-
1
-
-
84938301217
-
A call for systematic research on solute carriers
-
César-Razquin, A., Snijder, B., Frappier-Brinton, T., Isserlin, R., Gyimesi, G., Bai, X., Reithmeier, R. A., Hepworth, D., Hediger, M. A., Edwards, A. M., and Superti-Furga, G. (2015) A call for systematic research on solute carriers. Cell 162, 478-487
-
(2015)
Cell
, vol.162
, pp. 478-487
-
-
César-Razquin, A.1
Snijder, B.2
Frappier-Brinton, T.3
Isserlin, R.4
Gyimesi, G.5
Bai, X.6
Reithmeier, R.A.7
Hepworth, D.8
Hediger, M.A.9
Edwards, A.M.10
Superti-Furga, G.11
-
2
-
-
84925285641
-
What do drug transporters really do? Nat
-
Nigam, S. K. (2015) What do drug transporters really do? Nat. Rev. Drug Discov. 14, 29-44
-
(2015)
Rev. Drug Discov
, vol.14
, pp. 29-44
-
-
Nigam, S.K.1
-
3
-
-
84884698943
-
Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways
-
Wu, W., Jamshidi, N., Eraly, S. A., Liu, H. C., Bush, K. T., Palsson, B. O., and Nigam, S. K. (2013) Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways. Drug Metab. Dispos. 41, 1825-1834
-
(2013)
Drug Metab. Dispos
, vol.41
, pp. 1825-1834
-
-
Wu, W.1
Jamshidi, N.2
Eraly, S.A.3
Liu, H.C.4
Bush, K.T.5
Palsson, B.O.6
Nigam, S.K.7
-
4
-
-
79954998791
-
Remote communication through solute carriers and ATP binding cassette drug transporter pathways: An update on the remote sensing and signaling hypothesis
-
Wu, W., Dnyanmote, A. V., and Nigam, S. K. (2011) Remote communication through solute carriers and ATP binding cassette drug transporter pathways: an update on the remote sensing and signaling hypothesis. Mol. Pharmacol. 79, 795-805
-
(2011)
Mol. Pharmacol
, vol.79
, pp. 795-805
-
-
Wu, W.1
Dnyanmote, A.V.2
Nigam, S.K.3
-
5
-
-
84946739389
-
Shared ligands between organic anion transporters (OAT1 and OAT6) and odorant receptors
-
Wu, W., Bush, K. T., Liu, H. C., Zhu, C., Abagyan, R., and Nigam, S. K. (2015) Shared ligands between organic anion transporters (OAT1 and OAT6) and odorant receptors. Drug Metab. Dispos. 43, 1855-1863
-
(2015)
Drug Metab. Dispos
, vol.43
, pp. 1855-1863
-
-
Wu, W.1
Bush, K.T.2
Liu, H.C.3
Zhu, C.4
Abagyan, R.5
Nigam, S.K.6
-
6
-
-
43749115381
-
Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination
-
Truong, D. M., Kaler, G., Khandelwal, A., Swaan, P. W., and Nigam, S. K. (2008) Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination. J. Biol. Chem. 283, 8654-8663
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 8654-8663
-
-
Truong, D.M.1
Kaler, G.2
Khandelwal, A.3
Swaan, P.W.4
Nigam, S.K.5
-
7
-
-
84919784518
-
The organic anion transporter (OAT) family: A systems biology perspective
-
Nigam, S. K., Bush, K. T., Martovetsky, G., Ahn, S. Y., Liu, H. C., Richard, E., Bhatnagar, V., and Wu, W. (2015) The organic anion transporter (OAT) family: a systems biology perspective. Physiol. Rev. 95, 83-123
-
(2015)
Physiol. Rev
, vol.95
, pp. 83-123
-
-
Nigam, S.K.1
Bush, K.T.2
Martovetsky, G.3
Ahn, S.Y.4
Liu, H.C.5
Richard, E.6
Bhatnagar, V.7
Wu, W.8
-
8
-
-
33750821441
-
Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions
-
Kaler, G., Truong, D. M., Sweeney, D. E., Logan, D. W., Nagle, M., Wu, W., Eraly, S. A., and Nigam, S. K. (2006) Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions. Biochem. Biophys. Res. Commun. 351, 872- 876
-
(2006)
Biochem. Biophys. Res. Commun
, vol.351
, pp. 872-876
-
-
Kaler, G.1
Truong, D.M.2
Sweeney, D.E.3
Logan, D.W.4
Nagle, M.5
Wu, W.6
Eraly, S.A.7
Nigam, S.K.8
-
9
-
-
34547196949
-
Structural variation governs substrate spec-ificity for organic anion transporter (OAT) homologs: Potential remote sensing by OAT family members
-
Kaler, G., Truong, D. M., Khandelwal, A., Nagle, M., Eraly, S. A., Swaan, P. W., and Nigam, S. K. (2007) Structural variation governs substrate spec-ificity for organic anion transporter (OAT) homologs: potential remote sensing by OAT family members. J. Biol. Chem. 282, 23841-23853
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 23841-23853
-
-
Kaler, G.1
Truong, D.M.2
Khandelwal, A.3
Nagle, M.4
Eraly, S.A.5
Swaan, P.W.6
Nigam, S.K.7
-
10
-
-
69549103730
-
Toward a systems level understanding of organic anion and other multispecific drug transporters: A remote sensing and signaling hypothesis
-
Ahn, S. Y., and Nigam, S. K. (2009) Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis. Mol. Pharmacol. 76, 481-490
