy
    • Emami Riedmaier, A., Nies, A. T., Schaeffeler, E., and Schwab, M. (2012) Organic anion transporters and their implications in pharmacotherapy. Pharmacol. Rev. 64, 421-449
    • (2012) Pharmacol. Rev , vol.64 , pp. 421-449
    • Emami Riedmaier, A.1    Nies, A.T.2    Schaeffeler, E.3    Schwab, M.4
  • 21
    • 0034004157 scopus 로고    scopus 로고
    • Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct
    • Pavlova, A., Sakurai, H., Leclercq, B., Beier, D. R., Yu, A. S., and Nigam, S. K. (2000) Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct. Am. J. Physiol. Renal Physiol. 278, F635- 643
    • (2000) Am. J. Physiol. Renal Physiol , vol.278 , pp. F635-F643
    • Pavlova, A.1    Sakurai, H.2    Leclercq, B.3    Beier, D.R.4    Yu, A.S.5    Nigam, S.K.6
  • 22
    • 75349105185 scopus 로고    scopus 로고
    • Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology
    • VanWert, A. L., Gionfriddo, M. R., and Sweet, D. H. (2010) Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology. Biopharm. Drug Dispos. 31, 1-71
    • (2010) Biopharm. Drug Dispos , vol.31 , pp. 1-71
    • VanWert, A.L.1    Gionfriddo, M.R.2    Sweet, D.H.3
  • 24
    • 0020273461 scopus 로고
    • Renal organic anion transport system: Pharmacological, physiological, and biochemical aspects
    • Møller, J. V., and Sheikh, M. I. (1982) Renal organic anion transport system: pharmacological, physiological, and biochemical aspects. Pharmacol Rev 34, 315-358
    • (1982) Pharmacol Rev , vol.34 , pp. 315-358
    • Møller, J.V.1    Sheikh, M.I.2
  • 25
    • 72049089059 scopus 로고    scopus 로고
    • Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: Pharmacological and toxicological implications
    • Saito, H. (2010) Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: pharmacological and toxicological implications. Pharmacol. Ther. 125, 79-91
    • (2010) Pharmacol. Ther , vol.125 , pp. 79-91
    • Saito, H.1
  • 27
    • 79958226930 scopus 로고    scopus 로고
    • Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1)
    • Wikoff, W. R., Nagle, M. A., Kouznetsova, V. L., Tsigelny, I. F., and Nigam, S. K. (2011) Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J. Proteome Res. 10, 2842-2851
    • (2011) J. Proteome Res. , vol.10 , pp. 2842-2851
    • Wikoff, W.R.1    Nagle, M.A.2    Kouznetsova, L.3    Tsigelny, I.F.4    Nigam, S.K.5
  • 29
    • 54749112371 scopus 로고    scopus 로고
    • Contributes to the regulation of blood pressure
    • contributes to the regulation of blood pressure. J. Am. Soc. Nephrol. 19, 1732-1740
    • J. Am. Soc. Nephrol , vol.19 , pp. 1732-1740
  • 31
    • 77957924740 scopus 로고    scopus 로고
    • Ø A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1
    • Sigurdsson, M. I., Jamshidi, N., Steingrimsson, E., Thiele, I., and Palsson, B. Ø . (2010) A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1. BMC Syst Biol 4, 140
    • (2010) BMC Syst Biol , vol.4 , pp. 140
    • Sigurdsson, M.I.1    Jamshidi, N.2    Steingrimsson, E.3    Thiele, I.4    Palsson, B.5
  • 32
    • 44949225040 scopus 로고    scopus 로고
    • Context-specific metabolic networks are consistent with experiments
    • Becker, S. A., and Palsson, B. O. (2008) Context-specific metabolic networks are consistent with experiments. PLoS Comput. Biol. 4, e1000082
    • (2008) PLoS Comput. Biol , vol.4 , pp. e1000082
    • Becker, S.A.1    Palsson, B.O.2
  • 33
    • 1642457253 scopus 로고    scopus 로고
