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Volumn 43, Issue 12, 2015, Pages 1855-1863

Shared ligands between organic anion transporters (OAT1 and OAT6) and odorant receptors

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHYLHEXANOATE; 2 HYDROXYGLUTARIC ACID; 2 METHYLBUTYRIC ACID; BENZOIC ACID; BUTYRIC ACID; DIETHYL 2 HYDROXYGLUTARATE; HEPTANOIC ACID DERIVATIVE; HEXANOIC ACID; LIGAND; OAT6 PROTEIN; OCTANOIC ACID; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1; PROPIONIC ACID; UNCLASSIFIED DRUG; METHYL OCTANOATE; OAT6 PROTEIN, MOUSE; OCTANOIC ACID DERIVATIVE; OLFACTORY RECEPTOR; SLC22A6 PROTEIN, MOUSE;

EID: 84946739389     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.115.065250     Document Type: Article
Times cited : (18)

References (54)
  • 1
    • 58149357521 scopus 로고    scopus 로고
    • Update on the molecular physiology of organic anion transporters
    • Ahn SY and Bhatnagar V (2008) Update on the molecular physiology of organic anion transporters. Curr Opin Nephrol Hypertens 17:499-505.
    • (2008) Curr Opin Nephrol Hypertens , vol.17 , pp. 499-505
    • Ahn, S.Y.1    Bhatnagar, V.2
  • 2
    • 71449118407 scopus 로고    scopus 로고
    • Interaction of organic cations with organic anion transporters
    • Ahn SY, Eraly SA, Tsigelny I, and Nigam SK (2009) Interaction of organic cations with organic anion transporters. J Biol Chem 284:31422-31430.
    • (2009) J Biol Chem , vol.284 , pp. 31422-31430
    • Ahn, S.Y.1    Eraly, S.A.2    Tsigelny, I.3    Nigam, S.K.4
  • 4
    • 69549103730 scopus 로고    scopus 로고
    • Toward a systems level understanding of organic anion and other multispecific drug transporters: A remote sensing and signaling hypothesis
    • Ahn SY and Nigam SK (2009) Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis. Mol Pharmacol 76: 481-490.
    • (2009) Mol Pharmacol , vol.76 , pp. 481-490
    • Ahn, S.Y.1    Nigam, S.K.2
  • 5
    • 79959975084 scopus 로고    scopus 로고
    • ChemMine tools: An online service for analyzing and clustering small molecules
    • Backman TW, Cao Y, and Girke T (2011) ChemMine tools: an online service for analyzing and clustering small molecules. Nucleic Acids Res 39:W486-491.
    • (2011) Nucleic Acids Res , vol.39 , pp. W486-W491
    • Backman, T.W.1    Cao, Y.2    Girke, T.3
  • 6
    • 22944433202 scopus 로고    scopus 로고
    • Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6)
    • Bleasby K, Hall LA, Perry JL, Mohrenweiser HW, and Pritchard JB (2005) Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). J Pharmacol Exp Ther 314:923-931.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 923-931
    • Bleasby, K.1    Hall, L.A.2    Perry, J.L.3    Mohrenweiser, H.W.4    Pritchard, J.B.5
  • 10
    • 84925873653 scopus 로고    scopus 로고
    • Nutrient-sensing mechanisms across evolution
    • Chantranupong L, Wolfson RL, and Sabatini DM (2015) Nutrient-sensing mechanisms across evolution. Cell 161:67-83.
    • (2015) Cell , vol.161 , pp. 67-83
    • Chantranupong, L.1    Wolfson, R.L.2    Sabatini, D.M.3
  • 11
    • 84911914091 scopus 로고    scopus 로고
    • Docking to multiple pockets or ligand fields for screening, activity prediction and scaffold hopping
    • Chen YC, Totrov M, and Abagyan R (2014) Docking to multiple pockets or ligand fields for screening, activity prediction and scaffold hopping. Future Med Chem 6:1741-1755.
    • (2014) Future Med Chem , vol.6 , pp. 1741-1755
    • Chen, Y.C.1    Totrov, M.2    Abagyan, R.3
  • 13
    • 84930483089 scopus 로고    scopus 로고
    • Organic anion transporters and their implications in pharmacotherapy
    • Emami Riedmaier A, Nies AT, Schaeffeler E, and Schwab M (2012) Organic anion transporters and their implications in pharmacotherapy. Pharmacol Rev 64:421-449.