-
(2009)
Mol. Pharmacol
, vol.76
, pp. 481-490
-
-
Ahn, S.Y.1
Nigam, S.K.2
-
11
-
-
80052406750
-
Linkage of organic anion transporter-1 to metabolic pathways through integrated omics -driven network and functional analysis
-
Ahn, S. Y., Jamshidi, N., Mo, M. L., Wu, W., Eraly, S. A., Dnyanmote, A., Bush, K. T., Gallegos, T. F., Sweet, D. H., Palsson, B.Ø ., and Nigam, S. K. (2011) Linkage of organic anion transporter-1 to metabolic pathways through integrated "omics"-driven network and functional analysis. J. Biol. Chem. 286, 31522-31531
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 31522-31531
-
-
Ahn, S.Y.1
Jamshidi, N.2
Mo, M.L.3
Wu, W.4
Eraly, S.A.5
Dnyanmote, A.6
Bush, K.T.7
Gallegos, T.F.8
Sweet, D.H.9
Palsson, B.Ø.10
Nigam, S.K.11
-
12
-
-
84856694815
-
HIV medications: An update and review of metabolic complications
-
Hester, E. K. (2012) HIV medications: an update and review of metabolic complications. Nutr. Clin. Pract. 27, 51-64
-
(2012)
Nutr. Clin. Pract
, vol.27
, pp. 51-64
-
-
Hester, E.K.1
-
13
-
-
84889982236
-
Impact of chronic diuretic treatment on glucose homeostasis
-
Buscemi, S., Nicolucci, A., Lucisano, G., Galvano, F., Grosso, G., Massenti, F. M., Amodio, E., Bonura, A., Sprini, D., and Rini, G. B. (2013) Impact of chronic diuretic treatment on glucose homeostasis. Diabetol. Metab. Syndr. 5, 80
-
(2013)
Diabetol. Metab. Syndr
, vol.5
, pp. 80
-
-
Buscemi, S.1
Nicolucci, A.2
Lucisano, G.3
Galvano, F.4
Grosso, G.5
Massenti, F.M.6
Amodio, E.7
Bonura, A.8
Sprini, D.9
Rini, G.B.10
-
14
-
-
84897556949
-
The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction
-
Prentice, K. J., Luu, L., Allister, E. M., Liu, Y., Jun, L. S., Sloop, K. W., Hardy, A. B., Wei, L., Jia, W., Fantus, I. G., Sweet, D. H., Sweeney, G., Retnakaran, R., Dai, F. F., and Wheeler, M. B. (2014) The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction. Cell Metab. 19, 653-666
-
(2014)
Cell Metab
, vol.19
, pp. 653-666
-
-
Prentice, K.J.1
Luu, L.2
Allister, E.M.3
Liu, Y.4
Jun, L.S.5
Sloop, K.W.6
Hardy, A.B.7
Wei, L.8
Jia, W.9
Fantus, I.G.10
Sweet, D.H.11
Sweeney, G.12
Retnakaran, R.13
Dai, F.F.14
Wheeler, M.B.15
-
15
-
-
84887108045
-
Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease
-
Sharma, K., Karl, B., Mathew, A. V., Gangoiti, J. A., Wassel, C. L., Saito, R., Pu, M., Sharma, S., You, Y. H., Wang, L., Diamond-Stanic, M., Lindenmeyer, M. T., Forsblom, C., Wu, W., Ix, J. H., et al. (2013) Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J. Am. Soc. Nephrol. 24, 1901-1912
-
(2013)
J. Am. Soc. Nephrol.
, vol.24
, pp. 1901-1912
-
-
Sharma, K.1
Karl, B.2
Mathew, A.V.3
Gangoiti, J.A.4
Wassel, C.L.5
Saito, R.6
Pu, M.7
Sharma, S.8
You, Y.H.9
Wang, L.10
Diamond-Stanic, M.11
Lindenmeyer, M.T.12
Forsblom, C.13
Wu, W.14
Ix, J.H.15
-
16
-
-
1342338182
-
Molecular cloning and characterization of a novel transport protein with very high expression in the kidney
-
Lopez-Nieto, C. E., You, G., Barros, E. J. G., Beier, D. R., and Nigam, S. K. (1996) Molecular cloning and characterization of a novel transport protein with very high expression in the kidney. J. Am. Soc. Nephrol. 7, 1301
-
(1996)
J. Am. Soc. Nephrol.
, vol.7
, pp. 1301
-
-
Lopez-Nieto, C.E.1
You, G.2
Barros, E.J.G.3
Beier, D.R.4
Nigam, S.K.5
-
17
-
-
0030940999
-
Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney
-
Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J., Beier, D. R., and Nigam, S. K. (1997) Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J. Biol. Chem. 272, 6471- 6478
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6471-6478
-
-
Lopez-Nieto, C.E.1
You, G.2
Bush, K.T.3
Barros, E.J.4
Beier, D.R.5
Nigam, S.K.6
-
18
-
-
71449118407
-
Interaction of organic cations with organic anion transporters
-
Ahn, S. Y., Eraly, S. A., Tsigelny, I., and Nigam, S. K. (2009) Interaction of organic cations with organic anion transporters. J. Biol. Chem. 284, 31422-31430
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 31422-31430
-
-
Ahn, S.Y.1
Eraly, S.A.2
Tsigelny, I.3
Nigam, S.K.4
-
19
-
-
78649665012
-
Vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy
-
Burckhardt, G., and Burckhardt, B. C. (2011) In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy. Handb. Exp. Pharmacol. 201, 29-104
-
(2011)
Handb. Exp. Pharmacol.