    • The effects of alternate optimal solutions in constraint-based genome-scale metabolic models
    • Mahadevan, R., and Schilling, C. H. (2003) The effects of alternate optimal solutions in constraint-based genome-scale metabolic models. Metab. Eng. 5, 264-276
    • (2003) Metab. Eng , vol.5 , pp. 264-276
    • Mahadevan, R.1    Schilling, C.H.2
  • 34
    • 67449096729 scopus 로고    scopus 로고
    • Flux balance analysis of biological systems: Applications and challenges
    • Raman, K., and Chandra, N. (2009) Flux balance analysis of biological systems: applications and challenges. Brief Bioinform. 10, 435-449
    • (2009) Brief Bioinform , vol.10 , pp. 435-449
    • Raman, K.1    Chandra, N.2
  • 35
    • 85006232737 scopus 로고    scopus 로고
    • Modeling and simulation of optimal resource management during the diurnal cycle in Emiliania huxleyi by genome-scale reconstruction and an extended flux balance analysis approach
    • Knies, D., Wittmüβ, P., Appel, S., Sawodny, O., Ederer, M., and Feuer, R. (2015) Modeling and simulation of optimal resource management during the diurnal cycle in Emiliania huxleyi by genome-scale reconstruction and an extended flux balance analysis approach. Metabolites 5, 659-676
    • (2015) Metabolites , vol.5 , pp. 659-676
    • Knies, D.1    Wittmü, P.2    Appel, S.3    Sawodny, O.4    Ederer, M.5    Feuer, R.6
  • 36
    • 78049445175 scopus 로고    scopus 로고
    • Drug off-target effects predicted using structural analysis in the context of a metabolic network model
    • Chang, R. L., Xie, L., Xie, L., Bourne, P. E., and Palsson, B. Ø . (2010) Drug off-target effects predicted using structural analysis in the context of a metabolic network model. PLoS Comput. Biol. 6, e1000938
    • (2010) PLoS Comput. Biol. , vol.6 , pp. e1000938
    • Chang, R.L.1    Xie, L.2    Xie, L.3    Bourne, P.E.4    Palsson, B.5    Oslash6
  • 37
    • 0037313750 scopus 로고    scopus 로고
    • Genomescale reconstruction of the Saccharomyces cerevisiae metabolic network
    • Förster, J., Famili, I., Fu, P., Palsson, B. Ø ., and Nielsen, J. (2003) Genomescale reconstruction of the Saccharomyces cerevisiae metabolic network. Genome Res 13, 244-253
    • (2003) Genome Res , vol.13 , pp. 244-253
    • Förster, J.1    Famili, I.2    Fu, P.3    Palsson, B.Ø.4    Nielsen, J.5
  • 38
    • 84855929956 scopus 로고    scopus 로고
    • Using the reconstructed genomescale human metabolic network to study physiology and pathology
    • Bordbar, A., and Palsson, B. O. (2012) Using the reconstructed genomescale human metabolic network to study physiology and pathology. J. Intern. Med. 271, 131-141
    • (2012) J. Intern. Med. , vol.271 , pp. 131-141
    • Bordbar, A.1    Palsson, B.O.2
  • 39
    • 84868583572 scopus 로고    scopus 로고
    • Potent inhibitors of human organic anion transporters 1 and 3 from clinical drug libraries: Discovery and molecular characterization
    • Duan, P., Li, S., Ai, N., Hu, L., Welsh, W. J., and You, G. (2012) Potent inhibitors of human organic anion transporters 1 and 3 from clinical drug libraries: discovery and molecular characterization. Mol. Pharm. 9, 3340-3346
    • (2012) Mol. Pharm , vol.9 , pp. 3340-3346
    • Duan, P.1    Li, S.2    Ai, N.3    Hu, L.4    Welsh, W.J.5    You, G.6
  • 41
    • 0024744116 scopus 로고
    • Nobel lecture: The purine path to chemotherapy
    • Elion, G. B. (1989) Nobel lecture: the purine path to chemotherapy. Biosci. Rep. 9, 509-529
    • (1989) Biosci. Rep , vol.9 , pp. 509-529
    • Elion, G.B.1
  • 42