    • (2012) Pharmacol Rev , vol.64 , pp. 421-449
    • Emami Riedmaier, A.1    Nies, A.T.2    Schaeffeler, E.3    Schwab, M.4
  • 14
    • 3042630508 scopus 로고    scopus 로고
    • Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters
    • Eraly SA, Monte JC, and Nigam SK (2004) Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Physiol Genomics 18: 12-24.
    • (2004) Physiol Genomics , vol.18 , pp. 12-24
    • Eraly, S.A.1    Monte, J.C.2    Nigam, S.K.3
  • 16
    • 68649108876 scopus 로고    scopus 로고
    • Uptake of materials from the nasal cavity into the blood and brain: Are we finally beginning to understand these processes at the molecular level?
    • Genter MB, Kendig EL, and Knutson MD (2009) Uptake of materials from the nasal cavity into the blood and brain: are we finally beginning to understand these processes at the molecular level? Ann N Y Acad Sci 1170:623-628.
    • (2009) Ann N y Acad Sci , vol.1170 , pp. 623-628
    • Genter, M.B.1    Kendig, E.L.2    Knutson, M.D.3
  • 17
    • 33846692496 scopus 로고    scopus 로고
    • Human renal organic anion transporter 4 operates as an asymmetric urate transporter
    • Hagos Y, Stein D, Ugele B, Burckhardt G, and Bahn A (2007) Human renal organic anion transporter 4 operates as an asymmetric urate transporter. J Am Soc Nephrol 18:430-439.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 430-439
    • Hagos, Y.1    Stein, D.2    Ugele, B.3    Burckhardt, G.4    Bahn, A.5
  • 19
    • 84923107538 scopus 로고    scopus 로고
    • A determinant of odorant specificity is located at the extracellular loop 2-transmembrane domain 4 interface of an Anopheles gambiae odorant receptor subunit
    • Hughes DT, Wang G, Zwiebel LJ, and Luetje CW (2014) A determinant of odorant specificity is located at the extracellular loop 2-transmembrane domain 4 interface of an Anopheles gambiae odorant receptor subunit. Chem Senses 39:761-769.
    • (2014) Chem Senses , vol.39 , pp. 761-769
    • Hughes, D.T.1    Wang, G.2    Zwiebel, L.J.3    Luetje, C.W.4
  • 20
    • 34547124353 scopus 로고    scopus 로고
    • Distinct sensor pathways in the hierarchical control of SNAT2, a putative amino acid transceptor, by amino acid availability
    • Hyde R, Cwiklinski EL, MacAulay K, Taylor PM, and Hundal HS (2007) Distinct sensor pathways in the hierarchical control of SNAT2, a putative amino acid transceptor, by amino acid availability. J Biol Chem 282:19788-19798.
    • (2007) J Biol Chem , vol.282 , pp. 19788-19798
    • Hyde, R.1    Cwiklinski, E.L.2    MacAulay, K.3    Taylor, P.M.4    Hundal, H.S.5
  • 21
    • 0346734163 scopus 로고    scopus 로고
    • Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion
    • Ichida K, Hosoyamada M, Hisatome I, Enomoto A, Hikita M, Endou H, and Hosoya T (2004) Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion. J Am Soc Nephrol 15:164-173.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 164-173
    • Ichida, K.1    Hosoyamada, M.2    Hisatome, I.3    Enomoto, A.4    Hikita, M.5    Endou, H.6    Hosoya, T.7
  • 23
    • 34547196949 scopus 로고    scopus 로고
    • Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members
    • Kaler G, Truong DM, Khandelwal A, Nagle M, Eraly SA, Swaan PW, and Nigam SK (2007) Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem 282:23841-23853.
    • (2007) J Biol Chem , vol.282 , pp. 23841-23853
    • Kaler, G.1    Truong, D.M.2    Khandelwal, A.3    Nagle, M.4    Eraly, S.A.5    Swaan, P.W.6    Nigam, S.K.7
  • 24
  • 27
    • 0029937095 scopus 로고    scopus 로고
    • Selective amplification of protein-coding regions of large sets of genes using statistically designed primer sets
    • López-Nieto CE and Nigam SK (1996) Selective amplification of protein-coding regions of large sets of genes using statistically designed primer sets. Nat Biotechnol 14:857-861.