, vol.201
, pp. 29-104
-
-
Burckhardt, G.1
Burckhardt, B.C.2
-
20
-
-
84930483089
-
Organic anion transporters and their implications in pharmacotherapy
-
Emami Riedmaier, A., Nies, A. T., Schaeffeler, E., and Schwab, M. (2012) Organic anion transporters and their implications in pharmacotherapy. Pharmacol. Rev. 64, 421-449
-
(2012)
Pharmacol. Rev
, vol.64
, pp. 421-449
-
-
Emami Riedmaier, A.1
Nies, A.T.2
Schaeffeler, E.3
Schwab, M.4
-
21
-
-
0034004157
-
Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct
-
Pavlova, A., Sakurai, H., Leclercq, B., Beier, D. R., Yu, A. S., and Nigam, S. K. (2000) Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct. Am. J. Physiol. Renal Physiol. 278, F635- 643
-
(2000)
Am. J. Physiol. Renal Physiol
, vol.278
, pp. F635-F643
-
-
Pavlova, A.1
Sakurai, H.2
Leclercq, B.3
Beier, D.R.4
Yu, A.S.5
Nigam, S.K.6
-
22
-
-
75349105185
-
Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology
-
VanWert, A. L., Gionfriddo, M. R., and Sweet, D. H. (2010) Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology. Biopharm. Drug Dispos. 31, 1-71
-
(2010)
Biopharm. Drug Dispos
, vol.31
, pp. 1-71
-
-
VanWert, A.L.1
Gionfriddo, M.R.2
Sweet, D.H.3
-
23
-
-
33646165531
-
Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice
-
Eraly, S. A., Vallon, V., Vaughn, D. A., Gangoiti, J. A., Richter, K., Nagle, M., Monte, J. C., Rieg, T., Truong, D. M., Long, J. M., Barshop, B. A., Kaler, G., and Nigam, S. K. (2006) Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J. Biol. Chem. 281, 5072-5083
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 5072-5083
-
-
Eraly, S.A.1
Vallon, V.2
Vaughn, D.A.3
Gangoiti, J.A.4
Richter, K.5
Nagle, M.6
Monte, J.C.7
Rieg, T.8
Truong, D.M.9
Long, J.M.10
Barshop, B.A.11
Kaler, G.12
Nigam, S.K.13
-
24
-
-
0020273461
-
Renal organic anion transport system: Pharmacological, physiological, and biochemical aspects
-
Møller, J. V., and Sheikh, M. I. (1982) Renal organic anion transport system: pharmacological, physiological, and biochemical aspects. Pharmacol Rev 34, 315-358
-
(1982)
Pharmacol Rev
, vol.34
, pp. 315-358
-
-
Møller, J.V.1
Sheikh, M.I.2
-
25
-
-
72049089059
-
Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: Pharmacological and toxicological implications
-
Saito, H. (2010) Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: pharmacological and toxicological implications. Pharmacol. Ther. 125, 79-91
-
(2010)
Pharmacol. Ther
, vol.125
, pp. 79-91
-
-
Saito, H.1
-
26
-
-
43049121374
-
Multiple organic anion transporters contribute to net renal excretion of uric acid
-
Eraly, S. A., Vallon, V., Rieg, T., Gangoiti, J. A., Wikoff, W. R., Siuzdak, G., Barshop, B. A., and Nigam, S. K. (2008) Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol. Genomics 33, 180-192
-
(2008)
Physiol. Genomics
, vol.33
, pp. 180-192
-
-
Eraly, S.A.1
Vallon, V.2
Rieg, T.3
Gangoiti, J.A.4
Wikoff, W.R.5
Siuzdak, G.6
Barshop, B.A.7
Nigam, S.K.8
-
27
-
-
79958226930
-
Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1)
-
Wikoff, W. R., Nagle, M. A., Kouznetsova, V. L., Tsigelny, I. F., and Nigam, S. K. (2011) Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J. Proteome Res. 10, 2842-2851
-
(2011)