    • 0024652645 scopus 로고
    • Nobel lecture in physiology or medicine-1988: Selective inhibitors of dihydrofolate reductase
    • Hitchings, G. H., Jr.(1989) Nobel lecture in physiology or medicine-1988: selective inhibitors of dihydrofolate reductase. In Vitro Cell Dev. Biol. 25, 303-310
    • (1989) Vitro Cell Dev Biol. , vol.25 , pp. 303-310
    • Hitchings, G.H.1
  • 43
    • 34247345395 scopus 로고    scopus 로고
    • Comparing the chemical spaces of metabolites and.available chemicals: Models of metabolite-likeness
    • Gupta, S., and Aires-de-Sousa, J. (2007) Comparing the chemical spaces of metabolites and available chemicals: models of metabolite-likeness. Mol. Divers 11, 23-36
    • (2007) Mol. Divers , vol.11 , pp. 23-36
    • Gupta, S.1    Aires-De-Sousa, J.2
  • 44
    • 33750321101 scopus 로고    scopus 로고
    • Comparative QSARand fragments distribution analysis of drugs, druglikes, metabolic substances, and antimicrobial compounds
    • Karakoc, E., Sahinalp, S. C., and Cherkasov, A. (2006) Comparative QSARand fragments distribution analysis of drugs, druglikes, metabolic substances, and antimicrobial compounds. J. Chem. Inf. Model 46, 2167-2182
    • (2006) J. Chem. Inf. Model , vol.46 , pp. 2167-2182
    • Karakoc, E.1    Sahinalp, S.C.2    Cherkasov, A.3
  • 45
    • 71549138352 scopus 로고    scopus 로고
    • Physiochemical property space distribution among human metabolites, drugs and toxins
    • Khanna, V., and Ranganathan, S. (2009) Physiochemical property space distribution among human metabolites, drugs and toxins. BMC Bioinform. 10, S10
    • (2009) BMC Bioinform , vol.10 , pp. S10
    • Khanna, V.1    Ranganathan, S.2
  • 46
    • 84930617065 scopus 로고    scopus 로고
    • Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites
    • O'Hagan, S., and Kell, D. B. (2015) Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites. Front Pharmacol 6, 105
    • (2015) Front Pharmacol , vol.6 , pp. 105
    • O'Hagan, S.1    Kell, D.B.2
  • 47
    • 79957453890 scopus 로고    scopus 로고
    • Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1)
    • Kouznetsova, V. L., Tsigelny, I. F., Nagle, M. A., and Nigam, S. K. (2011) Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1). Bioorg. Med. Chem. 19, 3320-3340
    • (2011) Bioorg. Med. Chem. , vol.19 , pp. 3320-3340
    • Kouznetsova, L.1    Tsigelny, I.F.2    Nagle, M.A.3    Nigam, S.K.4
  • 48
    • 41949132916 scopus 로고    scopus 로고
    • Flexible ligand docking to multiple receptor conformations: A practical alternative
    • Totrov, M., and Abagyan, R. (2008) Flexible ligand docking to multiple receptor conformations: a practical alternative. Curr. Opin. Struct. Biol. 18, 178-184
    • (2008) Curr. Opin. Struct. Biol , vol.18 , pp. 178-184
    • Totrov, M.1    Abagyan, R.2
  • 49
    • 84988661387 scopus 로고    scopus 로고
    • Analysis of molecular properties of drugs interacting with SLC22 transporters, OAT1, OAT3, OCT1, OCT2: A machine-learning approach
    • pii: jpet.116.232660 Downloaded from at ELSEVIER BV on September 9, 2016
    • Liu, H. C., Goldenberg, A., Chen, Y., Lun, C., Wu, W., Bush, K. T., Balac, N., Rodriguez, P., Abagyan, R., and Nigam, S. K. (2016) Analysis of molecular properties of drugs interacting with SLC22 transporters, OAT1, OAT3, OCT1, OCT2: A machine-learning approach. J. Pharmacol. Exp. Ther. pii: jpet.116.232660 Downloaded from http://www.jbc.org/ at ELSEVIER BV on September 9, 2016
    • (2016) J. Pharmacol. Exp. Ther.