    • (1996) Nat Biotechnol , vol.14 , pp. 857-861
    • López-Nieto, C.E.1    Nigam, S.K.2
  • 28
    • 1342338182 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel transporter protein with very high expression in the kidney. Abstract
    • Lopez-Nieto CE, You G, Barros EJG, Beier DR, and Nigam SK (1996) Molecular cloning and characterization of a novel transporter protein with very high expression in the kidney. abstract J Am Soc Nephrol 7:1301.
    • (1996) J Am Soc Nephrol , vol.7 , pp. 1301
    • Lopez-Nieto, C.E.1    You, G.2    Barros, E.J.G.3    Beier, D.R.4    Nigam, S.K.5
  • 29
    • 0030940999 scopus 로고    scopus 로고
    • Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney
    • Lopez-Nieto CE, You G, Bush KT, Barros EJ, Beier DR, and Nigam SK (1997) Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem 272:6471-6478.
    • (1997) J Biol Chem , vol.272 , pp. 6471-6478
    • Lopez-Nieto, C.E.1    You, G.2    Bush, K.T.3    Barros, E.J.4    Beier, D.R.5    Nigam, S.K.6
  • 33
    • 4544322271 scopus 로고    scopus 로고
    • Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa
    • Monte JC, Nagle MA, Eraly SA, and Nigam SK (2004) Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun 323:429-436.
    • (2004) Biochem Biophys Res Commun , vol.323 , pp. 429-436
    • Monte, J.C.1    Nagle, M.A.2    Eraly, S.A.3    Nigam, S.K.4
  • 35
    • 78649757442 scopus 로고    scopus 로고
    • Enzymatic conversion of odorants in nasal mucus affects olfactory glomerular activation patterns and odor perception
    • Nagashima A and Touhara K (2010) Enzymatic conversion of odorants in nasal mucus affects olfactory glomerular activation patterns and odor perception. J Neurosci 30:16391-16398.
    • (2010) J Neurosci , vol.30 , pp. 16391-16398
    • Nagashima, A.1    Touhara, K.2
  • 36
    • 84873059003 scopus 로고    scopus 로고
    • Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue
    • Nagle MA, Wu W, Eraly SA, and Nigam SK (2013) Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue. Neurosci Lett 534:133-138.
    • (2013) Neurosci Lett , vol.534 , pp. 133-138
    • Nagle, M.A.1    Wu, W.2    Eraly, S.A.3    Nigam, S.K.4
  • 37
    • 84925285641 scopus 로고    scopus 로고
    • What do drug transporters really do?
    • Nigam SK (2015) What do drug transporters really do? Nat Rev Drug Discov 14:29-44.
    • (2015) Nat Rev Drug Discov , vol.14 , pp. 29-44
    • Nigam, S.K.1
  • 41
    • 77956237495 scopus 로고    scopus 로고
    • Organic anion transporter 6 (Slc22a20) specificity and Sertoli cell-specific expression provide new insight on potential endogenous roles
    • Schnabolk GW, Gupta B, Mulgaonkar A, Kulkarni M, and Sweet DH (2010) Organic anion transporter 6 (Slc22a20) specificity and Sertoli cell-specific expression provide new insight on potential endogenous roles. J Pharmacol Exp Ther 334:927-935.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 927-935
    • Schnabolk, G.W.1    Gupta, B.2    Mulgaonkar, A.3    Kulkarni, M.4    Sweet, D.H.5
  • 42
    • 33746657602 scopus 로고    scopus 로고
    • Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20)
    • Schnabolk GW, Youngblood GL, and Sweet DH (2006) Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20). Am J Physiol Renal Physiol 291:F314-F321.
    • (2006) Am J Physiol Renal Physiol , vol.291 , pp. F314-F321
    • Schnabolk, G.W.1    Youngblood, G.L.2    Sweet, D.H.3
  • 43
    • 0037178852 scopus 로고    scopus 로고
    • Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice
    • Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, and Nigam SK (2002) Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem 277:26934-26943.
    • (2002) J Biol Chem , vol.277 , pp. 26934-26943
    • Sweet, D.H.1    Miller, D.S.2    Pritchard, J.B.3    Fujiwara, Y.4    Beier, D.R.5    Nigam, S.K.6
  • 44
    • 73349092148 scopus 로고    scopus 로고
    • Functioning and evolutionary significance of nutrient transceptors
    • Thevelein JM and Voordeckers K (2009) Functioning and evolutionary significance of nutrient transceptors. Mol Biol Evol 26:2407-2414.