J. Proteome Res.
, vol.10
, pp. 2842-2851
-
-
Wikoff, W.R.1
Nagle, M.A.2
Kouznetsova, L.3
Tsigelny, I.F.4
Nigam, S.K.5
-
28
-
-
84987652061
-
-
Vallon, V., Eraly, S. A., Wikoff, W. R., Rieg, T., Kaler, G., Truong, D. M., Ahn, S. Y., Mahapatra, N. R., Mahata, S. K., Gangoiti, J. A., Wu, W., Barshop, B. A., Siuzdak, G., and Nigam, S. K. (2008) Organic anion transporter
-
(2008)
Organic anion transporter
-
-
Vallon, V.1
Eraly, S.A.2
Wikoff, W.R.3
Rieg, T.4
Kaler, G.5
Truong, D.M.6
Ahn, S.Y.7
Mahapatra, N.R.8
Mahata, S.K.9
Gangoiti, J.A.10
Wu, W.11
Barshop, B.A.12
Siuzdak, G.13
Nigam, S.K.14
-
29
-
-
54749112371
-
Contributes to the regulation of blood pressure
-
contributes to the regulation of blood pressure. J. Am. Soc. Nephrol. 19, 1732-1740
-
J. Am. Soc. Nephrol
, vol.19
, pp. 1732-1740
-
-
-
30
-
-
84861152254
-
A role for the organic anion transporter OAT3 in renal creatinine secretion in mice
-
Vallon, V., Eraly, S. A., Rao, S. R., Gerasimova, M., Rose, M., Nagle, M., Anzai, N., Smith, T., Sharma, K., Nigam, S. K., and Rieg, T. (2012) A role for the organic anion transporter OAT3 in renal creatinine secretion in mice. Am. J. Physiol. Renal Physiol. 302, F1293-1299
-
(2012)
Am. J. Physiol. Renal Physiol
, vol.302
, pp. F1293-F1299
-
-
Vallon, V.1
Eraly, S.A.2
Rao, S.R.3
Gerasimova, M.4
Rose, M.5
Nagle, M.6
Anzai, N.7
Smith, T.8
Sharma, K.9
Nigam, S.K.10
Rieg, T.11
-
31
-
-
77957924740
-
Ø A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1
-
Sigurdsson, M. I., Jamshidi, N., Steingrimsson, E., Thiele, I., and Palsson, B. Ø . (2010) A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1. BMC Syst Biol 4, 140
-
(2010)
BMC Syst Biol
, vol.4
, pp. 140
-
-
Sigurdsson, M.I.1
Jamshidi, N.2
Steingrimsson, E.3
Thiele, I.4
Palsson, B.5
-
32
-
-
44949225040
-
Context-specific metabolic networks are consistent with experiments
-
Becker, S. A., and Palsson, B. O. (2008) Context-specific metabolic networks are consistent with experiments. PLoS Comput. Biol. 4, e1000082
-
(2008)
PLoS Comput. Biol
, vol.4
, pp. e1000082
-
-
Becker, S.A.1
Palsson, B.O.2
-
33
-
-
1642457253
-
The effects of alternate optimal solutions in constraint-based genome-scale metabolic models
-
Mahadevan, R., and Schilling, C. H. (2003) The effects of alternate optimal solutions in constraint-based genome-scale metabolic models. Metab. Eng. 5, 264-276
-
(2003)
Metab. Eng
, vol.5
, pp. 264-276
-
-
Mahadevan, R.1
Schilling, C.H.2
-
34
-
-
67449096729
-
Flux balance analysis of biological systems: Applications and challenges
-
Raman, K., and Chandra, N. (2009) Flux balance analysis of biological systems: applications and challenges. Brief Bioinform. 10, 435-449
-
(2009)
Brief Bioinform
, vol.10
, pp. 435-449
-
-
Raman, K.1
Chandra, N.2
-
35
-
-
85006232737
-
Modeling and simulation of optimal resource management during the diurnal cycle in Emiliania huxleyi by genome-scale reconstruction and an extended flux balance analysis approach
-
Knies, D., Wittmüβ, P., Appel, S., Sawodny, O., Ederer, M., and Feuer, R. (2015) Modeling and simulation of optimal resource management during the diurnal cycle in Emiliania huxleyi by genome-scale reconstruction and an extended flux balance analysis approach. Metabolites 5, 659-676
-
(2015)
Metabolites
, vol.5
, pp. 659-676
-
-
Knies, D.1
Wittmü, P.2
Appel, S.3
Sawodny, O.4
Ederer, M.5
Feuer, R.6
-
36
-
-
78049445175
-
Drug off-target effects predicted using structural analysis in the context of a metabolic network model
-
Chang, R. L., Xie, L., Xie, L., Bourne, P. E., and Palsson, B. Ø . (2010) Drug off-target effects predicted using structural analysis in the context of a metabolic network model. PLoS Comput. Biol. 6, e1000938
-
(2010)
PLoS Comput. Biol.
, vol.6
, pp. e1000938
-
-
Chang, R.L.1
Xie, L.2
Xie, L.3
Bourne, P.E.4
Palsson, B.5
Oslash6
-
37
-
-
0037313750
-
Genomescale reconstruction of the Saccharomyces cerevisiae metabolic network
-
Förster, J., Famili, I., Fu, P., Palsson, B. Ø ., and Nielsen, J. (2003) Genomescale reconstruction of the Saccharomyces cerevisiae metabolic network. Genome Res 13, 244-253
-
(2003)
Genome Res
, vol.13
, pp. 244-253
-
-
Förster, J.1
Famili, I.2
Fu, P.3
Palsson, B.Ø.4
Nielsen, J.5
-
38
-
-
84855929956
-
Using the reconstructed genomescale human metabolic network to study physiology and pathology
-
Bordbar, A., and Palsson, B. O. (2012) Using the reconstructed genomescale human metabolic network to study physiology and pathology. J. Intern. Med. 271, 131-141
-
(2012)
J. Intern. Med.
, vol.271
, pp. 131-141
-
-
Bordbar, A.1
Palsson, B.O.2
-
39
-
-
84868583572
-
Potent inhibitors of human organic anion transporters 1 and 3 from clinical drug libraries: Discovery and molecular characterization
-
Duan, P., Li, S., Ai, N., Hu, L., Welsh, W. J., and You, G. (2012) Potent inhibitors of human organic anion transporters 1 and 3 from clinical drug libraries: discovery and molecular characterization. Mol. Pharm. 9, 3340-3346
-
(2012)
Mol. Pharm
, vol.9
, pp. 3340-3346
-
-
Duan, P.1
Li, S.2
Ai, N.3
Hu, L.4
Welsh, W.J.5
You, G.6
-
40
-
-
84875822465
-
Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics
-
Wolman, A. T., Gionfriddo, M. R., Heindel, G. A., Mukhija, P., Witkowski, S., Bommareddy, A., and Vanwert, A. L. (2013) Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. Drug Metab. Dispos. 41, 791- 800
-
(2013)
Drug Metab. Dispos.
