Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter - Organic anion transporter1 (Oat1)

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 11, 2011, Pages 3320-3340

  Kouznetsova, Valentina L ^a,b,f   Tsigelny, Igor F ^c,g   Nagle, Megha A ^a   Nigam, Sanjay K ^a,d,e  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Metabolite; Molecular database screening; Molecular fingerprint; Molecular flexible alignment; Organic anion transporter; Pharmacophore consensus

Indexed keywords

2 HYDROXY 3 METHYLVALERIC ACID; 2 HYDROXYISOVALERIC ACID; 2 OXO 3 METHYLVALERATE ALPHA KETO BETA METHYLVALERIC ACID; 2 OXOGLUTARATE ALPHA KETOGLUTARIC ACID; 2 OXOISOCAPROIC ACID; 3 HYDROXY 2 METHYLPROPIONIC ACID; 3 HYDROXYBUTYRIC ACID; 3 HYDROXYVALERATE BETA HYDROXYVALERIC ACID; 3 METHYLCROTONYLGLYCINE; 4 AMINOHIPPURIC ACID; 4 HYDROXYPHENYLACETIC ACID; 4 HYDROXYPHENYLLACTATE; 4 HYDROXYPHENYLPYRUVIC ACID; BENZOIC ACID; BETAMIPRON; CHLORPROPAMIDE; CITRININ; ETODOLAC; HEXANOYLGLYCINE; HIPPURIC ACID; N ACETYLASPARTIC ACID; N PROPIONYLGLYCINE; NATEGLINIDE; ORGANIC ANION TRANSPORTER 1; OROTIC ACID; PHENYLPYRUVIC ACID; PRAVASTATIN; TOLBUTAMIDE; UNCLASSIFIED DRUG; URACIL;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HUMAN CELL; HYDROGEN BOND; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEIVER OPERATING CHARACTERISTIC;

ANIMALS; CLUSTER ANALYSIS; COMPUTER SIMULATION; DATABASES, FACTUAL; DRUG DESIGN; MICE; MICE, KNOCKOUT; ORGANIC ANION TRANSPORT PROTEIN 1; PHARMACEUTICAL PREPARATIONS; ROC CURVE;

MURINAE;

EID: 79957453890     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.04.045     Document Type: Article

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