    • (2009) Mol Biol Evol , vol.26 , pp. 2407-2414
    • Thevelein, J.M.1    Voordeckers, K.2
  • 46
    • 37849034064 scopus 로고    scopus 로고
    • Atomic property fields: Generalized 3D pharmacophoric potential for automated ligand superposition, pharmacophore elucidation and 3D QSAR
    • Totrov M (2008) Atomic property fields: generalized 3D pharmacophoric potential for automated ligand superposition, pharmacophore elucidation and 3D QSAR. Chem Biol Drug Des 71: 15-27.
    • (2008) Chem Biol Drug des , vol.71 , pp. 15-27
    • Totrov, M.1
  • 47
    • 43749115381 scopus 로고    scopus 로고
    • Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination
    • Truong DM, Kaler G, Khandelwal A, Swaan PW, and Nigam SK (2008) Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination. J Biol Chem 283:8654-8663.
    • (2008) J Biol Chem , vol.283 , pp. 8654-8663
    • Truong, D.M.1    Kaler, G.2    Khandelwal, A.3    Swaan, P.W.4    Nigam, S.K.5
  • 48
    • 80955151668 scopus 로고    scopus 로고
    • Conformational changes of the multispecific transporter organic anion transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport
    • Tsigelny IF, Kovalskyy D, Kouznetsova VL, Balinskyi O, Sharikov Y, Bhatnagar V, and Nigam SK (2011) Conformational changes of the multispecific transporter organic anion transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport. Cell Biochem Biophys 61:251-259.
    • (2011) Cell Biochem Biophys , vol.61 , pp. 251-259
    • Tsigelny, I.F.1    Kovalskyy, D.2    Kouznetsova, V.L.3    Balinskyi, O.4    Sharikov, Y.5    Bhatnagar, V.6    Nigam, S.K.7
  • 50
    • 75349105185 scopus 로고    scopus 로고
    • Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology
    • VanWert AL, Gionfriddo MR, and Sweet DH (2010) Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology. Biopharm Drug Dispos 31:1-71.
    • (2010) Biopharm Drug Dispos , vol.31 , pp. 1-71
    • VanWert, A.L.1    Gionfriddo, M.R.2    Sweet, D.H.3
  • 51
    • 79958226930 scopus 로고    scopus 로고
    • Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1)
    • Wikoff WR, Nagle MA, Kouznetsova VL, Tsigelny IF, and Nigam SK (2011) Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J Proteome Res 10:2842-2851.
    • (2011) J Proteome Res , vol.10 , pp. 2842-2851
    • Wikoff, W.R.1    Nagle, M.A.2    Kouznetsova, V.L.3    Tsigelny, I.F.4    Nigam, S.K.5
  • 52
    • 67650266683 scopus 로고    scopus 로고
    • Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members
    • Wu W, Baker ME, Eraly SA, Bush KT, and Nigam SK (2009) Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Physiol Genomics 38:116-124.
    • (2009) Physiol Genomics , vol.38 , pp. 116-124
    • Wu, W.1    Baker, M.E.2    Eraly, S.A.3    Bush, K.T.4    Nigam, S.K.5
  • 53
    • 79954998791 scopus 로고    scopus 로고
    • Remote communication through solute carriers and ATP binding cassette drug transporter pathways: An update on the remote sensing and signaling hypothesis
    • Wu W, Dnyanmote AV, and Nigam SK (2011) Remote communication through solute carriers and ATP binding cassette drug transporter pathways: an update on the remote sensing and signaling hypothesis. Mol Pharmacol 79:795-805.
    • (2011) Mol Pharmacol , vol.79 , pp. 795-805
    • Wu, W.1    Dnyanmote, A.V.2    Nigam, S.K.3
  • 54
    • 84884698943 scopus 로고    scopus 로고
    • Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways
    • Wu W, Jamshidi N, Eraly SA, Liu HC, Bush KT, Palsson BO, and Nigam SK (2013) Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways. Drug Metab Dispos 41:1825-1834.
    • (2013) Drug Metab Dispos , vol.41 , pp. 1825-1834
    • Wu, W.1    Jamshidi, N.2    Eraly, S.A.3    Liu, H.C.4    Bush, K.T.5    Palsson, B.O.6    Nigam, S.K.7


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