, vol.41
, pp. 791-800
-
-
Wolman, A.T.1
Gionfriddo, M.R.2
Heindel, G.A.3
Mukhija, P.4
Witkowski, S.5
Bommareddy, A.6
Vanwert, A.L.7
-
41
-
-
0024744116
-
Nobel lecture: The purine path to chemotherapy
-
Elion, G. B. (1989) Nobel lecture: the purine path to chemotherapy. Biosci. Rep. 9, 509-529
-
(1989)
Biosci. Rep
, vol.9
, pp. 509-529
-
-
Elion, G.B.1
-
42
-
-
0024652645
-
Nobel lecture in physiology or medicine-1988: Selective inhibitors of dihydrofolate reductase
-
Hitchings, G. H., Jr.(1989) Nobel lecture in physiology or medicine-1988: selective inhibitors of dihydrofolate reductase. In Vitro Cell Dev. Biol. 25, 303-310
-
(1989)
Vitro Cell Dev Biol.
, vol.25
, pp. 303-310
-
-
Hitchings, G.H.1
-
43
-
-
34247345395
-
Comparing the chemical spaces of metabolites and.available chemicals: Models of metabolite-likeness
-
Gupta, S., and Aires-de-Sousa, J. (2007) Comparing the chemical spaces of metabolites and available chemicals: models of metabolite-likeness. Mol. Divers 11, 23-36
-
(2007)
Mol. Divers
, vol.11
, pp. 23-36
-
-
Gupta, S.1
Aires-De-Sousa, J.2
-
44
-
-
33750321101
-
Comparative QSARand fragments distribution analysis of drugs, druglikes, metabolic substances, and antimicrobial compounds
-
Karakoc, E., Sahinalp, S. C., and Cherkasov, A. (2006) Comparative QSARand fragments distribution analysis of drugs, druglikes, metabolic substances, and antimicrobial compounds. J. Chem. Inf. Model 46, 2167-2182
-
(2006)
J. Chem. Inf. Model
, vol.46
, pp. 2167-2182
-
-
Karakoc, E.1
Sahinalp, S.C.2
Cherkasov, A.3
-
45
-
-
71549138352
-
Physiochemical property space distribution among human metabolites, drugs and toxins
-
Khanna, V., and Ranganathan, S. (2009) Physiochemical property space distribution among human metabolites, drugs and toxins. BMC Bioinform. 10, S10
-
(2009)
BMC Bioinform
, vol.10
, pp. S10
-
-
Khanna, V.1
Ranganathan, S.2
-
46
-
-
84930617065
-
Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites
-
O'Hagan, S., and Kell, D. B. (2015) Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites. Front Pharmacol 6, 105
-
(2015)
Front Pharmacol
, vol.6
, pp. 105
-
-
O'Hagan, S.1
Kell, D.B.2
-
47
-
-
79957453890
-
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1)
-
Kouznetsova, V. L., Tsigelny, I. F., Nagle, M. A., and Nigam, S. K. (2011) Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1). Bioorg. Med. Chem. 19, 3320-3340
-
(2011)
Bioorg. Med. Chem.
, vol.19
, pp. 3320-3340
-
-
Kouznetsova, L.1
Tsigelny, I.F.2
Nagle, M.A.3
Nigam, S.K.4
-
48
-
-
41949132916
-
Flexible ligand docking to multiple receptor conformations: A practical alternative
-
Totrov, M., and Abagyan, R. (2008) Flexible ligand docking to multiple receptor conformations: a practical alternative. Curr. Opin. Struct. Biol. 18, 178-184
-
(2008)
Curr. Opin. Struct. Biol
, vol.18
, pp. 178-184
-
-
Totrov, M.1
Abagyan, R.2
-
49
-
-
84988661387
-
Analysis of molecular properties of drugs interacting with SLC22 transporters, OAT1, OAT3, OCT1, OCT2: A machine-learning approach
-
pii: jpet.116.232660 Downloaded from at ELSEVIER BV on September 9, 2016
-
Liu, H. C., Goldenberg, A., Chen, Y., Lun, C., Wu, W., Bush, K. T., Balac, N., Rodriguez, P., Abagyan, R., and Nigam, S. K. (2016) Analysis of molecular properties of drugs interacting with SLC22 transporters, OAT1, OAT3, OCT1, OCT2: A machine-learning approach. J. Pharmacol. Exp. Ther. pii: jpet.116.232660 Downloaded from http://www.jbc.org/ at ELSEVIER BV on September 9, 2016
-
(2016)