    • Liu, H.C.1    Goldenberg, A.2    Chen, Y.3    Lun, C.4    Wu, W.5    Bush, K.T.6    Balac, N.7    Rodriguez, P.8    Abagyan, R.9    Nigam, S.K.10
  • 50
    • 84873407575 scopus 로고    scopus 로고
    • Is there something special about palmitoleate? Curr
    • Hodson, L., and Karpe, F. (2013) Is there something special about palmitoleate? Curr. Opin. Clin. Nutr. Metab. Care 16, 225-231
    • (2013) Opin. Clin. Nutr. Metab. Care , vol.16 , pp. 225-231
    • Hodson, L.1    Karpe, F.2
  • 52
    • 84979865433 scopus 로고    scopus 로고
    • MetaboAnalyst 3.0: Making metabolomics more meaningful
    • Xia, J., Sinelnikov, I. V., Han, B., and Wishart, D. S. (2015) MetaboAnalyst 3.0: making metabolomics more meaningful. Nucleic Acids Res. 43, W251-257
    • (2015) Nucleic Acids Res. , vol.43 , pp. W251-W257
    • Xia, J.1    Sinelnikov, I.V.2    Han, B.3    Wishart, D.S.4
  • 53
    • 0029121732 scopus 로고
    • Intracellular α-ketoglutarate controls the efficacy of renal organic anion transport
    • Pritchard, J. B. (1995) Intracellular α-ketoglutarate controls the efficacy of renal organic anion transport. J. Pharmacol. Exp. Ther. 274, 1278-1284
    • (1995) J. Pharmacol. Exp. Ther , vol.274 , pp. 1278-1284
    • Pritchard, J.B.1
  • 57
    • 84927154577 scopus 로고    scopus 로고
    • Regulatory science perspectives on transporter studies in drug development
    • nd Ed. John Wiley & Sons, Inc., Hoboken, NJ
    • Lee, S. C., Zhang, L., and Huang, S. M. (2014) Regulatory science perspectives on transporter studies in drug development. in Drug Transporters: Molecular Characterization and Role in Drug Disposition (You, G., and Morris, M. E., eds) 2nd Ed., pp. 473-487, John Wiley & Sons, Inc., Hoboken, NJ
    • (2014) Drug Transporters: Molecular Characterization and Role in Drug Disposition , pp. 473-487
    • Lee, S.C.1    Zhang, L.2    Huang, S.M.3
  • 59
    • 84946733480 scopus 로고    scopus 로고
    • Handling of drugs, metabolites, and uremic toxins by kidney proximal tubule drug transporters
    • Nigam, S. K., Wu, W., Bush, K. T., Hoenig, M. P., Blantz, R. C., and Bhatnagar, V. (2015) Handling of drugs, metabolites, and uremic toxins by kidney proximal tubule drug transporters. Clin. J. Am. Soc. Nephrol. 10, 2039-2049
    • (2015) Clin. J. Am. Soc. Nephrol , vol.10 , pp. 2039-2049
    • Nigam, S.K.1    Wu, W.2    Bush, K.T.3    Hoenig, M.P.4    Blantz, R.C.5    Bhatnagar, V.6
  • 60
    • 84978966834 scopus 로고    scopus 로고
    • Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: Potential role of remote sensing and signaling
    • Bhatnagar, V., Richard, E. L., Wu, W., Nievergelt, C. M., Lipkowitz, M. S., Jeff, J., Maihofer, A. X., and Nigam, S. K. (2016) Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling. Clin. Kidney J. 9, 444-453
    • (2016) Clin. Kidney J , vol.9 , pp. 444-453
    • Bhatnagar, V.1    Richard, E.L.2    Wu, W.3    Nievergelt, C.M.4    Lipkowitz, M.S.5    Jeff, J.6    Maihofer, A.X.7    Nigam, S.K.8
  • 61
    • 84896124417 scopus 로고    scopus 로고
    • The role of transporters in toxicity and disease