J. Pharmacol. Exp. Ther.
-
-
Liu, H.C.1
Goldenberg, A.2
Chen, Y.3
Lun, C.4
Wu, W.5
Bush, K.T.6
Balac, N.7
Rodriguez, P.8
Abagyan, R.9
Nigam, S.K.10
-
50
-
-
84873407575
-
Is there something special about palmitoleate? Curr
-
Hodson, L., and Karpe, F. (2013) Is there something special about palmitoleate? Curr. Opin. Clin. Nutr. Metab. Care 16, 225-231
-
(2013)
Opin. Clin. Nutr. Metab. Care
, vol.16
, pp. 225-231
-
-
Hodson, L.1
Karpe, F.2
-
51
-
-
84856562561
-
Metscape 2 bioinformatics tool for the analysis and visualization of metabolomics and gene expression data
-
Karnovsky, A., Weymouth, T., Hull, T., Tarcea, V. G., Scardoni, G., Laudanna, C., Sartor, M. A., Stringer, K. A., Jagadish, H. V., Burant, C., Athey, B., and Omenn, G. S. (2012) Metscape 2 bioinformatics tool for the analysis and visualization of metabolomics and gene expression data. Bioinformatics 28, 373-380
-
(2012)
Bioinformatics
, vol.28
, pp. 373-380
-
-
Karnovsky, A.1
Weymouth, T.2
Hull, T.3
Tarcea, V.G.4
Scardoni, G.5
Laudanna, C.6
Sartor, M.A.7
Stringer, K.A.8
Jagadish, H.V.9
Burant, C.10
Athey, B.11
Omenn, G.S.12
-
52
-
-
84979865433
-
MetaboAnalyst 3.0: Making metabolomics more meaningful
-
Xia, J., Sinelnikov, I. V., Han, B., and Wishart, D. S. (2015) MetaboAnalyst 3.0: making metabolomics more meaningful. Nucleic Acids Res. 43, W251-257
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. W251-W257
-
-
Xia, J.1
Sinelnikov, I.V.2
Han, B.3
Wishart, D.S.4
-
53
-
-
0029121732
-
Intracellular α-ketoglutarate controls the efficacy of renal organic anion transport
-
Pritchard, J. B. (1995) Intracellular α-ketoglutarate controls the efficacy of renal organic anion transport. J. Pharmacol. Exp. Ther. 274, 1278-1284
-
(1995)
J. Pharmacol. Exp. Ther
, vol.274
, pp. 1278-1284
-
-
Pritchard, J.B.1
-
54
-
-
0037406406
-
Review on uremic toxins: Classification, concentration, and interindividual variability
-
Vanholder, R., De Smet, R., Glorieux, G., Argiles, A., Baurmeister, U., Brunet, P., Clark, W., Cohen, G., De Deyn, P. P., Deppisch, R., Descamps-Latscha, B., Henle, T., Jorres, A., Lemke, H. D., et al. (2003) Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int. 63, 1934-1943
-
(2003)
Kidney Int.
, vol.63
, pp. 1934-1943
-
-
Vanholder, R.1
De Smet, R.2
Glorieux, G.3
Argiles, A.4
Baurmeister, U.5
Brunet, P.6
Clark, W.7
Cohen, G.8
De Deyn, P.P.9
Deppisch, R.10
Descamps-Latscha, B.11
Henle, T.12
Jorres, A.13
Lemke, H.D.14
-
55
-
-
84863528247
-
Normal and pathologic concentrations of uremic toxins
-
European Uremic Toxin Work Group
-
Duranton, F., Cohen, G., De Smet, R., Rodriguez, M., Jankowski, J., Vanholder, R., Argiles, A., and European Uremic Toxin Work Group (2012) Normal and pathologic concentrations of uremic toxins. J. Am. Soc. Nephrol. 23, 1258-1270
-
(2012)
J. Am. Soc. Nephrol.
, vol.23
, pp. 1258-1270
-
-
Duranton, F.1
Cohen, G.2
De Smet, R.3
Rodriguez, M.4
Jankowski, J.5
Vanholder, R.6
Argiles, A.7
-
56
-
-
84927130771
-
Organic anion transporters
-
nd Ed. John Wiley & Sons, Inc., Hoboken, NJ
-
Bush, K. T., Nagle, M., Truong, D. M., Bhatnagar, V., Kaler, G., Eraly, S. A., Wu, W., and Nigam, S. K. (2014) Organic anion transporters. in Drug transporters: Molecular characterization and role in drug disposition (You, G., and Morris, M. E., eds) 2nd Ed., pp. 25-42, John Wiley & Sons, Inc., Hoboken, NJ
-
(2014)
Drug Transporters: Molecular Characterization and Role in Drug Disposition
, pp. 25-42
-
-
Bush, K.T.1
Nagle, M.2
Truong, D.M.3
Bhatnagar, V.4
Kaler, G.5
Eraly, S.A.6
Wu, W.7
Nigam, S.K.8
-
57
-
-
84927154577
-
Regulatory science perspectives on transporter studies in drug development
-
nd Ed. John Wiley & Sons, Inc., Hoboken, NJ
-
Lee, S. C., Zhang, L., and Huang, S. M. (2014) Regulatory science perspectives on transporter studies in drug development. in Drug Transporters: Molecular Characterization and Role in Drug Disposition (You, G., and Morris, M. E., eds) 2nd Ed., pp. 473-487, John Wiley & Sons, Inc., Hoboken, NJ
-
(2014)
Drug Transporters: Molecular Characterization and Role in Drug Disposition
, pp. 473-487
-
-
Lee, S.C.1
Zhang, L.2
Huang, S.M.3
-
58
-
-
0041831237
-
Novel aspects of renal organic anion transporters
-
Eraly, S. A., Blantz, R. C., Bhatnagar, V., and Nigam, S. K. (2003) Novel aspects of renal organic anion transporters. Curr. Opin. Nephrol. Hypertens. 12, 551-558
-
(2003)
Curr. Opin. Nephrol. Hypertens
, vol.12
, pp. 551-558
-
-
Eraly, S.A.1
Blantz, R.C.2
Bhatnagar, V.3
Nigam, S.K.4
-
59
-
-
84946733480
-
Handling of drugs, metabolites, and uremic toxins by kidney proximal tubule drug transporters
-
Nigam, S. K., Wu, W., Bush, K. T., Hoenig, M. P., Blantz, R. C., and Bhatnagar, V. (2015) Handling of drugs, metabolites, and uremic toxins by kidney proximal tubule drug transporters. Clin. J. Am. Soc. Nephrol. 10, 2039-2049
-
(2015)
Clin. J. Am. Soc. Nephrol
, vol.10
, pp. 2039-2049
-
-
Nigam, S.K.1
Wu, W.2
Bush, K.T.3
Hoenig, M.P.4
Blantz, R.C.5
Bhatnagar, V.6
-
60
-
-
84978966834
-
Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: Potential role of remote sensing and signaling
-
Bhatnagar, V., Richard, E. L., Wu, W., Nievergelt, C. M., Lipkowitz, M. S., Jeff, J., Maihofer, A. X., and Nigam, S. K. (2016) Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling. Clin. Kidney J. 9, 444-453
-
(2016)
Clin. Kidney J
, vol.9
, pp. 444-453
-
-
Bhatnagar, V.1
Richard, E.L.2
Wu, W.3
Nievergelt, C.M.4
Lipkowitz, M.S.5
Jeff, J.6
Maihofer, A.X.7
Nigam, S.K.8
-
61
-
-
84896124417
-
The role of transporters in toxicity and disease
-
Schuetz, J. D., Swaan, P. W., and Tweedie, D. J. (2014) The role of transporters in toxicity and disease. Drug Metab. Dispos. 42, 541-545
-
(2014)
Drug Metab. Dispos
, vol.42
, pp. 541-545
-
-
Schuetz, J.D.1
Swaan, P.W.2
Tweedie, D.J.3
-
62
-
-
84951128933
-
Evolutionary analysis and classification of OATs, OCTs, OCTNs, and other SLC22 transporters: Structurefunction implications and analysis of sequence motifs
-
Zhu, C., Nigam, K. B., Date, R. C., Bush, K. T., Springer, S. A., Saier, M. H., Jr, Wu, W., and Nigam, S. K. (2015) Evolutionary analysis and classification of OATs, OCTs, OCTNs, and other SLC22 transporters: structurefunction implications and analysis of sequence motifs. PLoS ONE 10, e0140569
-
(2015)
PLoS ONE
, vol.10
, pp. e0140569
-
-
Zhu, C.1
Nigam, K.B.2
Date, R.C.3
Bush, K.T.4
Springer, S.A.5
Saier, M.H.6
Wu, W.7
Nigam, S.K.8
-
63
-
-
78650936423
-
Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling
-
Nagle, M. A., Truong, D. M., Dnyanmote, A. V., Ahn, S. Y., Eraly, S. A., Wu, W., and Nigam, S. K. (2011) Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling. J. Biol. Chem. 286, 243-251
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 243-251
-
-
Nagle, M.A.1
Truong, D.M.2
Dnyanmote, A.V.3
Ahn, S.Y.4
Eraly, S.A.5
Wu, W.6
Nigam, S.K.7
-
64
-
-
84873059003
-
Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue
-
Nagle, M. A., Wu, W., Eraly, S. A., and Nigam, S. K. (2013) Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue. Neurosci. Lett. 534, 133-138
-
(2013)
Neurosci. Lett.
, vol.534
, pp. 133-138
-
-
Nagle, M.A.1
Wu, W.2
Eraly, S.A.3
Nigam, S.K.4
-
65
-
-
84879163885
-
Mitochondrial genomics and antiretroviral therapy-associated metabolic complications in HIV-infected black South Africans: A pilot study
-
Sinxadi, P. Z., Dave, J. A., Samuels, D. C., Heckmann, J. M., Maartens, G., Levitt, N. S., Wester, C. W., Haas, D. W., and Hulgan, T. (2013) Mitochondrial genomics and antiretroviral therapy-associated metabolic complications in HIV-infected black South Africans: a pilot study. AIDS Res. Hum. Retroviruses 29, 1031-1039
-
(2013)
AIDS Res. Hum. Retroviruses
, vol.29
, pp. 1031-1039
-
-
Sinxadi, P.Z.1
Dave, J.A.2
Samuels, D.C.3
Heckmann, J.M.4
Maartens, G.5
Levitt, N.S.6
Wester, C.W.7
Haas, D.W.8
Hulgan, T.9
-
66
-
-
3242718713
-
Metabolic complications associated with the use of highly active antiretroviral therapy in HIV-1-infected adults. Am
-
Monier, P. L., and Wilcox, R. (2004) Metabolic complications associated with the use of highly active antiretroviral therapy in HIV-1-infected adults. Am. J. Med. Sci. 328, 48-56
-
(2004)