    • Schuetz, J. D., Swaan, P. W., and Tweedie, D. J. (2014) The role of transporters in toxicity and disease. Drug Metab. Dispos. 42, 541-545
    • (2014) Drug Metab. Dispos , vol.42 , pp. 541-545
    • Schuetz, J.D.1    Swaan, P.W.2    Tweedie, D.J.3
  • 62
    • 84951128933 scopus 로고    scopus 로고
    • Evolutionary analysis and classification of OATs, OCTs, OCTNs, and other SLC22 transporters: Structurefunction implications and analysis of sequence motifs
    • Zhu, C., Nigam, K. B., Date, R. C., Bush, K. T., Springer, S. A., Saier, M. H., Jr, Wu, W., and Nigam, S. K. (2015) Evolutionary analysis and classification of OATs, OCTs, OCTNs, and other SLC22 transporters: structurefunction implications and analysis of sequence motifs. PLoS ONE 10, e0140569
    • (2015) PLoS ONE , vol.10 , pp. e0140569
    • Zhu, C.1    Nigam, K.B.2    Date, R.C.3    Bush, K.T.4    Springer, S.A.5    Saier, M.H.6    Wu, W.7    Nigam, S.K.8
  • 63
    • 78650936423 scopus 로고    scopus 로고
    • Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling
    • Nagle, M. A., Truong, D. M., Dnyanmote, A. V., Ahn, S. Y., Eraly, S. A., Wu, W., and Nigam, S. K. (2011) Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling. J. Biol. Chem. 286, 243-251
    • (2011) J. Biol. Chem. , vol.286 , pp. 243-251
    • Nagle, M.A.1    Truong, D.M.2    Dnyanmote, A.V.3    Ahn, S.Y.4    Eraly, S.A.5    Wu, W.6    Nigam, S.K.7
  • 64
    • 84873059003 scopus 로고    scopus 로고
    • Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue
    • Nagle, M. A., Wu, W., Eraly, S. A., and Nigam, S. K. (2013) Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue. Neurosci. Lett. 534, 133-138
    • (2013) Neurosci. Lett. , vol.534 , pp. 133-138
    • Nagle, M.A.1    Wu, W.2    Eraly, S.A.3    Nigam, S.K.4
  • 66
    • 3242718713 scopus 로고    scopus 로고
    • Metabolic complications associated with the use of highly active antiretroviral therapy in HIV-1-infected adults. Am
    • Monier, P. L., and Wilcox, R. (2004) Metabolic complications associated with the use of highly active antiretroviral therapy in HIV-1-infected adults. Am. J. Med. Sci. 328, 48-56
    • (2004) J. Med. Sci. , vol.328 , pp. 48-56
    • Monier, P.L.1    Wilcox, R.2
  • 67
    • 1442351728 scopus 로고    scopus 로고
    • The cellular pharmacology of nucleoside- and nucleotide-analogue reverse-transcriptase inhibitors and its relationship to clinical toxicities
    • Anderson, P. L., Kakuda, T. N., and Lichtenstein, K. A. (2004) The cellular pharmacology of nucleoside- and nucleotide-analogue reverse-transcriptase inhibitors and its relationship to clinical toxicities. Clin. Infect. Dis. 38, 743-753
    • (2004) Clin. Infect. Dis , vol.38 , pp. 743-753
    • Anderson, P.L.1    Kakuda, T.N.2    Lichtenstein, K.A.3
  • 68
    • 0037217858 scopus 로고    scopus 로고
    • Mitochondrial DNA replication, nucleoside reversetranscriptase inhibitors, and AIDS cardiomyopathy
    • Lewis, W. (2003) Mitochondrial DNA replication, nucleoside reversetranscriptase inhibitors, and AIDS cardiomyopathy. Prog. Cardiovasc. Dis. 45, 305-318
    • (2003) Prog. Cardiovasc. Dis , vol.45 , pp. 305-318
    • Lewis, W.1