J. Med. Sci.
, vol.328
, pp. 48-56
-
-
Monier, P.L.1
Wilcox, R.2
-
67
-
-
1442351728
-
The cellular pharmacology of nucleoside- and nucleotide-analogue reverse-transcriptase inhibitors and its relationship to clinical toxicities
-
Anderson, P. L., Kakuda, T. N., and Lichtenstein, K. A. (2004) The cellular pharmacology of nucleoside- and nucleotide-analogue reverse-transcriptase inhibitors and its relationship to clinical toxicities. Clin. Infect. Dis. 38, 743-753
-
(2004)
Clin. Infect. Dis
, vol.38
, pp. 743-753
-
-
Anderson, P.L.1
Kakuda, T.N.2
Lichtenstein, K.A.3
-
68
-
-
0037217858
-
Mitochondrial DNA replication, nucleoside reversetranscriptase inhibitors, and AIDS cardiomyopathy
-
Lewis, W. (2003) Mitochondrial DNA replication, nucleoside reversetranscriptase inhibitors, and AIDS cardiomyopathy. Prog. Cardiovasc. Dis. 45, 305-318
-
(2003)
Prog. Cardiovasc. Dis
, vol.45
, pp. 305-318
-
-
Lewis, W.1
-
69
-
-
44949088665
-
Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics
-
Vallon, V., Rieg, T., Ahn, S. Y., Wu, W., Eraly, S. A., and Nigam, S. K. (2008) Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. Am. J. Physiol. Renal Physiol. 294, F867- 873
-
(2008)
Am. J. Physiol. Renal Physiol
, vol.294
, pp. F867-F873
-
-
Vallon, V.1
Rieg, T.2
Ahn, S.Y.3
Wu, W.4
Eraly, S.A.5
Nigam, S.K.6
-
70
-
-
79959313678
-
Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney
-
Sweeney, D. E., Vallon, V., Rieg, T., Wu, W., Gallegos, T. F., and Nigam, S. K. (2011) Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney. Mol. Pharmacol. 80, 147-154
-
(2011)
Mol. Pharmacol
, vol.80
, pp. 147-154
-
-
Sweeney, D.E.1
Vallon, V.2
Rieg, T.3
Wu, W.4
Gallegos, T.F.5
Nigam, S.K.6
-
71
-
-
79960666822
-
Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury
-
Torres, A. M., Dnyanmote, A. V., Bush, K. T., Wu, W., and Nigam, S. K. (2011) Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury. J. Biol. Chem. 286, 26391-26395
-
(2011)
J. Biol. Chem
, vol.286
, pp. 26391-26395
-
-
Torres, A.M.1
Dnyanmote, A.V.2
Bush, K.T.3
Wu, W.4
Nigam, S.K.5
-
72
-
-
84911914091
-
Docking to multiple pockets or ligand fields for screening, activity prediction and scaffold hopping
-
Chen, Y. C., Totrov, M., and Abagyan, R. (2014) Docking to multiple pockets or ligand fields for screening, activity prediction and scaffold hopping. Future Med. Chem. 6, 1741-1755
-
(2014)
Future Med. Chem
, vol.6
, pp. 1741-1755
-
-
Chen, Y.C.1
Totrov, M.2
Abagyan, R.3
-
73
-
-
37849034064
-
Atomic property fields: Generalized 3D pharmacophoric potential for automated ligand superposition, pharmacophore elucidation and 3D QSAR
-
Totrov, M. (2008) Atomic property fields: generalized 3D pharmacophoric potential for automated ligand superposition, pharmacophore elucidation and 3D QSAR. Chem. Biol. Drug Des. 71, 15-27
-
(2008)
Chem. Biol. Drug Des
, vol.71
, pp. 15-27
-
-
Totrov, M.1
-
74
-
-
84893009656
-
Methods and approaches in the topology-based analysis of biological pathways
-
Mitrea, C., Taghavi, Z., Bokanizad, B., Hanoudi, S., Tagett, R., Donato, M., Voichita, C., and DrǍghici, S. (2013) Methods and approaches in the topology-based analysis of biological pathways. Front. Physiol. 4, 278
-
(2013)
Front. Physiol.
, vol.4
, pp. 278
-
-
Mitrea, C.1
Taghavi, Z.2
Bokanizad, B.3
Hanoudi, S.4
Tagett, R.5
Donato, M.6
Voichita, C.7
DrǍghici, S.8
-
75
-
-
84910157029
-
Network-based association of hypoxia-responsive genes with cardiovascular diseases
-
Wang, R. S., Oldham, W. M., and Loscalzo, J. (2014) Network-based association of hypoxia-responsive genes with cardiovascular diseases. New J. Phys. 16, 105014
-
(2014)
New J. Phys
, vol.16
, pp. 105014
-
-
Wang, R.S.1
Oldham, W.M.2
Loscalzo, J.3
-
76
-
-
84890087353
-
Network analysis reveals functional cross-links between disease and inflammation genes
-
Zhang, Y., Fan, H., Xu, J., Xiao, Y., Xu, Y., Li, Y., and Li, X. (2013) Network analysis reveals functional cross-links between disease and inflammation genes. Sci. Rep. 3, 3426
-
(2013)
Sci. Rep
, vol.3
, pp. 3426
-
-
Zhang, Y.1
Fan, H.2
Xu, J.3
Xiao, Y.4
Xu, Y.5
Li, Y.6
Li, X.7
|