  • 69
    • 44949088665 scopus 로고    scopus 로고
    • Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics
    • Vallon, V., Rieg, T., Ahn, S. Y., Wu, W., Eraly, S. A., and Nigam, S. K. (2008) Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. Am. J. Physiol. Renal Physiol. 294, F867- 873
    • (2008) Am. J. Physiol. Renal Physiol , vol.294 , pp. F867-F873
    • Vallon, V.1    Rieg, T.2    Ahn, S.Y.3    Wu, W.4    Eraly, S.A.5    Nigam, S.K.6
  • 70
    • 79959313678 scopus 로고    scopus 로고
    • Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney
    • Sweeney, D. E., Vallon, V., Rieg, T., Wu, W., Gallegos, T. F., and Nigam, S. K. (2011) Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney. Mol. Pharmacol. 80, 147-154
    • (2011) Mol. Pharmacol , vol.80 , pp. 147-154
    • Sweeney, D.E.1    Vallon, V.2    Rieg, T.3    Wu, W.4    Gallegos, T.F.5    Nigam, S.K.6
  • 71
    • 79960666822 scopus 로고    scopus 로고
    • Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury
    • Torres, A. M., Dnyanmote, A. V., Bush, K. T., Wu, W., and Nigam, S. K. (2011) Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury. J. Biol. Chem. 286, 26391-26395
    • (2011) J. Biol. Chem , vol.286 , pp. 26391-26395
    • Torres, A.M.1    Dnyanmote, A.V.2    Bush, K.T.3    Wu, W.4    Nigam, S.K.5
  • 72
    • 84911914091 scopus 로고    scopus 로고
    • Docking to multiple pockets or ligand fields for screening, activity prediction and scaffold hopping
    • Chen, Y. C., Totrov, M., and Abagyan, R. (2014) Docking to multiple pockets or ligand fields for screening, activity prediction and scaffold hopping. Future Med. Chem. 6, 1741-1755
    • (2014) Future Med. Chem , vol.6 , pp. 1741-1755
    • Chen, Y.C.1    Totrov, M.2    Abagyan, R.3
  • 73
    • 37849034064 scopus 로고    scopus 로고
    • Atomic property fields: Generalized 3D pharmacophoric potential for automated ligand superposition, pharmacophore elucidation and 3D QSAR
    • Totrov, M. (2008) Atomic property fields: generalized 3D pharmacophoric potential for automated ligand superposition, pharmacophore elucidation and 3D QSAR. Chem. Biol. Drug Des. 71, 15-27
    • (2008) Chem. Biol. Drug Des , vol.71 , pp. 15-27
    • Totrov, M.1
  • 75
    • 84910157029 scopus 로고    scopus 로고
    • Network-based association of hypoxia-responsive genes with cardiovascular diseases
    • Wang, R. S., Oldham, W. M., and Loscalzo, J. (2014) Network-based association of hypoxia-responsive genes with cardiovascular diseases. New J. Phys. 16, 105014
    • (2014) New J. Phys , vol.16 , pp. 105014
    • Wang, R.S.1    Oldham, W.M.2    Loscalzo, J.3
  • 76
    • 84890087353 scopus 로고    scopus 로고
    • Network analysis reveals functional cross-links between disease and inflammation genes
    • Zhang, Y., Fan, H., Xu, J., Xiao, Y., Xu, Y., Li, Y., and Li, X. (2013) Network analysis reveals functional cross-links between disease and inflammation genes. Sci. Rep. 3, 3426
    • (2013) Sci. Rep , vol.3 , pp. 3426
    • Zhang, Y.1    Fan, H.2    Xu, J.3    Xiao, Y.4    Xu, Y.5    Li, Y.6    Li, X.7


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